amitriptyline and Ache
amitriptyline has been researched along with Ache in 215 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT])." | 9.69 | Is low-dose naltrexone effective in chronic pain management? ( DeSanto, K; Huang, H; Lyon, C; Radi, R; Rivera, J, 2023) |
| "Sixty-seven participants with painful diabetic neuropathy were randomized to receive either 2 mg naltrexone or 10 mg amitriptyline daily following a 2-week run-in period." | 9.41 | Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial. ( Bansal, D; Bhansali, AK; Chakrabarti, A; Dutta, P; Hota, D; Srinivasan, A, 2021) |
| " Our aim is to identify and compare the efficacy of amitriptyline (AMT), duloxetine (DLX), and pregabalin (PGB) for reducing pain intensity by 30% (R30%) and 50% (R50%) in adult patients with fibromyalgia." | 9.22 | Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis. ( Alberti, FF; Becker, MW; Blatt, CR; da Silva Dal Pizzol, T; Pilger, D; Ziegelmann, PK, 2022) |
| "Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia." | 9.22 | Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022) |
| "The combination of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients." | 9.22 | Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study. ( Albertoni Giraldes, AL; Brunialti, MK; Leal, PD; Sakata, RK; Salomão, R, 2016) |
| "We conducted a randomized, double-blind, placebo-controlled, crossover study at a single center in South Africa, to ascertain whether amitriptyline is an effective analgesic for painful HIV-associated sensory neuropathy of moderate to severe intensity in: i) antiretroviral drug naive individuals, and ii) antiretroviral drug users." | 9.20 | Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy. ( Dinat, N; Kamerman, PR; Marinda, E; Moch, S; Rice, AS, 2015) |
| " Melatonin can improve sleep quality, pain and pain threshold." | 9.19 | Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014) |
| "To compare the efficacy and safety of pregabalin and amitriptyline in alleviating pain associated with diabetic peripheral neuropathy." | 9.14 | Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial. ( Bansal, D; Bhansali, A; Chakrabarti, A; Dutta, P; Hota, D, 2009) |
| "Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome." | 9.14 | Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. ( Burks, DA; Cen, L; Chai, TC; FitzGerald, MP; Foster, HE; Hanno, PM; Kreder, KJ; Kusek, JW; Landis, JR; Lukacz, ES; Mayer, RD; Nickel, JC; Nyberg, LM; Payne, CK; Peters, KM; Propert, KJ; Yang, CC; Yang, W, 2010) |
| "Oral amitriptyline, a tricyclic antidepressant, is effective for treating neuropathic pain." | 9.13 | Topical amitriptyline versus lidocaine in the treatment of neuropathic pain. ( Ho, KY; Huh, BK; Miller, EJ; White, WD; Yeh, CC, 2008) |
| "Little is known about the effects of low doses of amitriptyline, prescribed in the treatment of neuropathic pain, on attentional processing capacity." | 9.12 | Acute and subchronic effects of amitriptyline on processing capacity in neuropathic pain patients using visual event-related potentials: preliminary findings. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Volkerts, ER, 2006) |
| "The acute and subchronic effects of low doses nocturnally administered amitriptyline were compared to placebo in a double-blind crossover randomized study on driving ability and driving-related skills involving seven chronic neuropathic pain patients." | 9.12 | Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Verster, JC; Volkerts, ER, 2006) |
| "To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine." | 9.12 | Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007) |
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 9.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| "We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain." | 9.10 | Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002) |
| "Reports of gabapentin use in diabetic peripheral neuropathy pain stimulate a need for controlled trials to determine its comparative efficacy to the therapeutic standard of amitriptyline hydrochloride." | 9.09 | Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. ( Leckband, SG; Moorhouse, DF; Morello, CM; Sahagian, GA; Stoner, CP, 1999) |
| "The objective of this study was to compare the efficacy and tolerability of gabapentin and amitriptyline monotherapy in painful diabetic neuropathy." | 9.09 | Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study. ( Buffa, C; Chiroli, S; Dallocchio, C; Mazzarello, P, 2000) |
| " These data do not support the use of acute systemic administration of amitriptyline for acute pain, hyperalgesia, and allodynia, although the roles of chronic treatment and spinal administration are being investigated." | 9.08 | Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans. ( Curry, R; Eisenach, JC; Hood, DD; Tong, C, 1997) |
| "To compare amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics." | 9.08 | A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics. ( Arnqvist, H; Boivie, J; Holmgren, H; Lindström, T; Thorell, LH; Vrethem, M, 1997) |
| "To evaluate the efficacy of a standardized acupuncture regimen (SAR) and amitriptyline hydrochloride for the relief of pain due to HIV-related peripheral neuropathy in HIV-infected patients." | 9.08 | Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. ( Brizz, B; Chaloner, K; Cohn, DL; Flaws, B; Hillman, S; Max, MB; Reichelderfer, P; Shlay, JC; Wentworth, D, 1998) |
| "Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy." | 9.08 | A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998) |
| "The analgesic efficacy of amitriptyline 25 mg was compared with placebo in 41 patients with chronic (more than 3 months) nonmalignant pain, using a double-blind randomised multiple-dose 3-week treatment period crossover design." | 9.07 | Low dose amitriptyline in the treatment of chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1992) |
| "Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions." | 9.07 | Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. ( Dubner, R; Lynch, SA; Max, MB; Muir, J; Shoaf, SE; Smoller, B, 1992) |
| "In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder." | 9.07 | Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder? ( Edelbroek, PM; Linssen, ACG; Van Kempen, GMJ; Zitman, FG, 1991) |
| "A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine." | 9.07 | The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991) |
| "A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression." | 9.06 | Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine. ( Boivie, J; Leijon, G, 1989) |
| "The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 9.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
| "We conducted a double-blind, placebo-controlled, crossover study of the effectiveness of amitriptyline and fluphenazine in alleviating the pain of diabetic peripheral neuropathy in six diabetic patients." | 9.06 | A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy. ( Chappell, DA; Dere, WH; Gertz, BJ; Grunfeld, C; Karam, JH; Klein, RF; Lavin, TN; Mendel, CM, 1986) |
| "To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study." | 9.05 | Amitriptyline versus placebo in postherpetic neuralgia. ( Evans, RJ; Goldsmith, L; Merskey, H; Reed, K; Warsh, J; Watson, CP, 1982) |
| "All RCTs and quasi-RCTs reporting use of cyclobenzaprine for treating MP with pain assessment as a primary or secondary outcome." | 8.85 | Cyclobenzaprine for the treatment of myofascial pain in adults. ( Andriolo, RB; Atallah, AN; da Silva, EM; El Dib, R; Grossmann, E; Januzzi, E; Leite, FM, 2009) |
| "To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia." | 8.82 | Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004) |
| "This post-hoc analysis examined time to recovery in patients with acute, painful musculoskeletal conditions following cyclobenzaprine extended release (CER; AMRIX(®), Cephalon, Inc." | 7.77 | Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine. ( Altman, CA; Landy, S; Xie, F, 2011) |
| " The analgesic activity of amitriptyline was observed in mouse models of acute pain." | 7.74 | Antinociceptive effect of amitriptyline in mice of acute pain models. ( Bhattacharya, SK; Das, BP; Deo, S; Paudel, KR; Rauniar, GP; Sangraula, H, 2007) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 7.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 7.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| "We assessed if derivatives of amitriptyline could alleviate mechanical allodynia in a rat model of neuropathic pain." | 7.72 | Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. ( Sung, B; Wang, GK, 2004) |
| "Amitriptyline is a tricyclic antidepressant, which also alleviates various pain syndromes at its therapeutic plasma concentration (0." | 7.72 | State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. ( Russell, C; Wang, GK; Wang, SY, 2004) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 7.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "To evaluate the usefulness of amitriptyline (AMI) in the treatment of patients with urinary frequency or genital, pelvic, or suprapubic pain syndromes." | 7.70 | The use of amitriptyline in patients with urinary frequency and pain. ( Constantino, G; Pranikoff, K, 1998) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 7.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 7.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "A study was carried out in a multidisciplinary pain clinic with the purpose of comparing the effectiveness of outpatient cognitive-behavioural therapy (CBT) with amitriptyline (AMI) to that of supportive therapy with AMI." | 7.69 | Out-patient cognitive-behavioural therapy with amitriptyline for chronic non-malignant pain: a comparative study with 6-month follow-up. ( Forsten, C; Pilowsky, I; Rounsefell, B; Soda, J; Spence, N, 1995) |
| "To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain." | 7.69 | Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996) |
| "Baseline measures associated with outcome are described for amitriptyline and brief psychotherapy used in the outpatient treatment of chronic "psychogenic" pain." | 7.68 | Predictors of outcome in the treatment of chronic "psychogenic" pain with amitriptyline and brief psychotherapy. ( Barrow, G; Pilowsky, I, 1992) |
