amitriptyline has been researched along with Arrhythmia in 84 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline (AMT) is commonly used in the management of children with irritable bowel syndrome." | 7.78 | Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain. ( Hussain, SZ; Jackson, R; Patra, KP; Sankararaman, S, 2012) |
| "We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline." | 7.73 | Prolonged clinical effects in modified-release amitriptyline poisoning. ( Dargan, P; Greene, S; Jones, A; O'Connor, N; Wyncoll, D, 2006) |
| " The aim of this study was to compare the effects of several inotropic drugs on survival and the occurrence of arrhythmias in the treatment of amitriptyline poisoning." | 7.69 | Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat. ( Abrahamsson, J; Knudsen, K, 1994) |
| "The effects of amitriptyline and maprotiline, standard tricyclic and tetracyclic antidepressants, on intraventricular conduction, the effective refractory period (ERP), and the incidence of ventricular arrhythmias induced by programmed stimulation were studied and compared in dog hearts after myocardial infarction." | 7.68 | Comparative effects of antidepressants, amitriptyline, and maprotiline on intraventricular conduction, effective refractory period, and incidence of ventricular arrhythmias induced by programmed stimulation in dog hearts after myocardial infarction. ( Hashimoto, H; Nakashima, M; Nishimoto, M; Oohara, K; Ozaki, T, 1990) |
| "The purpose of this study was to quantify the degree of muscle weakness and myotonia in 12 patients with myotonic dystrophy (MD), and to quantitatively determine the effects of a four- to six-month therapeutic trial of amitriptyline." | 7.68 | Myotonic dystrophy: quantification of muscle weakness and myotonia and the effect of amitriptyline and exercise. ( Miller, RG; Milner-Brown, HS, 1990) |
| " Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl." | 7.66 | [Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium]. ( Pallmert, N; Seitz, R; Wehr, M, 1982) |
| "A case is described of ventricular arrhythmias associated with doxepin and amitriptyline treatment in a patient with preexisting heart disease." | 7.66 | Ventricular arrhythmias induced by doxepin and amitriptyline: case report. ( Faber, R; Todd, RD, 1983) |
| "Malignant arrhythmias appeared in 7% of all animals, whereas a progressive decline of cardiac contractility caused cardiac arrest in 36% of all animals." | 5.29 | Effects of epinephrine and norepinephrine on hemodynamic parameters and arrhythmias during a continuous infusion of amitriptyline in rats. ( Abrahamsson, J; Knudsen, K, 1993) |
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 5.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| "Amitriptyline (AMT) is commonly used in the management of children with irritable bowel syndrome." | 3.78 | Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain. ( Hussain, SZ; Jackson, R; Patra, KP; Sankararaman, S, 2012) |
| " Patients with an amitriptyline overdose were more likely to have seizure, coma, tachycardia, a wide QRS or ventricular dysrhythmia, and have received sodium bicarbonate or be intubated." | 3.77 | Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose. ( Bebarta, VS; Borys, DJ; Maddry, J; Morgan, DL, 2011) |
| " We report the case of a 49-year old women with ingestion of 2500 mg of amitriptyline who suffered from multiple cardiac arrhythmias with following cardiac arrests and who required multiple defibrillations and resuscitation." | 3.73 | [Resuscitation after intoxication with amitriptylin]. ( Berkel, H; Finkemeyer, S; Fippel, A; Hoitz, J; Knape, R, 2005) |
