amitriptyline and Alcoholism studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

Research Excerpts

Excerpt	Relevance	Reference
"90 patients with alcoholism stage II suffering from secondary affective disorders (anxiety, depression) were divided into 4 groups: treated with GABA-B-receptor ligand baclofen (group 1), with sibazon (group 2), amitriptylin (group 3), placebo (group 4)."	9.07	[The use of baclofen for treating affective disorders in alcoholism]. ( Borodkin, IuS; Burakov, AM; Grinenko, AIa; Ivanov, VB; Karandashova, GF; Krupitskiĭ, EM; Lapin, IP, 1994)
"Mirtazapine was tolerated better than amitriptyline treatment."	6.73	Effectiveness and tolerability of mirtazapine and amitriptyline in alcoholic patients with co-morbid depressive disorder: a randomized, double-blind study. ( Akdeniz, F; Altintoprak, AE; Coskunol, H; Kitapcioglu, G; Zorlu, N, 2008)
"90 patients with alcoholism stage II suffering from secondary affective disorders (anxiety, depression) were divided into 4 groups: treated with GABA-B-receptor ligand baclofen (group 1), with sibazon (group 2), amitriptylin (group 3), placebo (group 4)."	5.07	[The use of baclofen for treating affective disorders in alcoholism]. ( Borodkin, IuS; Burakov, AM; Grinenko, AIa; Ivanov, VB; Karandashova, GF; Krupitskiĭ, EM; Lapin, IP, 1994)
"Mirtazapine was tolerated better than amitriptyline treatment."	2.73	Effectiveness and tolerability of mirtazapine and amitriptyline in alcoholic patients with co-morbid depressive disorder: a randomized, double-blind study. ( Akdeniz, F; Altintoprak, AE; Coskunol, H; Kitapcioglu, G; Zorlu, N, 2008)
"The drug also decreased alcohol addiction, had vegetostabilising and sedative effects."	2.68	[The efficacy and mechanisms of action of lerivon in alcoholism]. ( Anokhina, IP; Chirko, VV; Ivanets, NN; Kogan, BM; Nebarakova, TP; Rusinov, AV, 1996)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (74.51)	18.7374
1990's	6 (11.76)	18.2507
2000's	5 (9.80)	29.6817
2010's	1 (1.96)	24.3611
2020's	1 (1.96)	2.80

Authors	Studies
Greene, MC	1
Kane, J	1
Alto, M	1
Giusto, A	1
Lovero, K	1
Stockton, M	1
McClendon, J	1
Nicholson, T	1
Wainberg, ML	1
Johnson, RM	1
Tol, WA	1
Scanlon, KA	1
Stoppacher, R	1
Blum, LM	1
Starkey, SJ	1
Stiakakis, I	1
Belivanis, SD	1
Tzatzarakis, MN	1
Fragoulis, M	1
Tsatsakis, AM	1
Litvintsev, SV	1
Reznik, AM	1
Arbuzov, AL	1
Kutushev, OT	1
Martyniuk, IuL	1
Khurbatova, IG	1
GREENFIELD, AR	2
OHNELL, LK	1
Schürks, M	1
Overlack, M	1
Bonnet, U	1
Buonopane, A	1
Petrakis, IL	1
Altintoprak, AE	1
Zorlu, N	1
Coskunol, H	1
Akdeniz, F	1
Kitapcioglu, G	1
Arnold, OH	1
Krypsin-Exner, K	1
Olesen, OV	1
Gamburg, AL	1
Aranovich, AG	1
Rasniuk, VA	1
Vol'fson, VL	1
Sandoz, M	1
Vandel, S	1
Vandel, B	1
Bonin, B	1
Allers, G	1
Volmat, R	1
Maany, I	1
Hayashida, M	1
Pfeffer, SL	1
Kron, RE	1
Busch, KT	1
Schulz, H	1
Schou, M	1
Krupitskiĭ, EM	2
Burakov, AM	3
Ivanov, VB	2
Karandashova, GF	1
Lapin, IP	2
Grinenko, AIa	2
Borodkin, IuS	2
Krupitsky, EM	1
Krandashova, GF	1
Ivanets, NN	1
Anokhina, IP	1
Kogan, BM	1
Chirko, VV	1
Nebarakova, TP	1
Rusinov, AV	1
Rosenbaum, AH	1
Niven, RG	1
Hanson, NP	1
Swanson, DW	1
Pinder, RM	1
Brogden, RN	1
Speight, TM	1
Avery, GS	1
Huapaya, LV	1
Hasenbush, LL	1
Petit, JM	1
Spiker, DG	1
Biggs, JT	1
Kluger, NJ	1
Clifford, JS	1
Cavanagh, RJ	1
Griffith, WL	1
Rickels, K	1
Feighner, JP	1
Smith, WT	1
Brahams, D	1
Lôo, H	1
Malka, R	1
Defrance, R	1
Barrucand, D	1
Benard, JY	1
Niox-Rivière, H	1
Raab, A	1
Sarda, A	1
Vachonfrance, G	1
Kamoun, A	1
MacCallum, WA	2
Fava, GA	1
Lisansky, J	1
Kellner, R	1
Zielezny, M	1
Gol'dovskaia, IL	1
Hollister, LE	1
Kashiwagi, T	1
McClure, JN	1
Wetzel, RD	1
Richou, H	1
Overall, JE	1
Brown, D	1
Williams, JD	1
Neill, LT	1
Charnoff, SM	1
Kissin, B	1
Gross, MM	1
Chaftez, ME	1
Rawson, RA	1
Lipscomb, WR	1
Rozynko, J	1
Braasch, F	1
Bolzani, L	1
Slivar, G	1
Boleloucky-Bolen, P	1
Hofmann, G	1
Post, F	1
Dallos, V	1
Heathfield, K	1
Rosengren, E	1
Frederiksen, K	1

