amitriptyline has been researched along with Acute Liver Injury, Drug-Induced in 18 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (50.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Kampa, JM | 1 |
| Sahin, M | 1 |
| Slopianka, M | 1 |
| Giampà, M | 1 |
| Bednarz, H | 1 |
| Ernst, R | 1 |
| Riefke, B | 1 |
| Niehaus, K | 1 |
| Fatangare, A | 1 |
| Saito, K | 1 |
| Maekawa, K | 1 |
| Ishikawa, M | 1 |
| Senoo, Y | 1 |
| Urata, M | 1 |
| Murayama, M | 1 |
| Nakatsu, N | 1 |
| Yamada, H | 1 |
| Saito, Y | 1 |
| INVERNIZZI, G | 1 |
| Biagi, RW | 1 |
| Bapat, BN | 1 |
| Kramp, JL | 1 |
| Danan, G | 1 |
| Bernuau, J | 1 |
| Moullot, X | 1 |
| Degott, C | 1 |
| Pessayre, D | 1 |
| Bach, O | 1 |
| Kästner, I | 1 |
| Kuhn, WF | 1 |
| Jones, DR | 1 |
| Lippmann, SB | 1 |
| Embry, CK | 1 |
| Williams, WM | 1 |
| Manshadi, MS | 1 |
| Hurst, HE | 1 |
| Pies, R | 1 |
| Hall, TJ | 1 |
| James, PR | 1 |
| Cambridge, G | 1 |
| Yon, J | 1 |
| Anuras, S | 1 |
| Lajeunesse, BS | 1 |
1 review available for amitriptyline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
17 other studies available for amitriptyline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Bile Acids and Salts; Chemical and Drug In | 2020 |
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.
Topics: Amitriptyline; Animals; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatograp | 2014 |
[OBSERVATIONS ON THE USE OF PHENYLPYRROLIDINOPENTANE AS AN ANTIASTHENIC AGENT IN TREATMENT WITH PSYCHOPHARMACOLOGICAL DRUGS].
Topics: Amitriptyline; Anxiety; Anxiety Disorders; Asthenia; Bipolar Disorder; Chemical and Drug Induced Liv | 1964 |
Intrahepatic obstructive jaundice from amitriptyline.
Topics: Amitriptyline; Chemical and Drug Induced Liver Injury; Cholestasis; Depression; Female; Humans | 1967 |
Glutamic pyruvic acid transaminases during treatment with amitriptyline and imipramine.
Topics: Aged; Alanine Transaminase; Amitriptyline; Chemical and Drug Induced Liver Injury; Female; Humans; I | 1967 |
Amitriptyline-induced fulminant hepatitis.
Topics: Amitriptyline; Chemical and Drug Induced Liver Injury; Female; Humans; Middle Aged | 1984 |
[Undesired drug side effects and drug-induced damage. II. Centrally acting drugs].
Topics: Adult; Amitriptyline; Autonomic Nervous System Diseases; Basal Ganglia Diseases; Central Nervous Sys | 1984 |
Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chemical and Drug Induced Liver Injury; Fema | 1984 |
Capgras phenomenon, delirium, and transient hepatic dysfunction.
Topics: Adolescent; Amitriptyline; Capgras Syndrome; Chemical and Drug Induced Liver Injury; Delirium; Drug | 1982 |
Development of an in vitro hepatotoxicity assay for assessing the effects of chronic drug exposure.
Topics: Acetaminophen; Amitriptyline; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Hu | 1993 |
Hepatitis caused by amitriptyline therapy.
Topics: Administration, Oral; Adult; Alanine Transaminase; Alkaline Phosphatase; Amitriptyline; Aspartate Am | 1975 |
[True and false adverse effects of thymoanaleptic medications].
Topics: Amitriptyline; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressio | 1968 |