amitriptyline has been researched along with Cardiovascular Diseases in 29 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline was for a long time the sole medication for the management of depression in cardiological patients despite a large number of side effects." | 4.88 | [Antidepressants in cardiology]. ( Kolesnikov, DB; Kotov, AM; Stotsky, AD, 2012) |
| "Mianserin is a tetracyclic compound advocated for the treatment of depressive illness and depression associated with anxiety." | 4.75 | Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1978) |
| "To conduct population-based analyses comparing the risk of serious cardiovascular (CV) events (eg, acute myocardial infarction, stroke, congestive heart failure) associated with treatment with milnacipran compared with venlafaxine and amitriptyline, 2 other commonly prescribed drugs that also inhibit reuptake of norepinephrine and serotonin." | 3.77 | Epidemiologic Evaluation of Cardiovascular Risk in Patients Receiving Milnacipran, Venlafaxine, or Amitriptyline: Evidence from French Health Data. ( Boerstoel-Streefland, M; Duh, MS; Guérin, A; Jiang, W; Lefebvre, P; Mease, PJ; Vekeman, F; Zimetbaum, PJ, 2011) |
| "Adenosine antagonists were found to be effective in improving hypotension, QRS prolongation and survival time in our rat model of amitriptyline toxicity." | 3.72 | Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? ( Akgun, A; Aygoren, O; Gidener, S; Guven, H; Kalkan, S; Tuncok, Y, 2004) |
| " To compare the effects of antidepressant drugs, the electrocardiogram (ECG), vectorcardiogram (VCG), and body surface maps (BSM) were recorded in psychiatric patients without cardiovascular diseases treated by a) TCA amitriptyline or dosulepin (daily dose 50-200 mg, 22 patients), b) lithium (serum level 0." | 3.70 | Antidepressant drugs and heart electrical field. ( Hamplová, J; Horácek, BM; Kittnar, O; Paclt, I; Slavícek, J; Trefný, Z, 1998) |
| "Migraine, particularly migraine with aura, and increased body weight are independent risk factors for cardiovascular disease (CVD)." | 2.74 | Weight change and clinical markers of cardiovascular disease risk during preventive treatment of migraine. ( Bigal, ME; Biondi, DM; Hulihan, J; Lipton, RB; Xiang, J, 2009) |
| "Amitriptyline infusion rats were then randomized into three groups." | 1.35 | Effect of glucagon on amitriptyline-induced cardiovascular toxicity in rats. ( Hocaoglu, N; Kalkan, S; Kaplan, YC; Oransay, K; Tuncok, Y, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (62.07) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aydin, B | 1 |
| Hocaoglu, N | 2 |
| Micili, SC | 1 |
| Ergur, BU | 1 |
| Kalkan, S | 4 |
| Rheker, J | 1 |
| Winkler, A | 1 |
| Doering, BK | 1 |
| Rief, W | 1 |
| Kaplan, YC | 1 |
| Oransay, K | 1 |
| Tuncok, Y | 3 |
| Bigal, ME | 1 |
| Lipton, RB | 1 |
| Biondi, DM | 1 |
| Xiang, J | 1 |
| Hulihan, J | 1 |
| Mease, PJ | 1 |
| Zimetbaum, PJ | 1 |
| Duh, MS | 1 |
| Vekeman, F | 1 |
| Guérin, A | 1 |
| Boerstoel-Streefland, M | 1 |
| Jiang, W | 1 |
| Lefebvre, P | 1 |
| Arıcı, MA | 1 |
| Buyukdeligoz, M | 1 |
| Wielage, R | 1 |
| Bansal, M | 1 |
| Wilson, K | 1 |
| Klein, R | 1 |
| Happich, M | 1 |
| Kotov, AM | 1 |
| Stotsky, AD | 1 |
| Kolesnikov, DB | 1 |
| HORDERN, A | 1 |
| BURT, CG | 1 |
| GORDON, WF | 1 |
| HOLT, NF | 1 |
| Aygoren, O | 1 |
| Akgun, A | 1 |
| Gidener, S | 1 |
| Guven, H | 1 |
| Spencer, PS | 1 |
| Kopera, H | 1 |
| Wenger, TL | 1 |
| Stern, WC | 1 |
| Burgess, CD | 1 |
| Montgomery, SA | 1 |
| Montgomery, DB | 1 |
| Wadsworth, J | 1 |
| James, B | 1 |
| Follmer, CH | 1 |
| Lum, BK | 1 |
| Slavícek, J | 1 |
| Paclt, I | 1 |
| Hamplová, J | 1 |
| Kittnar, O | 1 |
| Trefný, Z | 1 |
| Horácek, BM | 1 |
| Pinder, RM | 1 |
| Brogden, RN | 2 |
| Speight, TM | 2 |
| Avery, GS | 2 |
| Heel, RC | 1 |
| Rollin, P | 1 |
| Antaki, AJ | 1 |
| Harvengt, C | 1 |
| Desager, JP | 1 |
| Vanderbist, M | 1 |
| Bogaert, M | 1 |
| Moerman, E | 1 |
| Boyer, P | 1 |
| Guelfi, JD | 1 |
| Chekalina, ND | 1 |
| Cairncross, KD | 1 |
| Pieschl, D | 1 |
| Richtberg, W | 1 |
| Brüning, J | 1 |
| Jouglard, J | 1 |
| Ohresser, P | 1 |
| Poyen, D | 1 |
| Austran, P | 1 |
| Gouin, F | 1 |
| Leonardelli, M | 1 |
| Tassy, J | 1 |
| Delius, L | 1 |
| Pebay-Peyroula, F | 1 |
| Bismuth, C | 1 |
| Frejaville, JP | 1 |
7 reviews available for amitriptyline and Cardiovascular Diseases
| Article | Year |
|---|---|
Cost-effectiveness of duloxetine in chronic low back pain: a Quebec societal perspective.
