Page last updated: 2024-10-22

amitriptyline and Autism

amitriptyline has been researched along with Autism in 5 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

ExcerptRelevanceReference
"The absence of neonatal seizures is a robust and important clinical differentiator between KCNQ2 gain-of-function and loss-of-function variants."1.72KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism. ( Ambrosino, P; Amin, H; Bayat, A; Brilstra, E; Carotenuto, L; Cooper, EC; de Bellescize, J; Devinsky, O; Edery, P; Emrick, L; Goizet, C; Hong, W; Kleefstra, T; Kluger, G; Korenke, GC; Lee, HK; Lesca, G; Mefford, HC; Miceli, F; Michaud, V; Milh, M; Millevert, C; Mosca, I; Møller, RS; Risen, S; Riviello, J; Sands, T; Schrader, D; Soldovieri, MV; Taglialatela, M; Van-Gils, J; Ville, D; Weckhuysen, S; Willemsen, MH, 2022)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Miceli, F1
Millevert, C1
Soldovieri, MV1
Mosca, I1
Ambrosino, P1
Carotenuto, L1
Schrader, D1
Lee, HK1
Riviello, J1
Hong, W1
Risen, S1
Emrick, L1
Amin, H1
Ville, D1
Edery, P1
de Bellescize, J1
Michaud, V1
Van-Gils, J1
Goizet, C1
Willemsen, MH1
Kleefstra, T1
Møller, RS1
Bayat, A1
Devinsky, O1
Sands, T1
Korenke, GC1
Kluger, G1
Mefford, HC1
Brilstra, E1
Lesca, G1
Milh, M1
Cooper, EC1
Taglialatela, M1
Weckhuysen, S1
Pollard, AJ1
Prendergast, M1
Kehrer, HE1
Ginestet, D1
Peters, UH1
Glück, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectivity of Incentive Spirometry on Postoperative Pulmonary Complication After Major Abdominal Surgery In Indonesia Three Major Tertiary Hospitals: A Randomized Controlled Trial[NCT05795608]46 participants (Actual)Interventional2015-07-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for amitriptyline and Autism

ArticleYear
[Infantile autism and drug therapy].
    Bibliotheca psychiatrica, 1978, Issue:157

    Topics: Adolescent; Amitriptyline; Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Clo

1978

Other Studies

4 other studies available for amitriptyline and Autism

ArticleYear
KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism.
    EBioMedicine, 2022, Volume: 81

    Topics: Amitriptyline; Autistic Disorder; Epilepsy; Gain of Function Mutation; Humans; Infant, Newborn; Infa

2022
Depressive pseudodementia in a child with autism.
    Developmental medicine and child neurology, 2004, Volume: 46, Issue:7

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Autistic Disorder; Child; Dementia; Depressive Diso

2004
The psychiatrist attitudes and therapeutic means when faced with resistant depressions.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1974, Volume: 7, Issue:4

    Topics: Amitriptyline; Amphetamine; Antidepressive Agents; Autistic Disorder; Depression; Drug Resistance; D

1974
[Personality at the end of a depressive phase. Observations after cessation of the endogenous depressive phases].
    Der Nervenarzt, 1973, Volume: 44, Issue:1

    Topics: Amitriptyline; Autistic Disorder; Bipolar Disorder; Defense Mechanisms; Female; Humans; Hypochondria

1973