amitriptyline has been researched along with Adverse Drug Event in 23 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The leading candidate, 4,4'-bis((E)-1-(2-(4-fluorophenyl)hydrazono)ethyl)-1,1'-biphenyl, displayed less hemolysis of murine red blood cells at concentrations at or below that of a control antifungal agent (voriconazole), was fungistatic in a time-kill study, and possessed no mammalian cytotoxicity and no toxicity with respect to hERG inhibition." | 3.91 | N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents. ( Deaciuc, AG; Dennis, EK; Dwoskin, LP; Garneau-Tsodikova, S; Green, KD; Kwiatkowski, S; Ngo, HX; Shrestha, SK; Thamban Chandrika, N; Watt, DS, 2019) |
| "Patients with complaints of migraine attacks were randomly divided into two groups." | 3.11 | Venlafaxine can reduce the migraine attacks as well as amitriptyline: A noninferiority randomized trial. ( Hedayat, M; Heidari, M; Nazarbaghi, S; Sharifi, H, 2022) |
| " In addition, adverse events are usually assessed in patient samples, which can bias results because of the misattribution of symptoms that are part of the illness to medication intake." | 2.87 | Assessment of adverse events in clinical drug trials: Identifying amitriptyline's placebo- and baseline-controlled side effects. ( Doering, BK; Rheker, J; Rief, W; Winkler, A, 2018) |
| "MagnepH liposomes were added to albumin solution containing amitriptyline and dosed intravenously in rats prior to amitriptyline injection." | 1.48 | Magnetic extraction of toxin binding liposomes; a method to ameliorate drug toxicity? Preliminary in vitro/ in vivo study. ( Cave, G; Harvey, M; Kanamala, M; Sleigh, J; Wu, Z, 2018) |
| "Drug-induced phospholipidosis is marked by an excessive accumulation of phospholipids in lysosomes which can occur after exposure to cationic amphiphilic drugs." | 1.37 | High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis. ( Havinga, J; Horbach, GJ; Ravesloot, WT; Schoonen, WG; van de Water, FM, 2011) |
| "Amitriptyline was involved in 37 859 (78." | 1.33 | Frequency of high-risk use of QT-prolonging medications. ( Allen LaPointe, NM; Chan, KA; Curtis, LH; Gurwitz, JH; Kramer, JM; Lafata, JE; Platt, R; Raebel, MA, 2006) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "Treatment with amitriptyline was offered to patients in whom no improvement had been achieved." | 1.31 | Withdrawal therapy improves chronic daily headache associated with long-term misuse of headache medication: a retrospective study. ( Dahlöf, C; Linde, M; Linton-Dahlöf, P, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (26.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Thamban Chandrika, N | 1 |
| Dennis, EK | 1 |
| Shrestha, SK | 1 |
| Ngo, HX | 1 |
| Green, KD | 1 |
| Kwiatkowski, S | 1 |
| Deaciuc, AG | 1 |
| Dwoskin, LP | 1 |
| Watt, DS | 1 |
| Garneau-Tsodikova, S | 1 |
| Hedayat, M | 1 |
| Nazarbaghi, S | 1 |
| Heidari, M | 1 |
| Sharifi, H | 1 |
| Ahomäki, I | 1 |
| Böckerman, P | 1 |
| Pehkonen, J | 1 |
| Saastamoinen, L | 1 |
| Al-Azzawi, F | 1 |
| Mahmoud, I | 1 |
| Haguinet, F | 1 |
| Bate, A | 1 |
| Sessa, M | 1 |
| Brueckle, MS | 1 |
| Thomas, ET | 1 |
| Seide, SE | 1 |
| Pilz, M | 1 |
| Gonzalez-Gonzalez, AI | 1 |
| Nguyen, TS | 1 |
| Harder, S | 1 |
| Glasziou, PP | 1 |
| Gerlach, FM | 1 |
| Muth, C | 1 |
| Rheker, J | 1 |
| Rief, W | 1 |
| Doering, BK | 1 |
| Winkler, A | 1 |
| Cave, G | 1 |
| Harvey, M | 1 |
| Sleigh, J | 1 |
| Kanamala, M | 1 |
| Wu, Z | 1 |
| van de Water, FM | 1 |
| Havinga, J | 1 |
| Ravesloot, WT | 1 |
| Horbach, GJ | 1 |
| Schoonen, WG | 1 |
| Lacroix, P | 1 |
| Lokajová, J | 1 |
| Holopainen, JM | 1 |
| Wiedmer, SK | 1 |
| Allen LaPointe, NM | 1 |
| Curtis, LH | 1 |
| Chan, KA | 1 |
| Kramer, JM | 1 |
| Lafata, JE | 1 |
| Gurwitz, JH | 1 |
| Raebel, MA | 1 |
| Platt, R | 1 |
| Cairella, M | 1 |
| Linton-Dahlöf, P | 1 |
| Linde, M | 1 |
| Dahlöf, C | 1 |
| Vancura, EJ | 1 |
| Lewit, T | 1 |
| Savitsky, E | 1 |
| Moses, AM | 1 |
| Miller, M | 1 |
| Kilpatrick, R | 1 |
| Smith, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacological Conditioning of Sleep Patterns in Healthy Participants Using Amitriptylin[NCT02127736] | 0 participants | Interventional | Completed | ||||
| Effects of Myofascial Trigger Points Therapy in Migraine.[NCT05646160] | 100 participants (Anticipated) | Interventional | 2018-01-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for amitriptyline and Adverse Drug Event
| Article | Year |
|---|---|
[Pulmonary diseases due to drugs. II].
