amitriptyline has been researched along with Cardiotoxicity in 7 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Cardiotoxicity: Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED)." | 7.96 | Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [ ( Aygun, H; Basol, N; Gul, SS, 2020) |
| "Amitriptyline (AMT) cardiotoxicity is commonly seen with high morbidity and mortality rates in emergency departments." | 7.91 | Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats. ( Aygun, H; Basol, N; Gul, SS, 2019) |
| " We assessed the effect of lipid emulsion on reversing amitriptyline-induced cardiotoxicity, in vivo and in vitro, compared to alkalinization." | 7.88 | Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. ( Hori, K; Kuno, M; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S, 2018) |
| " The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED)." | 3.96 | Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [ ( Aygun, H; Basol, N; Gul, SS, 2020) |
| "Amitriptyline (AMT) cardiotoxicity is commonly seen with high morbidity and mortality rates in emergency departments." | 3.91 | Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats. ( Aygun, H; Basol, N; Gul, SS, 2019) |
| " We assessed the effect of lipid emulsion on reversing amitriptyline-induced cardiotoxicity, in vivo and in vitro, compared to alkalinization." | 3.88 | Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. ( Hori, K; Kuno, M; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Aygun, H | 2 |
| Basol, N | 2 |
| Gul, SS | 2 |
| Tsujikawa, S | 2 |
| Matsuura, T | 2 |
| Hori, K | 2 |
| Mori, T | 2 |
| Kuno, M | 2 |
| Nishikawa, K | 2 |
| Wang, JJ | 1 |
| Villeneuve, E | 1 |
| Gosselin, S | 1 |
| Smolinske, SC | 1 |
| Hoegberg, LCG | 1 |
| Hoffman, RS | 1 |
| Butt, K | 1 |
| Ambati, S | 1 |
| Aydin, B | 1 |
| Hocaoglu, N | 1 |
| Micili, SC | 1 |
| Ergur, BU | 1 |
| Kalkan, S | 1 |
7 other studies available for amitriptyline and Cardiotoxicity
| Article | Year |
|---|---|
Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biomarkers; Cardiotoxic | 2020 |
Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig.
Topics: Acid-Base Equilibrium; Action Potentials; Alkalies; Amitriptyline; Animals; Arterial Pressure; Cardi | 2018 |
In Response.
Topics: Amitriptyline; Animals; Cardiotoxicity; Guinea Pigs; Lipids | 2018 |
Tsujikawa and Lipid Emulsion.
Topics: Amitriptyline; Animals; Cardiotoxicity; Fat Emulsions, Intravenous; Guinea Pigs; Lipids | 2018 |
A Peculiar Wide Complex Tachycardia.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cardiotoxicity; Drug Overdose; Electrocardiography; | 2019 |
Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cardiotonic Agents; Cardiotoxicity; Diseas | 2019 |
Effects of 2-Hydroxypropyl-Beta-Cyclodextrin on Cardiovascular Signs of Amitriptyline Poisoning in a Rat Model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Amitriptyline; Animals; Antidotes; Apoptosis; Arterial Pressure; | 2016 |