| "We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline." | 3.73 | Prolonged clinical effects in modified-release amitriptyline poisoning. ( Dargan, P; Greene, S; Jones, A; O'Connor, N; Wyncoll, D, 2006) |
| " The aim of this study was to compare the effects of several inotropic drugs on survival and the occurrence of arrhythmias in the treatment of amitriptyline poisoning." | 3.69 | Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat. ( Abrahamsson, J; Knudsen, K, 1994) |
| "The effects of amitriptyline and maprotiline, standard tricyclic and tetracyclic antidepressants, on intraventricular conduction, the effective refractory period (ERP), and the incidence of ventricular arrhythmias induced by programmed stimulation were studied and compared in dog hearts after myocardial infarction." | 3.68 | Comparative effects of antidepressants, amitriptyline, and maprotiline on intraventricular conduction, effective refractory period, and incidence of ventricular arrhythmias induced by programmed stimulation in dog hearts after myocardial infarction. ( Hashimoto, H; Nakashima, M; Nishimoto, M; Oohara, K; Ozaki, T, 1990) |
| "The purpose of this study was to quantify the degree of muscle weakness and myotonia in 12 patients with myotonic dystrophy (MD), and to quantitatively determine the effects of a four- to six-month therapeutic trial of amitriptyline." | 3.68 | Myotonic dystrophy: quantification of muscle weakness and myotonia and the effect of amitriptyline and exercise. ( Miller, RG; Milner-Brown, HS, 1990) |
| "The effects of mianserin, a tetracyclic antidepressant, and adinazolam, a new triazolobenzodiazepine which has antidepressant activity, on intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation were studied in the dog heart after myocardial infarction and compared to the effects of amitriptyline, a standard tricyclic antidepressant." | 3.68 | Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction. ( Hashimoto, H; Nagashima, S; Nakashima, M; Nishimoto, M; Ozaki, T, 1990) |
| "Overdose with amitriptyline and other tricyclic antidepressants can result in ventricular conduction abnormalities as well as severe ventricular arrhythmias." | 3.67 | Experimental amitriptyline intoxication: treatment of cardiac toxicity with sodium bicarbonate. ( Jhamandas, V; Sasyniuk, BI; Valois, M, 1986) |
| " Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl." | 3.66 | [Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium]. ( Pallmert, N; Seitz, R; Wehr, M, 1982) |
| "A case is described of ventricular arrhythmias associated with doxepin and amitriptyline treatment in a patient with preexisting heart disease." | 3.66 | Ventricular arrhythmias induced by doxepin and amitriptyline: case report. ( Faber, R; Todd, RD, 1983) |
| " In 1 patient, acute myocardial infarction developed after two 10-mg doses of nortriptyline." | 3.66 | Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged. ( Oei, LS; Rodstein, M, 1979) |
| " Cardiac arrhythmias induced in children by amitriptyline and imipramine are prominent and dangerous." | 3.65 | Amitriptyline and imipramine poisoning in children. ( Goel, KM; Shanks, RA, 1974) |
| "Severe cardiovascular arrhythmias occurred in both groups with 3 in the CAC-HP group versus 1 incident with premature death in the CG." | 2.87 | Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion. ( Belhage, B; Dalhoff, K; Eriksen, T; Haarmark, C; Hoegberg, LCG; Jansen, T, 2018) |