| "A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans." | 7.68 | Amitriptyline produces analgesia in the formalin pain test. ( Acton, J; McKenna, JE; Melzack, R, 1992) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 7.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| "Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities." | 7.66 | Diabetic neuropathic pain: control by amitriptyline and fluphenazine in renal insufficiency. ( Drager, AM; Mitas, JA; Mosley, CA, 1983) |
| "A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia." | 7.66 | Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982) |
| "Amitriptyline (AM) has long been known to exert analgesic activity as a result of blocking the Na⁺ channels." | 6.76 | Development of amitriptyline buccoadhesive tablets for management of pain in dental procedures. ( Adibkia, K; Afzalifar, R; Alaeddini, M; Barzegar-Jalali, M; Hamedyazdan, S; Mohammadi, G; Movassaghian, S; Zakeri-Milani, P, 2011) |
| " In the context of chronic pain, the analgesic effect of amitriptyline was shown to have a dose-response unrelated to mood elevation, but there was a dose-response for the incidence of adverse effects." | 6.67 | Dose-response for analgesic effect of amitriptyline in chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1993) |
| "Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties." | 6.39 | Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996) |
| "Kinesiotherapy and electrotherapy additions to amitriptyline administration as well as amitriptyline alone, were effective at improving vestibular pain in women with vulvodynia." | 5.69 | Does the addition of electrical stimulation or kinesiotherapy improve outcomes of amitriptyline treatment for women with vulvodynia? A randomized clinical trial. ( Bardin, MG; De Mira, TAA; Giraldo, PC; Lenzi, J; Morin, M; Witkin, SS, 2023) |
| " Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT])." | 5.69 | Is low-dose naltrexone effective in chronic pain management? ( DeSanto, K; Huang, H; Lyon, C; Radi, R; Rivera, J, 2023) |
| "Morphine dependency was induced using the oral method, and then, amitriptyline-induced antinociceptive effects were measured at 4 doses (2." | 5.48 | The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia? ( Akbari, E; Haghparast, A; Mirzaei, E; Rezaee, L; Zarrabian, S, 2018) |
| "Sixty-seven participants with painful diabetic neuropathy were randomized to receive either 2 mg naltrexone or 10 mg amitriptyline daily following a 2-week run-in period." | 5.41 | Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial. ( Bansal, D; Bhansali, AK; Chakrabarti, A; Dutta, P; Hota, D; Srinivasan, A, 2021) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 5.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 5.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| " A treatment plan was developed consisting of a low-dose morphine infusion with increasing dosage until pain was relieved." | 5.29 | Successful treatment of painful crises of Fabry disease with low dose morphine. ( Finley, GA; Gordon, KE; Ludman, MD, 1995) |
| "Various pharmacologic approaches have been advocated for treatment of chronic pain in spinal cord injury, including the use of either anticonvulsants or antidepressants." | 5.28 | Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury. ( Haddox, JD; Lindblom, LB; Sandford, PR, 1992) |
| " Our aim is to identify and compare the efficacy of amitriptyline (AMT), duloxetine (DLX), and pregabalin (PGB) for reducing pain intensity by 30% (R30%) and 50% (R50%) in adult patients with fibromyalgia." | 5.22 | Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis. ( Alberti, FF; Becker, MW; Blatt, CR; da Silva Dal Pizzol, T; Pilger, D; Ziegelmann, PK, 2022) |
| "Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia." | 5.22 | Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022) |
| "The combination of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients." | 5.22 | Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study. ( Albertoni Giraldes, AL; Brunialti, MK; Leal, PD; Sakata, RK; Salomão, R, 2016) |
| "We conducted a randomized, double-blind, placebo-controlled, crossover study at a single center in South Africa, to ascertain whether amitriptyline is an effective analgesic for painful HIV-associated sensory neuropathy of moderate to severe intensity in: i) antiretroviral drug naive individuals, and ii) antiretroviral drug users." | 5.20 | Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy. ( Dinat, N; Kamerman, PR; Marinda, E; Moch, S; Rice, AS, 2015) |
| " Melatonin can improve sleep quality, pain and pain threshold." | 5.19 | Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014) |
| "We are motivated by a randomized clinical trial evaluating the efficacy of amitriptyline for the treatment of interstitial cystitis and painful bladder syndrome in treatment-naïve patients." | 5.19 | Estimating the efficacy of an interstitial cystitis/painful bladder syndrome medication in a randomized trial with both non-adherence and loss to follow-up. ( Landis, JR; Propert, KJ; Yang, W, 2014) |
| "To conduct a prospective study to determine the efficacy of self-management interventions, amitriptyline, and amitriptyline plus topical triamcinolone in reducing vulvar pain in women with vulvodynia." | 5.14 | Self-management, amitriptyline, and amitripyline plus triamcinolone in the management of vulvodynia. ( Bachmann, G; Brown, CS; Rosen, R; Wan, J, 2009) |
| "To compare the efficacy and safety of pregabalin and amitriptyline in alleviating pain associated with diabetic peripheral neuropathy." | 5.14 | Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial. ( Bansal, D; Bhansali, A; Chakrabarti, A; Dutta, P; Hota, D, 2009) |
| "Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome." | 5.14 | Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. ( Burks, DA; Cen, L; Chai, TC; FitzGerald, MP; Foster, HE; Hanno, PM; Kreder, KJ; Kusek, JW; Landis, JR; Lukacz, ES; Mayer, RD; Nickel, JC; Nyberg, LM; Payne, CK; Peters, KM; Propert, KJ; Yang, CC; Yang, W, 2010) |
| "Oral amitriptyline, a tricyclic antidepressant, is effective for treating neuropathic pain." | 5.13 | Topical amitriptyline versus lidocaine in the treatment of neuropathic pain. ( Ho, KY; Huh, BK; Miller, EJ; White, WD; Yeh, CC, 2008) |
| "Little is known about the effects of low doses of amitriptyline, prescribed in the treatment of neuropathic pain, on attentional processing capacity." | 5.12 | Acute and subchronic effects of amitriptyline on processing capacity in neuropathic pain patients using visual event-related potentials: preliminary findings. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Volkerts, ER, 2006) |
| "The acute and subchronic effects of low doses nocturnally administered amitriptyline were compared to placebo in a double-blind crossover randomized study on driving ability and driving-related skills involving seven chronic neuropathic pain patients." | 5.12 | Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Verster, JC; Volkerts, ER, 2006) |
| "To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine." | 5.12 | Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007) |
| "The antidepressant amitriptyline is used as an adjuvant in the treatment of chronic pain conditions." | 5.11 | Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy. ( Eappen, S; Fridrich, P; Gerner, P; Jaeger, W; Schernhammer, E; Wang, GK; Zizza, AM, 2004) |
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 5.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| " This study examined the association of patient and research nurse/physician pretreatment expectations of pain relief with actual pain relief, the accuracy of patient and research nurse guesses about patient medication assignment, and changes in research nurse and patient pain relief expectations over the course of a randomized double-blind trial of amitriptyline versus an active placebo for patients with chronic pain and spinal cord injuries (SCI)." | 5.10 | Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial. ( Cardenas, DD; Jensen, MP; Turner, JA; Warms, CA, 2002) |
| "We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain." | 5.10 | Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002) |
| "Reports of gabapentin use in diabetic peripheral neuropathy pain stimulate a need for controlled trials to determine its comparative efficacy to the therapeutic standard of amitriptyline hydrochloride." | 5.09 | Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. ( Leckband, SG; Moorhouse, DF; Morello, CM; Sahagian, GA; Stoner, CP, 1999) |
| "The objective of this study was to compare the efficacy and tolerability of gabapentin and amitriptyline monotherapy in painful diabetic neuropathy." | 5.09 | Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study. ( Buffa, C; Chiroli, S; Dallocchio, C; Mazzarello, P, 2000) |
| "In a randomized, double-blind, parallel study, fluoxetine and amitriptyline were compared with placebo in the treatment of chronic rheumatic pain." | 5.08 | An evaluation of antidepressants in rheumatic pain conditions. ( Naidu, MU; Prasad, VB; Rani, PU; Rao, TR; Shobha, JC, 1996) |
| " These data do not support the use of acute systemic administration of amitriptyline for acute pain, hyperalgesia, and allodynia, although the roles of chronic treatment and spinal administration are being investigated." | 5.08 | Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans. ( Curry, R; Eisenach, JC; Hood, DD; Tong, C, 1997) |
| "To compare amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics." | 5.08 | A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics. ( Arnqvist, H; Boivie, J; Holmgren, H; Lindström, T; Thorell, LH; Vrethem, M, 1997) |
| "To evaluate the efficacy of a standardized acupuncture regimen (SAR) and amitriptyline hydrochloride for the relief of pain due to HIV-related peripheral neuropathy in HIV-infected patients." | 5.08 | Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. ( Brizz, B; Chaloner, K; Cohn, DL; Flaws, B; Hillman, S; Max, MB; Reichelderfer, P; Shlay, JC; Wentworth, D, 1998) |
| "Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy." | 5.08 | A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998) |
| "The analgesic efficacy of amitriptyline 25 mg was compared with placebo in 41 patients with chronic (more than 3 months) nonmalignant pain, using a double-blind randomised multiple-dose 3-week treatment period crossover design." | 5.07 | Low dose amitriptyline in the treatment of chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1992) |
| "Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions." | 5.07 | Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. ( Dubner, R; Lynch, SA; Max, MB; Muir, J; Shoaf, SE; Smoller, B, 1992) |
