amitriptyline has been researched along with Aging in 35 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline treatment from midlife preserved water maze performance with aging (p < 0." | 5.31 | Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats. ( Hibberd, C; Meaney, MJ; Morris, RG; Noble, J; Rowe, WB; Seckl, JR; Yau, JL, 2002) |
| " In this study relaxation training, administered in a limited contact format, and amitriptyline were compared for juvenile episodic tension-type headache." | 5.12 | Pharmacological treatment compared to behavioural treatment for juvenile tension-type headache: results at two-year follow-up. ( Andrasik, F; Bussone, G; Grazzi, L; Usai, S, 2007) |
| " Ninety-one hospitalised patients with a major depression (DSM-III) aged 65 and over from six Austrian and one German center were entered into the study, which compared the efficacy and tolerability of paroxetine versus amitriptyline." | 5.08 | Multicenter double blind study of paroxetine and amitriptyline in elderly depressed inpatients. ( Fartacek, R; Geretsegger, C; Heim, M; Mair, M; Platz, T; Stuppaeck, CH, 1995) |
| "Concentrations of amitriptyline (AT), nortriptyline (NT) and E-10-hydroxynortriptyline (E-10-OH-NT) were measured in 18 women with bulimia receiving 100 mg AT/day for at least 6 wk." | 3.67 | Therapeutic drug monitoring of amitriptyline: impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women. ( de Wolff, FA; Edelbroek, PM; Knoppert-van der Klein, EA; van Putten, PM; Zitman, FG, 1987) |
| " The effects of oestrogen treatment and maturation were studied in female rabbits and of aging and amitriptyline treatment in male rabbits." | 3.67 | A comparison of alpha 2-adrenoceptor regulation in brain and platelets. ( Barr, S; Hamilton, CA; Jones, CR; Mishra, N; Reid, JL, 1985) |
| "Amitriptyline was superior to placebo in number with improvement in frequency of ≥ 50% at 8 weeks (25% vs 5% [P = ." | 2.76 | Amitriptyline in the prophylactic treatment of migraine and chronic daily headache. ( Couch, JR, 2011) |
| " Outcome measures included area under the plasma cyclobenzaprine concentration versus time curve (AUC) to 168 hours (AUC168) and infinity (AUC infinity), peak plasma cyclobenzaprine concentration (Cmax), time to observed Cmax (tmax) and terminal elimination half-life of cyclobenzaprine." | 2.74 | Comparison of the single-dose pharmacokinetics of once-daily cyclobenzaprine extended-release 30 mg and cyclobenzaprine immediate-release 10 mg three times daily in the elderly: a randomized, open-label, crossover study. ( Darwish, M; Xie, F, 2009) |
| " The adverse effects were less frequent in the experimental group." | 2.71 | Comparison of efficacy and safety between individualized and empiric dose regimen of amitriptyline in the treatment of major depressive episode. ( Jankovic, SM; Mihajlovic, GS; Milovanovic, DR, 2003) |
| "It is important to understand both the kinetic and the dynamic implications of dosing TCAs and BZs in the elderly, for whom these drugs are frequently prescribed." | 2.37 | Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. ( Cutler, NR; Narang, PK, 1984) |
| "Buspirone was not removed by hemodialysis." | 2.37 | Metabolism and disposition of buspirone. ( Gammans, RE; LaBudde, JA; Mayol, RF, 1986) |
| "Amitriptyline treatment from midlife preserved water maze performance with aging (p < 0." | 1.31 | Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats. ( Hibberd, C; Meaney, MJ; Morris, RG; Noble, J; Rowe, WB; Seckl, JR; Yau, JL, 2002) |