| "The association of migraine and depression has been confirmed in numerous studies and it has been suggested that both diseases influence each other in a bidirectional way." | 2.44 | [A clinical challenge. Pragmatic treatment of migraine and concomitant depression]. ( Jürgens, TP; Koch, HJ; Leinisch, E, 2008) |
| "The physiologically based pharmacokinetic (PBPK) models allow for predictive assessment of variability in population of interest." | 1.48 | Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals. ( Mendyk, A; Polak, S; Tylutki, Z, 2018) |
| "In the present case, arrhythmia and circulatory shock responded neither to alkalization and elevated sodium levels after infusion of sodium bicarbonate, nor to any other established therapies." | 1.48 | [Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication]. ( Fischer, B; Otte, S; Sayk, F, 2018) |
| "In addition, arrhythmia was produced by the administration of amitriptyline under dark conditions." | 1.32 | Influence of the light schedule on the toxicity of amitriptyline in chick embryos. ( Kanke, M; Sugiyama, T; Yoshiyama, Y, 2004) |
| "Malignant arrhythmias appeared in 7% of all animals, whereas a progressive decline of cardiac contractility caused cardiac arrest in 36% of all animals." | 1.29 | Effects of epinephrine and norepinephrine on hemodynamic parameters and arrhythmias during a continuous infusion of amitriptyline in rats. ( Abrahamsson, J; Knudsen, K, 1993) |
| "The patient died on day 3 from cardiocirculatory collapse and arrhythmias." | 1.29 | Hyperthermia complicating tricyclic antidepressant overdose. ( Baud, FJ; Benaissa, M; Clemessy, JL; Hantson, P, 1996) |
| "Midazolam was replaced by saline in the other 12." | 1.28 | Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog. ( Askenasi, R; Leduc, D; Lheureux, P; Vranckx, M, 1992) |
| " We report on a case of cardiac arrhythmia during low dosage therapy of post-herpetic neuralgia with Carbamazepine and Amitriptyline in a patient with chronic renal rejection and cirrhosis." | 1.27 | [Acute cardiotoxicity of tricyclic compounds: remarks on a clinical case]. ( Arisi, L; Paganelli, E, 1988) |
| "When amitriptyline was infused into dogs with formalin-induced atrioventricular (AV) block to evaluate a broad range of pacing frequencies, the drug produced dose-related QRS prolongation that was markedly frequency dependent." | 1.27 | Frequency-dependent effects of amitriptyline on ventricular conduction and cardiac rhythm in dogs. ( Nattel, S, 1985) |
| "Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin." | 1.26 | Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin. ( Brown, TC; Leversha, A, 1979) |
| " It is concluded that all four drugs show the toxic effects classically associated with tricyclic antidepressants but the relative toxicity amongst these agents varies considerably and is in the order amitriptyline greater than imipramine greater than maprotiline greater than mianserin." | 1.26 | The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo. ( Hughes, IE; Radwan, S, 1979) |
| "Ventricular arrhythmias were observed in only one case, the sole fatality, who demonstrated the highest amitriptyline plus nortriptyline plasma level." | 1.26 | Cardiovascular changes and plasma drug levels after amitriptyline overdose. ( Rudorfer, MV, 1982) |
| "Physostigmine is a commonly used therapy for the anticholinergic manifestations of tricyclic antidepressant (TCA) overdose." | 1.26 | Asystole complicating physostigmine treatment of tricyclic antidepressant overdose. ( Pentel, P; Peterson, CD, 1980) |
