amitriptyline has been researched along with Cardiac Diseases in 32 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED)." | 7.96 | Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [ ( Aygun, H; Basol, N; Gul, SS, 2020) |
| "Amitriptyline (AMT) cardiotoxicity is commonly seen with high morbidity and mortality rates in emergency departments." | 7.91 | Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats. ( Aygun, H; Basol, N; Gul, SS, 2019) |
| " We assessed the effect of lipid emulsion on reversing amitriptyline-induced cardiotoxicity, in vivo and in vitro, compared to alkalinization." | 7.88 | Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. ( Hori, K; Kuno, M; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S, 2018) |
| " The cardiotoxicity of amitriptyline (AMT) is a commonly observed toxicity with high morbidity and mortality rates in emergency departments (ED)." | 3.96 | Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [ ( Aygun, H; Basol, N; Gul, SS, 2020) |
| "Amitriptyline (AMT) cardiotoxicity is commonly seen with high morbidity and mortality rates in emergency departments." | 3.91 | Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats. ( Aygun, H; Basol, N; Gul, SS, 2019) |
| " We assessed the effect of lipid emulsion on reversing amitriptyline-induced cardiotoxicity, in vivo and in vitro, compared to alkalinization." | 3.88 | Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig. ( Hori, K; Kuno, M; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S, 2018) |
| "Amitriptyline was infused at 0." | 1.27 | Protective actions of carbocromene against amitriptyline-induced cardiotoxicity in anesthetized rats. ( Fiedler, VB; Martorana, PA; Nitz, RE, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (81.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Aygun, H | 2 |
| Basol, N | 2 |
| Gul, SS | 2 |
| Tsujikawa, S | 1 |
| Matsuura, T | 1 |
| Hori, K | 1 |
| Mori, T | 1 |
| Kuno, M | 1 |
| Nishikawa, K | 1 |
| Akgun, A | 1 |
| Kalkan, S | 1 |
| Hocaoglu, N | 1 |
| Gidener, S | 1 |
| Tuncok, Y | 1 |
| Bek, K | 1 |
| Ozkaya, O | 1 |
| Mutlu, B | 1 |
| Dağdemir, A | 1 |
| Sungur, M | 1 |
| Açikgöz, Y | 1 |
| Işlek, I | 1 |
| Baysal, K | 1 |
| Wolfrum, C | 1 |
| Klieser, E | 1 |
| Lehmann, E | 1 |
| Adams, F | 1 |
| Antelman, SM | 1 |
| Kocan, D | 1 |
| Rowland, N | 1 |
| de Giovanni, L | 1 |
| Chiodo, LA | 1 |
| Kopera, H | 1 |
| Klein, W | 1 |
| Schenk, H | 1 |
| Agnoli, A | 1 |
| Martucci, N | 1 |
| Ciabatti, P | 1 |
| Caratozzolo, P | 1 |
| Rulli, V | 1 |
| Sollecito, A | 1 |
| Matsuda, M | 1 |
| Ma, Y | 1 |
| Henry, JA | 1 |
| Petch, MC | 1 |
| Nayler, WG | 1 |
| Peet, M | 1 |
| Tienari, P | 1 |
| Jaskari, MO | 1 |
| O'Keeffe, DB | 1 |
| Crome, P | 2 |
| Medd, RK | 1 |
| Newman, B | 1 |
| Horák, J | 1 |
| Basová, J | 1 |
| Bartáková, L | 1 |
| Benesová, O | 1 |
| Soucek, K | 1 |
| Zatecká, I | 1 |
| Jelínek, R | 1 |
| Dunn, CG | 1 |
| Gross, D | 1 |
| Knudsen, K | 1 |
| Ricksten, SE | 1 |
| Heath, A | 1 |
| Fiedler, VB | 1 |
| Martorana, PA | 1 |
| Nitz, RE | 1 |
| Mattila, MJ | 1 |
| Saarnivaara, L | 1 |
| Pritchard, MJ | 1 |
| Coull, DC | 1 |
| Crooks, J | 2 |
| Dingwall-Fordyce, I | 2 |
| Scott, AM | 1 |
| Wier, RD | 1 |
| Moir, DC | 2 |
| Weir, RD | 2 |
| Sawyer, P | 1 |
| Turnbull, MJ | 1 |
| Voelkel, A | 1 |
| Postlethwaite, RJ | 1 |
| Price, DA | 1 |
| Crane, GE | 1 |
| Kilpatrick, R | 1 |
| Smith, AJ | 1 |
| Luke, CM | 1 |
| Fiegel, G | 1 |
2 reviews available for amitriptyline and Cardiac Diseases
| Article | Year |
|---|---|
Cardiac toxicity and psychotropic drugs.
Topics: Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Death, Sudden; Electrocardiography; Heart | 1970 |
Advances in medicine.
Topics: Amitriptyline; Cholera; Coronary Disease; Crohn Disease; Diabetes Mellitus; Diet Therapy; Diverticul | 1971 |
2 trials available for amitriptyline and Cardiac Diseases
| Article | Year |
|---|---|
A comparison of the cardiac effects of mianserin and amitriptyline in man.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depression; Dibenzazepines; Electrocardiography; Fem | 1977 |
Medicines evaluation and monitoring group. A follow-up study of cardiac patients receiving amitriptyline.