| "In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder." | 5.07 | Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder? ( Edelbroek, PM; Linssen, ACG; Van Kempen, GMJ; Zitman, FG, 1991) |
| "A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine." | 5.07 | The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991) |
| "A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression." | 5.06 | Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine. ( Boivie, J; Leijon, G, 1989) |
| "Forty-seven patients with definite rheumatoid arthritis (RA) were treated in a 32 week, double blind, crossover trial of amitriptyline, desipramine, trazodone, and placebo." | 5.06 | Antidepressant analgesia in rheumatoid arthritis. ( Atwood, C; Beck, NC; Brownlee-Duffeck, M; Elliott, TR; Frank, RG; Haut, AE; Kashani, JH; Kay, DR; Parker, JC; Smith, E, 1988) |
| "The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 5.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
| "We conducted a double-blind, placebo-controlled, crossover study of the effectiveness of amitriptyline and fluphenazine in alleviating the pain of diabetic peripheral neuropathy in six diabetic patients." | 5.06 | A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy. ( Chappell, DA; Dere, WH; Gertz, BJ; Grunfeld, C; Karam, JH; Klein, RF; Lavin, TN; Mendel, CM, 1986) |
| "To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study." | 5.05 | Amitriptyline versus placebo in postherpetic neuralgia. ( Evans, RJ; Goldsmith, L; Merskey, H; Reed, K; Warsh, J; Watson, CP, 1982) |
| "All RCTs and quasi-RCTs reporting use of cyclobenzaprine for treating MP with pain assessment as a primary or secondary outcome." | 4.85 | Cyclobenzaprine for the treatment of myofascial pain in adults. ( Andriolo, RB; Atallah, AN; da Silva, EM; El Dib, R; Grossmann, E; Januzzi, E; Leite, FM, 2009) |
| "Amitriptyline 25-50 mg/day reduces pain, fatigue, and depressiveness in patients with FMS and improves sleep and quality of life." | 4.84 | A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. ( Häuser, W; Sommer, C; Uçeyler, N, 2008) |
| "To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia." | 4.82 | Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004) |
| "The purpose of this review is to present relatively detailed information on the characteristics of tricyclic antidepressants, mainly amitriptyline hydrochloride and doxepin hydrochloride, for use as an integral part of the safe and effective management of fibromyalgia and, to a lesser extent, other chronic pain syndromes." | 4.79 | A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. ( Godfrey, RG, 1996) |
| "Cyclobenzaprine is a skeletal muscle relaxant primarily used in the treatment of pain." | 3.91 | Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure. ( Baker, T; Burra, B; Datta, P; Hale, TW; Rewers-Felkins, K, 2019) |
| " Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 3.83 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| "It is established that mebicar, amitriptyline, and diazepam administered intraperitoneally at therapeutic doses increase the pain thresholds in mice as manifested in "hot plate" analgesia test." | 3.81 | [Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam]. ( Khaziakhmetova, VN; Luchai, KV; Ziganshina, LE, 2015) |
| "Urinary excretion data were obtained from 55,296 patients with pain and were analyzed using liquid chromatography tandem mass spectrometry in a multiplex assay which included amitriptyline, nortriptyline, and imipramine." | 3.80 | Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. ( Atayee, RS; Best, BM; Bordson, SJ; Ma, JD, 2014) |
| " We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone." | 3.79 | Neuropsychiatric side effects of cyclobenzaprine. ( Sederholm, B; Shprecher, D; Sloan, CT, 2013) |
| " She suffered from central poststroke pain and reactive depression as poststroke complications, for which amitriptyline was prescribed." | 3.78 | Neuropsychiatric manifestation after a stroke: newly developed symptoms or side-effect of drug? ( Ahmad, S; Aziz, NA; Tan, EC, 2012) |
| "This post-hoc analysis examined time to recovery in patients with acute, painful musculoskeletal conditions following cyclobenzaprine extended release (CER; AMRIX(®), Cephalon, Inc." | 3.77 | Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine. ( Altman, CA; Landy, S; Xie, F, 2011) |
| " Amitriptyline (5, 10 mg/ kg), maprotiline (10, 20 mg/kg) and fluvoxamine (20 and 30 mg/kg) effectively inhibited pain induction caused by the second phase of the formalin test." | 3.77 | Effect of glibenclamide on antinociceptive effects of antidepressants of different classes. ( Amin, B; Hajhashemi, V, 2011) |
| "As a result of amitriptyline's vast array of actions, it could potentially be used as an intraspinal adjuvant in neuraxial anesthesia and/or in the treatment of refractory neuropathic pain." | 3.75 | The neuraxial effects of intraspinal amitriptyline at low concentrations. ( Barros, GA; Fukushima, FB; Ganem, EM; Marques, ME; Vidal, EI, 2009) |
| "Amitriptyline is used to treat neuropathic pain in humans." | 3.74 | Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. ( Fredholm, BB; Reid, AR; Sawynok, J, 2008) |
| " The analgesic activity of amitriptyline was observed in mouse models of acute pain." | 3.74 | Antinociceptive effect of amitriptyline in mice of acute pain models. ( Bhattacharya, SK; Das, BP; Deo, S; Paudel, KR; Rauniar, GP; Sangraula, H, 2007) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| " The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition." | 3.74 | Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 3.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "Participants in a clinical trial of amitriptyline for pain (n = 84 with spinal cord injury [SCI], n = 38 with amputation) provided responses to the study measures via telephone interview." | 3.73 | Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain. ( Cardenas, DD; Ehde, D; Hanley, M; Jensen, MP; Masedo, AI, 2005) |
| " administration of either of two antidepressants used for the treatment of neuropathic pain, amitriptyline (10 mg/kg) and fluoxetine (5 mg/kg), to rats for 7 days modifies GABA(B) receptor function and subunit expression in the lumbar spinal cord." | 3.73 | GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants. ( Duric, V; Enna, SJ; McCarson, KE; Reisman, SA; Winter, M, 2006) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 3.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| "We assessed if derivatives of amitriptyline could alleviate mechanical allodynia in a rat model of neuropathic pain." | 3.72 | Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. ( Sung, B; Wang, GK, 2004) |
| "Amitriptyline is a tricyclic antidepressant, which also alleviates various pain syndromes at its therapeutic plasma concentration (0." | 3.72 | State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. ( Russell, C; Wang, GK; Wang, SY, 2004) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 3.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "In the formalin test, amitriptyline produces different effects on pain behaviors after systemic, spinal administration and peripheral administration." | 3.71 | Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord. ( Allen, GV; Chase, TD; Heughan, CE; Sawynok, J, 2002) |
| "By use of the rat formalin test, a model of persistent pain, we examined the effect of a combination of amitriptyline and gabapentin, which are used to treat chronic pain in humans." | 3.71 | The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration. ( Heughan, CE; Sawynok, J, 2002) |
| "To evaluate the usefulness of amitriptyline (AMI) in the treatment of patients with urinary frequency or genital, pelvic, or suprapubic pain syndromes." | 3.70 | The use of amitriptyline in patients with urinary frequency and pain. ( Constantino, G; Pranikoff, K, 1998) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 3.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 3.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "A study was carried out in a multidisciplinary pain clinic with the purpose of comparing the effectiveness of outpatient cognitive-behavioural therapy (CBT) with amitriptyline (AMI) to that of supportive therapy with AMI." | 3.69 | Out-patient cognitive-behavioural therapy with amitriptyline for chronic non-malignant pain: a comparative study with 6-month follow-up. ( Forsten, C; Pilowsky, I; Rounsefell, B; Soda, J; Spence, N, 1995) |
| "Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions." | 3.69 | Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994) |
| "To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain." | 3.69 | Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996) |
| "Baseline measures associated with outcome are described for amitriptyline and brief psychotherapy used in the outpatient treatment of chronic "psychogenic" pain." | 3.68 | Predictors of outcome in the treatment of chronic "psychogenic" pain with amitriptyline and brief psychotherapy. ( Barrow, G; Pilowsky, I, 1992) |
| "A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans." | 3.68 | Amitriptyline produces analgesia in the formalin pain test. ( Acton, J; McKenna, JE; Melzack, R, 1992) |
| "The tail flick assay was used to evaluate pain perception in mice treated acutely with either of the two classical antidepressant drugs (AD) imipramine or amitriptyline, or the atypical antidepressant iprindole." | 3.67 | Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin. ( de Ceballos, ML; de Felipe, MC; Fuentes, JA, 1986) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 3.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| "Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities." | 3.66 | Diabetic neuropathic pain: control by amitriptyline and fluphenazine in renal insufficiency. ( Drager, AM; Mitas, JA; Mosley, CA, 1983) |
| "A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia." | 3.66 | Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982) |
| "This severe pain is mostly refractory to palliative analgesic treatment, and the latter was only detected by specific and sensitive outcomes." | 2.87 | Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial. ( Beauchamp, G; Blair, J; de Lorimier, LP; Lussier, B; Monteiro, BP; Moreau, M; Pelletier, JP; Troncy, E, 2018) |
| "Amitriptyline (AM) has long been known to exert analgesic activity as a result of blocking the Na⁺ channels." | 2.76 | Development of amitriptyline buccoadhesive tablets for management of pain in dental procedures. ( Adibkia, K; Afzalifar, R; Alaeddini, M; Barzegar-Jalali, M; Hamedyazdan, S; Mohammadi, G; Movassaghian, S; Zakeri-Milani, P, 2011) |