| "Amitriptyline treatment decreased 5-HT1A receptor mRNA expression in the dorsal raphe nucleus of the aged rats (24% fall compared to saline treated controls, p<0." | 1.30 | Serotonin receptor subtype gene expression in the hippocampus of aged rats following chronic amitriptyline treatment. ( Noble, J; Olsson, T; Seckl, JR; Yau, JL, 1999) |
| " More cautions dosage regimens of these drug should be considered for elderly patients." | 1.27 | Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline. ( Hazama, H; Honma, H; Kawahara, K; Kishimoto, A; Mizukawa, R; Ogura, C, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (34.29) | 18.7374 |
| 1990's | 16 (45.71) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Darwish, M | 1 |
| Xie, F | 1 |
| Couch, JR | 1 |
| Rantamäki, T | 1 |
| Vesa, L | 1 |
| Antila, H | 1 |
| Di Lieto, A | 1 |
| Tammela, P | 1 |
| Schmitt, A | 1 |
| Lesch, KP | 1 |
| Rios, M | 1 |
| Castrén, E | 1 |
| Suri, D | 1 |
| Veenit, V | 1 |
| Sarkar, A | 1 |
| Thiagarajan, D | 1 |
| Kumar, A | 1 |
| Nestler, EJ | 1 |
| Galande, S | 1 |
| Vaidya, VA | 1 |
| HORDERN, A | 1 |
| HOLT, NF | 1 |
| BURT, CG | 1 |
| GORDON, WF | 1 |
| Mihajlovic, GS | 1 |
| Milovanovic, DR | 1 |
| Jankovic, SM | 1 |
| Andrasik, F | 1 |
| Grazzi, L | 1 |
| Usai, S | 1 |
| Bussone, G | 1 |
| Branconnier, RJ | 2 |
| Harto-Truax, NE | 1 |
| Cole, JO | 2 |
| Cutler, NR | 1 |
| Narang, PK | 1 |
| Ogura, C | 1 |
| Kishimoto, A | 1 |
| Mizukawa, R | 1 |
| Hazama, H | 1 |
| Honma, H | 1 |
| Kawahara, K | 1 |
| DeVitt, DR | 1 |
| Spera, KF | 1 |
| Henderson, MG | 2 |
| McMillen, BA | 2 |
| Schmider, J | 1 |
| Deuschle, M | 1 |
| Schweiger, U | 1 |
| Körner, A | 1 |
| Gotthardt, U | 1 |
| Heuser, IJ | 1 |
| Yau, JL | 4 |
| Olsson, T | 3 |
| Morris, RG | 2 |
| Meaney, MJ | 2 |
| Seckl, JR | 4 |
| Suzuki, M | 1 |
| Yamaguchi, T | 1 |
| Ozawa, Y | 1 |
| Iwai, A | 1 |
| Yamamoto, M | 1 |
| Geretsegger, C | 1 |
| Stuppaeck, CH | 1 |
| Mair, M | 1 |
| Platz, T | 1 |
| Fartacek, R | 1 |
| Heim, M | 1 |
| Rechlin, T | 1 |
| Claus, D | 1 |
| Weis, M | 1 |
| Monteleone, P | 1 |
| Fabrazzo, M | 1 |
| Amitai, Y | 1 |
| Kennedy, EJ | 1 |
| DeSandre, P | 1 |
| Frischer, H | 1 |
| Rao, ML | 1 |
| Deister, A | 1 |
| Laux, G | 1 |
| Staberock, U | 1 |
| Höflich, G | 1 |
| Möller, HJ | 1 |
| Schiffman, SS | 1 |
| Graham, BG | 1 |
| Suggs, MS | 1 |
| Sattely-Miller, EA | 1 |
| Kelly, PA | 1 |
| Noble, J | 3 |
| Lehofer, M | 1 |
| Moser, M | 1 |
| Hoehn-Saric, R | 1 |
| McLeod, D | 1 |
| Hildebrandt, G | 1 |
| Egner, S | 1 |
| Steinbrenner, B | 1 |
| Liebmann, P | 1 |
| Zapotoczky, HG | 1 |
| Hibberd, C | 1 |
| Rowe, WB | 1 |
| Reveley, MA | 1 |
| Glover, V | 1 |
| Slander, M | 1 |
| Coppen, A | 1 |
| Goldblatt, D | 1 |
| McConnaughey, MM | 1 |
| Fukuchi, H | 1 |
| Kitaura, T | 1 |
| Miyake, K | 1 |
| Kimura, M | 1 |
| Kimura, Y | 1 |
| Sarai, K | 1 |
| Nakahara, T | 1 |
| Corona, GL | 1 |
| Cucchi, ML | 1 |
| Frattini, P | 1 |
| Santagostino, G | 1 |
| Schinelli, S | 1 |
| Zerbi, F | 1 |
| Savoldi, F | 1 |
| McMahon, TF | 1 |
| Weiner, M | 1 |
| Lesko, L | 1 |
| Emm, T | 1 |
| Gammans, RE | 1 |
| Mayol, RF | 1 |
| LaBudde, JA | 1 |
| Edelbroek, PM | 1 |
| Zitman, FG | 1 |
| Knoppert-van der Klein, EA | 1 |
| van Putten, PM | 1 |
| de Wolff, FA | 1 |
| Hamilton, CA | 1 |
| Jones, CR | 1 |
| Mishra, N | 1 |
| Barr, S | 1 |
| Reid, JL | 1 |
| Rosenthal, SH | 1 |