| "Practolol, although reversing the arrhythmias, tends to cause hypotension." | 1.26 | Tricyclic antidepressant overdosage: experimental studies on the management of circulatory complications. ( Brown, TC, 1976) |
| " Dx infused intravenously to conscious or anaesthetized guinea-pigs proved as cardiotoxic as amitriptyline but more toxic than protriptyline, thus confirming our previous results in rabbits." | 1.26 | Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea-pigs. ( Elonen, E; Eränkö, P; Mattila, MJ; Puisto, EL, 1980) |
| "Five of the 10 patients had arrhythmias and two of these died." | 1.25 | Cardiac abnormalities in poisoning with tricyclic antidepressants. ( Beattie, RR; Freeman, JW; Mundy, GR; Ryan, C, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (63.10) | 18.7374 |
| 1990's | 12 (14.29) | 18.2507 |
| 2000's | 8 (9.52) | 29.6817 |
| 2010's | 9 (10.71) | 24.3611 |
| 2020's | 2 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Garrett, P | 1 |
| Klupfel, S | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Otte, S | 1 |
| Fischer, B | 1 |
| Sayk, F | 1 |
| Jansen, T | 1 |
| Hoegberg, LCG | 1 |
| Eriksen, T | 1 |
| Haarmark, C | 1 |
| Dalhoff, K | 1 |
| Belhage, B | 1 |
| Stock, EM | 1 |
| Zeber, JE | 1 |
| McNeal, CJ | 1 |
| Banchs, JE | 1 |
| Copeland, LA | 1 |
| Tylutki, Z | 1 |
| Mendyk, A | 1 |
| Polak, S | 1 |
| Basol, N | 1 |
| Erbas, O | 1 |
| Radnic, B | 1 |
| Radojevic, N | 1 |
| Vucinic, J | 1 |
| Duborija-Kovacevic, N | 1 |
| Bebarta, VS | 1 |
| Maddry, J | 1 |
| Borys, DJ | 1 |
| Morgan, DL | 1 |
| Patra, KP | 1 |
| Sankararaman, S | 1 |
| Jackson, R | 1 |
| Hussain, SZ | 1 |
| Lak, NS | 1 |
| Malingre, MM | 1 |
| Hogeman, PH | 1 |
| SUNSHINE, P | 1 |
| YAFFE, SJ | 1 |
| Yoshiyama, Y | 1 |
| Sugiyama, T | 1 |
| Kanke, M | 1 |
| Fippel, A | 1 |
| Berkel, H | 1 |
| Finkemeyer, S | 1 |
| Knape, R | 1 |
| Hoitz, J | 1 |
| O'Connor, N | 1 |
| Greene, S | 1 |
| Dargan, P | 1 |
| Wyncoll, D | 1 |
| Jones, A | 1 |
| Shinya, H | 1 |
| Hakoda, S | 1 |
| Kinouchi, S | 1 |
| Djonlagic, I | 1 |
| Djonlagic, H | 1 |
| Kibbel, T | 1 |
| Suefke, S | 1 |
| Dodt, C | 1 |
| Roberts-Thomson, KC | 1 |
| Teo, KS | 1 |
| Young, GD | 1 |
| Jürgens, TP | 1 |
| Leinisch, E | 1 |
| Koch, HJ | 1 |
| Seitz, R | 1 |
| Wehr, M | 1 |
| Pallmert, N | 1 |
| Dilsaver, SC | 1 |
| Greden, JF | 1 |
| van de Merwe, TJ | 1 |
| Silverstone, T | 1 |
| Ankier, SI | 1 |
| Warrington, SJ | 1 |
| Turner, P | 1 |
| Todd, RD | 1 |
| Faber, R | 1 |
| Puisto, EL | 1 |
| Mattila, MJ | 1 |
| Elonen, E | 1 |
| Eränkö, P | 1 |
| Pentel, P | 1 |
| Peterson, CD | 1 |
| Marshall, JB | 1 |
| Forker, AD | 1 |
| Rudorfer, MV | 1 |
| George, DT | 1 |
| Taska, RJ | 1 |
| Follmer, CH | 1 |
| Lockwood, RH | 1 |
| Lum, BK | 1 |
| Zhou, TX | 1 |
| Nissimov, R | 1 |
| Weiss, S | 1 |
| Sahavi, I | 1 |
| Mozes, K | 1 |
| Rechlin, T | 2 |
| Knudsen, K | 3 |
| Abrahamsson, J | 3 |
| Hantson, P | 1 |
| Benaissa, M | 1 |
| Clemessy, JL | 1 |
| Baud, FJ | 1 |
| Brown, TC | 5 |
| Chouinard, G | 1 |
| Annable, L | 1 |
| Rodstein, M | 1 |
| Oei, LS | 1 |
| Leversha, A | 1 |
| Hughes, IE | 2 |
| Radwan, S | 1 |
| Baum, T | 1 |
| Peters, JR | 1 |
| Butz, F | 1 |
| Much, DR | 1 |
| Harper, B | 1 |
| Weinberger, DR | 1 |
| Tobis, J | 1 |
| Das, BN | 1 |
| Raymond, CW | 1 |
| Lheureux, P | 1 |
| Vranckx, M | 1 |
| Leduc, D | 1 |
| Askenasi, R | 1 |
| Hashimoto, H | 2 |
| Nishimoto, M | 2 |
| Ozaki, T | 2 |
| Oohara, K | 1 |
| Nakashima, M | 2 |