| " In the context of chronic pain, the analgesic effect of amitriptyline was shown to have a dose-response unrelated to mood elevation, but there was a dose-response for the incidence of adverse effects." | 2.67 | Dose-response for analgesic effect of amitriptyline in chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1993) |
| "We conclude that patients with fibrositis have a neurotransmitter plasma profile like other chronic pain states having stress and increased vasomotor activity with the possible exception of having low circulating epinephrine." | 2.66 | The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: a 5-month study. ( Hamaty, D; Howard, CW; Howard, R; Patten, MS; Valentine, JL; Wakefield, V, 1989) |
| "Pain is one of the most troublesome sequelae of stroke, occurring in 19-74% of patients." | 2.45 | Post-stroke pain. ( Kim, JS, 2009) |
| "Interstitial cystitis/painful bladder syndrome is a chronic disease characterized by pain, frequency, urgency, and nocturia and diagnosed primarily in women." | 2.44 | Interstitial cystitis/painful bladder syndrome. ( Warren, JW, 2007) |
| "The most common risk factor for shingles and its potential sequela, PHN, is advanced age." | 2.42 | Post-herpetic neuralgia case study: optimizing pain control. ( Baron, R, 2004) |
| "Pain is associated with myriad medical conditions and affects millions of Americans." | 2.41 | Pharmacologic management of chronic pain. ( Argoff, CE, 2002) |
| "Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties." | 2.39 | Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996) |
| "Neurogenic pain is defined as pain due to dysfunction of the peripheral or central nervous system, in the absence of nociceptor (nerve terminal) stimulation by trauma or disease." | 2.38 | Neurogenic pain syndromes and their management. ( Bowsher, D, 1991) |
| "Vulvodynia is chronic vulvar pain or a burning sensation lasting for at least 3 months without a cause." | 1.72 | A multidisciplinary approach to a patient with vulvodynia: a successful treatment and outcome. ( Crnković, M; Djaković, I; Lugović-Mihić, L; Magdić-Turković, T; Novak-Hlebar, I; Petričević, T, 2022) |
| "Pain is a hallmark of this condition and can be extremely difficult to control." | 1.56 | Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020) |
| "Morphine dependency was induced using the oral method, and then, amitriptyline-induced antinociceptive effects were measured at 4 doses (2." | 1.48 | The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia? ( Akbari, E; Haghparast, A; Mirzaei, E; Rezaee, L; Zarrabian, S, 2018) |
| " Initial pharmacokinetics evaluation indicated an excellent brain exposure following oral dosing in mice, suggesting that further investigation into the use of alkoxyisoxazoles as σ1 ligands for antinociception is warranted." | 1.43 | Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. ( Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM, 2016) |
| "Uliginosin B is a natural phloroglucinol derivative, obtained from Hypericum species native to South America." | 1.40 | Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis. ( Antonio, CB; da Costa, PF; Müller, LG; Noël, F; Rates, SM; Stolz, ED; von Poser, GL, 2014) |
| "Cyclobenzaprine effectively treated our patient's LAS." | 1.38 | Treatment of levator ani syndrome with cyclobenzaprine. ( Kunka, CA; Ota, KS; Sheikh, M, 2012) |
| " Specifically, doxepin was more neurotoxic than amitriptyline, and both imipramine and trimipramine were more toxic than desipramine or amitriptyline." | 1.34 | Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. ( Gerner, P; Haller, I; Keller, C; Klimaschewski, L; Lirk, P; Wang, GK, 2007) |
| "Amitriptyline (10 mg/kg) has analgesic effect as expected." | 1.33 | [Low doses of prazosin potantiates the antinociceptive/analgesic effect of amitriptyline]. ( Büyükşekerci, M; Gültekin, H, 2005) |
| "Familial rectal pain is a very rare entity that must always be considered as a possible aetiology of any life-threatening event in an infant because of the availability of a very effective treatment." | 1.33 | Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby. ( Arbuès, AS; Bednarek, N; Morville, P; Motte, J; Plouin, P; Sabouraud, P, 2005) |
| "The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)." | 1.33 | Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 1.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 1.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| " A treatment plan was developed consisting of a low-dose morphine infusion with increasing dosage until pain was relieved." | 1.29 | Successful treatment of painful crises of Fabry disease with low dose morphine. ( Finley, GA; Gordon, KE; Ludman, MD, 1995) |
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
| "Various pharmacologic approaches have been advocated for treatment of chronic pain in spinal cord injury, including the use of either anticonvulsants or antidepressants." | 1.28 | Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury. ( Haddox, JD; Lindblom, LB; Sandford, PR, 1992) |
| " Chronic administration of amitriptyline (5 and 10 mg/kg/day, i." | 1.28 | Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats. ( Abad, F; Boada, J; Feria, M, 1989) |
| " Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication." | 1.27 | Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987) |
| " Unit dose packaging is used because the oral solid dosage forms (including placebos) are made to look alike." | 1.25 | Drug use and distribution in a pain rehabilitation center. ( Beckner, TF; Idsvoog, P, 1975) |
Research
Studies (215)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (23.26) | 18.7374 |
| 1990's | 49 (22.79) | 18.2507 |
| 2000's | 71 (33.02) | 29.6817 |
| 2010's | 33 (15.35) | 24.3611 |
| 2020's | 12 (5.58) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Macsari, I | 1 |
| Besidski, Y | 1 |
| Csjernyik, G | 1 |
| Nilsson, LI | 1 |
| Sandberg, L | 1 |
| Yngve, U | 1 |
| Ahlin, K | 1 |
| Bueters, T | 1 |
| Eriksson, AB | 1 |
| Lund, PE | 1 |
| Venyike, E | 1 |
| Oerther, S | 1 |
| Hygge Blakeman, K | 1 |
| Luo, L | 1 |
| Arvidsson, PI | 1 |
| Sun, H | 1 |
| Shi, M | 1 |
| Zhang, W | 1 |
| Zheng, YM | 1 |
| Xu, YZ | 1 |
| Shi, JJ | 1 |
| Liu, T | 1 |
| Gunosewoyo, H | 1 |
| Pang, T | 1 |
| Gao, ZB | 1 |
| Yang, F | 1 |
| Tang, J | 1 |
| Yu, LF | 1 |
| Ali, SHK | 1 |
| Raja, KWA | 1 |
| Irfan, N | 1 |
| Habeeb, M | 1 |
| Ismail, Y | 1 |
| Chen, CM | 1 |
| Ding, H | 1 |
| Mabry, KM | 1 |
| Ko, MC | 1 |
| Alberti, FF | 1 |
| Becker, MW | 1 |
| Blatt, CR | 1 |
| Ziegelmann, PK | 1 |
| da Silva Dal Pizzol, T | 1 |
| Pilger, D | 1 |
| Farag, HM | 1 |
| Yunusa, I | 1 |
| Goswami, H | 1 |
| Sultan, I | 1 |
| Doucette, JA | 1 |
| Eguale, T | 1 |
| Asgardoon, MH | 1 |
| Jazayeri, SB | 1 |
| Behkar, A | 1 |
| Dabbagh Ohadi, MA | 1 |
| Yarmohammadi, H | 1 |
| Ghodsi, Z | 1 |
| Pomerani, TI | 1 |
| Mojtahedzadeh, M | 1 |
| Rahimi-Movaghar, V | 1 |
| Novak-Hlebar, I | 1 |
| Crnković, M | 1 |
| Djaković, I | 1 |
| Magdić-Turković, T | 1 |
| Petričević, T | 1 |
| Lugović-Mihić, L | 1 |
| Barry, HC | 1 |
| Bardin, MG | 1 |
| Giraldo, PC | 1 |
| Lenzi, J | 1 |
| Witkin, SS | 1 |
| De Mira, TAA | 1 |
| Morin, M | 1 |
| García-Iglesias, C | 1 |
| González-Celestino, A | 1 |
| Sierra Mencía, Á | 1 |
| González Osorio, Y | 1 |
| Recio García, A | 1 |
| Martínez-Badillo, C | 1 |
| Echavarría Íñiguez, A | 1 |
| Varona-Galán, B | 1 |
| García-Azorín, D | 1 |
| Guerrero-Peral, ÁL | 1 |
| Radi, R | 1 |
| Huang, H | 1 |
| Rivera, J | 1 |
| Lyon, C | 1 |
| DeSanto, K | 1 |
| Chinnadurai, R | 1 |
| Sinha, S | 1 |
| Lowney, AC | 1 |
| Miller, M | 1 |
| Srinivasan, A | 1 |
| Dutta, P | 2 |
| Bansal, D | 2 |
| Chakrabarti, A | 2 |
| Bhansali, AK | 1 |
| Hota, D | 2 |
| Akbari, E | 1 |
| Mirzaei, E | 1 |
| Rezaee, L | 1 |
| Zarrabian, S | 1 |
| Haghparast, A | 1 |
| Monteiro, BP | 1 |
| de Lorimier, LP | 1 |
| Moreau, M | 1 |
| Beauchamp, G | 1 |
| Blair, J | 1 |
| Lussier, B | 1 |
| Pelletier, JP | 1 |
| Troncy, E | 1 |
| Burra, B | 1 |
| Datta, P | 1 |
| Rewers-Felkins, K | 1 |
| Baker, T | 1 |
| Hale, TW | 1 |
| Shprecher, D | 1 |
| Sloan, CT | 1 |
| Sederholm, B | 1 |
| Patel, D | 1 |
| Naik, S | 1 |
| Chuttani, K | 1 |
| Mathur, R | 1 |
| Mishra, AK | 1 |
| Misra, A | 1 |
| Calixto-Campos, C | 1 |
| Zarpelon, AC | 1 |
| Corrêa, M | 1 |
| Cardoso, RD | 1 |
| Pinho-Ribeiro, FA | 1 |
| Cecchini, R | 1 |
| Moreira, EG | 1 |
| Crespigio, J | 1 |
| Bernardy, CC | 1 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Bordson, SJ | 1 |
| Atayee, RS | 1 |
| Ma, JD | 1 |
| Best, BM | 1 |
| Haviv, Y | 1 |
| Zadik, Y | 1 |
| Sharav, Y | 3 |
| Benoliel, R | 2 |
| de Zanette, SA | 1 |
| Vercelino, R | 1 |
| Laste, G | 1 |
| Rozisky, JR | 1 |
| Schwertner, A | 1 |
| Machado, CB | 1 |
| Xavier, F | 1 |
| de Souza, IC | 1 |
| Deitos, A | 1 |
| Torres, IL | 1 |
| Caumo, W | 1 |
| Stolz, ED | 1 |
| Müller, LG | 1 |
| Antonio, CB | 1 |
| da Costa, PF | 1 |
| von Poser, GL | 1 |
| Noël, F | 1 |
| Rates, SM | 1 |
| Dinat, N | 1 |
| Marinda, E | 1 |
| Moch, S | 1 |
| Rice, AS | 1 |
| Kamerman, PR | 1 |
| Khaziakhmetova, VN | 1 |
| Luchai, KV | 1 |
| Ziganshina, LE | 1 |
| Dogishi, K | 1 |
| Kodera, M | 1 |
| Oyama, S | 1 |
| Shirakawa, H | 1 |
| Nakagawa, T | 1 |
| Kaneko, S | 1 |
| Davis, AM | 1 |
| Dean, K | 1 |
| Mousa, H | 1 |
| Edwards, S | 1 |
| Cocjin, J | 1 |
| Almadhoun, O | 1 |
| He, J | 1 |
| Bruce, A | 1 |
| Hyman, PE | 1 |
| Albertoni Giraldes, AL | 1 |
| Salomão, R | 1 |
| Leal, PD | 1 |
| Brunialti, MK | 1 |
| Sakata, RK | 1 |
| Macfarlane, GJ | 1 |
| Kronisch, C | 1 |
| Dean, LE | 1 |
| Atzeni, F | 1 |
| Häuser, W | 2 |
| Fluß, E | 1 |
| Choy, E | 1 |
| Kosek, E | 1 |
| Amris, K | 1 |
| Branco, J | 1 |
| Dincer, F | 1 |
| Leino-Arjas, P | 1 |
| Longley, K | 1 |
| McCarthy, GM | 1 |
| Makri, S | 1 |
| Perrot, S | 1 |
| Sarzi-Puttini, P | 1 |
| Taylor, A | 1 |
| Jones, GT | 1 |
| Yin, K | 1 |
| Deuis, JR | 1 |
| Lewis, RJ | 1 |
| Vetter, I | 1 |
| Söylev, GÖ | 1 |
| Boya, H | 1 |
| Sawynok, J | 10 |
| Reid, AR | 4 |
| Fredholm, BB | 1 |
| Lin, JA | 1 |
| Tsai, RY | 1 |
| Lin, YT | 1 |
| Lee, MS | 1 |
| Cherng, CH | 1 |
| Wong, CS | 1 |
| Tzeng, JI | 1 |
| Uçeyler, N | 1 |
| Sommer, C | 1 |
| Wicksell, RK | 1 |
| Melin, L | 1 |
| Lekander, M | 1 |
| Olsson, GL | 1 |
| Lehman, JS | 1 |
| Sciallis, GF | 1 |
| Brown, CS | 1 |
| Wan, J | 1 |
| Bachmann, G | 1 |
| Rosen, R | 1 |
| Sea, J | 1 |
| Teichman, JM | 1 |
| Kim, JS | 1 |
| Leite, FM | 1 |