2 reviews available for amitriptyline and Aging
| Article | Year |
|---|---|
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorde | 1984 |
Metabolism and disposition of buspirone.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Aged; Aging; Amitriptyline; Animals; Anxiety Di | 1986 |
12 trials available for amitriptyline and Aging
| Article | Year |
|---|---|
Comparison of the single-dose pharmacokinetics of once-daily cyclobenzaprine extended-release 30 mg and cyclobenzaprine immediate-release 10 mg three times daily in the elderly: a randomized, open-label, crossover study.
Topics: Aged; Aging; Amitriptyline; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Male; M | 2009 |
Amitriptyline in the prophylactic treatment of migraine and chronic daily headache.
Topics: Adolescent; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method | 2011 |
Comparison of efficacy and safety between individualized and empiric dose regimen of amitriptyline in the treatment of major depressive episode.
Topics: Adult; Aged; Aging; Amitriptyline; Antidepressive Agents; Bayes Theorem; Depressive Disorder, Major; | 2003 |
Pharmacological treatment compared to behavioural treatment for juvenile tension-type headache: results at two-year follow-up.
Topics: Adolescent; Age Factors; Aging; Amitriptyline; Analgesics, Non-Narcotic; Child; Disability Evaluatio | 2007 |
Amitriptyline selectively disrupts verbal recall from secondary memory of the normal aged.
Topics: Aged; Aging; Amitriptyline; Female; Humans; Male; Memory; Mental Recall; Middle Aged; Visual Percept | 1982 |
Amitriptyline metabolism in elderly depressed patients and normal controls in relation to hypothalamic-pituitary-adrenal system function.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; | 1995 |
Multicenter double blind study of paroxetine and amitriptyline in elderly depressed inpatients.
Topics: Aged; Aging; Amitriptyline; Depression; Double-Blind Method; Female; Humans; Male; Paroxetine; Time | 1995 |
Heart rate analysis in 24 patients treated with 150 mg amitriptyline per day.
Topics: Adult; Aged; Aging; Amitriptyline; Autonomic Nervous System Diseases; Depressive Disorder; Electroca | 1994 |
Blood levels of mianserin and amitriptyline and clinical response in aged depressed patients.
Topics: Aged; Aged, 80 and over; Aging; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Diso | 1994 |
Low serum levels of tricyclic antidepressants in amitriptyline- and doxepin-treated inpatients with depressive syndromes are associated with nonresponse.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Body Mass In | 1996 |
Influence of age on the parasympatholytic property of tricyclic antidepressants.
Topics: Adult; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Female; H | 1999 |
Absence of platelet monamine oxidase inhibition during amitriptyline or zimelidine treatment.
Topics: Adult; Aging; Allylamine; Amitriptyline; Antidepressive Agents; Blood Platelets; Depression; Humans; | 1979 |
21 other studies available for amitriptyline and Aging
| Article | Year |
|---|---|
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade.
Topics: Aging; Amitriptyline; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Glyc | 2011 |
Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition.
Topics: Aging; Amitriptyline; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Brain-Derived Neu | 2013 |
AMITRIPTYLINE IN DEPRESSIVE STATES: PHENOMENOLOGY AND PROGNOSTIC CONSIDERATIONS.