Article	Year
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries. The Cochrane database of systematic reviews, 2023, 05-09, Volume: 5 Topics: Acamprosate; Alcoholism; Amitriptyline; Developing Countries; Disulfiram; Humans; Male; Mirtazapine;	2023
Pharmacotherapy of alcohol use disorders. Substance use & misuse, 2005, Volume: 40, Issue:13-14 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Amitriptyline; Antidepressive Agents, Tricyclic; Comorb	2005
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression. Drugs, 1977, Volume: 13, Issue:3 Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Inte	1977
Drugs in the treatment of alcoholism. The Medical clinics of North America, 1967, Volume: 51, Issue:5 Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Chlord	1967

Article	Year
[Correction of affective disorders in patients with alcohol dependence]. Voenno-meditsinskii zhurnal, 2002, Volume: 323, Issue:7 Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, T	2002
Effectiveness and tolerability of mirtazapine and amitriptyline in alcoholic patients with co-morbid depressive disorder: a randomized, double-blind study. Human psychopharmacology, 2008, Volume: 23, Issue:4 Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blin	2008
[The use of baclofen for treating affective disorders in alcoholism]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1994, Volume: 94, Issue:1 Topics: Adult; Alcoholism; Amitriptyline; Baclofen; Diazepam; Drug Evaluation; Humans; Ligands; Mood Disorde	1994
Baclofen administration for the treatment of affective disorders in alcoholic patients. Drug and alcohol dependence, 1993, Volume: 33, Issue:2 Topics: Administration, Oral; Adult; Alcoholism; Amitriptyline; Anxiety Disorders; Baclofen; Blood Platelets	1993
[Effect of pharmacotherapy of affective disorders on the psycho-semantics of alcoholic patients]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1995, Volume: 95, Issue:6 Topics: Alcoholism; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Baclofen; Color Pe	1995
[The efficacy and mechanisms of action of lerivon in alcoholism]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1996, Volume: 96, Issue:5 Topics: Adolescent; Adult; Alcohol Deterrents; Alcoholism; Amitriptyline; Anti-Anxiety Agents; Antidepressiv	1996
Alprazolam, amitriptyline, doxepin, and placebo in the treatment of depression. Archives of general psychiatry, 1985, Volume: 42, Issue:2 Topics: Adult; Alcoholism; Alprazolam; Ambulatory Care; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines;	1985
Tianeptine and amitriptyline. Controlled double-blind trial in depressed alcoholic patients. Neuropsychobiology, 1988, Volume: 19, Issue:2 Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depres	1988
Doxepin hydrochloride. Annals of internal medicine, 1974, Volume: 81, Issue:3 Topics: Alcoholism; Amitriptyline; Anxiety; Clinical Trials as Topic; Depression; Doxepin; Drug Evaluation;	1974
Drug treatment of anxiety and depression in detoxified alcoholic patients. Archives of general psychiatry, 1973, Volume: 29, Issue:2 Topics: Alcoholism; Amitriptyline; Analysis of Variance; Anxiety; Ascorbic Acid; Chlordiazepoxide; Depressio	1973
Long-term treatment of alcoholism with amitriptyline and emylcamate. A double-blind evaluation. Quarterly journal of studies on alcohol, 1967, Volume: 28, Issue:2 Topics: Alcoholism; Amitriptyline; Carbamates; Clinical Trials as Topic; Follow-Up Studies; Humans; Placebos	1967
Drug therapy in alcoholism. The American journal of psychiatry, 1968, Volume: 125, Issue:1 Topics: Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Benactyzine; Carbamates; C	1968
[Clinical study of an anxiolytic antidepressive drug]. Psychiatria et neurologia, 1967, Volume: 153, Issue:5 Topics: Adjustment Disorders; Adult; Aged; Alcoholism; Amitriptyline; Bipolar Disorder; Chlordiazepoxide; Cl	1967