| Milner-Brown, HS | 1 |
| Miller, RG | 1 |
| Colenda, CC | 1 |
| Sirota, P | 1 |
| Ori, J | 1 |
| Schild, K | 1 |
| Appel, S | 1 |
| Brandis, S | 1 |
| Zahavi, I | 1 |
| Nagashima, S | 1 |
| Paganelli, E | 1 |
| Arisi, L | 1 |
| Levitt, MA | 1 |
| Sullivan, JB | 1 |
| Owens, SM | 1 |
| Burnham, L | 1 |
| Finley, PR | 1 |
| Hedges, JR | 1 |
| Baker, PB | 1 |
| Tasset, JJ | 1 |
| Otten, EJ | 1 |
| Dalsey, WC | 1 |
| Syverud, SA | 1 |
| Sasyniuk, BI | 1 |
| Jhamandas, V | 1 |
| Valois, M | 1 |
| Battegay, R | 1 |
| Hager, M | 1 |
| Rauchfleisch, U | 1 |
| Mayron, R | 1 |
| Ruiz, E | 1 |
| Mahapatra, RK | 1 |
| Paul, SK | 1 |
| Mahapatra, D | 1 |
| Winter, S | 1 |
| Savina, AS | 1 |
| Luzhnikov, EA | 1 |
| Galankina, IE | 1 |
| Vagin, NA | 1 |
| Fisch, C | 1 |
| Nattel, S | 1 |
| Moir, DC | 1 |
| Cornwell, WB | 1 |
| Dingwall-Fordyce, I | 1 |
| Crooks, J | 1 |
| O'Malley, K | 1 |
| Turnbull, MJ | 1 |
| Weir, RD | 1 |
| Brackenridge, RG | 1 |
| Scollins, MJ | 1 |
| Robinson, DS | 1 |
| Nies, A | 1 |
| Freeman, JW | 2 |
| Loughhead, MG | 1 |
| Nĕmec, J | 1 |
| Snyder, BD | 1 |
| Blonde, L | 1 |
| McWhirter, WR | 1 |
| Roberts, RJ | 1 |
| Mueller, S | 1 |
| Lauer, RM | 1 |
| Barker, GA | 1 |
| Dunlop, ME | 1 |
| Loughnan, PM | 1 |
| Goel, KM | 1 |
| Shanks, RA | 1 |
| Sedal, L | 1 |
| Korman, MG | 1 |
| Williams, PO | 1 |
| Mushin, G | 1 |
| Dwyer, ME | 1 |
| Stocks, JG | 1 |
| Slovis, TL | 1 |
| Ott, JE | 1 |
| Teitebaum, DT | 1 |
| Lipscomb, W | 1 |
| Jensen, AM | 1 |
| Sagardiluz, J | 1 |
| Clèdes, J | 1 |
| Potaux, L | 1 |
| Favarel-Garrigues, JC | 1 |
| Jacobsen, JR | 1 |
| Mundy, GR | 1 |
| Beattie, RR | 1 |
| Ryan, C | 1 |
3 reviews available for amitriptyline and Arrhythmia
| Article | Year |
|---|---|
[A clinical challenge. Pragmatic treatment of migraine and concomitant depression].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Second-Generation; Antidepressive Ag | 2008 |
Antidepressant withdrawal phenomena.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; | 1984 |
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular S | 1982 |
5 trials available for amitriptyline and Arrhythmia
| Article | Year |
|---|---|
Advanced Electrocardiogram Analysis in the Amitriptyline-poisoned Pig Treated with Activated Charcoal Haemoperfusion.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac | 2018 |
A double-blind non-crossover placebo-controlled study between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder.
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Clinical Trials as Topic; Depressive Disorder; Double-Bl | 1984 |
Phenothiazine-induced ECG abnormalities: effect of a glucose load.
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Drug Ther | 1977 |
Double-blind comparative study of paroxetine and amitriptyline in depressed patients of a university psychiatric outpatient clinic (pilot study).
Topics: Adolescent; Adult; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Double-Blind Method; El | 1985 |
Cardiotoxicity of amitriptyline.
Topics: Acute Disease; Adult; Amitriptyline; Arrhythmias, Cardiac; Clinical Trials as Topic; Death, Sudden; | 1972 |
76 other studies available for amitriptyline and Arrhythmia
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Esmolol for intractable ventricular arrhythmias in major amitriptyline toxicity.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Humans; Propanolamines; Tachy | 2022 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
[Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication].
