amitriptyline has been researched along with Brain Concussion in 5 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Brain Concussion: A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The author compared the response to amitriptyline in headache associated with depression between twelve patients having primary depression (control group) and ten patients with depression after minor closed head injury." | 5.06 | Antidepressants not effective in headache associated with minor closed head injury. ( Saran, A, 1988) |
| "Mild traumatic brain injury affects over one million pediatric patients annually." | 1.42 | Demographics and treatment of adolescent posttraumatic headache in a regional concussion clinic. ( Bramley, H; Heverley, S; Kong, L; Lewis, MM; Rivera, R; Silvis, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hurwitz, M | 1 |
| Lucas, S | 1 |
| Bell, KR | 1 |
| Temkin, N | 1 |
| Dikmen, S | 1 |
| Hoffman, J | 1 |
| Niziolek, GM | 1 |
| Hoehn, RS | 1 |
| Seitz, AP | 1 |
| Jernigan, PL | 1 |
| Makley, AT | 1 |
| Gulbins, E | 1 |
| Edwards, MJ | 1 |
| Goodman, MD | 1 |
| Bramley, H | 1 |
| Heverley, S | 1 |
| Lewis, MM | 1 |
| Kong, L | 1 |
| Rivera, R | 1 |
| Silvis, M | 1 |
| Bisges, J | 1 |
| Baldwin, P | 1 |
| Saran, A | 1 |
2 trials available for amitriptyline and Brain Concussion
| Article | Year |
|---|---|
Use of Amitriptyline in the Treatment of Headache After Traumatic Brain Injury: Lessons Learned From a Clinical Trial.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Brain Concussion; Feasibility Studies; F | 2020 |
Antidepressants not effective in headache associated with minor closed head injury.
Topics: Adult; Amitriptyline; Brain Concussion; Clinical Trials as Topic; Depressive Disorder; Drug Therapy, | 1988 |
3 other studies available for amitriptyline and Brain Concussion
| Article | Year |
|---|---|
The Role of Acid Sphingomyelinase Inhibition in Repetitive Mild Traumatic Brain Injury.
Topics: Amitriptyline; Animals; Brain Concussion; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Pr | 2021 |
Demographics and treatment of adolescent posttraumatic headache in a regional concussion clinic.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Brain Concussion; Demography; Female; Humans; M | 2015 |
You're the flight surgeon. Concussion and post-concussion syndrome.
Topics: Accidents, Traffic; Aerospace Medicine; Amitriptyline; Antidepressive Agents, Tricyclic; Brain Concu | 2009 |