| Atallah, AN | 1 |
| El Dib, R | 1 |
| Grossmann, E | 1 |
| Januzzi, E | 1 |
| Andriolo, RB | 1 |
| da Silva, EM | 1 |
| Jiang, CJ | 1 |
| Tan, YC | 1 |
| Yang, YJ | 1 |
| Zhang, EZ | 1 |
| Liu, J | 1 |
| Yao, SQ | 1 |
| Yu, JL | 1 |
| Fukushima, FB | 1 |
| Barros, GA | 1 |
| Marques, ME | 1 |
| Vidal, EI | 1 |
| Ganem, EM | 1 |
| Pettersen, VL | 1 |
| Zapata-Sudo, G | 1 |
| Raimundo, JM | 1 |
| Trachez, MM | 1 |
| Sudo, RT | 1 |
| Mao, QX | 1 |
| Yang, TD | 1 |
| Ziegler, D | 1 |
| Bhansali, A | 1 |
| Mahmood, D | 1 |
| Akhtar, M | 1 |
| Vohora, D | 1 |
| Khanam, R | 1 |
| Foster, HE | 1 |
| Hanno, PM | 1 |
| Nickel, JC | 1 |
| Payne, CK | 1 |
| Mayer, RD | 1 |
| Burks, DA | 1 |
| Yang, CC | 1 |
| Chai, TC | 1 |
| Kreder, KJ | 1 |
| Peters, KM | 1 |
| Lukacz, ES | 1 |
| FitzGerald, MP | 1 |
| Cen, L | 1 |
| Landis, JR | 2 |
| Propert, KJ | 2 |
| Yang, W | 2 |
| Kusek, JW | 1 |
| Nyberg, LM | 1 |
| Movassaghian, S | 1 |
| Barzegar-Jalali, M | 1 |
| Alaeddini, M | 1 |
| Hamedyazdan, S | 1 |
| Afzalifar, R | 1 |
| Zakeri-Milani, P | 1 |
| Mohammadi, G | 1 |
| Adibkia, K | 1 |
| Landy, S | 1 |
| Altman, CA | 1 |
| Xie, F | 1 |
| Hajhashemi, V | 1 |
| Amin, B | 1 |
| Bissay, V | 1 |
| Keymolen, K | 1 |
| Lissens, W | 1 |
| Laureys, G | 1 |
| Schmedding, E | 1 |
| De Keyser, J | 1 |
| Song, Z | 1 |
| Meyerson, BA | 1 |
| Linderoth, B | 1 |
| Tan, EC | 1 |
| Aziz, NA | 1 |
| Ahmad, S | 1 |
| Sheikh, M | 1 |
| Kunka, CA | 1 |
| Ota, KS | 1 |
| Boyle, J | 1 |
| Eriksson, ME | 1 |
| Gribble, L | 1 |
| Gouni, R | 1 |
| Johnsen, S | 1 |
| Coppini, DV | 1 |
| Kerr, D | 1 |
| Oya, H | 1 |
| Matoba, M | 1 |
| Murakami, S | 1 |
| Ohshiro, T | 1 |
| Kishino, T | 1 |
| Satoh, Y | 1 |
| Tsukahara, T | 1 |
| Hori, S | 1 |
| Maeda, M | 1 |
| Makino, T | 1 |
| Maeda, T | 1 |
| Alvarez López, JC | 1 |
| González De Zárate, J | 1 |
| Herrero Gento, E | 1 |
| Murphy, D | 2 |
| Redman, C | 2 |
| Thomas, E | 2 |
| Turner, JA | 2 |
| Jensen, MP | 2 |
| Warms, CA | 2 |
| Cardenas, DD | 3 |
| Argoff, CE | 1 |
| Lampl, C | 1 |
| Yazdi, K | 1 |
| Röper, C | 1 |
| Reid, A | 1 |
| Yen, HL | 1 |
| Chan, W | 1 |
| Abdel-Salam, OM | 1 |
| Nofal, SM | 1 |
| El-Shenawy, SM | 1 |
| Tofferi, JK | 1 |
| Jackson, JL | 1 |
| O'Malley, PG | 1 |
| Sung, B | 1 |
| Wang, GK | 4 |
| Kuraishi, Y | 2 |
| Takasaki, I | 2 |
| Nojima, H | 2 |
| Shiraki, K | 2 |
| Takahata, H | 2 |
| Baron, R | 1 |
| Shin, SW | 1 |
| Eisenach, JC | 2 |
| Fridrich, P | 1 |
| Eappen, S | 1 |
| Jaeger, W | 1 |
| Schernhammer, E | 1 |
| Zizza, AM | 1 |
| Gerner, P | 2 |
| Iyengar, S | 1 |
| Webster, AA | 1 |
| Hemrick-Luecke, SK | 1 |
| Xu, JY | 1 |
| Simmons, RM | 1 |
| Russell, C | 1 |
| Wang, SY | 1 |
| Waldron, JB | 1 |
| Rosenlicht, NZ | 1 |
| Riley-Lazo, KP | 1 |
| Bomholt, SF | 1 |
| Mikkelsen, JD | 1 |
| Blackburn-Munro, G | 1 |
| Masedo, AI | 1 |
| Hanley, M | 1 |
| Ehde, D | 1 |
| Büyükşekerci, M | 1 |
| Gültekin, H | 1 |
| Hong, HB | 1 |
| Xu, RJ | 1 |
| Nordmann, GR | 1 |
| Lauder, GR | 1 |
| Grier, DJ | 1 |
| Lynch, ME | 1 |
| Clark, AJ | 1 |
| Sullivan, MJ | 1 |
| Kumar, S | 1 |
| Veldhuijzen, DS | 2 |
| Kenemans, JL | 2 |
| van Wijck, AJ | 2 |
| Olivier, B | 2 |
| Kalkman, CJ | 2 |
| Volkerts, ER | 2 |
| Bednarek, N | 1 |
| Arbuès, AS | 1 |
| Motte, J | 1 |
| Sabouraud, P | 1 |
| Plouin, P | 1 |
| Morville, P | 1 |
| McCarson, KE | 1 |
| Duric, V | 1 |
| Reisman, SA | 1 |
| Winter, M | 1 |
| Enna, SJ | 1 |
| Verster, JC | 1 |
| Kaptchuk, TJ | 2 |
| Stason, WB | 1 |
| Davis, RB | 1 |
| Legedza, AR | 1 |
| Schnyer, RN | 1 |
| Kerr, CE | 1 |
| Stone, DA | 1 |
| Nam, BH | 1 |
| Kirsch, I | 1 |
| Goldman, RH | 1 |
| Son, BC | 1 |
| Lee, SW | 1 |
| Choi, ES | 1 |
| Sung, JH | 1 |
| Hong, JT | 1 |
| Eksioglu, E | 1 |
| Yazar, D | 1 |
| Bal, A | 1 |
| Usan, HD | 1 |
| Cakci, A | 1 |
| Felicio, AC | 1 |
| Godeiro, Cde O | 1 |
| Borges, V | 1 |
| Silva, SM | 1 |
| Ferraz, HB | 1 |
| Haller, I | 1 |
| Lirk, P | 1 |
| Keller, C | 1 |
| Klimaschewski, L | 1 |
| Huber, AM | 1 |
| Tomlinson, GA | 1 |
| Koren, G | 1 |
| Feldman, BM | 1 |
| Loram, LC | 1 |
| Mitchell, D | 1 |
| Skosana, M | 1 |
| Fick, LG | 1 |
| Paudel, KR | 1 |
| Das, BP | 1 |
| Rauniar, GP | 1 |
| Sangraula, H | 1 |
| Deo, S | 1 |
| Bhattacharya, SK | 1 |
| Warren, JW | 1 |
| Gil, DW | 1 |
| Cheevers, CV | 1 |
| Donello, JE | 1 |
| Jerome, L | 1 |
| Rintala, DH | 1 |
| Holmes, SA | 1 |
| Courtade, D | 1 |
| Fiess, RN | 1 |
| Tastard, LV | 1 |
| Loubser, PG | 1 |
| Ho, KY | 1 |
| Huh, BK | 1 |
| White, WD | 1 |
| Yeh, CC | 1 |
| Miller, EJ | 1 |
| Millecamps, M | 1 |
| Coderre, TJ | 1 |
| Cormack, J | 1 |
| Dalessio, DJ | 1 |
| Watson, CP | 1 |
| Evans, RJ | 1 |
| Reed, K | 1 |
| Merskey, H | 1 |
| Goldsmith, L | 1 |
| Warsh, J | 1 |
| Shea, JJ | 1 |
| Morse, RH | 1 |
| Portenoy, RK | 1 |
| Rapscak, S | 1 |
| Kanner, R | 1 |
| Jay, GW | 1 |
| Renelli, D | 1 |
| Mead, T | 1 |
| Pilowsky, I | 3 |
| Hallett, EC | 1 |
| Bassett, DL | 1 |
| Thomas, PG | 1 |
| Penhall, RK | 1 |
| Mitas, JA | 1 |
| Mosley, CA | 1 |
| Drager, AM | 1 |
| Schaefer, MC | 1 |
| Weis, O | 1 |
| Sriwatanakul, K | 1 |
| Weintraub, M | 1 |
| Spitaels, JM | 1 |
| Lindsay, PG | 1 |
| Wyckoff, M | 1 |
| Ortega-Alvaro, A | 1 |
| Gibert-Rahola, J | 1 |
| Chover, AJ | 1 |
| Tejedor-Real, P | 1 |
| Casas, J | 1 |
| Mico, JA | 1 |
| Gordon, KE | 1 |
| Ludman, MD | 1 |
| Finley, GA | 1 |
| Klein, M | 1 |
| Mahoney, JE | 1 |
| Gray, SL | 1 |
| Carnes, M | 1 |
| Spence, N | 1 |
| Rounsefell, B | 1 |
| Forsten, C | 1 |
| Soda, J | 1 |
| Eliav, E | 1 |
| Elishoov, H | 1 |
| Kopecki, RA | 1 |
| Strouse, WS | 1 |
| McQuay, HJ | 2 |
| Carroll, D | 2 |
| Glynn, CJ | 2 |
| Godfrey, RG | 1 |
| Taniguchi, K | 1 |
| Yoshitake, S | 1 |
| Iwasaka, H | 1 |
| Honda, N | 1 |
| Oyama, T | 1 |
| Rani, PU | 1 |
| Naidu, MU | 1 |
| Prasad, VB | 1 |
| Rao, TR | 1 |
| Shobha, JC | 1 |
| Bartusch, SL | 1 |
| Sanders, BJ | 1 |
| D'Alessio, JG | 1 |
| Jernigan, JR | 1 |
| Bryson, HM | 1 |
| Wilde, MI | 1 |
| Hood, DD | 1 |
| Curry, R | 1 |
| Tong, C | 1 |
| Brenne, E | 1 |
| van der Hagen, K | 1 |
| Maehlum, E | 1 |
| Husebø, S | 1 |
| Vrethem, M | 1 |
| Boivie, J | 2 |
| Arnqvist, H | 1 |
| Holmgren, H | 1 |
| Lindström, T | 1 |
| Thorell, LH | 1 |
| Pranikoff, K | 1 |
| Constantino, G | 1 |
| Scholz, MJ | 1 |
| Jourdan, D | 1 |
| Ardid, D | 1 |
| Chapuy, E | 1 |
| Le Bars, D | 1 |
| Eschalier, A | 1 |
| Shlay, JC | 1 |
| Chaloner, K | 1 |
| Max, MB | 3 |
| Flaws, B | 1 |
| Reichelderfer, P | 1 |
| Wentworth, D | 1 |
| Hillman, S | 1 |
| Brizz, B | 1 |
| Cohn, DL | 1 |
| Kieburtz, K | 1 |
| Simpson, D | 1 |
| Yiannoutsos, C | 1 |
| Hall, CD | 1 |
| Ellis, RJ | 1 |
| Marra, CM | 1 |
| McKendall, R | 1 |
| Singer, E | 1 |
| Dal Pan, GJ | 1 |
| Clifford, DB | 1 |
| Tucker, T | 1 |
| Cohen, B | 1 |
| Scott, MA | 1 |
| Letrent, KJ | 1 |
| Hager, KL | 1 |
| Burch, JL | 1 |
| Yasuda, T | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Esser, MJ | 4 |
| Field, MJ | 1 |
| McCleary, S | 1 |
| Hughes, J | 1 |
| Singh, L | 1 |
| Ulett, GA | 1 |
| King, SA | 1 |
| Onal, A | 1 |
| Tuğlular, I | 1 |
| Morello, CM | 1 |
| Leckband, SG | 1 |
| Stoner, CP | 1 |
| Moorhouse, DF | 1 |
| Sahagian, GA | 1 |
| Kiefer, G | 1 |
| Fischer, W | 1 |
| Feuerstein, TJ | 1 |
| Andoh, T | 1 |
| Nitta, M | 1 |
| Nemoto, H | 1 |
| Dallocchio, C | 1 |
| Buffa, C | 1 |
| Mazzarello, P | 1 |
| Chiroli, S | 1 |
| Lofland, JH | 1 |
| Szarlej, D | 1 |
| Buttaro, T | 1 |
| Shermock, S | 1 |
| Jalali, S | 1 |
| Lein, B | 1 |
| Refaeian, M | 1 |
| King, JC | 1 |
| Dumitru, D | 1 |
| Chase, T | 1 |
| Allen, GV | 2 |
| Heughan, CE | 2 |
| Chase, TD | 1 |
| Marshall, H | 1 |
| Brooke, MM | 1 |
| Loeser, JD | 1 |
| Poitras, P | 1 |
| Riberdy Poitras, M | 1 |
| Plourde, V | 1 |
| Boivin, M | 1 |
| Verrier, P | 1 |
| Sinnott, C | 1 |
| Davis, JL | 1 |
| Lewis, SB | 1 |
| Gerich, JE | 1 |
| Kaplan, RA | 1 |
| Schultz, TA | 1 |
| Wallin, JD | 1 |
| Montgomery, BJ | 1 |
| Raftery, H | 1 |
| Pfister, AK | 1 |
| Moore, DS | 1 |
| Nally, FF | 1 |
| Beckner, TF | 1 |
| Idsvoog, P | 1 |
| Fong, GR | 1 |
| Sanders, DY | 1 |
| Severance, HW | 1 |
| Pollack, CV | 1 |
| Zitman, FG | 4 |
| Linssen, AC | 3 |
| Edelbroek, PM | 4 |
| Van Kempen, GM | 2 |
| Barrow, G | 1 |
| Sandford, PR | 1 |
| Lindblom, LB | 1 |
| Haddox, JD | 1 |
| Lynch, SA | 1 |
| Muir, J | 1 |
| Shoaf, SE | 1 |
| Smoller, B | 1 |
| Dubner, R | 1 |
| Acton, J | 1 |
| McKenna, JE | 1 |
| Melzack, R | 1 |
| Linssen, ACG | 1 |
| Van Kempen, GMJ | 1 |
| Bowsher, D | 1 |
| Reynolds, WJ | 1 |
| Moldofsky, H | 1 |
| Saskin, P | 1 |
| Lue, FA | 1 |
| Gastmeier, K | 1 |
| Hass, M | 1 |
| Schott, H | 1 |
| Kuteifan, K | 1 |
| Egbunike, IG | 1 |
| Chaffee, BJ | 1 |
| Tura, B | 1 |
| Tura, SM | 1 |
| Leijon, G | 1 |
| Hamaty, D | 1 |
| Valentine, JL | 1 |
| Howard, R | 1 |
| Howard, CW | 1 |
| Wakefield, V | 1 |
| Patten, MS | 1 |
| Lechin, F | 1 |
| van der Dijs, B | 1 |
| Rada, I | 1 |
| Jara, H | 1 |
| Lechin, M | 1 |
| Cabrera, A | 1 |
| Lechin, A | 1 |
| Gomez, F | 1 |
| Jimenez, V | 1 |
| Arocha, L | 1 |
| Goldenberg, DL | 1 |
| Rogers, AG | 1 |
| Abad, F | 1 |
| Feria, M | 1 |
| Boada, J | 1 |
| Seltzer, Z | 1 |
| Tal, M | 1 |
| Frances, A | 1 |
| de Felipe, MC | 1 |
| de Ceballos, ML | 1 |
| Fuentes, JA | 1 |
| Frank, RG | 1 |
| Kashani, JH | 1 |
| Parker, JC | 1 |
| Beck, NC | 1 |
| Brownlee-Duffeck, M | 1 |
| Elliott, TR | 1 |
| Haut, AE | 1 |
| Atwood, C | 1 |
| Smith, E | 1 |
| Kay, DR | 1 |
| Tollison, CD | 1 |
| Kriegel, ML | 1 |
| Rascol, O | 1 |
| Tran, MA | 1 |
| Bonnevialle, P | 1 |
| Belin, J | 1 |
| Cotonat, J | 1 |
| Guiraud-Chaumeil, B | 1 |
| Montastruc, JL | 1 |
| Dove, J | 1 |
| Rooymans, HG | 1 |
| de Wolff, FA | 1 |
| Mendel, CM | 1 |
| Klein, RF | 1 |
| Chappell, DA | 1 |
| Dere, WH | 1 |
| Gertz, BJ | 1 |
| Karam, JH | 1 |
| Lavin, TN | 1 |
| Grunfeld, C | 1 |
| Reinhardt, U | 1 |
| Godefroy, F | 2 |
| Butler, SH | 2 |
| Weil-Fugazza, J | 2 |
| Besson, JM | 2 |
| Callies, AL | 1 |
| Popkin, MK | 1 |
| Sandyk, R | 1 |
| Gillman, MA | 1 |
| Taub, A | 1 |
| Liederman, PC | 1 |
| Green, R | 1 |
| Liederman, VR | 1 |
| Kapusta, MA | 1 |
| Gannon, P | 1 |
| Itil, T | 1 |
| Keskiner, A | 1 |
| Hsu, B | 1 |
| Hislop, IG | 1 |
| Singh, G | 1 |
| Verma, HC | 1 |
| Straube, W | 1 |
| Opitz, K | 1 |
| Borchert, U | 1 |
Clinical Trials (30)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| Phase II Role of Immune-pineal Axis in Fibromyalgia: Noradrenergic Modulation and Chronotherapeutic Aspects[NCT02041455] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2010-06-30 | Recruiting | ||