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Arrhythmias, Cardiac; Drug Overdose; Female; Hum | 2018 |
Psychotropic Pharmacotherapy Associated With QT Prolongation Among Veterans With Posttraumatic Stress Disorder.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Arrhythmias, Cardiac; Buspirone; Female; Humans; Male | 2018 |
Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.
Topics: Adolescent; Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Electrophysiology; Female; Heart; Hear | 2018 |
The effects of diltiazem and metoprolol in QTc prolongation due to amitriptyline intoxication.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular Agent | 2016 |
The association between pro-arrhythmic agents and aortic stenosis in young adults: is it sufficient to clarify the sudden unexpected deaths?
Topics: Adult; Amitriptyline; Aortic Valve Stenosis; Arrhythmias, Cardiac; Autopsy; Caffeine; Death, Sudden, | 2017 |
Incidence of tricyclic antidepressant-like complications after cyclobenzaprine overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Chi-Square Distributio | 2011 |
Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Arrhythmias, Cardiac; Child; Dr | 2012 |
Amitriptyline cream ingestion in a 1-year-old boy.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Humans; Infant; Male; Poisoni | 2012 |
AMITRIPTYLINE POISONING. CLINICAL AND PATHOLOGICAL FINDINGS IN A FATAL CASE.
Topics: Amitriptyline; Amobarbital; Antidepressive Agents; Apnea; Arrhythmias, Cardiac; Coma; Dialysis; Flui | 1963 |
Influence of the light schedule on the toxicity of amitriptyline in chick embryos.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Chick Embryo; Darkne | 2004 |
[Resuscitation after intoxication with amitriptylin].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiopulmonary Resuscitation | 2005 |
Prolonged clinical effects in modified-release amitriptyline poisoning.
Topics: Acidosis; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Central Nerv | 2006 |
[Plasma drug levels in amitriptyline overdose patient with complicated delayed cardiac arrhythmia and convulsions].
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Drug Overdose; Female; | 2006 |
Heart rate variability reveals risk of arrhythmias after intoxication with antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Heart Rate; Humans; Ma | 2007 |
Drug-induced Brugada syndrome with ST-T wave alternans and long QT.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Cardiac; | 2007 |
[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Dibenzazepines; Female; Human | 1982 |
Ventricular arrhythmias induced by doxepin and amitriptyline: case report.
Topics: Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Doxepin; Humans; Male; Middle Aged | 1983 |
Prostaglandins and the cardiotoxic effects of doxepin in rabbits and guinea-pigs.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Barium; Doxep | 1980 |
Asystole complicating physostigmine treatment of tricyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bradycardia; Electroca | 1980 |
Cardiovascular changes and plasma drug levels after amitriptyline overdose.
Topics: Adolescent; Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Blood Pressure; Electrocardiography; F | 1982 |
Atrial arrhythmia in a patient receiving a tricyclic antidepressant.
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Humans; Male | 1982 |
Effects of cardiac stimulants of amitriptyline toxicity.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Dobutamine; Dopamine; Electrocar | 1981 |
[Treatment of depression with domestic amitriptyline (author's transl)].
Topics: Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Female; Humans; Male; Middle | 1981 |
[Cardiac arrhythmias and electrocardiographic abnormalities in amitriptyline poisoning].
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Diagnosis, Differential; Electrocardiography; Female; Hu | 1981 |
[Effects of psychopharmacologic therapy on heart rate variation].
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Autonomic Nervous System; Clozapine; Depressive Disorder | 1995 |
Decreased R-R variation: a criterium for overdosage of tricyclic psychotropic drugs.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Car | 1995 |
Effects of epinephrine, norepinephrine, magnesium sulfate, and milrinone on survival and the occurrence of arrhythmias in amitriptyline poisoning in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Chi-Square D | 1994 |
Effects of epinephrine and norepinephrine on hemodynamic parameters and arrhythmias during a continuous infusion of amitriptyline in rats.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; | 1993 |
Hyperthermia complicating tricyclic antidepressant overdose.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Body Temperature; Bromocripti | 1996 |
Epinephrine and sodium bicarbonate independently and additively increase survival in experimental amitriptyline poisoning.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Disease Models, Anim | 1997 |
Tricyclic antidepressant overdosage: experimental studies on the management of circulatory complications.
