amitriptyline has been researched along with Bradycardia in 9 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 5.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| " Activities of the compounds in antagonizing reserpine-induced ptosis in rabbits and prolongation of alcohol hypnosis in mice give good correlation with their clinical actions, whilst their activities in augmenting excitation of rats by amphetamine and yohimbine toxicity in mice, and in reversing reserpine-induced bradycardia in rats offer further evidence for drug-induced sensitization to adrenergic or tryptaminic mechanisms, which is not however specific for antidepressant agents." | 3.64 | A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE. ( HALLIWELL, G; QUINTON, RM; WILLIAMS, FE, 1964) |
| " We therefore investigated the adverse effects of preoperative intravenous amitriptyline in a typical phase 1A trial." | 2.73 | Phase 1A safety assessment of intravenous amitriptyline. ( Colvin, HP; Fridrich, P; Gerner, P; Hamp, T; Lirk, P; Lukanich, J; Saria, A; Wasan, AD; Zernig, G; Zizza, A, 2007) |
| "Familial rectal pain is a very rare entity that must always be considered as a possible aetiology of any life-threatening event in an infant because of the availability of a very effective treatment." | 1.33 | Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby. ( Arbuès, AS; Bednarek, N; Morville, P; Motte, J; Plouin, P; Sabouraud, P, 2005) |
| " Finally we explored whether acute and/or chronic administration of amoxapine or amitriptyline affected the levels of opioid peptides and the mu and delta classes of opioid receptors in various regions of the brain and the spinal cord." | 1.28 | [Preclinical pharmacology of amoxapine and amitriptyline. Implications of serotoninergic and opiodergic systems in their central effect in rats]. ( Gozlan, H; Hamon, M; Laguzzi, R; Merahi, N; Saddiki-Traki, F, 1991) |
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 1.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FEKETE, M | 1 |
| BORSY, J | 1 |
| HALLIWELL, G | 1 |
| QUINTON, RM | 1 |
| WILLIAMS, FE | 1 |
| LOEW, D | 1 |
| TAESCHLER, M | 1 |
| Bednarek, N | 1 |
| Arbuès, AS | 1 |
| Motte, J | 1 |
| Sabouraud, P | 1 |
| Plouin, P | 1 |
| Morville, P | 1 |
| Fridrich, P | 1 |
| Colvin, HP | 1 |
| Zizza, A | 1 |
| Wasan, AD | 1 |
| Lukanich, J | 1 |
| Lirk, P | 1 |
| Saria, A | 1 |
| Zernig, G | 1 |
| Hamp, T | 1 |
| Gerner, P | 1 |
| Nymark, M | 1 |
| Rasmussen, J | 1 |
| Pentel, P | 1 |
| Peterson, CD | 1 |
| Gozlan, H | 1 |
| Saddiki-Traki, F | 1 |
| Merahi, N | 1 |
| Laguzzi, R | 1 |
| Hamon, M | 1 |
| Burda, CD | 1 |
1 trial available for amitriptyline and Bradycardia
| Article | Year |
|---|---|
Phase 1A safety assessment of intravenous amitriptyline.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Bradycardia; Cohort Studies; Dose-Response Rel | 2007 |
8 other studies available for amitriptyline and Bradycardia
| Article | Year |
|---|---|
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound | 1964 |
A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE.
Topics: Alcoholic Intoxication; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Autonomic Nervou | 1964 |
[RESEARCH ON ANTICHOLINERGIC EFFECTS OF ANTIDEPRESSIVE SUBSTANCES IN THE RABBIT].
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Bradycardia; Cholinergic Antagonists; Desip | 1964 |
Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby.
Topics: Amitriptyline; Anticonvulsants; Apnea; Autonomic Nervous System Diseases; Bradycardia; Bronchial Spa | 2005 |
Effect of certain drugs upon amitriptyline induced electrocardiographic changes.
Topics: Acetylcholine; Amitriptyline; Animals; Atropine; Blood Pressure; Bradycardia; Bundle-Branch Block; E | 1966 |
Asystole complicating physostigmine treatment of tricyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bradycardia; Electroca | 1980 |
[Preclinical pharmacology of amoxapine and amitriptyline. Implications of serotoninergic and opiodergic systems in their central effect in rats].
Topics: Amitriptyline; Amoxapine; Animals; Bradycardia; Central Nervous System; Male; Neuropeptides; Radioim | 1991 |
Cardiotoxic effects of Mellaril.
Topics: Amitriptyline; Bradycardia; Electrocardiography; Humans; Imipramine; Tachycardia; Thioridazine | 1970 |