amitriptyline has been researched along with Anesthesia in 12 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As a result of amitriptyline's vast array of actions, it could potentially be used as an intraspinal adjuvant in neuraxial anesthesia and/or in the treatment of refractory neuropathic pain." | 3.75 | The neuraxial effects of intraspinal amitriptyline at low concentrations. ( Barros, GA; Fukushima, FB; Ganem, EM; Marques, ME; Vidal, EI, 2009) |
| "Adenosine antagonists were found to be effective in improving hypotension, QRS prolongation and survival time in our rat model of amitriptyline toxicity." | 3.72 | Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? ( Akgun, A; Aygoren, O; Gidener, S; Guven, H; Kalkan, S; Tuncok, Y, 2004) |
| " In anaesthetized dogs (n = 5), dose-response curves were obtained by intravenous infusion of increasing doses of dopexamine (5-20 micrograms kg-1 min-1)." | 1.29 | Cardiovascular actions of dopexamine in anaesthetized and conscious dogs. ( Abdul-Hussein, N; Chang, DH; Einstein, R; Matthews, R; Richardson, DP; Wong, TW, 1994) |
| "Amitriptyline was infused at 0." | 1.27 | Protective actions of carbocromene against amitriptyline-induced cardiotoxicity in anesthetized rats. ( Fiedler, VB; Martorana, PA; Nitz, RE, 1986) |
| " It is concluded that all four drugs show the toxic effects classically associated with tricyclic antidepressants but the relative toxicity amongst these agents varies considerably and is in the order amitriptyline greater than imipramine greater than maprotiline greater than mianserin." | 1.26 | The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo. ( Hughes, IE; Radwan, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukushima, FB | 1 |
| Barros, GA | 1 |
| Marques, ME | 1 |
| Vidal, EI | 1 |
| Ganem, EM | 1 |
| Lacroix, P | 1 |
| LAI, G | 1 |
| JENKINS, LC | 1 |
| GRAVES, HB | 1 |
| LEVESQUE, PR | 1 |
| LINDSLEY, OR | 1 |
| ETSTEN, BE | 1 |
| Kalkan, S | 1 |
| Aygoren, O | 1 |
| Akgun, A | 1 |
| Gidener, S | 1 |
| Guven, H | 1 |
| Tuncok, Y | 1 |
| Follmer, CH | 1 |
| Lum, BK | 1 |
| Einstein, R | 1 |
| Abdul-Hussein, N | 1 |
| Wong, TW | 1 |
| Chang, DH | 1 |
| Matthews, R | 1 |
| Richardson, DP | 1 |
| Hughes, IE | 1 |
| Radwan, S | 1 |
| Yokota, S | 1 |
| Ishikura, Y | 1 |
| Ono, H | 1 |
| Fiedler, VB | 1 |
| Martorana, PA | 1 |
| Nitz, RE | 1 |
| Davidson, J | 1 |
12 other studies available for amitriptyline and Anesthesia
| Article | Year |
|---|---|
The neuraxial effects of intraspinal amitriptyline at low concentrations.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthesia; Animals; Central Nervous System; Dogs; Female; | 2009 |
Electrocardiographic toxicity in the guinea pig.
Topics: Amitriptyline; Anesthesia; Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Re | 2002 |
[STIMULATION AND SEDATION IN THE TREATMENT OF DEPRESSIVE STATES].
Topics: Amitriptyline; Anesthesia; Depression; Depressive Disorder; Humans | 1963 |
POTENTIAL HAZARDS OF PSYCHOACTIVE DRUGS IN ASSOCIATION WITH ANAESTHESIA.
Topics: Adjuvants, Anesthesia; Amino Alcohols; Amitriptyline; Anesthesia; Antidepressive Agents; Depression; | 1965 |
AMITRIPTYLINE (ELAVIL): A SEDATING ANTIDEPRESSANT WITH PRESSOR ACTIVITY FOR PREOPERATIVE MEDICATION.
Topics: Amitriptyline; Anesthesia; Anesthesiology; Antidepressive Agents; Geriatrics; Halothane; Pharmacolog | 1965 |
Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats?
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiovascular | 2004 |
Protective action of diazepam and of sympathomimetic amines against amitryptyline-induced toxicity.
Topics: Amitriptyline; Anesthesia; Animals; Cardiovascular Diseases; Cats; Diazepam; Female; Male; Myocardia | 1982 |
Cardiovascular actions of dopexamine in anaesthetized and conscious dogs.
Topics: Adrenergic beta-Antagonists; Amitriptyline; Anesthesia; Animals; Blood Pressure; Dogs; Dopamine; Dos | 1994 |
The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo.
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Behavior | 1979 |
Cardiovascular effects of paroxetine, a newly developed antidepressant, in anesthetized dogs in comparison with those of imipramine, amitriptyline and clomipramine.
Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents; Atrioventricular Node; Blood Pressure; Cl | 1987 |
Protective actions of carbocromene against amitriptyline-induced cardiotoxicity in anesthetized rats.
Topics: Amitriptyline; Anesthesia; Animals; Blood Pressure; Chromonar; Coumarins; Electrocardiography; Heart | 1986 |
The management of resistant depression.
Topics: Amitriptyline; Anesthesia; Depression; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 1974 |