amitriptyline has been researched along with Affective Disorders, Psychotic in 23 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Affective Disorders, Psychotic: Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The introduction of two tricyclic compounds (iprindole and mianserin) that are reported to have antidepressant properties but to be relatively devoid of effects on central amine neurotransmitter systems has raised questions about the amine hypothesis of depression and about the mechanism of action of tricyclics in general." | 7.66 | Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin. ( Goodwin, FK; Zis, AP, 1979) |
| "When depression was accompanied by character disorder, the response was generally poor." | 6.64 | A comparison of electroconvulsive therapy and combined phenelzine-amitriptyline in refractory depression. ( Davidson, J; Law-Yone, B; Linnoila, M; McLeod, M, 1978) |
| "The introduction of two tricyclic compounds (iprindole and mianserin) that are reported to have antidepressant properties but to be relatively devoid of effects on central amine neurotransmitter systems has raised questions about the amine hypothesis of depression and about the mechanism of action of tricyclics in general." | 3.66 | Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin. ( Goodwin, FK; Zis, AP, 1979) |
| "When depression was accompanied by character disorder, the response was generally poor." | 2.64 | A comparison of electroconvulsive therapy and combined phenelzine-amitriptyline in refractory depression. ( Davidson, J; Law-Yone, B; Linnoila, M; McLeod, M, 1978) |
| " These findings suggest that these antidepressant drugs act as a partial agonists at beta-adrenergic receptors on astrocytes, and that the down-regulation of beta-adrenergic activity that occurs in vivo after chronic administration of antidepressant drugs may, to a large extent, take place in astrocytes and may result from the partial beta-agonist nature of the drugs." | 1.27 | Acute and chronic effects of antidepressant drugs on beta-adrenergic function in astrocytes in primary cultures: an indication of glial involvement in affective disorders? ( Hertz, L; Richardson, JS, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (78.26) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ajiboye, PO | 1 |
| Yusuf, AD | 1 |
| Hertz, L | 1 |
| Richardson, JS | 1 |
| Brown, RP | 1 |
| Sweeney, J | 1 |
| Frances, A | 1 |
| Kocsis, JH | 1 |
| Loutsch, E | 1 |
| Linnoila, M | 2 |
| Gold, P | 1 |
| Potter, WZ | 1 |
| Wehr, TA | 1 |
| Jann, MW | 1 |
| Bitar, AH | 1 |
| Rao, A | 1 |
| Nasrallah, HA | 1 |
| Lyskowksi, J | 1 |
| Schroeder, D | 1 |
| Welner, A | 1 |
| Welner, Z | 1 |
| Robins, E | 1 |
| Rosenbaum, AH | 1 |
| O'Connor, MK | 1 |
| Duane, DD | 1 |
| Auger, RG | 1 |
| Steele, TE | 1 |
| Taylor, CI | 1 |
| Kashani, JH | 1 |
| Hodges, KK | 1 |
| Shekim, WO | 1 |
| Mirin, SM | 1 |
| Schatzberg, AF | 1 |
| Creasey, DE | 1 |
| Rush, AJ | 1 |
| Greil, W | 2 |
| Ludwig-Mayerhofer, W | 1 |
| Steller, B | 1 |
| Czernik, A | 1 |
| Giedke, H | 1 |
| Müller-Oerlinghausen, B | 2 |
| Osterheider, M | 1 |
| Rudolf, GA | 1 |
| Sauer, H | 1 |
| Tegeler, J | 1 |
| Anton, RF | 1 |
| Burch, EA | 1 |
| Thies-Flechtner, K | 1 |
| Seibert, W | 1 |
| Walther, A | 1 |
| McClelland, HA | 1 |
| Kerr, TA | 1 |
| Little, JC | 1 |
| Prusoff, BA | 1 |
| Paykel, ES | 1 |
| Watanabe, S | 1 |
| Yokoyama, S | 1 |
| Kubo, S | 1 |
| Iwai, H | 1 |
| Kuyama, C | 1 |
| Zis, AP | 1 |
| Goodwin, FK | 1 |
| Davidson, J | 1 |
| McLeod, M | 1 |
| Law-Yone, B | 1 |
| Egan, WH | 1 |
| Smith, JA | 1 |
| Kontsevoĭ, VA | 1 |
| Kolibash, E | 1 |
| Piatnitskiĭ, AN | 1 |
| Korzhinkova, V | 1 |
| Andrusenko, MP | 1 |
| Kostrikina, IE | 1 |
| Han, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00335946] | Phase 1 | 40 participants | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 trials available for amitriptyline and Affective Disorders, Psychotic
| Article | Year |
|---|---|
Effect of tricyclic antidepressants on individual symptoms.
