amitriptyline has been researched along with Back Ache in 11 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective, randomized, open-label, multicenter, community-based study was conducted to compare cyclobenzaprine 5 mg three times daily (TID) orally (CYC5) given for 7 days as monotherapy or in combination with ibuprofen 400 mg TID (CYC5/IBU400) or 800 mg TID (CYC5/IBU800) in adults with acute neck or back pain with muscle spasm." | 9.11 | Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial. ( Borenstein, D; Brown, RL; Childers, MK; Gershon, S; Hale, ME; Harrison, DD; Laudadio, C; Petri, M; Wan, GJ, 2005) |
| "Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions." | 9.10 | Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials. ( Borenstein, DG; Korn, S, 2003) |
| "Back pain is a common problem for which cyclobenzaprine hydrochloride is frequently prescribed." | 8.81 | Cyclobenzaprine and back pain: a meta-analysis. ( Browning, R; Jackson, JL; O'Malley, PG, 2001) |
| "This prospective, randomized, open-label, multicenter, community-based study was conducted to compare cyclobenzaprine 5 mg three times daily (TID) orally (CYC5) given for 7 days as monotherapy or in combination with ibuprofen 400 mg TID (CYC5/IBU400) or 800 mg TID (CYC5/IBU800) in adults with acute neck or back pain with muscle spasm." | 5.11 | Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial. ( Borenstein, D; Brown, RL; Childers, MK; Gershon, S; Hale, ME; Harrison, DD; Laudadio, C; Petri, M; Wan, GJ, 2005) |
| "Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions." | 5.10 | Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials. ( Borenstein, DG; Korn, S, 2003) |
| "Back pain is a common problem for which cyclobenzaprine hydrochloride is frequently prescribed." | 4.81 | Cyclobenzaprine and back pain: a meta-analysis. ( Browning, R; Jackson, JL; O'Malley, PG, 2001) |
| "No differences were seen in the neuropathic pain questionnaire values at any time point during treatment between the three groups." | 2.80 | Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator. ( De Vooght, P; Heylen, R; Kozicz, T; Mestrum, R; Puylaert, M; Roubos, E; Van Zundert, J; Vanelderen, P; Vissers, K, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vanelderen, P | 1 |
| Van Zundert, J | 1 |
| Kozicz, T | 1 |
| Puylaert, M | 1 |
| De Vooght, P | 1 |
| Mestrum, R | 1 |
| Heylen, R | 1 |
| Roubos, E | 1 |
| Vissers, K | 1 |
| Braschi, E | 1 |
| Garrison, S | 1 |
| Allan, GM | 1 |
| Borenstein, DG | 1 |
| Korn, S | 1 |
| Childers, MK | 1 |
| Borenstein, D | 1 |
| Brown, RL | 1 |
| Gershon, S | 1 |
| Hale, ME | 1 |
| Petri, M | 1 |
| Wan, GJ | 1 |
| Laudadio, C | 1 |
| Harrison, DD | 1 |
| Hibi, S | 1 |
| Yamaguchi, Y | 1 |
| Teramoto, S | 1 |
| Yamamoto, H | 1 |
| Eto, M | 1 |
| Akishita, M | 1 |
| Ouchi, Y | 1 |
| Alim, M | 1 |
| Edelson, GW | 1 |
| Browning, R | 1 |
| Jackson, JL | 1 |
| O'Malley, PG | 1 |
| Egbunike, IG | 1 |
| Chaffee, BJ | 1 |
| Basmajian, JV | 1 |
| Vree, PH | 1 |
| Zwart, P | 1 |
| Snapinn, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Glia-mediated NeuroInflammation and Treatment Efficacy (the IGNITE Study)[NCT03106740] | Phase 2 | 145 participants (Anticipated) | Interventional | 2017-10-10 | Recruiting | ||
| Flexeril� (Cyclobenzaprine Hydrochloride) Community Based Study - An Evaluation of Cyclobenzaprine HCl Monotherapy and in Combination With Ibuprofen for Acute Back or Neck Muscle Pain With Muscle Spasm[NCT00246389] | Phase 4 | 1,000 participants (Actual) | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for amitriptyline and Back Ache
| Article | Year |
|---|---|
Cyclobenzaprine for acute back pain.
Topics: Acute Disease; Adult; Aged; Amitriptyline; Back Pain; Humans; Middle Aged; Muscle Relaxants, Central | 2015 |
Syncope in a young woman with chronic back pain.
Topics: Adult; Amitriptyline; Back Pain; Diagnosis, Differential; Emergency Medical Services; Female; Humans | 1993 |
Cyclobenzaprine and back pain: a meta-analysis.
Topics: Amitriptyline; Back Pain; Humans; Muscle Relaxants, Central; Randomized Controlled Trials as Topic | 2001 |
Antidepressants in the management of chronic pain syndromes.
Topics: Amitriptyline; Antidepressive Agents; Arthritis; Back Pain; Chronic Disease; Diabetic Neuropathies; | 1990 |
5 trials available for amitriptyline and Back Ache
| Article | Year |
|---|---|
Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Back Pain; Brai | 2015 |
Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials.
Topics: Acute Disease; Adult; Amitriptyline; Back Pain; Dose-Response Relationship, Drug; Double-Blind Metho | 2003 |
Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial.
Topics: Adolescent; Adult; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Dose-Response | 2005 |
Acute back pain and spasm. A controlled multicenter trial of combined analgesic and antispasm agents.
Topics: Acute Disease; Amitriptyline; Back Pain; Diflunisal; Double-Blind Method; Drug Therapy, Combination; | 1989 |
Evaluating the efficacy of a combination therapy.
Topics: Amitriptyline; Analgesics; Back Pain; Biometry; Clinical Trials as Topic; Diflunisal; Double-Blind M | 1987 |
2 other studies available for amitriptyline and Back Ache
| Article | Year |
|---|---|
[Reproducible efficacy of tricyclic antidepressant on chronic pain in an elderly patient with osteoporosis].
Topics: Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Back P | 2007 |
[A newborn infant with amitriptyline poisoning].
Topics: Adult; Amitriptyline; Antipsychotic Agents; Back Pain; Female; Humans; Infant, Newborn; Male; Matern | 1985 |