amitriptyline has been researched along with Brugada Syndrome in 8 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Brugada Syndrome: An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome." | 7.88 | Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome. ( Ando, K; Cao, X; Chiba, K; Izumi-Nakaseko, H; Lubna, NJ; Naito, AT; Nakamura, Y; Satoh, Y; Sugiyama, A; Wada, T, 2018) |
| "Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome." | 3.88 | Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome. ( Ando, K; Cao, X; Chiba, K; Izumi-Nakaseko, H; Lubna, NJ; Naito, AT; Nakamura, Y; Satoh, Y; Sugiyama, A; Wada, T, 2018) |
| "Our data suggest that amitriptyline-induced inhibition of I(Na) unmasks the Brugada ECG phenotype and facilitates development of an arrhythmogenic substrate only in the setting of a genetic predisposition by creating repolarization heterogeneities that give rise to phase 2 reentry and VT." | 3.78 | Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. ( Antzelevitch, C; Barajas-Martínez, H; Di Diego, JM; Hu, D; Minoura, Y; Sicouri, S; Zygmunt, AC, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, HS | 1 |
| Ingalsbe, GS | 1 |
| Lank, PM | 1 |
| Lubna, NJ | 1 |
| Wada, T | 1 |
| Nakamura, Y | 1 |
| Chiba, K | 1 |
| Cao, X | 1 |
| Izumi-Nakaseko, H | 1 |
| Ando, K | 1 |
| Naito, AT | 1 |
| Satoh, Y | 1 |
| Sugiyama, A | 1 |
| Fernández-Anguita, MJ | 1 |
| Martínez-Mateo, V | 1 |
| Cejudo Díaz Del Campo, L | 1 |
| Galindo-Andugar, MÁ | 1 |
| Chan, HY | 1 |
| Chan, YC | 1 |
| Lau, FL | 1 |
| Minoura, Y | 1 |
| Di Diego, JM | 1 |
| Barajas-Martínez, H | 1 |
| Zygmunt, AC | 1 |
| Hu, D | 1 |
| Sicouri, S | 1 |
| Antzelevitch, C | 1 |
| Roberts-Thomson, KC | 1 |
| Teo, KS | 1 |
| Young, GD | 1 |
| Bebarta, VS | 2 |
| Waksman, JC | 2 |
8 other studies available for amitriptyline and Brugada Syndrome
| Article | Year |
|---|---|
Unresponsive Male.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Drug Overdose; Electrocardiograph | 2017 |
Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome.
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brugada Syndrome; Dogs; | 2018 |
The Brugada pattern in a patient treated with amitriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Cognitive Dysfunction; Cold Tempe | 2020 |
Reversal of Brugada electrocardiographic pattern with sodium bicarbonate solution after amitriptyline overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Drug Overdose; Electrocard | 2008 |
Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants.
Topics: Action Potentials; Adrenergic beta-Agonists; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidep | 2012 |
Drug-induced Brugada syndrome with ST-T wave alternans and long QT.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Cardiac; | 2007 |
Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Drug Overdose; Electrocardiograph | 2007 |
Reply to: "Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate".
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brugada Syndrome; Electrocardiography; Hum | 2008 |