amitriptyline has been researched along with Affective Disorders in 27 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "90 patients with alcoholism stage II suffering from secondary affective disorders (anxiety, depression) were divided into 4 groups: treated with GABA-B-receptor ligand baclofen (group 1), with sibazon (group 2), amitriptylin (group 3), placebo (group 4)." | 9.07 | [The use of baclofen for treating affective disorders in alcoholism]. ( Borodkin, IuS; Burakov, AM; Grinenko, AIa; Ivanov, VB; Karandashova, GF; Krupitskiĭ, EM; Lapin, IP, 1994) |
| " As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments." | 7.80 | Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. ( Almeida, A; Amorim, D; David-Pereira, A; Pertovaara, A; Pinto-Ribeiro, F, 2014) |
| "90 patients with alcoholism stage II suffering from secondary affective disorders (anxiety, depression) were divided into 4 groups: treated with GABA-B-receptor ligand baclofen (group 1), with sibazon (group 2), amitriptylin (group 3), placebo (group 4)." | 5.07 | [The use of baclofen for treating affective disorders in alcoholism]. ( Borodkin, IuS; Burakov, AM; Grinenko, AIa; Ivanov, VB; Karandashova, GF; Krupitskiĭ, EM; Lapin, IP, 1994) |
| " As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments." | 3.80 | Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. ( Almeida, A; Amorim, D; David-Pereira, A; Pertovaara, A; Pinto-Ribeiro, F, 2014) |
| "Patients with major affective disorders are more likely to complete suicide than patients in any other medical group." | 3.79 | Anticonvulsant therapy and suicide risk in affective disorders. ( Goodwin, FK, 1999) |
| "Anhedonia is often the cause for recurrence in heroine addiction, therefore, an appropriate treatment is an important aspect in recurrence prevention and remission stabilization." | 2.71 | [Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention]. ( Grinenko, AIa; Krupitskiĭ, EM; Zvartau, EE, 2003) |
| " The results of this study indicated that amitriptyline hydrochloride at a dosage of 150 mg at bedtime had significant antidepressant activity in this group of patients." | 2.65 | A placebo-controlled, double-blind trial of amitriptyline in bulimia. ( Groat, R; Mitchell, JE, 1984) |
| " In this respect, the effect of QTP is similar to that obtained after chronic administration of AMI 2 or 5 mg/kg/day." | 1.34 | Quetiapine prevents anhedonia induced by acute or chronic stress. ( Canonico, PL; Colella, L; Dellarole, A; Di Brisco, F; Ghi, P; Orsetti, M, 2007) |
| "Binswanger's disease is a cerebrovascular disorder affecting deep white matter and is associated with dementia and affective disturbance." | 1.28 | Treatment of mood disorder associated with Binswanger's disease. ( Joyce, EM; Levy, R, 1989) |
| "Chronic mood disorders were also assessed using RDC criteria." | 1.26 | Chronic mood disorders in depressed outpatient--diagnosis and response to pharmacotherapy. ( Prusoff, BA; Rounsaville, BJ; Sholomskas, D, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (40.74) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| McLaren, JR | 1 |
| Shi, W | 1 |
| Misko, AL | 1 |
| Emerton, BC | 1 |
| Chu, CJ | 1 |
| Amorim, D | 1 |
| David-Pereira, A | 1 |
| Pertovaara, A | 1 |
| Almeida, A | 1 |
| Pinto-Ribeiro, F | 1 |
| Anderson, JM | 1 |
| Brodsky, MC | 1 |
| Litvintsev, SV | 1 |
| Reznik, AM | 1 |
| Arbuzov, AL | 1 |
| Kutushev, OT | 1 |
| Martyniuk, IuL | 1 |
| Khurbatova, IG | 1 |
| OLTMAN, JE | 1 |
| FRIEDMAN, S | 1 |
| Grinenko, AIa | 3 |
| Krupitskiĭ, EM | 3 |
| Zvartau, EE | 1 |
| Trifirò, G | 1 |
| Barbui, C | 1 |
| Spina, E | 1 |
| Moretti, S | 1 |
| Tari, M | 1 |
| Alacqua, M | 1 |
| Caputi, AP | 1 |
| Arcoraci, V | 1 |
| Rachid, F | 1 |
| Golaz, J | 1 |
| Bondolfi, G | 1 |
| Bertschy, G | 1 |
| Orsetti, M | 1 |
| Canonico, PL | 1 |
| Dellarole, A | 1 |
| Colella, L | 1 |
| Di Brisco, F | 1 |
| Ghi, P | 1 |
| Koval'chuk, VV | 1 |
| Mitchell, JE | 1 |
| Groat, R | 1 |
| Standish-Barry, HM | 1 |
| Bouras, N | 1 |
| Bridges, PK | 1 |
| Watson, JP | 1 |
| Rounsaville, BJ | 1 |
| Sholomskas, D | 1 |
| Prusoff, BA | 1 |
| Rickels, K | 1 |
| James, B | 1 |
| Shipley, JE | 1 |
| Kupfer, DJ | 1 |
| Spiker, DG | 1 |
| Shaw, DH | 1 |
| Coble, PA | 1 |
| Neil, JF | 1 |
| Cofsky, J | 1 |
| Holsboer, F | 1 |
| Grasser, A | 1 |
| Friess, E | 1 |
| Wiedemann, K | 1 |
| Burakov, AM | 2 |
| Ivanov, VB | 1 |
| Karandashova, GF | 1 |
| Lapin, IP | 1 |
| Borodkin, IuS | 2 |
| Deary, IJ | 1 |
| Wilson, JA | 1 |
| Goodwin, FK | 1 |
| Leroi, AM | 1 |
| Lalaude, O | 1 |
| Antonietti, M | 1 |
| Touchais, JY | 1 |
| Ducrotte, P | 1 |
| Menard, JF | 1 |
| Denis, P | 1 |
| Colenda, CC | 1 |
| Holmes, VF | 1 |
| Fricchione, GL | 1 |
| Joyce, EM | 1 |
| Levy, R | 1 |
| Horodnicki, JM | 1 |
| Szakowski, A | 1 |
| Wdowiak, J | 1 |
| Dilsaver, SC | 1 |
3 reviews available for amitriptyline and Affective Disorders
| Article | Year |
|---|---|
Steroid effects on central neurons and implications for psychiatric and neurological disorders.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Benzamides; Brain; Corticotropin-Releasing Hormone; Dexa | 1994 |
Anticonvulsant therapy and suicide risk in affective disorders.
