amitriptyline has been researched along with Amyotrophic Lateral Sclerosis in 10 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Excerpt | Relevance | Reference |
---|---|---|
"There were 1948 treatment histories for modafinil and 1394 treatment reports for amitriptyline reported across five PatientsLikeMe communities (multiple sclerosis, Parkinson's disease, mood conditions, fibromyalgia/chronic fatigue syndrome, and amyotrophic lateral sclerosis)." | 3.77 | Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe. ( Frost, J; Heywood, J; Okun, S; Vaughan, T; Wicks, P, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (50.00) | 18.7374 |
1990's | 1 (10.00) | 18.2507 |
2000's | 1 (10.00) | 29.6817 |
2010's | 3 (30.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Banks, DB | 1 |
Chan, GN | 1 |
Evans, RA | 1 |
Miller, DS | 1 |
Cannon, RE | 1 |
Pinto, S | 1 |
Gromicho, M | 1 |
de Carvalho, M | 1 |
Sawada, J | 1 |
Yamashita, T | 1 |
Aizawa, H | 1 |
Aburakawa, Y | 1 |
Hasebe, N | 1 |
Kwak, S | 1 |
Frost, J | 1 |
Okun, S | 1 |
Vaughan, T | 1 |
Heywood, J | 1 |
Wicks, P | 1 |
Smith, RA | 1 |
Norris, FH | 1 |
Goldblatt, D | 1 |
Leys, D | 1 |
Petit, H | 1 |
Pascuzzi, RM | 1 |
Dorman, JD | 1 |
10 other studies available for amitriptyline and Amyotrophic Lateral Sclerosis
Article | Year |
---|---|
Lysophosphatidic acid and amitriptyline signal through LPA1R to reduce P-glycoprotein transport at the blood-brain barrier.
Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Animals; Antidepressive Agents, Tricyclic; ATP Binding | 2018 |
Sialorrhoea and reversals in ALS functional rating scale.
Topics: Aged; Amitriptyline; Amyotrophic Lateral Sclerosis; Atropine; Cholinergic Antagonists; Deglutition D | 2017 |
Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line.
Topics: Adenosine Deaminase; Amitriptyline; Amyotrophic Lateral Sclerosis; Antidepressive Agents; Arginine; | 2009 |
Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.
Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Benzhydryl Compounds; Cognition Disorders; Community N | 2011 |
Symptomatic care of patients with amyotrophic lateral sclerosis.
Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Aphonia; Braces; Deglutition Disorders; Edetic Acid; E | 1975 |
Treatment of amyotrophic lateral sclerosis.
Topics: Aging; Amitriptyline; Amyotrophic Lateral Sclerosis; Baclofen; Braces; Dantrolene; Deglutition Disor | 1977 |
Clinical signs of amyotrophic lateral sclerosis developing after polyradiculoneuropathy associated with amitriptyline.
Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Drug Overdose; Humans; Polyradiculoneuropathy; Reflex, | 1990 |
Amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amitriptyline; Amyotrophic Lateral Sclerosis; Cholinesterase Inhibitors; Diagnosis, Dif | 1988 |
Amitriptyline in amyotrophic lateral sclerosis.
Topics: Adult; Amitriptyline; Amyotrophic Lateral Sclerosis; Emotions; Humans; Male; Methylphenidate; Parkin | 1985 |
Treatment of amyotrophic lateral sclerosis.
Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Humans | 1969 |