Article	Year
Comprehensive Duloxetine Analysis in a Fatal Overdose. Journal of analytical toxicology, 2016, Volume: 40, Issue:2 Topics: Aged; Alcoholism; Amitriptyline; Depression; Diphenhydramine; Drug Overdose; Duloxetine Hydrochlorid	2016
Disputed case of homicide by smothering due to severe amitriptyline intoxication of the victim. Journal of forensic and legal medicine, 2009, Volume: 16, Issue:5 Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Tricyclic; Asphyxia; Contusions; Facial Inj	2009
Control of alcoholic agitation and depression with perphenazine and amitriptyline combined. Medical times, 1963, Volume: 91 Topics: Alcoholism; Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Humans; Perphenaz	1963
CONTROL OF ALCOHOLIC AGITATION AND DEPRESSION. Current therapeutic research, clinical and experimental, 1963, Volume: 5 Topics: Alcoholism; Amitriptyline; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Humans; Perp	1963
[EXPERIMENTS WITH AMITRIPTYLINE IN ALCOHOLISM]. Svenska lakartidningen, 1964, May-27, Volume: 61 Topics: Alcoholism; Amitriptyline; Depression; Depressive Disorder; Humans; Sweden	1964
Naltrexone treatment of combined alcohol and opioid dependence: deterioration of co-morbid major depression. Pharmacopsychiatry, 2005, Volume: 38, Issue:2 Topics: Alcoholism; Amitriptyline; Depressive Disorder, Major; Ethanol; Humans; Male; Middle Aged; Morphine;	2005
[Spontaneous and experimental delirium]. Arzneimittel-Forschung, 1966, Volume: 16, Issue:2 Topics: Alcoholism; Amitriptyline; Brain; Delirium; Hallucinations; Hallucinogens; Humans; Judgment; Psychos	1966
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine. Archives of neurology, 1967, Volume: 16, Issue:6 Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra	1967
[Therapeutic indications for high dosage of oxazepam]. Annales medico-psychologiques, 1967, Volume: 125, Issue:3 Topics: Alcoholism; Amitriptyline; Dibenzazepines; Humans; Hypnotics and Sedatives; Mental Disorders; Methot	1967
[Various aspects of current treatment of patients with alcoholic delirium]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1983, Volume: 83, Issue:2 Topics: Adult; Alcoholism; Amitriptyline; Disulfiram; Fluphenazine; Humans; Male; Methotrimeprazine; Middle	1983
Biotransformation of amitriptyline in alcoholic depressive patients. European journal of clinical pharmacology, 1983, Volume: 24, Issue:5 Topics: Adult; Aged; Alcoholism; Amitriptyline; Biotransformation; Dealkylation; Depressive Disorder; Female	1983
Possible toxic interaction between disulfiram and amitriptyline. Archives of general psychiatry, 1982, Volume: 39, Issue:6 Topics: Adult; Alcoholism; Amitriptyline; Depressive Disorder; Disulfiram; Drug Interactions; Humans; Male;	1982
[The acute psychiatric emergency]. Zeitschrift fur Alternsforschung, 1981, Volume: 36, Issue:4 Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D	1981
Mortality-lowering effect of prophylactic lithium treatment: a look at the evidence. Pharmacopsychiatry, 1995, Volume: 28, Issue:1 Topics: Alcoholism; Amitriptyline; Bipolar Disorder; Carbamazepine; Humans; Lithium; Mortality; Suicide	1995
Tardive dyskinesia: relationship with a primary affective disorder. Diseases of the nervous system, 1977, Volume: 38, Issue:6 Topics: Adult; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Antipsychotic Agents; Chlordiazepoxide;	1977
Seven cases of somnambulism induced by drugs. The American journal of psychiatry, 1979, Volume: 136, Issue:7 Topics: Adult; Alcoholism; Amitriptyline; Chlorprothixene; Depression; Drug Therapy, Combination; Ethchlorvy	1979
Successful brief therapy of a retired elderly man with intractable pain, depression, and drug and alcohol dependence. Journal of geriatric psychiatry, 1977, Volume: 10, Issue:1 Topics: Aged; Alcoholism; Amitriptyline; Compulsive Personality Disorder; Dependent Personality Disorder; De	1977