| A Phase II, Randomized-Controlled, Multicenter Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age[NCT01206478] | Phase 2 | 21 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Benefits of Kinesio Taping and Inhibitory Treatment Techniques in Patients With Fibromyalgia Syndrome[NCT02859467] | 64 participants (Anticipated) | Interventional | 2016-08-31 | Suspended | |||
| Museums as Health Spaces: Design and Evaluation of the Effectiveness of an Arts in Health Intervention to Improve the Quality of Life and Functional Capacity Regarding the Pain of People With Fibromyalgia. Mixed Methodology Study.[NCT05993663] | 121 participants (Anticipated) | Interventional | 2023-10-02 | Recruiting | |||
| Effects of Manipulative Therapy in the Lower Thoracic and Cervical Spine in Subjects With Fibromyalgia Syndrome[NCT02864524] | 64 participants (Anticipated) | Interventional | 2016-08-31 | Active, not recruiting | |||
| Effectiveness of Pain Neuroscience Education and Strength Training Program in Patients With Fibromyalgia[NCT04855851] | 60 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | |||
| A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®[NCT03347669] | 100 participants (Anticipated) | Interventional | 2017-11-06 | Recruiting | |||
| Effectiveness of High-intensity Interval Training Combined With Resistance Training in Patients With Fibromyalgia[NCT03924960] | 55 participants (Actual) | Interventional | 2019-04-22 | Completed | |||
| Effectiveness of Spinal Manipulation in Addition to Standard Pharmacological Treatment in Fibromyalgia : A Blinded Randomized Clinical Trial[NCT04673058] | 60 participants (Actual) | Interventional | 2021-01-26 | Completed | |||
| Virtual Acceptance Commitment Therapy (ACT): A Randomized Controlled Trial to Evaluate a Web-Based Intervention for Stress in Adolescents With Chronic Conditions[NCT04978610] | 144 participants (Anticipated) | Interventional | 2021-03-03 | Suspended (stopped due to Lack of lab resources) | |||
| IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder Syndrome a Randomized Placebo-controlled Prospective Trial[NCT04313972] | Phase 4 | 2 participants (Actual) | Interventional | 2021-09-07 | Completed | ||
| A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients[NCT00124306] | Phase 3 | 271 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| A Randomized Trial of Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome[NCT04401176] | Phase 2 | 58 participants (Actual) | Interventional | 2020-09-15 | Completed | ||
| Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief[NCT02265848] | Phase 4 | 22 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| The Effect of Foot and Ankle Exercise on Pain and Quality of Life in Patients With Diabetic Neuropathy[NCT05670600] | 100 participants (Actual) | Interventional | 2021-07-19 | Completed | |||
| A Double-blind, Randomised, Parallel Groups Investigation Into the Effects of Pregabalin, Duloxetine and Amitriptyline on Aspects of Pain, Sleep, and Next Day Performance in Patients Suffering From Diabetic Peripheral Neuropathy[NCT00370656] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2007-02-28 | Completed | ||
| Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313] | 152 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | |||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904] | 15 participants (Anticipated) | Observational | 2011-06-30 | Recruiting | |||
| The Effect of Acupuncture on in Vitro Fertilization Outcomes in Women Undergoing Euploid Embryo Transfer - A Pilot Study[NCT03981120] | 100 participants (Anticipated) | Interventional | 2019-09-15 | Not yet recruiting | |||
| A Phase I/II, Randomized, Study for Diabetic Macular Edema Using 0.3mg Ranibizumab Combined With Targeted PRP Monthly for 4 Months,Then PRN vs. 0.3mg Ranibizumab 4 Months Monotherapy, Then as Needed(DME-AntiVEgf) DAVE[NCT01552408] | Phase 1/Phase 2 | 29 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Internet-Enhanced Management of Fibromyalgia[NCT00423631] | 118 participants (Actual) | Interventional | 2006-09-30 | Completed | |||
| Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia[NCT00373893] | Phase 1 | 12 participants | Interventional | 2005-12-31 | Completed | ||
| The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients[NCT00000817] | 260 participants (Actual) | Interventional | 1994-11-30 | Completed | |||
| A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection[NCT00000793] | Phase 2 | 240 participants | Interventional | Completed | |||
| A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy[NCT00000842] | Phase 2 | 270 participants | Interventional | Completed | |||
| Management of Chronic Pain in Rehabilitation Project I - Management of Chronic Pain in Persons With Spinal Cord Injury[NCT00006428] | Phase 4 | 100 participants | Interventional | 1996-08-31 | Completed | ||
| Subcutaneous Injection of Botulinum Toxin A for At--Level Back Pain in Patients With Spinal Cord Injury[NCT02736890] | Phase 2 | 8 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to funding not available to continue) | ||
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
% Calories Taken Orally
Percent Kilocalories (kcal) Obtained Orally. This measure was obtained using the 24 hour food recall, a standardized five-pass method developed by the US Department of Agriculture for use in national dietary surveillance. This measure has been widely used in several large trials and data suggest it is the most valid and reliable method of dietary assessment for children (20). The data were collected at week 0, week 10, and week 24 using standardized probes by highly trained research staff, and parents were presented with paper food models and measuring devices prior to interviews to reference during the recall. Recalls were analyzed with the Nutritional Data System for Research, version 2005; University of Minnesota, Minneapolis, MN. (NCT01206478)
Timeframe: baseline, 24 weeks
| Intervention | change in percent kcal obtained orally (Mean) |
|---|---|
| Amitriptyline, Megestrol | 68.62 |
| Placebo, Megestrol | 76.89 |
Change in Non-communicating Children's Pain Checklist - Revised (NCCPC-R) Scores
Non-communicating Children's Pain Checklist - Revised (NCCPC-R) used to measure outcome. The NCCPC-R is a 30 item measure intended to assess pain in children who are unable to speak because of cognitive or physical impairments. There are 7 sub-scales including vocal, social, facial, activity, body/limbs, physiological, and eating/sleeping. Each question has a potential score of 0 to 3. Scores are totaled for each sub-scale. Sub-scale scores are then added together for the Total Score. Total Scores can range from 0 to 90. The higher the score, the higher level of pain indicated by the child. This measure was completed by parents at week 0, week 10, and week 24. (NCT01206478)
Timeframe: baseline, 24 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Amitriptyline, Megestrol | -2.5 |
| Placebo, Megestrol | -6.86 |
Numeric Pain Rating Scale (NPRS)
Digital pain rating system that scores patient's subjective pain rating from 0 to 10; with greater number indicating progressively worsening pain. NPRS were measured at baseline (visit1), and at each follow ups visits at visit 2, 3 and 4. Visit 2 and 4 captured post treatment (either 1000 Hz or standard stimulation depending on the randomization) results, and visit 3 captured NPRS after the wash off from the spinal cord stimulation. (NCT02265848)
Timeframe: Baseline (visit 1), and at each follow up visits (visits 2, 3, and 4)
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Average Baseline NPRS Score | Average NPRS after 1000 Hz. stimulation | Average NPRS after standard stimulation | Average NPRS after Wash off | Best Baseline NPRS score | Best NPRS score after 1000 Hz. stimulation | Best NPRS score after standard stimulation | Best NPRS after Wash off | Worst Baseline NPRS score | Worst NPRS score after 1000 Hz. stimulation | Worst NPRS score after standard stimulation | Worst NPRS after Wash off | |
| Treatment Group A | 6.09 | 3.73 | 5.64 | 6.45 | 3.72 | 2.64 | 3.46 | 4.54 | 7.90 | 6.64 | 8.18 | 8.72 |
| Treatment Group B | 6.27 | 3.82 | 6.09 | 7.18 | 4.45 | 2.18 | 4.45 | 5.36 | 8.09 | 6.64 | 8.36 | 8.81 |
Oswestry Disability Index Questionnaire (ODI).
ODI is a outcome metrics that is design to assess the severity of disability based on 10 activity categories. ODI is based on 0 to 100% scale, where larger percentage implies worse disability. (There are 5 categories: 0-20%: Minimal disability, 21-40%: Moderate disability, 41-60%: Severe disability, 61-80%: Crippled. 81-100%: Either bed bound or exaggerating symptoms). ODI were measured at baseline (visit1), and at each follow ups visits at visit 2, 3 and 4. Visit 2 and 4 captured post treatment (either 1000 Hz or standard stimulation depending on the randomization) results, and visit 3 captured NPRS after the wash off from the spinal cord stimulation. (NCT02265848)
Timeframe: Baseline (visit 1), and at each follow up visits (visits 2, 3, and 4)
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline ODI score | ODI after 1000 Hz. stimluation | ODI after standard stimulation | ODI after wash off | |
| Treatment Group A | 47.49 | 39.23 | 49.63 | 52.87 |
| Treatment Group B | 51.25 | 33.77 | 49.05 | 56.77 |
Patient's Global Impression of Change (PGIC)
PGIC is a 7-point scale that requires study subjects to rate the severity of their illness or medical condition after a specific treatment. 1: No change, 2: Almost the same, 3: A little better, 4: Somewhat better, 5: Moderately better, 6: Better, 7: A great deal better. Study subjects were asked to report their impression of changes at baseline visit, visit 2 through 4. (NCT02265848)
Timeframe: Baseline (visit 1), and at each follow up visits (visits 2, 3, and 4)
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| PGIC After 1000 Hz. stimulation | PGIC after standard stimulation | PGIC after Wash off | |
| Treatment Group A | 4.27 | 2.54 | 1.45 |
| Treatment Group B | 5.91 | 2.45 | 1.27 |
Preferability
At the conclusion of the study, subjects were asked to report which spinal cord stimulation modes they preferred. Subjects were presented with two boxes (1000 Hz. stimulation and Standard stimulation) and asked to check one. (NCT02265848)
Timeframe: End of treatment visit on visit 4
| Intervention | participants (Number) | |
|---|---|---|
| Subjects who prefer 1000 Hz. stimulation | Subjects who prefer standard stimulation | |
| Treatment Group A | 8 | 3 |
| Treatment Group B | 10 | 1 |
Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Mechanical Thresholds (Mechanical Detection and Pain).
