amitriptyline has been researched along with Cardiovascular Stroke in 18 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As with other cardiovascular complications, amitriptyline toxicity may cause acute myocardial infarction." | 7.73 | Acute myocardial infarction associated with amitriptyline overdose. ( Aksay, E; Atilla, R; Ersel, M; Kiyan, S; Yanturali, S, 2006) |
| "We studied the effects of fluvoxamine and amitriptyline on epicardial activation delay of premature excitations, the effective refractory period, and the incidence of ventricular arrhythmias by programmed electrical ventricular stimulation in the canine heart after myocardial infarction." | 7.69 | Comparative electrophysiological effects of the antidepressants fluvoxamine and amitriptyline in the canine heart after myocardial infarction. ( Hashimoto, H; Ikeda, Y; Nakashima, M; Nishimoto, M; Shimazu, Y; Umemura, K, 1996) |
| "The effects of amitriptyline and maprotiline, standard tricyclic and tetracyclic antidepressants, on intraventricular conduction, the effective refractory period (ERP), and the incidence of ventricular arrhythmias induced by programmed stimulation were studied and compared in dog hearts after myocardial infarction." | 7.68 | Comparative effects of antidepressants, amitriptyline, and maprotiline on intraventricular conduction, effective refractory period, and incidence of ventricular arrhythmias induced by programmed stimulation in dog hearts after myocardial infarction. ( Hashimoto, H; Nakashima, M; Nishimoto, M; Oohara, K; Ozaki, T, 1990) |
| "The antiarrhythmic effects of amitriptyline (1), its secondary amine metabolite nortriptyline (2), as well as cyclobenzaprine (3) and cyproheptadine (4), tertiary amine analogues of 1, were studied in conscious dogs 24 h after myocardial infarction." | 7.66 | Antiarrhythmic activity of amitriptyline analogues in conscious dogs after myocardial infarction: cyproheptadinium methiodide. ( Henderson, JD; Wilkerson, RD, 1980) |
| "To conduct population-based analyses comparing the risk of serious cardiovascular (CV) events (eg, acute myocardial infarction, stroke, congestive heart failure) associated with treatment with milnacipran compared with venlafaxine and amitriptyline, 2 other commonly prescribed drugs that also inhibit reuptake of norepinephrine and serotonin." | 3.77 | Epidemiologic Evaluation of Cardiovascular Risk in Patients Receiving Milnacipran, Venlafaxine, or Amitriptyline: Evidence from French Health Data. ( Boerstoel-Streefland, M; Duh, MS; Guérin, A; Jiang, W; Lefebvre, P; Mease, PJ; Vekeman, F; Zimetbaum, PJ, 2011) |
| " As with other cardiovascular complications, amitriptyline toxicity may cause acute myocardial infarction." | 3.73 | Acute myocardial infarction associated with amitriptyline overdose. ( Aksay, E; Atilla, R; Ersel, M; Kiyan, S; Yanturali, S, 2006) |
| "We studied the effects of fluvoxamine and amitriptyline on epicardial activation delay of premature excitations, the effective refractory period, and the incidence of ventricular arrhythmias by programmed electrical ventricular stimulation in the canine heart after myocardial infarction." | 3.69 | Comparative electrophysiological effects of the antidepressants fluvoxamine and amitriptyline in the canine heart after myocardial infarction. ( Hashimoto, H; Ikeda, Y; Nakashima, M; Nishimoto, M; Shimazu, Y; Umemura, K, 1996) |
| "The effects of amitriptyline and maprotiline, standard tricyclic and tetracyclic antidepressants, on intraventricular conduction, the effective refractory period (ERP), and the incidence of ventricular arrhythmias induced by programmed stimulation were studied and compared in dog hearts after myocardial infarction." | 3.68 | Comparative effects of antidepressants, amitriptyline, and maprotiline on intraventricular conduction, effective refractory period, and incidence of ventricular arrhythmias induced by programmed stimulation in dog hearts after myocardial infarction. ( Hashimoto, H; Nakashima, M; Nishimoto, M; Oohara, K; Ozaki, T, 1990) |
| "The effects of mianserin, a tetracyclic antidepressant, and adinazolam, a new triazolobenzodiazepine which has antidepressant activity, on intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation were studied in the dog heart after myocardial infarction and compared to the effects of amitriptyline, a standard tricyclic antidepressant." | 3.68 | Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction. ( Hashimoto, H; Nagashima, S; Nakashima, M; Nishimoto, M; Ozaki, T, 1990) |
| "The antiarrhythmic effects of amitriptyline (1), its secondary amine metabolite nortriptyline (2), as well as cyclobenzaprine (3) and cyproheptadine (4), tertiary amine analogues of 1, were studied in conscious dogs 24 h after myocardial infarction." | 3.66 | Antiarrhythmic activity of amitriptyline analogues in conscious dogs after myocardial infarction: cyproheptadinium methiodide. ( Henderson, JD; Wilkerson, RD, 1980) |
