amitriptyline has been researched along with Asystole in 24 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 5.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| "In this case report, a 22-year-old male developed severe hypothermia after an accidental overdose of cyclobenzaprine." | 3.81 | Use of an Intravascular Heat Exchange Catheter and Intravenous Lipid Emulsion for Hypothermic Cardiac Arrest After Cyclobenzaprine Overdose. ( Awad, NI; Bridgeman, PJ; Jeges, J; McCoy, JV; Page, E; Westrol, MS, 2015) |
| " We report the case of a 49-year old women with ingestion of 2500 mg of amitriptyline who suffered from multiple cardiac arrhythmias with following cardiac arrests and who required multiple defibrillations and resuscitation." | 3.73 | [Resuscitation after intoxication with amitriptylin]. ( Berkel, H; Finkemeyer, S; Fippel, A; Hoitz, J; Knape, R, 2005) |
| "She suffered a cardiac arrest followed by cardiovascular and neurological complications." | 1.56 | Successful Outcome Following Intravenous Lipid Emulsion Rescue Therapy in a Patient with Cardiac Arrest Due to Amitriptyline Overdose. ( Angel-Isaza, AM; Bustamante-Cristancho, LA; Uribe-B, FL, 2020) |
| "Cyclobenzaprine has potential for sodium channel blockade and ventricular dysrhythmias although cardiac toxicity due to cyclobenzaprine alone is rare." | 1.42 | Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report. ( Cao, D; Chua-Tuan, JL; Hoyte, CO; Iwanicki, JL, 2015) |
| "7 mg/kg per dose) (the drug dosage was not known in 13 children)." | 1.33 | Acute amitriptyline intoxication: an analysis of 44 children. ( Akbayram, S; Akgün, C; Caksen, H; Erol, M; Odabaş, D; Ozbek, H; Tuncer, O; Yilmaz, C, 2006) |
| "The causes of sudden cardiac arrest (SCA) and its associated early death were examined in 179 patients with acute intoxications due to amitriptyline, antiarrhythmic agents and cardiac glycosides." | 1.28 | [Acute heart failure and its treatment in cardiologic drug poisoning]. ( Savina, AS, 1992) |
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 1.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (41.67) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Angel-Isaza, AM | 1 |
| Bustamante-Cristancho, LA | 1 |
| Uribe-B, FL | 1 |
| Chua-Tuan, JL | 1 |
| Cao, D | 1 |
| Iwanicki, JL | 1 |
| Hoyte, CO | 1 |
| Westrol, MS | 1 |
| Awad, NI | 1 |
| Bridgeman, PJ | 1 |
| Page, E | 1 |
| McCoy, JV | 1 |
| Jeges, J | 1 |
| Abeyaratne, DD | 1 |
| Liyanapathirana, C | 1 |
| Gamage, A | 1 |
| Karunarathne, P | 1 |
| Botheju, M | 1 |
| Indrakumar, J | 1 |
| Le Fevre, P | 1 |
| Gosling, M | 1 |
| Acharya, K | 1 |
| Georgiou, A | 1 |
| Huge, V | 1 |
| Baschnegger, H | 1 |
| Moehnle, P | 1 |
| Peraud, A | 1 |
| Briegel, J | 1 |
| Lacroix, P | 1 |
| Levine, M | 1 |
| Brooks, DE | 1 |
| Franken, A | 1 |
| Graham, R | 1 |
| Srinivasa, V | 1 |
| Gerner, P | 1 |
| Haderer, A | 1 |
| Abdi, S | 1 |
| Jarolim, P | 1 |
| Wang, GK | 1 |
| Fippel, A | 1 |
| Berkel, H | 1 |
| Finkemeyer, S | 1 |
| Knape, R | 1 |
| Hoitz, J | 1 |
| Deegan, C | 1 |
| O'Brien, K | 1 |
| Caksen, H | 1 |
| Akbayram, S | 1 |
| Odabaş, D | 1 |
| Ozbek, H | 1 |
| Erol, M | 1 |
| Akgün, C | 1 |
| Tuncer, O | 1 |
| Yilmaz, C | 1 |
| Dhanikula, AB | 1 |
| Lamontagne, D | 1 |
| Leroux, JC | 1 |
| Pentel, P | 1 |
| Peterson, CD | 1 |
| Hese, RT | 1 |
| Coryell, W | 1 |
| Sherman, A | 1 |
| Jelínek, R | 1 |
| Benesová, O | 1 |
| Horák, J | 1 |
| Soucek, K | 1 |
| Siemkowicz, E | 1 |
| Savina, AS | 1 |
| Moir, DC | 1 |
| Glogner, P | 1 |
| Heni, N | 1 |
| Herkel, L | 1 |
| Höfer, G | 1 |
| Crane, GE | 1 |
| Attree, T | 1 |
| Sawyer, P | 1 |
| Turnbull, MJ | 1 |
| Williams, RB | 1 |
| Sherter, C | 1 |
1 review available for amitriptyline and Asystole
| Article | Year |
|---|---|
Cardiac toxicity and psychotropic drugs.