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Thermal Threshold Detection (Warmth and Heat Pain)
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
Mean Change in Peripheral Visual Field as Measured by Goldmann Visual Field at Screen and Month and 36.
Mean change in peripheral visual field as measured by Goldmann visual field at screen and Month 36 in the ranibizumab and targeted PRP with ranibizumab cohorts. (NCT01552408)
Timeframe: 36 Months
| Intervention | degrees squared (Mean) |
|---|---|
| 0.3 mg Ranibizumab | -215 |
| Targeted PRP With 0.3 mg Ranibizumab | -1723 |
Mean Change Over Time in Early Treatment Diabetic Retinopathy Study Best Corrected Visual Acuity (ETDRS BCVA) Through Month 36
Evaluate the mean change over time in ETDRS BCVA in the ranibizumab and targeted PRP with ranibizumab cohorts through Month 36. (NCT01552408)
Timeframe: 36 Months
| Intervention | letters (Mean) |
|---|---|
| 0.3 mg Ranibizumab | 13.9 |
| Targeted PRP With 0.3 mg Ranibizumab | 8.2 |
Patients With Persistent Macular Edema Post-intravitreal Injection.
Percentage of patients with persistent macular edema post-intravitreal injection in the ranibizumab and targeted PRP with ranibizumab cohorts. (NCT01552408)
Timeframe: Month 36
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.3 mg Ranibizumab | 9 |
| Targeted Pan-retinal Photocoagulation With 0.3 mg Ranibizumab | 12 |
Total Number of Ranibizumab Injections in Each of the Two Cohorts in a 36 Month Period
Assess the number of ranibizumab injections in the ranibizumab and targeted panretinal photocoagulation (PRP) with ranibizumab cohorts through Month 36. (NCT01552408)
Timeframe: 36 Months
| Intervention | injections (Mean) |
|---|---|
| 0.3 mg Ranibizumab | 24.4 |
| Targeted PRP With 0.3 mg Ranibizumab | 27.1 |
Determine Percentage of Patients Who Experience a Gain of 15 or More Letters From Baseline to Month 12, 24, and 36 in ETDRS BCVA
Determine percentage of patients who experience a gain of 15 or more letters from Baseline to Month 12, 24, and 36 in ETDRS BCVA in the ranibizumab and targeted PRP with ranibizumab cohorts. (NCT01552408)
Timeframe: Month 12, 24, and 36
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Month 12 | Month 24 | Month 36 | |
| 0.3 mg Ranibizumab | 10 | 10 | 9 |
| Targeted PRP With 0.3 mg Ranibizumab | 5 | 6 | 5 |
Evaluate Mean Change in Central Retinal Thickness Over Time Through Month 12, 24, and 36 as Assessed by High Resolution OCT's.
Evaluate mean change in central retinal thickness in the ranibizumab and targeted PRP with ranibizumab cohorts over time through Month 12, 24, and 36 as assessed by high resolution OCT's. (NCT01552408)
Timeframe: Month 12, 24, and 36
| Intervention | microns (Mean) | ||
|---|---|---|---|
| Month 12 | Month 24 | Month 36 | |
| 0.3 mg Ranibizumab | -301 | -296 | -302 |
| Targeted PRP With 0.3 mg Ranibizumab | -161 | -169 | -152 |
Incidence and Severity of Ocular and Non-ocular Adverse Events (AE's) Through Month 36.
Incidence and severity of ocular and non-ocular adverse events (AE's) in the monotherapy and combination cohorts through Month 36. (NCT01552408)
Timeframe: 36 Months
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Participants Experiencing Serious Ocular AE | Participants Experiencing Serious Systemic AE | |
| 0.3 mg Ranibizumab | 2 | 7 |
| Targeted PRP With 0.3 mg Ranibizumab | 1 | 9 |
Patients Who Experience a Loss of 15 or More Letters From Baseline to Month 12, 24, and 36 in ETDRS BCVA.
Percentage of patients in the ranibizumab and targeted PRP with ranibizumab cohorts who experience a loss of 15 or more letters from Baseline to Month 12, 24, and 36 in ETDRS BCVA. (NCT01552408)
Timeframe: Month 12, 24, and 36
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| 12 Months | 24 Months | 36 Months | |
| 0.3 mg Ranibizumab | 0 | 0 | 0 |
| Targeted PRP With 0.3 mg Ranibizumab | 0 | 1 | 1 |
7-Point Guy/Farrar Patient Global Impression of Change (PGIC)
"Mean change from baseline. Participants are asked Taking into account your pain level and how it affects your life, are you feeling better, the same or worse than when you started treatment? and then to quantify the magnitude of the change. with the 7-Point guy Farrar which measures the global treatment effect from with scale from 0 to 6, higher score indicates worse outcomes." (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | score on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 2.2 | 2.4 | 2 | 2 | 0 | 0 | 0 | 0 |
| Placebo Then Botulinum Toxin A | 0.3 | 0.3 | 0 | 0 | 5 | 5 | 3 | 1 |
International Basic Pain Dataset - Pain Affecting Day-to-day Activities
The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting day-to-day activities subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 4.2 | 5.4 | 5 | 5 | 4.8 | 7 | 6.7 | 7 | 6.7 |
| Placebo Then Botulinum Toxin A | 5.3 | 2.7 | 2.7 | 2.7 | 2.7 | 2 | 3 | 4 | 5 |
International Basic Pain Dataset - Pain Affecting Mood
The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting mood subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 5.6 | 6.6 | 5.8 | 5.2 | 5.6 | 7 | 7 | 7.3 | 6.7 |
| Placebo Then Botulinum Toxin A | 5.7 | 2.7 | 2.7 | 4.3 | 5.7 | 2 | 3 | 4 | 7 |
International Basic Pain Dataset - Pain Affecting Sleep
The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting sleep subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 5.8 | 4.6 | 5 | 6 | 6.2 | 8 | 8 | 8 | 7.3 |
| Placebo Then Botulinum Toxin A | 6.7 | 4.7 | 3.3 | 6 | 6.7 | 1 | 3 | 4 | 5 |
Numeric Pain Rating Scale (NPRS)
Participant rated pain intensity from 0-10, with higher score indicating more pain (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | score on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 7.6 | 6.4 | 5.6 | 5.6 | 5.6 | 8 | 8 | 6.7 | 8 |
| Placebo Then Botulinum Toxin A | 8 | 8 | 8 | 8 | 8 | 5 | 5 | 6 | 7 |
Patient-generated Index (PGI)
PGI measures activity affected by pain. Full score is 0 to 10000, with higher score indicating better function (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | score on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 4250 | 5240 | 5219 | 3725 | 4330 | 3333.3 | 3333.3 | 3333.3 | 3333.3 |
| Placebo Then Botulinum Toxin A | 1500 | 1550 | 1825 | 2800 | 1800 | 3500 | 3750 | 3000 | 1500 |
Length of Hospitalization
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
Number of Participants Discharged to Home Within the First 24 Hours
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
Time to Vaso-occlusive Pain Crisis (VOC) Resolution
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
Number of Participants Readmitted to Hospital Within 30 Days After Discharge
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| during first 24 hours | during 30-day follow-up | |
| Inhaled Nitric Oxide | 0 | 9 |
| Placebo | 0 | 17 |
Total Dose of Opioids Received
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) | |
|---|---|---|
| within 8 hours | within 40 days | |
| Inhaled Nitric Oxide | 16.25 | 153.75 |
| Placebo | 17.25 | 211.37 |
Reviews
24 reviews available for amitriptyline and Ache
| Article | Year |
|---|---|
Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis.
Topics: Adolescent; Adult; Amitriptyline; Child; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Net | 2022 |
Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.
Topics: Amitriptyline; Duloxetine Hydrochloride; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; M | 2022 |
Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review.
Topics: Amitriptyline; Anticonvulsants; Gabapentin; Humans; Ketamine; Pain; Pregabalin; Spinal Cord Injuries | 2022 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
EULAR revised recommendations for the management of fibromyalgia.
Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi | 2017 |
A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome.
Topics: Amitriptyline; Antidepressive Agents; Databases, Bibliographic; Depression; Fatigue; Fibromyalgia; H | 2008 |
Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment.
Topics: Administration, Intravesical; Amitriptyline; Child; Cimetidine; Cystitis, Interstitial; Diet Therapy | 2009 |
Post-stroke pain.
Topics: Age Factors; Amitriptyline; Analgesics, Non-Narcotic; Humans; Pain; Stroke | 2009 |
Cyclobenzaprine for the treatment of myofascial pain in adults.
Topics: Adult; Amitriptyline; Anesthetics, Local; Clonazepam; Fascia; Humans; Lidocaine; Muscle Relaxants, C | 2009 |
Painful diabetic neuropathy: advantage of novel drugs over old drugs?
Topics: Amitriptyline; Analgesics; Antioxidants; Antipruritics; Capsaicin; Chronic Disease; Diabetic Neuropa | 2009 |
Essential vulvodynia (vulval pain).
Topics: Amitriptyline; Decompression, Surgical; Female; Humans; Pain; Pain Management; Randomized Controlled | 2002 |
Pharmacologic management of chronic pain.
Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2002 |
Essential vulvodynia (vulval pain).
Topics: Amitriptyline; Decompression, Surgical; Female; Humans; Pain; Pain Management; Vulva | 2002 |
Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis.
Topics: Amitriptyline; Databases, Factual; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; Muscle | 2004 |
Post-herpetic neuralgia case study: optimizing pain control.
Topics: Acetates; Aged; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Cyclohexanecarb | 2004 |
Local approaches to the pain of pressure ulcers.
Topics: Administration, Cutaneous; Amitriptyline; Anesthetics, Local; Bandages; Humans; Lidocaine; Lidocaine | 2005 |
[Progress on painful diabetic peripheral neuropathy treated by integrative medicine].
Topics: Amines; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Cyclohe | 2005 |
Interstitial cystitis/painful bladder syndrome.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; C | 2007 |
Medical treatment of tinnitus.
Topics: Amitriptyline; Anti-Arrhythmia Agents; Auditory Pathways; Drug Combinations; Humans; Lidocaine; Pain | 1984 |
A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin; Fibromyalgia; Humans; Lif | 1996 |
Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states.
Topics: Aged; Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Chronic Di | 1996 |
Isolated sural neuropathy presenting as lateral ankle pain.
Topics: Accidents, Occupational; Adult; Amitriptyline; Analgesics, Non-Narcotic; Ankle; Anti-Inflammatory Ag | 2001 |
Neurogenic pain syndromes and their management.
Topics: Amitriptyline; Chronic Disease; Humans; Nervous System Diseases; Pain; Pain Management; Syndrome | 1991 |
Antidepressants in the management of chronic pain syndromes.