Topics: Aging; Amitriptyline; Delusions; Depression; Depressive Disorder; Female; Humans; Menopause; Prognos | 1963 |
The effect of aging on the positive chronotropic response to amitriptyline.
Topics: Adult; Age Factors; Aged; Aging; Amitriptyline; Depressive Disorder; Female; Heart Rate; Humans; Mal | 1984 |
Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline.
Topics: Adult; Aged; Aging; Amitriptyline; Blood Pressure; Dibenzothiepins; Dothiepin; Flicker Fusion; Human | 1983 |
Changes in dopamine, serotonin and their metabolites in discrete brain areas of rat offspring after in utero exposure to cocaine or related drugs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amitriptyline; Amygdala; Analysis of Variance; Animals; Brain | 1993 |
Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats.
Topics: Aging; Amitriptyline; Animals; Corticosterone; Escape Reaction; Gene Expression; Hippocampus; In Sit | 1995 |
Effect of YM796, a novel muscarinic agonist, on the impairment of passive avoidance response in senescence-accelerated mice.
Topics: Aging; Aminoquinolines; Amitriptyline; Animals; Avoidance Learning; Cholinesterase Inhibitors; Mice; | 1995 |
Distribution of amitriptyline and nortriptyline in blood: role of alpha-1-glycoprotein.
Topics: Aging; Amitriptyline; Chromatography, High Pressure Liquid; Erythrocytes; Fetal Blood; Humans; Nortr | 1993 |
Effect of psychotropic drugs on taste responses in young and elderly persons.
Topics: Adult; Aged; Aging; Amitriptyline; Clomipramine; Desipramine; Doxepin; Female; Humans; Imipramine; M | 1998 |
Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats.
Topics: Aging; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Binding Sites; Carrier Proteins; De | 1999 |
Serotonin receptor subtype gene expression in the hippocampus of aged rats following chronic amitriptyline treatment.
Topics: Aging; Alternative Splicing; Amitriptyline; Animals; Cerebral Cortex; Diencephalon; Gene Expression | 1999 |
Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats.
Topics: Administration, Oral; Adrenal Glands; Aging; Amitriptyline; Animals; Antidepressive Agents, Tricycli | 2002 |
Treatment of amyotrophic lateral sclerosis.
Topics: Aging; Amitriptyline; Amyotrophic Lateral Sclerosis; Baclofen; Braces; Dantrolene; Deglutition Disor | 1977 |
Long-term consequences of prenatal exposure to cocaine or related drugs: effects on rat brain monoaminergic receptors.
Topics: Aging; Amitriptyline; Animals; Brain; Cerebral Cortex; Cocaine; Corpus Striatum; Female; Male; Nalid | 1991 |
Association between dosage and serum concentration of antidepressants.
Topics: Adult; Aged; Aging; Amitriptyline; Antidepressive Agents; Biotransformation; Chromatography, High Pr | 1990 |
Aspects of amitriptyline and nortriptyline plasma levels monitoring in depression.
Topics: Adult; Aged; Aging; Amitriptyline; Body Weight; Depressive Disorder; Female; Humans; Middle Aged; Mo | 1990 |
Effects of age on antidepressant kinetics and memory in Fischer 344 rats.
Topics: Aging; Amitriptyline; Animals; Kinetics; Learning; Male; Memory; Rats; Rats, Inbred F344; Scopolamin | 1987 |
Therapeutic drug monitoring of amitriptyline: impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women.
Topics: Adolescent; Adult; Aging; Amitriptyline; Bulimia; Chronic Disease; Contraceptives, Oral, Hormonal; D | 1987 |
A comparison of alpha 2-adrenoceptor regulation in brain and platelets.
Topics: Aging; Amitriptyline; Animals; Blood Platelets; Brain; Clonidine; Estradiol; Female; Injections, Int | 1985 |
Recognition of depression.
Topics: Aged; Aging; Amitriptyline; Brain Damage, Chronic; Depression; Humans; Imipramine; Social Isolation; | 1968 |