| " In 1 patient, acute myocardial infarction developed after two 10-mg doses of nortriptyline." | 3.66 | Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged. ( Oei, LS; Rodstein, M, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (50.00) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wilkerson, RD | 2 |
| Henderson, JD | 1 |
| Mease, PJ | 1 |
| Zimetbaum, PJ | 1 |
| Duh, MS | 1 |
| Vekeman, F | 1 |
| Guérin, A | 1 |
| Boerstoel-Streefland, M | 1 |
| Jiang, W | 1 |
| Lefebvre, P | 1 |
| Kiyan, S | 1 |
| Aksay, E | 1 |
| Yanturali, S | 1 |
| Atilla, R | 1 |
| Ersel, M | 1 |
| Nissimov, R | 1 |
| Weiss, S | 1 |
| Sahavi, I | 1 |
| Mozes, K | 1 |
| Galetta, F | 1 |
| Lunardi, M | 1 |
| Cini, G | 1 |
| Stella, MR | 1 |
| Giusti, C | 1 |
| Ikeda, Y | 1 |
| Nishimoto, M | 3 |
| Shimazu, Y | 1 |
| Hashimoto, H | 3 |
| Umemura, K | 1 |
| Nakashima, M | 3 |
| Bolognesi, R | 1 |
| Tsialtas, D | 1 |
| Vasini, P | 1 |
| Conti, M | 1 |
| Manca, C | 1 |
| Zakynthinos, E | 1 |
| Vassilakopoulos, T | 1 |
| Roussos, C | 1 |
| Zakynthinos, S | 1 |
| Rodstein, M | 1 |
| Oei, LS | 1 |
| Sanders, PW | 1 |
| Zaĭtsev, VP | 1 |
| Ozaki, T | 2 |
| Oohara, K | 1 |
| Nagashima, S | 1 |
| Szlabowicz, JW | 1 |
| Stewart, JT | 1 |
| Chamsi-Pasha, H | 1 |
| Barnes, PC | 1 |
| Guthrie, RM | 1 |
| Lott, JA | 1 |
| Silverman, G | 1 |
| Sweet, RL | 1 |
| Sheffield, LT | 1 |
18 other studies available for amitriptyline and Cardiovascular Stroke
| Article | Year |
|---|---|
Antiarrhythmic activity of amitriptyline analogues in conscious dogs after myocardial infarction: cyproheptadinium methiodide.
Topics: Amitriptyline; Animals; Anti-Arrhythmia Agents; Cyproheptadine; Dogs; Hemodynamics; Myocardial Infar | 1980 |
Epidemiologic Evaluation of Cardiovascular Risk in Patients Receiving Milnacipran, Venlafaxine, or Amitriptyline: Evidence from French Health Data.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; | 2011 |
Acute myocardial infarction associated with amitriptyline overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Creatine Kinase, MB Form; Drug Overdose; Ele | 2006 |
[Cardiac arrhythmias and electrocardiographic abnormalities in amitriptyline poisoning].
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Diagnosis, Differential; Electrocardiography; Female; Hu | 1981 |
[Cardiovascular effects of amitriptyline in therapeutic dosages. Echocardiographic study].
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Cardiac Surgical Procedures; Cardiovascular S | 1993 |
Comparative electrophysiological effects of the antidepressants fluvoxamine and amitriptyline in the canine heart after myocardial infarction.
Topics: Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; | 1996 |
Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; | 1997 |
Abnormal atrial and ventricular repolarisation resembling myocardial injury after tricyclic antidepressant drug intoxication.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Diagnosis, Differential; Electrocardiography | 2000 |
Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; | 1979 |
The antiarrhythmic action of amitriptyline on arrhythmias associated with myocardial infarction in dogs.
Topics: Amitriptyline; Animals; Anti-Arrhythmia Agents; Dogs; Female; Hemodynamics; Male; Methacholine Compo | 1978 |
[Use of amitriptyline for the treatment of mental disorders in patients with myocardial infarct].
Topics: Adult; Amitriptyline; Humans; Male; Middle Aged; Myocardial Infarction; Neurotic Disorders | 1975 |
Comparative effects of antidepressants, amitriptyline, and maprotiline on intraventricular conduction, effective refractory period, and incidence of ventricular arrhythmias induced by programmed stimulation in dog hearts after myocardial infarction.
Topics: Action Potentials; Amitriptyline; Animals; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Dogs; E | 1990 |
Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction.
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Antidepressive Agents; Arrhythmias, Cardiac; Benzodiaze | 1990 |
Amitriptyline treatment of agitation associated with anoxic encephalopathy.
Topics: Adult; Aggression; Amitriptyline; Cognition Disorders; Confusion; Humans; Hypoxia, Brain; Male; Myoc | 1990 |
Myocardial infarction: a complication of amitriptyline overdose.
Topics: Adult; Amitriptyline; Diazepam; Female; Humans; Myocardial Infarction | 1988 |
Abnormal serum creatine kinase and MB fraction following an amitriptyline overdose.
Topics: Adult; Amitriptyline; Cell Membrane Permeability; Clinical Enzyme Tests; Creatine Kinase; Female; Hu | 1986 |
Cardiotoxicity of amitriptyline.
Topics: Amitriptyline; Depression; Heart; Humans; Myocardial Infarction | 1972 |
Myocardial infarction after exercise-induced electrocardiographic changes in a patient with variant angina pectoris.
Topics: Amitriptyline; Angina Pectoris; Arteriosclerosis; Catheterization; Diabetes Complications; Electroca | 1974 |