Topics: Acid-Base Equilibrium; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyc | 1976 |
Cardiovascular side effects of long-term therapy with tricyclic antidepressants in the aged.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular System; | 1979 |
Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Cardiovascular System; Dogs; Doxepin; Hypotension; Imi | 1979 |
The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo.
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Behavior | 1979 |
Tricyclic antidepressants and cardiac conduction: changes in ventricular automaticity.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Dogs | 1976 |
A comparison in rabbit isolated hearts of the dysrhythmogenic potential of amitriptyline, maprotiline and mianserin in relation to their ability to block noradrenaline uptake.
Topics: Amitriptyline; Animals; Anthracenes; Arrhythmias, Cardiac; Dibenzazepines; Drug Interactions; Female | 1977 |
Tricyclic choice for ill elderly patients.
Topics: Aged; Amitriptyline; Arrhythmias, Cardiac; Doxepin; Drug Interactions; Humans; Male; Quinidine | 1977 |
Cardiac complications in amitriptyline poisoning. Successful treatment with physostigmine.
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Bundle-Branch Block; Female; Humans; Injections, Intrave | 1976 |
Sodium bicarbonate treatment for tricyclic antidepressant arrhythmias in children.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bicarbonates; Child; | 1976 |
Antidepressant drugs.
Topics: Age Factors; Amitriptyline; Antidepressive Agents; Anxiety; Arrhythmias, Cardiac; Bipolar Disorder; | 1975 |
Letter: Neostigmine methysulfate in the treatment of cardiac arryhthmia induced by perphenazine-amitriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child, Preschool; Drug Combin | 1976 |
Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drug Overdose; Electrocardiog | 1992 |
Comparative effects of antidepressants, amitriptyline, and maprotiline on intraventricular conduction, effective refractory period, and incidence of ventricular arrhythmias induced by programmed stimulation in dog hearts after myocardial infarction.
Topics: Action Potentials; Amitriptyline; Animals; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Dogs; E | 1990 |
Myotonic dystrophy: quantification of muscle weakness and myotonia and the effect of amitriptyline and exercise.
Topics: Action Potentials; Adult; Amitriptyline; Arrhythmias, Cardiac; Exercise Therapy; Female; Humans; Mal | 1990 |
Antiarrhythmic properties of amitriptyline.
Topics: Aged; Amitriptyline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bulbar Palsy, Progressive; Cerebr | 1990 |
Electrocardiographic effects of amitriptyline in therapeutic doses on 24-hr monitoring (Holter) with correlation to plasma levels.
Topics: Adult; Aged; Amitriptyline; Arrhythmias, Cardiac; Depressive Disorder; Electrocardiography, Ambulato | 1990 |
Effects of antidepressants on the intraventricular conduction and the incidence of arrhythmias induced by programmed ventricular stimulation in the dog heart after myocardial infarction.
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Antidepressive Agents; Arrhythmias, Cardiac; Benzodiaze | 1990 |
[Acute cardiotoxicity of tricyclic compounds: remarks on a clinical case].
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Carbamazepine; Electrocardiography; Female; Heart; Heart | 1988 |
Amitriptyline plasma protein binding: effect of plasma pH and relevance to clinical overdose.
Topics: Amitriptyline; Arrhythmias, Cardiac; Bicarbonates; Chromatography, Gas; Humans; Hydrogen-Ion Concent | 1986 |
Bicarbonate therapy for the cardiovascular toxicity of amitriptyline in an animal model.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Bicarbonates; Blood Gas Analysis; Dogs; Electrocardiog | 1985 |
Experimental amitriptyline intoxication: treatment of cardiac toxicity with sodium bicarbonate.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Bicarbonates; Dogs; Electrocardiography; Heart Conduct | 1986 |
Phenytoin: does it reverse tricyclic-antidepressant-induced cardiac conduction abnormalities?
