amitriptyline has been researched along with Alloxan Diabetes in 9 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the present investigation was to evaluate, firstly, the peripheral and systemic effects of amitriptyline on tactile allodynia in the streptozotocin (STZ)-induced diabetic rat model of neuropathic pain and, secondly, whether caffeine coadministration affects the actions of amitriptyline." | 3.71 | Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats. ( Aslantas, A; Dokmeci, I; Firat, Z; Karadag, HC; Tamer, M; Ulugol, A, 2002) |
| " However, sitagliptin was observed to have no effect when administered alone or in combination with the other three drugs." | 1.43 | Drug combinations in diabetic neuropathic pain: an experimental validation. ( Mehta, AK; Tripathi, CD; Yadav, AM, 2016) |
| " Analysis of the log dose-response curves for oxcarbazepine or gabapentin in a presence of amitriptyline and oxcarbazepine or gabapentin applied alone, revealed a synergism in oxcarbazepine-amitriptyline and additivity in gabapentin-amitriptyline combination." | 1.36 | Analysis of the antinociceptive interactions in two-drug combinations of gabapentin, oxcarbazepine and amitriptyline in streptozotocin-induced diabetic mice. ( Bosković, B; Micov, AM; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| " There is also a fairly broad consensus that gabapentin is safe and well tolerated, but the side-effect profile of gabapentin has not been adequately assessed in pain populations." | 1.33 | Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy. ( Bourin, C; Chen, P; Hogan, JB; Leet, JE; Lindner, MD; Machet, F; McElroy, JF; Stock, DA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Jin, SJ | 1 |
| Su, J | 1 |
| Li, XX | 1 |
| Xu, M | 1 |
| Tripathi, CD | 1 |
| Mehta, AK | 1 |
| Yadav, AM | 1 |
| Tomić, MA | 1 |
| Vucković, SM | 1 |
| Stepanović-Petrović, RM | 1 |
| Micov, AM | 1 |
| Ugresić, ND | 1 |
| Prostran, MS | 1 |
| Bosković, B | 1 |
| Mahmood, D | 1 |
| Akhtar, M | 1 |
| Vohora, D | 1 |
| Khanam, R | 1 |
| Ulugol, A | 1 |
| Karadag, HC | 1 |
| Tamer, M | 1 |
| Firat, Z | 1 |
| Aslantas, A | 1 |
| Dokmeci, I | 1 |
| Lindner, MD | 1 |
| Bourin, C | 1 |
| Chen, P | 1 |
| McElroy, JF | 1 |
| Leet, JE | 1 |
| Hogan, JB | 1 |
| Stock, DA | 1 |
| Machet, F | 1 |
| Coudoré, F | 2 |
| Besson, A | 2 |
| Courteix, C | 1 |
| Eschalier, A | 2 |
| Lavarenne, J | 2 |
| Fialip, J | 2 |
| Shrivastava, R | 1 |
| Chevalier, A | 1 |
| Massingham, R | 1 |
| Field, MJ | 1 |
| McCleary, S | 1 |
| Hughes, J | 1 |
| Singh, L | 1 |
9 other studies available for amitriptyline and Alloxan Diabetes
| Article | Year |
|---|---|
Acid Sphingomyelinase Down-regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.
Topics: Amitriptyline; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Down-Regulation; End | 2018 |
Drug combinations in diabetic neuropathic pain: an experimental validation.
Topics: Amitriptyline; Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug The | 2016 |
Analysis of the antinociceptive interactions in two-drug combinations of gabapentin, oxcarbazepine and amitriptyline in streptozotocin-induced diabetic mice.
Topics: Administration, Oral; Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Carbamazepine; C | 2010 |
Comparison of antinociceptive and antidiabetic effects of sertraline and amitriptyline on streptozotocin-induced diabetic rats.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Diabetes Mellit | 2010 |
Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Diabetes | 2002 |
Adverse effects of gabapentin and lack of anti-allodynic efficacy of amitriptyline in the streptozotocin model of painful diabetic neuropathy.
Topics: Amines; Amitriptyline; Animals; Cognition Disorders; Cyclohexanecarboxylic Acids; Diabetes Mellitus, | 2006 |
Pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites in streptozocin-induced diabetic rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Diabetes Mellitus, Experimental; Hy | 1996 |
Comparison of amitriptyline metabolism in hepatocytes from streptozocin-induced diabetic rats and from non-diabetic rats.
Topics: Amitriptyline; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucuronidase; Liver; Male | 1997 |
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus | 1999 |