Topics: Age Factors; Aged; Amitriptyline; Analgesics; Cardiovascular Diseases; Celecoxib; Chronic Disease; C | 2013 |
[Antidepressants in cardiology].
Topics: Acetamides; Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; Depression; Humans; Sertr | 2012 |
The cardiovascular profile of bupropion.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Blood Pressure; Bupropion; Cardiovascular Disease | 1983 |
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression.
Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Inte | 1977 |
Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness.
Topics: Amitriptyline; Animals; Antidepressive Agents; Carbohydrate Metabolism; Cardiovascular Diseases; Dep | 1978 |
[Poisoning due to tricyclic antidepressants in children and adolescents].
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Cardiovascular Diseases; Central Nervou | 1979 |
[Blood levels of tricyclic antidepressants and their clinical effectiveness (review of the literature)].
Topics: Amitriptyline; Cardiovascular Diseases; Depressive Disorder; Dose-Response Relationship, Drug; Human | 1991 |
5 trials available for amitriptyline and Cardiovascular Diseases
| Article | Year |
|---|---|
Learning to experience side effects after antidepressant intake - Results from a randomized, controlled, double-blind study.
Topics: Adult; Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; Conditioning, Classical; Depre | 2017 |
Weight change and clinical markers of cardiovascular disease risk during preventive treatment of migraine.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Biomarkers; Blood Pressure; Cardiovascular Diseases; | 2009 |
Lack of anticholinergic and cardiovascular effects of mianserin; studies in healthy subjects and heart patients.
Topics: Amitriptyline; Blood Pressure; Cardiovascular Diseases; Clinical Trials as Topic; Depressive Disorde | 1983 |
The cardiovascular profile of bupropion.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Blood Pressure; Bupropion; Cardiovascular Disease | 1983 |
A double-blind comparative clinical study of amoxapine and amitriptyline in depressed, hospitalised patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Amoxapine; Body Weight; Cardiovascular Diseases; Clinical Tr | 1982 |
18 other studies available for amitriptyline and Cardiovascular Diseases
| Article | Year |
|---|---|
Effects of 2-Hydroxypropyl-Beta-Cyclodextrin on Cardiovascular Signs of Amitriptyline Poisoning in a Rat Model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Amitriptyline; Animals; Antidotes; Apoptosis; Arterial Pressure; | 2016 |
Effect of glucagon on amitriptyline-induced cardiovascular toxicity in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiovascular Diseases; C | 2008 |
Epidemiologic Evaluation of Cardiovascular Risk in Patients Receiving Milnacipran, Venlafaxine, or Amitriptyline: Evidence from French Health Data.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; | 2011 |
Effects of BQ-788 on amitriptyline-induced cardiovascular toxicity.
Topics: Amitriptyline; Animals; Antidotes; Arterial Pressure; Cardiovascular Diseases; Endothelin B Receptor | 2013 |
AMITRIPTYLINE IN DEPRESSIVE STATES: SIX-MONTH TREATMENT RESULTS.
Topics: Amitriptyline; Bipolar Disorder; Cardiovascular Diseases; Depression; Depressive Disorder; Drug Ther | 1964 |
Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats?
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiovascular | 2004 |
Amitriptyline and the "cheese" reaction to MAOIs.
Topics: Amitriptyline; Cardiovascular Diseases; Catecholamines; Cheese; Humans; Monoamine Oxidase Inhibitors | 1982 |
Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients.
Topics: Adult; Amitriptyline; Antidepressive Agents; Blood Pressure; Brompheniramine; Cardiovascular Disease | 1980 |
Protective action of diazepam and of sympathomimetic amines against amitryptyline-induced toxicity.
Topics: Amitriptyline; Anesthesia; Animals; Cardiovascular Diseases; Cats; Diazepam; Female; Male; Myocardia | 1982 |
Antidepressant drugs and heart electrical field.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cardiovascular Diseas | 1998 |
Sympathetic nervous system response in acute cardiovascular toxicity induced by amitriptyline in conscious rabbits.
Topics: Amitriptyline; Animals; Blood Pressure; Body Temperature; Cardiovascular Diseases; Catecholamines; E | 1978 |
[Somatic disorders and depressive states].
Topics: Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; Depression; Disease; Drug Hypersensit | 1978 |
Adverse reactions to the tricyclic-antidepressant drugs. Report from Boston Collaborative Drug Surveillance Program.
Topics: Amitriptyline; Anxiety; Arrhythmias, Cardiac; Cardiovascular Diseases; Depression; Female; Heart; Hu | 1972 |
The tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; Depression; Humans; Imipramine | 1972 |
[Saroten retard and its therapeutic possibilities in chronic schizophrenic psychoses. Results of clinical-experimental tests].
Topics: Adult; Amitriptyline; Body Weight; Cardiovascular Diseases; Chronic Disease; Delayed-Action Preparat | 1971 |
[Acute poisoning due to tricyclic antidepressants].
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Cardiovascular Diseases; Female; Humans; Imipra | 1969 |
[Psychovegetative syndrome and its treatment].
Topics: Aged; Amitriptyline; Behavior Therapy; Cardiovascular Diseases; Chlordiazepoxide; Diazepam; Exercise | 1971 |
[Cardiac toxicity of imipramine and imipramine derivatives].
Topics: Adult; Amitriptyline; Cardiovascular Diseases; Female; Heart Block; Humans; Imipramine; Male | 1968 |