Topics: Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder | 1980 |
The recruitment process for a multicenter study on the long-term prophylactic treatment of affective disorders.
Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Bipolar Disorder; Carbamazepine; Depressive Di | 1993 |
Response of psychotic depression subtypes to pharmacotherapy.
Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Amoxapine; Depressive Disorder; Dose-Response | 1993 |
Effect of prophylactic treatment on suicide risk in patients with major affective disorders. Data from a randomized prospective trial.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Amitriptyline; Antidepressive Agents, Tricy | 1996 |
A clinical comparison of nomifensine and amitriptyline.
Topics: Adjustment Disorders; Adult; Affective Disorders, Psychotic; Amitriptyline; Clinical Trials as Topic | 1977 |
Typological prediction of response to amitriptyline: a replication study.
Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Analysis of Variance; Clinical Trials as Topic | 1977 |
A double-blind controlled study of clinical efficacy of maprotiline and amitriptyline in depression.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Amitriptyline; Anthracenes; Bipolar Disorde | 1978 |
A comparison of electroconvulsive therapy and combined phenelzine-amitriptyline in refractory depression.
Topics: Adjustment Disorders; Adult; Affective Disorders, Psychotic; Amitriptyline; Depression; Depressive D | 1978 |
[Comparative study of age-related effectiveness of tri- and tetracyclic antidepressants].
Topics: Affective Disorders, Psychotic; Age Factors; Aged; Amitriptyline; Bipolar Disorder; Depressive Disor | 1991 |
Electroacupuncture: an alternative to antidepressants for treating affective diseases?
Topics: Acupuncture Therapy; Adult; Affective Disorders, Psychotic; Amitriptyline; Animals; Brain; Clinical | 1986 |
13 other studies available for amitriptyline and Affective Disorders, Psychotic
| Article | Year |
|---|---|
Monosymptomatic Hypochondriacal Psychosis (somatic delusional disorder): a report of two cases.
Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychoti | 2013 |
Acute and chronic effects of antidepressant drugs on beta-adrenergic function in astrocytes in primary cultures: an indication of glial involvement in affective disorders?
Topics: Affective Disorders, Psychotic; Amitriptyline; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Dru | 1983 |
Age as a predictor of treatment response in endogenous depression.
Topics: Adult; Affective Disorders, Psychotic; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tric | 1983 |
Tricyclic antidepressants do not alter thyroid hormone levels in patients suffering from a major affective disorder.
Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Amitriptyline; Antidepressive Agents, Tricy | 1981 |
Lithium prophylaxis of tricyclic-antidepressant-induced mania in bipolar patients.
Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Diso | 1982 |
TCA-induced mania: differences between switchers and nonswitchers.
Topics: Adult; Affective Disorders, Psychotic; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; | 1982 |
Treatment of tardive dyskinesia in an agitated, depressed patient.
Topics: Affective Disorders, Psychotic; Aged; Amitriptyline; Dyskinesia, Drug-Induced; Electroconvulsive The | 1980 |
Hypomania and tricyclic antidepressant choice.
Topics: Adult; Affective Disorders, Psychotic; Aged; Amitriptyline; Bipolar Disorder; Depressive Disorder; F | 1980 |
Hypomanic reaction to amitriptyline in a depressed child.
Topics: Affective Disorders, Psychotic; Amitriptyline; Bipolar Disorder; Child; Depressive Disorder; Humans; | 1980 |
Hypomania and mania after withdrawal of tricyclic antidepressants.
Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Diso | 1981 |
Psychotherapy of the affective psychoses.
Topics: Adolescent; Affective Disorders, Psychotic; Aged; Amitriptyline; Child; Cognition; Delusions; Depres | 1980 |
Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin.
Topics: Adjustment Disorders; Affective Disorders, Psychotic; Amitriptyline; Biogenic Amines; Brain; Depress | 1979 |
The unremembered, unimproved depressed patient.
Topics: Adjustment Disorders; Affective Disorders, Psychotic; Amitriptyline; Depression; Electroshock; Human | 1977 |