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Electrocardiography; | 1986 |
Cardiovascular effects of polycyclic antidepressants.
Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depression; | 1986 |
[Clinical course and treatment of acute amitriptyline poisoning].
Topics: Acute Disease; Adolescent; Adult; Amitriptyline; Arrhythmias, Cardiac; Combined Modality Therapy; Cr | 1986 |
Effect of fluoxetine on the electrocardiogram.
Topics: Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch | 1985 |
Frequency-dependent effects of amitriptyline on ventricular conduction and cardiac rhythm in dogs.
Topics: Action Potentials; Amitriptyline; Animals; Arrhythmias, Cardiac; Dogs; Heart Conduction System; Hear | 1985 |
Adverse reactions to the tricyclic-antidepressant drugs. Report from Boston Collaborative Drug Surveillance Program.
Topics: Amitriptyline; Anxiety; Arrhythmias, Cardiac; Cardiovascular Diseases; Depression; Female; Heart; Hu | 1972 |
Cardiotoxicity of amitriptyline.
Topics: Age Factors; Amitriptyline; Arrhythmias, Cardiac; Heart; Humans | 1972 |
Cardiotoxicity of amitriptyline.
Topics: Amitriptyline; Arrhythmias, Cardiac; Heart; Humans; Male; Middle Aged | 1972 |
Beta blockade in the treatment of tricyclic antidepressant overdosage.
Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Amino Alcohols; Amitriptyline; Antidepressive Agen | 1973 |
Cardiotoxic effects of tricyclic antidepressants imipramine, amitriptiline and dosulepin (prothiaden spofa) in an acute experiment in rats.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dibenzothiepins; Dothiepin; Heart; Imipramine; Rats | 1974 |
Reversal of amitriptyline intoxication by physostigmine.
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Female; Humans; Injections, Intravenous; Injections, Sub | 1974 |
Propranolol in the treatment of cardiac arrhythmias associated with amitriptyline intoxication.
Topics: Amitriptyline; Arrhythmias, Cardiac; Atropine; Child, Preschool; Electrocardiography; Female; Humans | 1973 |
The use of sodium bicarbonate in the treatment of tricyclic antidepressant-induced arrhythmias.
Topics: Acid-Base Equilibrium; Acidosis; Amitriptyline; Animals; Antidepressive Agents; Arrhythmias, Cardiac | 1973 |
Amitriptyline and imipramine poisoning in children.
Topics: Amitriptyline; Arrhythmias, Cardiac; Child, Preschool; Depression; Enuresis; Female; Humans; Imipram | 1974 |
Overdosage of tricyclic antidepressants. A report of two deaths and a prospective study of 24 patients.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch Block; | 1972 |
Antidepressant overdosage in children--a new menace.
Topics: Accidents, Home; Adolescent; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Child; Chil | 1971 |
Physostigmine therapy in acute tricyclic antidepressant poisoning.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Barbiturates; Blood P | 1971 |
[Amitriptyline poisoning with severe cardiac arrhythmia treated with lidocaine].
Topics: Accidents, Home; Amitriptyline; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Infant; I | 1970 |
Amitryptiline and cardiac disease.
Topics: Amitriptyline; Arrhythmias, Cardiac; Depression; Female; Heart Block; Heart Diseases; Humans; Hypote | 1970 |
[Cardiac complications in acute poisoning].
Topics: Adolescent; Adult; Amitriptyline; Arrhythmias, Cardiac; Child; Child, Preschool; Chloroquine; Digita | 1967 |
[Amitriptyline poisoning with severe cardiac arrhythmia. Cardiac arrhythmia treated with propranolol].
Topics: Amitriptyline; Arrhythmias, Cardiac; Child, Preschool; Electrocardiography; Humans; Injections, Intr | 1969 |
Cardiac abnormalities in poisoning with tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Electrocardiography; | 1969 |