Psychiatric diagnosis and tricyclic plasma levels in 36 hospitalized overdose patients. The Journal of nervous and mental disease, 1976, Volume: 163, Issue:4 Topics: Adjustment Disorders; Adolescent; Adult; Affective Symptoms; Age Factors; Alcoholism; Amitriptyline;	1976
A case of a chemically dependent patient with a thalamic pain syndrome treated with amitriptyline. Journal of addictive diseases, 1991, Volume: 10, Issue:3 Topics: Alcoholism; Amitriptyline; Cerebral Infarction; Flurazepam; Follow-Up Studies; Humans; Male; Middle	1991
Prescribing safety precautions recommended for general practice. Lancet (London, England), 1986, Feb-22, Volume: 1, Issue:8478 Topics: Adult; Alcoholism; Amitriptyline; Beer; Drug Prescriptions; England; Family Practice; Female; Forens	1986
Disulfiram and antidepressants. The American journal of psychiatry, 1986, Volume: 143, Issue:10 Topics: Alcoholism; Amitriptyline; Disulfiram; Drug Interactions; Humans	1986
Treatment responses in primary and secondary melancholia: a preliminary report. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:8 Topics: Adult; Alcoholism; Amitriptyline; Depressive Disorder; Female; Hospitalization; Humans; Male; Obsess	1985
Drug interactions in aloholism treatment. Lancet (London, England), 1969, Feb-08, Volume: 1, Issue:7589 Topics: Alcoholism; Amitriptyline; Cyanides; Disulfiram; Drug Synergism; Humans	1969
[Drug therapy of alcoholics]. Lakartidningen, 1974, Jul-24, Volume: 71, Issue:30 Topics: Alcoholism; Amitriptyline; Antidepressive Agents; Humans; Opipramol; Phenothiazines; Time Factors	1974
[The possibilities and limitations of psychotropic drug therapy for patients with glaucoma]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:9 Topics: Aged; Alcoholism; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Chronic Disease; Dementia;	1974
Headache and psychiatric disorders. Diseases of the nervous system, 1972, Volume: 33, Issue:10 Topics: Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Alcoholism; Amitriptyline; Antisocial Pers	1972
[Value, in day hospitals, of intravenous perfusions of amitriptyline]. Annales medico-psychologiques, 1972, Volume: 2, Issue:4 Topics: Adjustment Disorders; Alcoholism; Amitriptyline; Anxiety; Day Care, Medical; Depression; Drug Tolera	1972
Acute delirium in amitriptyline-perphenazine therapy of alcoholism. Clinical toxicology, 1971, Volume: 4, Issue:1 Topics: Acute Disease; Adult; Alcoholism; Amitriptyline; Delirium; Diazepam; Drug Combinations; Hallucinatio	1971
[Therapy of agitated depression using Saroten retard 75 and psychopathologic reflexions on the disease]. Der Nervenarzt, 1971, Volume: 42, Issue:12 Topics: Alcoholism; Amitriptyline; Delayed-Action Preparations; Depression; Female; Humans; Middle Aged; Par	1971
[Delirious syndrome in connection with treatment and overdosis (SMV) amitriptyline]. Wiener klinische Wochenschrift, 1968, Oct-11, Volume: 80, Issue:41 Topics: Adult; Age Factors; Aged; Alcoholism; Amitriptyline; Central Nervous System Diseases; Delirium; Fema	1968
Management of senile psychiatric disorders. British medical journal, 1968, Dec-07, Volume: 4, Issue:5631 Topics: Adjustment Disorders; Affective Symptoms; Aged; Alcoholism; Amitriptyline; Dementia; Depressive Diso	1968
Iatrogenic epilepsy due to antidepressant drugs. British medical journal, 1969, Oct-11, Volume: 4, Issue:5675 Topics: Adolescent; Adult; Alcoholism; Amitriptyline; Antidepressive Agents; Barbiturates; Brain Damage, Chr	1969
[Treatment of alcoholics with amitriptyline]. Lakartidningen, 1966, Jan-19, Volume: 63, Issue:3 Topics: Alcoholism; Amitriptyline; Humans	1966
[Amitriptyline and alcohol--a commentary]. Lakartidningen, 1966, Mar-23, Volume: 63, Issue:12 Topics: Alcoholism; Amitriptyline; Depression; Humans	1966

amitriptyline and Alcoholism

Research Excerpts

Research

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