Topics: Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Death, Sudden; Electrocardiography; Heart | 1970 |
23 other studies available for amitriptyline and Asystole
| Article | Year |
|---|---|
Successful Outcome Following Intravenous Lipid Emulsion Rescue Therapy in a Patient with Cardiac Arrest Due to Amitriptyline Overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Electrocardiography; Fat Emul | 2020 |
Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report.
Topics: Acetamides; Adolescent; Amitriptyline; Anticonvulsants; Drug Interactions; Drug Overdose; Electrocar | 2015 |
Use of an Intravascular Heat Exchange Catheter and Intravenous Lipid Emulsion for Hypothermic Cardiac Arrest After Cyclobenzaprine Overdose.
Topics: Amitriptyline; Cardiopulmonary Bypass; Cardiopulmonary Resuscitation; Drug Overdose; Fat Emulsions, | 2015 |
Survival after severe amitriptyline poisoning with prolonged ventricular tachycardia and cardiac arrest.
Topics: Adult; Amitriptyline; Electrocardiography; Female; Heart Arrest; Humans; Pulmonary Edema; Survival A | 2016 |
Dramatic resuscitation with Intralipid in an epinephrine unresponsive cardiac arrest following overdose of amitriptyline and propranolol.
Topics: Adult; Amitriptyline; Drug Overdose; Epinephrine; Fat Emulsions, Intravenous; Female; Heart Arrest; | 2017 |
[Amitriptyline-induced cardiac arrest : treatment with fat emulsion].
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Cardiopulmonary Resuscitation; Electrocardio | 2011 |
Electrocardiographic toxicity in the guinea pig.
Topics: Amitriptyline; Anesthesia; Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Re | 2002 |
Delayed-onset seizure and cardiac arrest after amitriptyline overdose, treated with intravenous lipid emulsion therapy.
Topics: Adolescent; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Combined Modality Ther | 2012 |
The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats.
Topics: Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Bupiva | 2003 |
[Resuscitation after intoxication with amitriptylin].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation | 2005 |
Amitriptyline poisoning in a 2-year old.
Topics: Adrenergic beta-Agonists; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Blood Gas Analys | 2006 |
Acute amitriptyline intoxication: an analysis of 44 children.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Drug Overdose; | 2006 |
Rescue of amitriptyline-intoxicated hearts with nanosized vesicles.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Heart; Heart Arrest; Lipid Metabolism; Lip | 2007 |
Asystole complicating physostigmine treatment of tricyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bradycardia; Electroca | 1980 |
Cardiac arrest in a young woman treated with amitriptyline combined with levopromazine.
Topics: Adult; Amitriptyline; Depressive Disorder; Drug Therapy, Combination; Female; Heart Arrest; Humans; | 1982 |
Slow tricyclic antidepressant metabolism, polypharmacy, and cardiac arrest.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biological Availability; Drug Combinations; Drug In | 1980 |
Cardiotoxicity of tricyclic antidepressants and maprotiline in the chick embryo. A comparative study.
Topics: Amitriptyline; Animals; Anthracenes; Antidepressive Agents, Tricyclic; Chick Embryo; Dothiepin; Hear | 1978 |
[Cardiac arrest following amitriptylin and adrenaline].
Topics: Amitriptyline; Anesthesia, Local; Drug Interactions; Epinephrine; Female; Heart Arrest; Humans; Midd | 1975 |
[Acute heart failure and its treatment in cardiologic drug poisoning].
Topics: Adolescent; Adult; Amitriptyline; Anti-Arrhythmia Agents; Cardiac Glycosides; Heart Arrest; Hemoperf | 1992 |
Tricyclic antidepressants and cardiac disease.
Topics: Amitriptyline; Antidepressive Agents; Death, Sudden; Female; Heart; Heart Arrest; Humans; Imipramine | 1973 |
[Fatal limbratil-F intoxication with post mortem gas chromatographic demonstration of tissue levels of amitriptyline and nortriptyline (author's transl)].
Topics: Adjustment Disorders; Adult; Amitriptyline; Brain Chemistry; Chlordiazepoxide; Chromatography, Gas; | 1973 |
Interaction between digoxin and tricyclic antidepressants in the rat.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Digoxin; Dose-Response Relationship, Dru | 1972 |
Cardiac complications of tricyclic antidepressant therapy.
Topics: Adult; Amitriptyline; Antidepressive Agents; Autopsy; Catecholamines; Drug Synergism; Electrocardiog | 1971 |