Topics: Amitriptyline; Anticonvulsants; Bipolar Disorder; Carbamazepine; Double-Blind Method; Female; Follow | 1999 |
Pharmacological perturbation of cholinergic systems: applications to the study of pathophysiological mechanisms in affective disorders.
Topics: Amitriptyline; Animals; Biogenic Amines; Body Temperature; Humans; Male; Mood Disorders; Rats; Rats, | 1988 |
10 trials available for amitriptyline and Affective Disorders
| Article | Year |
|---|---|
[Correction of affective disorders in patients with alcohol dependence].
Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, T | 2002 |
[Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention].
Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Antidepressive Agents, Second-Gen | 2003 |
[Pharmacologic correction of psycho-emotive disorders in the rehabilitation of patients after removal of brain tumors].
Topics: Adult; Alprazolam; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain Neoplas | 2007 |
A placebo-controlled, double-blind trial of amitriptyline in bulimia.
Topics: Adult; Amitriptyline; Body Weight; Clinical Trials as Topic; Depression; Double-Blind Method; Emotio | 1984 |
A randomized double blind group comparative study of sulpiride and amitriptyline in affective disorder.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Ag | 1983 |
A double-blind comparative clinical study of amoxapine and amitriptyline in depressed, hospitalised patients.
Topics: Adolescent; Adult; Aged; Amitriptyline; Amoxapine; Body Weight; Cardiovascular Diseases; Clinical Tr | 1982 |
[The use of baclofen for treating affective disorders in alcoholism].
Topics: Adult; Alcoholism; Amitriptyline; Baclofen; Diazepam; Drug Evaluation; Humans; Ligands; Mood Disorde | 1994 |
Problems in treating globus pharyngis.
Topics: Adult; Amitriptyline; Anxiety; Conversion Disorder; Depression; Double-Blind Method; Female; Humans; | 1994 |
[Effect of pharmacotherapy of affective disorders on the psycho-semantics of alcoholic patients].
Topics: Alcoholism; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Baclofen; Color Pe | 1995 |
Anticonvulsant therapy and suicide risk in affective disorders.
Topics: Amitriptyline; Anticonvulsants; Bipolar Disorder; Carbamazepine; Double-Blind Method; Female; Follow | 1999 |
15 other studies available for amitriptyline and Affective Disorders
| Article | Year |
|---|---|
Hippocampal sharp wave ripples during invasive monitoring: A physiologic finding.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Electroencephalography; Epilepsy; Hippocampus; Huma | 2021 |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Arthritis; Carrageenan; Disease Models, Animal; Ex | 2014 |
Anticholinergic esotropia.
Topics: Accommodation, Ocular; Acetylcholine; Adult; Amitriptyline; Benztropine; Brain; Cholinergic Antagoni | 2008 |
Elavil in the treatment of affective disorders (and comparison with tofranil).
Topics: Amitriptyline; Depression; Depressive Disorder; Imipramine; Mood Disorders; Psychopharmacology | 1961 |
Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricycl | 2007 |
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive | 2006 |
Quetiapine prevents anhedonia induced by acute or chronic stress.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Behavior, Animal; Di | 2007 |
Chronic mood disorders in depressed outpatient--diagnosis and response to pharmacotherapy.
Topics: Adolescent; Adult; Affective Symptoms; Amitriptyline; Chronic Disease; Cyclothymic Disorder; Depress | 1980 |
Limbitrol (amitriptyline plus chlordiazepoxide) revisited.
Topics: Adult; Amitriptyline; Anxiety; Chlordiazepoxide; Drug Combinations; Female; Humans; Male; Middle Age | 1981 |
Neuropsychological assessment and EEG sleep in affective disorders.
Topics: Adult; Amitriptyline; Depressive Disorder; Double-Blind Method; Electroencephalography; Female; Huma | 1981 |
Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Anxiety Disorders; Cathartics; Cholinergic Antagonists; | 2000 |
Antiarrhythmic properties of amitriptyline.
Topics: Aged; Amitriptyline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bulbar Palsy, Progressive; Cerebr | 1990 |
Hypomania in an AIDS patient receiving amitriptyline for neuropathic pain.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amitriptyline; Humans; Male; Mood Disorders; Palliative C | 1989 |
Treatment of mood disorder associated with Binswanger's disease.
Topics: Aged; Amitriptyline; Dementia, Vascular; Humans; Lithium; Male; Mood Disorders | 1989 |
Influence of imipramine and amitriptyline on the hypothalamic function in affective disorders.
Topics: Adult; Amitriptyline; Dexamethasone; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; | 1989 |