Topics: Age Factors; Aged; Amitriptyline; Clinical Trials as Topic; Death, Sudden; Follow-Up Studies; Heart | 1973 |
28 other studies available for amitriptyline and Cardiac Diseases
| Article | Year |
|---|---|
Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Biomarkers; Cardiotoxic | 2020 |
Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig.
Topics: Acid-Base Equilibrium; Action Potentials; Alkalies; Amitriptyline; Animals; Arterial Pressure; Cardi | 2018 |
Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cardiotonic Agents; Cardiotoxicity; Diseas | 2019 |
Effects of adenosine receptor antagonists on amitriptyline-induced QRS prolongation in isolated rat hearts.
Topics: Amitriptyline; Animals; Caffeine; Dose-Response Relationship, Drug; Heart; Heart Diseases; In Vitro | 2008 |
Charcoal haemoperfusion in amitriptyline poisoning: experience in 20 children.
Topics: Acute Disease; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Charcoal; Chi | 2008 |
Single case experiments in psychopharmacological trials.
Topics: Adult; Amitriptyline; Chlordiazepoxide; Clinical Trials as Topic; Drug Combinations; Female; Flunitr | 1984 |
Cardiovascular effects of phenelzine and amitriptyline.
Topics: Adult; Aged; Amitriptyline; Cardiovascular System; Depressive Disorder; Heart Diseases; Humans; Midd | 1982 |
Amitriptyline provides long-lasting immunization against sudden cardiac death from cocaine.
Topics: Amitriptyline; Animals; Cocaine; Death, Sudden; Heart Diseases; Male; Rats | 1981 |
Psychotropic drugs and the heart: clinical implications.
Topics: Adult; Age Factors; Aged; Amitriptyline; Dibenzazepines; Double-Blind Method; Drug Therapy, Combinat | 1980 |
[The problem of side-effects: cardiotoxicity (author's transl)].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Dibenzocyclohept | 1981 |
[Cardiac disorders induced by antidepressant drugs (author's transl)].
Topics: Adult; Aged; Amitriptyline; Animals; Antidepressive Agents; Child; Dogs; Electrocardiography; Heart | 1980 |
The antidotal effect of alpha(1)-acid glycoprotein on amitriptyline toxicity in cardiac myocytes.
Topics: Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antidotes; Electroencephalogra | 2001 |
Uptake of catecholamines by human cardiac muscle in vitro.
Topics: Adolescent; Adult; Aged; Amitriptyline; Atrial Function; Biological Transport; Child; Coronary Arter | 1979 |
The effects of physostigmine on amitriptyline induced cardiotoxicity in dogs.
Topics: Amitriptyline; Animals; Dogs; Heart Diseases; Physostigmine | 1979 |
The problem of tricyclic antidepressant poisoning.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; C | 1979 |
Comparative study of the cardiotoxicity of amitriptyline and maprotiline in depressive patients.
Topics: Adult; Amitriptyline; Anthracenes; Depression; Female; Heart Diseases; Humans; Male; Maprotiline; Mi | 1979 |
Treatment of depression in the medically ill geriatric patient: a case report.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Heart Diseases; Humans; Lung Dise | 1977 |
Clonidine interaction in amitriptyline poisoning.
Topics: Amitriptyline; Animals; Blood Pressure; Clonidine; Heart Conduction System; Heart Diseases; Heart Ra | 1988 |
Protective actions of carbocromene against amitriptyline-induced cardiotoxicity in anesthetized rats.
Topics: Amitriptyline; Anesthesia; Animals; Blood Pressure; Chromonar; Coumarins; Electrocardiography; Heart | 1986 |
Amitriptyline toxicity.
Topics: Amitriptyline; Animals; Blood Pressure; Heart; Heart Diseases; Heart Rate; Humans; Norepinephrine; R | 1970 |
Cardiotoxicity of amitriptyline.
Topics: Amitriptyline; Death, Sudden; Heart; Heart Diseases; Humans | 1972 |
Amitriptyline and cardiac disease. Risk of sudden death identified by monitoring system.
Topics: Amitriptyline; Death, Sudden; Heart Diseases; Hospitalization; Humans | 1970 |
Proceedings: Cardiotoxicity of tricyclic antidepressants.
Topics: Amitriptyline; Death, Sudden; Evaluation Studies as Topic; Heart Diseases; Humans | 1972 |
[On the prophylactic treatment of cyclothymic diseases with a carboanhydrase inhibitor (author's transl)].
Topics: Acetazolamide; Amitriptyline; Aortic Valve Stenosis; Carbonic Anhydrase Inhibitors; Haloperidol; Hea | 1973 |
Letter: Amitriptyline and imipramine poisoning in children.
Topics: Amitriptyline; Child; Enuresis; Heart Diseases; Humans; Imipramine; Phenytoin; Poisoning | 1974 |
Tricyclic antidepressants and heart disease.
Topics: Amitriptyline; Antidepressive Agents; Heart Diseases; Humans; Nortriptyline | 1971 |
Amitryptiline and cardiac disease.
Topics: Amitriptyline; Arrhythmias, Cardiac; Depression; Female; Heart Block; Heart Diseases; Humans; Hypote | 1970 |
[Possibilities of treatment of depressive and vegetative conditions in heart patients].
Topics: Adjustment Disorders; Amitriptyline; Animals; Chlordiazepoxide; Heart Diseases; Humans; Male; Middle | 1967 |