amitriptyline and Bacterial Disease studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

Excerpt	Relevance	Reference
"Amitriptyline, a blocker of acid sphingomyelinase and acid ceramidase, significantly reduces Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) mice with concurrent increase of survival."	9.14	Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. ( Anthonysamy, J; Döring, G; Gulbins, E; Riethmüller, J; Schwab, M; Serra, E, 2009)
"Amitriptyline, a blocker of acid sphingomyelinase and acid ceramidase, significantly reduces Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) mice with concurrent increase of survival."	5.14	Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. ( Anthonysamy, J; Döring, G; Gulbins, E; Riethmüller, J; Schwab, M; Serra, E, 2009)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

amitriptyline and Bacterial Disease

Research Excerpts

Research

Studies (1)

Authors

Trials

Authors	Studies
Riethmüller, J	1
Anthonysamy, J	1
Serra, E	1
Schwab, M	1
Döring, G	1
Gulbins, E	1