Page last updated: 2024-10-22

amitriptyline and Analgesic Overuse Headache

amitriptyline has been researched along with Analgesic Overuse Headache in 5 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

Excerpt	Relevance	Reference
"Migraine is a disabling and prevalent condition that affects the pediatric and adolescent population."	2.58	The Changing Landscape of Pediatric Migraine Therapy: A Review. ( Patterson-Gentile, C; Szperka, CL, 2018)
"We define chronic migraine as that clinical situation in which migraine attacks appear 15 or more days per month."	2.48	[Chronic migraine: treatment]. ( Pascual, J, 2012)

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	4 (80.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Patterson-Gentile, C	1
Szperka, CL	1
Fan, W	1
Lv, Y	1
Ying, G	1
Li, W	1
Zhou, J	1
Hagen, K	1
Stovner, LJ	1
Pascual, J	1
Di Lorenzo, C	1
Ambrosini, A	1
Coppola, G	1
Pierelli, F	1

Clinical Trials (3)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department[NCT03576820]	Phase 3	50 participants (Anticipated)	Interventional	2018-10-15	Recruiting
Treatment of Medication-overuse Headache: 4 Years Follow up[NCT00918671]		60 participants (Actual)	Observational	2008-01-31	Completed
Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly? A Randomized Multi-centre Follow-up.[NCT00159588]		64 participants (Actual)	Interventional	2004-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Headache Days/Month After 4 Years Compared to Baseline

Change in headache days/month after 4 years compared to baseline (NCT00918671)
Timeframe: Baseline and after 4 years

Intervention	headache days/month (Mean)
Medication-overuse Headache	6.6

Change of Medication Days/Month Compared to Baseline

(NCT00918671)
Timeframe: Baseline and after 4 years' of follow-up

Intervention	medication days/month (Mean)
Medication-overuse Headache	9.53

Headache Days

Change in Headache days per month (NCT00159588)
Timeframe: 5 month

Intervention	days/month (Median)
Prophylaxis From the Start	7.2
Abrupt Withdrawal	4.2
Controls	1.6

Headache Index

Headache index (HI) per month calculated by the sum of products of headache days /month combined with mean daily hours with headache and mean daily headache severity on days with headache. High HI reflect high headache burden (NCT00159588)
Timeframe: 5-month follow-up

Intervention	headache index per month (Mean)
Preventive Drugs From the Start	169
Abrupt Withdrawal	371
Controls	302

Reviews

2 reviews available for amitriptyline and Analgesic Overuse Headache

Article	Year
The Changing Landscape of Pediatric Migraine Therapy: A Review. JAMA neurology, 2018, 07-01, Volume: 75, Issue:7 Topics: Adolescent; Adrenergic beta-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory	2018
[Chronic migraine: treatment]. Revista de neurologia, 2012, Apr-10, Volume: 54 Suppl 2 Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antihypertensiv	2012

Trials

2 trials available for amitriptyline and Analgesic Overuse Headache

Article	Year
Pilot study of amitriptyline in the prophylactic treatment of medication-overuse headache: a 1-year follow-up. Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:10 Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Female; Follow-Up Studies; Headache Disorders,	2014
A randomized controlled trial on medication-overuse headache: outcome after 1 and 4 years. Acta neurologica Scandinavica. Supplementum, 2011, Issue:191 Topics: Adolescent; Adult; Aged; Amines; Amitriptyline; Analgesics; Angiotensin Receptor Antagonists; Cycloh	2011
A randomized controlled trial on medication-overuse headache: outcome after 1 and 4 years. Acta neurologica Scandinavica. Supplementum, 2011, Issue:191 Topics: Adolescent; Adult; Aged; Amines; Amitriptyline; Analgesics; Angiotensin Receptor Antagonists; Cycloh	2011
A randomized controlled trial on medication-overuse headache: outcome after 1 and 4 years. Acta neurologica Scandinavica. Supplementum, 2011, Issue:191 Topics: Adolescent; Adult; Aged; Amines; Amitriptyline; Analgesics; Angiotensin Receptor Antagonists; Cycloh	2011
A randomized controlled trial on medication-overuse headache: outcome after 1 and 4 years. Acta neurologica Scandinavica. Supplementum, 2011, Issue:191 Topics: Adolescent; Adult; Aged; Amines; Amitriptyline; Analgesics; Angiotensin Receptor Antagonists; Cycloh	2011

Other Studies

1 other study available for amitriptyline and Analgesic Overuse Headache

Article	Year
Heat stress disorders and headache: a case of new daily persistent headache secondary to heat stroke. Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:5 Topics: Amines; Amitriptyline; Analgesics; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Dr	2008