amitriptyline has been researched along with Brain Injuries in 10 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)." | 1.33 | Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuczynski, A | 1 |
| Crawford, S | 1 |
| Bodell, L | 1 |
| Dewey, D | 1 |
| Barlow, KM | 1 |
| Mahesh, R | 1 |
| Pandey, DK | 1 |
| Katiyar, S | 1 |
| Kukade, G | 1 |
| Viyogi, S | 1 |
| Rudra, A | 1 |
| KRUEGER, H | 1 |
| ZUMPE, V | 1 |
| Son, BC | 1 |
| Lee, SW | 1 |
| Choi, ES | 1 |
| Sung, JH | 1 |
| Hong, JT | 1 |
| Boyeson, MG | 1 |
| Harmon, RL | 1 |
| Jones, JL | 1 |
| Reinhard, DL | 1 |
| Whyte, J | 1 |
| Sandel, ME | 1 |
| Lipper, S | 1 |
| Tuchman, MM | 1 |
| Jackson, RD | 3 |
| Mysiw, WJ | 2 |
| Corrigan, JD | 2 |
| Arnett, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PLAY GAME: Post-concussion Syndrome Affecting Youth: GABAergic Effects of Melatonin. A Randomized Double-blind Placebo-controlled Trial of MELATONIN[NCT01874847] | Phase 2/Phase 3 | 99 participants (Actual) | Interventional | 2013-09-30 | Active, not recruiting | ||
| Assessment of the Efficacy of Medrol Dose Pack for Post-Concussive Headaches[NCT04685772] | 25 participants (Anticipated) | Observational [Patient Registry] | 2021-04-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for amitriptyline and Brain Injuries
| Article | Year |
|---|---|
Treatment of chronic post-traumatic organic brain syndrome with dextroamphetamine: first reported case.
Topics: Accidents, Traffic; Adult; Amitriptyline; Brain Injuries; Chlorpromazine; Dextroamphetamine; Drug Th | 1976 |
Abnormal cortisol dynamics after traumatic brain injury. Lack of utility in predicting agitation or therapeutic response to tricyclic antidepressants.
Topics: Adolescent; Adult; Amitriptyline; Arousal; Brain Injuries; Clinical Trials as Topic; Desipramine; De | 1989 |
8 other studies available for amitriptyline and Brain Injuries
| Article | Year |
|---|---|
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Brain | 2013 |
Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats.
Topics: Acceleration; Amitriptyline; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain Injuri | 2010 |
[AMITRYPTILINE POISONING. A CONTRIBUTION TO THE CLINICAL PICTURE. PSYCHIATRIC AND PSYCHOLOGICAL TEST STUDIES ON THE PROBLEM OF THE TOXIC BRAIN DEGERERATION SYNDROME].
Topics: Amitriptyline; Antidepressive Agents; Brain; Brain Damage, Chronic; Brain Diseases; Brain Injuries; | 1965 |
Motor cortex stimulation for central pain following a traumatic brain injury.
Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju | 2006 |
Comparative effects of fluoxetine, amitriptyline and serotonin on functional motor recovery after sensorimotor cortex injury.
Topics: Amitriptyline; Brain Injuries; Fluoxetine; Motor Cortex; Psychomotor Performance; Serotonin; Time Fa | 1994 |
Improved arousal and initiation following tricyclic antidepressant use in severe brain injury.
Topics: Activities of Daily Living; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arousal; Brain I | 1996 |
Amitriptyline for post-traumatic agitation.
Topics: Adolescent; Adult; Amitriptyline; Amnesia; Brain Injuries; Cognition; Female; Humans; Male; Middle A | 1988 |
Amitriptyline for agitation in head injury.
Topics: Adult; Aggression; Amitriptyline; Brain Injuries; Female; Humans; Psychomotor Agitation | 1985 |