amitriptyline has been researched along with Anterior Cervical Pain in 7 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized controlled trial is the first to show the effectiveness and tolerance of a medication, low-dose amitriptyline, in managing idiopathic chronic neck pain and its related comorbidities." | 9.27 | Randomized double-blind controlled study of bedtime low-dose amitriptyline in chronic neck pain. ( Abdel Hay, J; Garcia-Larrea, L; Kobaiter-Maarrawi, S; Maarrawi, J; Peyron, R; Tabet, P, 2018) |
| "To evaluate efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15- and 30-mg capsules in patients with muscle spasm associated with acute, painful musculoskeletal conditions." | 9.14 | Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design. ( Altman, CA; Borenstein, DG; Malanga, GA; Ruoff, GE; Weil, AJ; Xie, F, 2009) |
| "This prospective, randomized, open-label, multicenter, community-based study was conducted to compare cyclobenzaprine 5 mg three times daily (TID) orally (CYC5) given for 7 days as monotherapy or in combination with ibuprofen 400 mg TID (CYC5/IBU400) or 800 mg TID (CYC5/IBU800) in adults with acute neck or back pain with muscle spasm." | 9.11 | Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial. ( Borenstein, D; Brown, RL; Childers, MK; Gershon, S; Hale, ME; Harrison, DD; Laudadio, C; Petri, M; Wan, GJ, 2005) |
| "Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions." | 9.10 | Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials. ( Borenstein, DG; Korn, S, 2003) |
| "This randomized controlled trial is the first to show the effectiveness and tolerance of a medication, low-dose amitriptyline, in managing idiopathic chronic neck pain and its related comorbidities." | 5.27 | Randomized double-blind controlled study of bedtime low-dose amitriptyline in chronic neck pain. ( Abdel Hay, J; Garcia-Larrea, L; Kobaiter-Maarrawi, S; Maarrawi, J; Peyron, R; Tabet, P, 2018) |
| "To evaluate efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15- and 30-mg capsules in patients with muscle spasm associated with acute, painful musculoskeletal conditions." | 5.14 | Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design. ( Altman, CA; Borenstein, DG; Malanga, GA; Ruoff, GE; Weil, AJ; Xie, F, 2009) |
| "This prospective, randomized, open-label, multicenter, community-based study was conducted to compare cyclobenzaprine 5 mg three times daily (TID) orally (CYC5) given for 7 days as monotherapy or in combination with ibuprofen 400 mg TID (CYC5/IBU400) or 800 mg TID (CYC5/IBU800) in adults with acute neck or back pain with muscle spasm." | 5.11 | Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial. ( Borenstein, D; Brown, RL; Childers, MK; Gershon, S; Hale, ME; Harrison, DD; Laudadio, C; Petri, M; Wan, GJ, 2005) |
| "Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions." | 5.10 | Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials. ( Borenstein, DG; Korn, S, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Mahmoud, AMS | 1 |
| Ragab, SG | 1 |
| Boules, ML | 1 |
| Botros, JM | 1 |
| Ellison, C | 1 |
| Lyndon, S | 1 |
| Maarrawi, J | 1 |
| Abdel Hay, J | 1 |
| Kobaiter-Maarrawi, S | 1 |
| Tabet, P | 1 |
| Peyron, R | 1 |
| Garcia-Larrea, L | 1 |
| Malanga, GA | 1 |
| Ruoff, GE | 1 |
| Weil, AJ | 1 |
| Altman, CA | 1 |
| Xie, F | 1 |
| Borenstein, DG | 2 |
| Korn, S | 1 |
| Childers, MK | 1 |
| Borenstein, D | 1 |
| Brown, RL | 1 |
| Gershon, S | 1 |
| Hale, ME | 1 |
| Petri, M | 1 |
| Wan, GJ | 1 |
| Laudadio, C | 1 |
| Harrison, DD | 1 |
| Schreiber, S | 1 |
| Vinokur, S | 1 |
| Shavelzon, V | 1 |
| Pick, CG | 1 |
| Zahavi, E | 1 |
| Shir, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Flexeril� (Cyclobenzaprine Hydrochloride) Community Based Study - An Evaluation of Cyclobenzaprine HCl Monotherapy and in Combination With Ibuprofen for Acute Back or Neck Muscle Pain With Muscle Spasm[NCT00246389] | Phase 4 | 1,000 participants (Actual) | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for amitriptyline and Anterior Cervical Pain
| Article | Year |
|---|---|
Comparison between Two Low Doses of Amitriptyline in the Management of Chronic Neck Pain: A Randomized, Double-Blind, Comparative Study.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Chronic Pain; Double-Blind Met | 2021 |
Randomized double-blind controlled study of bedtime low-dose amitriptyline in chronic neck pain.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Pain; Double-Blind Method; Female; Humans; M | 2018 |
Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design.
Topics: Adolescent; Adult; Aged; Algorithms; Amitriptyline; Delayed-Action Preparations; Double-Blind Method | 2009 |
Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials.
Topics: Acute Disease; Adult; Amitriptyline; Back Pain; Dose-Response Relationship, Drug; Double-Blind Metho | 2003 |
Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial.
Topics: Adolescent; Adult; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Dose-Response | 2005 |
A randomized trial of fluoxetine versus amitriptyline in musculo-skeletal pain.
Topics: Adolescent; Adult; Aged; Amitriptyline; Female; Fluoxetine; Humans; Low Back Pain; Male; Middle Aged | 2001 |
1 other study available for amitriptyline and Anterior Cervical Pain
| Article | Year |
|---|---|
Staying Topical: An Unusual Case of Serotonin Syndrome.
Topics: Amitriptyline; Female; Humans; Middle Aged; Neck Pain; Serotonin Syndrome | 2017 |