Topics: Amines; Amitriptyline; Beclomethasone; Drug-Related Side Effects and Adverse Reactions; Heroin; Huma | 1974 |
Drug-induced dilutional hyponatremia.
Topics: Acetaminophen; Amitriptyline; Animals; Anura; Body Fluids; Carbamazepine; Chlorpropamide; Clofibrate | 1974 |
Advances in medicine.
Topics: Amitriptyline; Cholera; Coronary Disease; Crohn Disease; Diabetes Mellitus; Diet Therapy; Diverticul | 1971 |
3 trials available for amitriptyline and Adverse Drug Event
| Article | Year |
|---|---|
Venlafaxine can reduce the migraine attacks as well as amitriptyline: A noninferiority randomized trial.
Topics: Adult; Amitriptyline; Drug-Related Side Effects and Adverse Reactions; Female; Headache; Humans; Mal | 2022 |
Assessment of adverse events in clinical drug trials: Identifying amitriptyline's placebo- and baseline-controlled side effects.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Dizziness; Drug-Related Side Effects and Adv | 2018 |
Psychopharmacology in the aged. Discussion.
Topics: Age Factors; Aged; Amitriptyline; Antipsychotic Agents; Bipolar Disorder; Brain Damage, Chronic; Dep | 1974 |
17 other studies available for amitriptyline and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents.
Topics: Animals; Antifungal Agents; Biphenyl Compounds; Drug-Related Side Effects and Adverse Reactions; Ery | 2019 |
Effect of Information Intervention on Prescribing Practice for Neuropathic Pain in Older Patients: A Nationwide Register-Based Study.
Topics: Aged; Amitriptyline; Drug-Related Side Effects and Adverse Reactions; Humans; Inappropriate Prescrib | 2023 |
Developing an Artificial Intelligence-Guided Signal Detection in the Food and Drug Administration Adverse Event Reporting System (FAERS): A Proof-of-Concept Study Using Galcanezumab and Simulated Data.
Topics: Adverse Drug Reaction Reporting Systems; Amitriptyline; Artificial Intelligence; Databases, Factual; | 2023 |
Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis.
Topics: Adult; Amitriptyline; Drug-Related Side Effects and Adverse Reactions; Humans; Meta-Analysis as Topi | 2020 |
Magnetic extraction of toxin binding liposomes; a method to ameliorate drug toxicity? Preliminary in vitro/ in vivo study.
Topics: Amitriptyline; Animals; Drug-Related Side Effects and Adverse Reactions; Ferrosoferric Oxide; Liposo | 2018 |
High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis.
Topics: Amiodarone; Amitriptyline; Animals; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Drug-Relate | 2011 |
Electrocardiographic toxicity in the guinea pig.
Topics: Amitriptyline; Anesthesia; Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Re | 2002 |
Comparison of lipid sinks in sequestering common intoxicating drugs.
Topics: Amiodarone; Amitriptyline; Antidepressive Agents; Drug-Related Side Effects and Adverse Reactions; H | 2012 |
Frequency of high-risk use of QT-prolonging medications.
Topics: Age Factors; Aged; Amitriptyline; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antidepressive Agen | 2006 |
[Drugs inducing obesity].
Topics: Adrenal Cortex Hormones; Amitriptyline; Antidepressive Agents; Antihypertensive Agents; Antipsychoti | 1984 |
Withdrawal therapy improves chronic daily headache associated with long-term misuse of headache medication: a retrospective study.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Drug-Related Side | 2000 |
Guard against unpredictable drug responses in the aging.
Topics: Absorption; Aged; Amitriptyline; Barbiturates; Cathartics; Dihydroergotoxine; Drug Interactions; Dru | 1979 |