Topics: Amitriptyline; Antidepressive Agents; Arthritis; Back Pain; Chronic Disease; Diabetic Neuropathies; | 1990 |
A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomechanical Phenomena; Clinical Trials as Topic; | 1989 |
Trials
54 trials available for amitriptyline and Ache
| Article | Year |
|---|---|
Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.
Topics: Acute Disease; Adult; Amitriptyline; Antioxidants; Ascorbic Acid; Dietary Supplements; Female; Human | 2022 |
Does the addition of electrical stimulation or kinesiotherapy improve outcomes of amitriptyline treatment for women with vulvodynia? A randomized clinical trial.
Topics: Amitriptyline; Electric Stimulation; Female; Humans; Pain; Pain Measurement; Vulvodynia | 2023 |
Is low-dose naltrexone effective in chronic pain management?
Topics: Amitriptyline; Fibromyalgia; Humans; Naltrexone; Pain; Pain Management | 2023 |
Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Neu | 2021 |
Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial.
Topics: Amitriptyline; Analgesics; Animals; Bone Neoplasms; Central Nervous System Sensitization; Dog Diseas | 2018 |
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial.
Topics: Adolescent; Adult; Amitriptyline; Analgesics; Brain-Derived Neurotrophic Factor; Double-Blind Method | 2014 |
Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anti-Retroviral Agents; Cross-Over Studies; Double-B | 2015 |
A Randomized Controlled Trial of an Outpatient Protocol for Transitioning Children from Tube to Oral Feeding: No Need for Amitriptyline.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Body Mass Index; Child; Enteral Nutrition; Feeding Behavior | 2016 |
Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study.
Topics: Administration, Intravenous; Adult; Amitriptyline; Anesthetics, Local; Biomarkers; Brazil; Double-Bl | 2016 |
Evaluating the effectiveness of exposure and acceptance strategies to improve functioning and quality of life in longstanding pediatric pain--a randomized controlled trial.
Topics: Activities of Daily Living; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Analysis of Varianc | 2009 |
Self-management, amitriptyline, and amitripyline plus triamcinolone in the management of vulvodynia.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cognitiv | 2009 |
Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Diabetic Neuropathies; Dose-Response Relationship, Drug; Do | 2009 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female; | 2010 |
Development of amitriptyline buccoadhesive tablets for management of pain in dental procedures.
Topics: Adhesiveness; Administration, Buccal; Adult; Amitriptyline; Analgesia; Analgesics, Non-Narcotic; Car | 2011 |
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g | 2012 |
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g | 2012 |
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g | 2012 |
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g | 2012 |
Estimating the efficacy of an interstitial cystitis/painful bladder syndrome medication in a randomized trial with both non-adherence and loss to follow-up.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Computer Simulation; Cystitis, Interstitial; Humans; Logist | 2014 |
Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Attitude of Health Personnel; Double-Blind Method; F | 2002 |
Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study.
Topics: Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricycli | 2002 |
Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy.
Topics: Adult; Amitriptyline; Bupivacaine; Double-Blind Method; Erythema; Female; Humans; Male; Middle Aged; | 2004 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Acute and subchronic effects of amitriptyline on processing capacity in neuropathic pain patients using visual event-related potentials: preliminary findings.
Topics: Adult; Amitriptyline; Antidepressive Agents; Attention; Cross-Over Studies; Double-Blind Method; Ele | 2006 |
Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Attention; Automobile Driving; Chronic Disea | 2006 |
Sham device v inert pill: randomised controlled trial of two placebo treatments.
Topics: Acupuncture Analgesia; Administration, Oral; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; A | 2006 |
Effects of Stanger bath therapy on fibromyalgia.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Combined Modality Therapy; Electric Stimulation Ther | 2007 |
Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials.
Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Arthritis, Juvenile; Bayes Theorem; Child; Dose | 2007 |
Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury.
Topics: Adult; Aged; Amines; Amitriptyline; Analgesics; Analysis of Variance; Antidepressive Agents, Tricycl | 2007 |
Topical amitriptyline versus lidocaine in the treatment of neuropathic pain.
Topics: Administration, Topical; Amitriptyline; Analgesics, Non-Narcotic; Anesthetics, Local; Double-Blind M | 2008 |
Amitriptyline versus placebo in postherpetic neuralgia.
Topics: Aged; Amitriptyline; Depression; Double-Blind Method; Female; Herpesviridae Infections; Humans; Male | 1982 |
A controlled study of amitriptyline in the treatment of chronic pain.
Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Pain | 1982 |
Dose-response for analgesic effect of amitriptyline in chronic pain.
Topics: Adult; Aged; Amitriptyline; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; Double-Bl | 1993 |
The effects of imipramine, amitriptyline and clonidine administered by iontophoresis on the pain threshold.
Topics: Adrenergic alpha-Agonists; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clonidine; Humans | 1995 |
An evaluation of antidepressants in rheumatic pain conditions.
Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents, Second-Generation; Antidepressive Agents, T | 1996 |
Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans.
Topics: Adult; Alfentanil; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Capsaicin; D | 1997 |
[Treatment chronic pain with amitriptyline. A double-blind dosage study with determination of serum levels].
Topics: Adult; Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Double-Bl | 1997 |
A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Cross-Over Studies; | 1997 |
Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS.
Topics: Acupuncture Therapy; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe | 1998 |
A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Anti-Arrhythmia Agents; Double-Blind Method; Dru | 1998 |
Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain.
Topics: Acetates; Adrenergic Uptake Inhibitors; Aged; Amines; Amitriptyline; Analgesics; Cross-Over Studies; | 1999 |
Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study.
Topics: Acetates; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Ataxia; Cyclohexanecarboxylic | 2000 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
Psychotropic agents finding analgesic use.
Topics: Amitriptyline; Analgesics; Chronic Disease; Clinical Trials as Topic; Drug Synergism; Fluphenazine; | 1978 |
Clinical effectiveness of antidepressants and antipsychotics in chronic benign pain.
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chronic Disease; Double-Blind Method; Hu | 1992 |
Low dose amitriptyline in the treatment of chronic pain.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Delayed-Action Preparations; Double-Blind Method; Fem | 1992 |
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Depression; Desipramine; Diabetic Neuropa | 1992 |
Biochemical measures in patients with a somatoform pain disorder, before, during, and after treatment with amitriptyline with or without flupentixol.
Topics: Adult; Amitriptyline; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Female; F | 1992 |
Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder?
Topics: Adult; Amitriptyline; Depressive Disorder; Double-Blind Method; Drug Synergism; Drug Therapy, Combin | 1991 |
The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia.
Topics: Adult; Affect; Amitriptyline; Double-Blind Method; Fatigue; Female; Fibromyalgia; Humans; Male; Midd | 1991 |
Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine.
Topics: Aged; Amitriptyline; Carbamazepine; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Dou | 1989 |
The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: a 5-month study.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; beta-Endorphin; Catecholamines; Dinoprostone | 1989 |
A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomechanical Phenomena; Clinical Trials as Topic; | 1989 |
Antidepressant analgesia in rheumatoid arthritis.
Topics: Aged; Amitriptyline; Antidepressive Agents; Arthritis, Rheumatoid; Depression; Desipramine; Double-B | 1988 |
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; | 1986 |
A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female; | 1986 |
Clinical and quantitative electroencephalographical effects of MK 940.
Topics: Adjustment Disorders; Adult; Amitriptyline; Anorexia Nervosa; Attention; Clinical Trials as Topic; C | 1970 |
Other Studies
138 other studies available for amitriptyline and Ache
| Article | Year |
|---|---|
3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.
Topics: Amides; Analgesics; Animals; Arthritis, Experimental; Carrageenan; CHO Cells; Chronic Pain; Cricetin | 2012 |
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injecti | 2016 |
Enhanced antidepressant-like effects of a delta opioid receptor agonist, SNC80, in rats under inflammatory pain.
Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents; Benzamides; Dose-Response Relatio | 2022 |
A multidisciplinary approach to a patient with vulvodynia: a successful treatment and outcome.
Topics: Amitriptyline; Female; Humans; Middle Aged; Pain; Quality of Life; Treatment Outcome; Vulvodynia | 2022 |
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better.
Topics: Amitriptyline; Analgesics; Diabetes Mellitus; Diabetic Neuropathies; Duloxetine Hydrochloride; Human | 2023 |
Long-term outcomes of nummular headache: A series of 168 patients and 1198 patient-years of follow-up.
Topics: Adult; Amitriptyline; Follow-Up Studies; Headache; Headache Disorders; Humans; Pain | 2023 |
Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.
Topics: Acetaminophen; Advance Care Planning; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesic | 2020 |
The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia?
Topics: Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr | 2018 |
Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure.
Topics: Adult; Amitriptyline; Breast Feeding; Diagnosis, Differential; Female; Humans; Infant, Newborn; Mass | 2019 |
Neuropsychiatric side effects of cyclobenzaprine.
Topics: Amitriptyline; Antidepressive Agents; Delirium; Humans; Male; Middle Aged; Movement Disorders; Muscl | 2013 |
Intranasal delivery of cyclobenzaprine hydrochloride-loaded thiolated chitosan nanoparticles for pain relief.
Topics: Administration, Intranasal; Amitriptyline; Animals; Brain; Cell Line, Tumor; Cell Survival; Chemistr | 2013 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode | 2013 |
Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interact | 2014 |
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto | 2014 |
Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis.
Topics: Amitriptyline; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Hyp | 2014 |
[Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Biureas; Diazepam; Female; Ma | 2015 |
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide.
Topics: Administration, Intravesical; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; | 2015 |
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai | 2016 |
A rare complication of total knee arthroplasty: Type l complex regional pain syndrome of the foot and ankle.
Topics: Aged; Amitriptyline; Analgesics; Ankle; Arthroplasty, Replacement, Knee; Complex Regional Pain Syndr | 2016 |
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2008 |
Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters.
Topics: Amino Acid Transport System X-AG; Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, | 2008 |
Effective use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% for analgesia in refractory proctodynia.
Topics: Administration, Topical; Amitriptyline; Anal Canal; Analgesics; Drug Combinations; Humans; Ketamine; | 2008 |
[Sequential drugs treatment for central pain following spinal cord injury].
Topics: Adult; Amitriptyline; Carbamazepine; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; | 2009 |
The neuraxial effects of intraspinal amitriptyline at low concentrations.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthesia; Animals; Central Nervous System; Dogs; Female; | 2009 |
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Anima | 2009 |
Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic pain rats.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Blotting, Western; Excitatory Amino Acid Transport | 2010 |
Comparison of antinociceptive and antidiabetic effects of sertraline and amitriptyline on streptozotocin-induced diabetic rats.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Diabetes Mellit | 2010 |
Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine.
Topics: Acute Disease; Administration, Oral; Adult; Amitriptyline; Delayed-Action Preparations; Disorders of | 2011 |
Effect of glibenclamide on antinociceptive effects of antidepressants of different classes.
Topics: Amitriptyline; Analgesics; Analysis of Variance; Animals; Antidepressive Agents; Drug Interactions; | 2011 |
Late onset painful cold-aggravated myotonia: three families with SCN4A L1436P mutation.
Topics: Acetazolamide; Adult; Age of Onset; Aged; Aged, 80 and over; Amitriptyline; Anticonvulsants; Belgium | 2011 |
The interaction between antidepressant drugs and the pain-relieving effect of spinal cord stimulation in a rat model of neuropathy.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; C | 2011 |
Neuropsychiatric manifestation after a stroke: newly developed symptoms or side-effect of drug?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depression; Female; Humans; Middl | 2012 |
Treatment of levator ani syndrome with cyclobenzaprine.
Topics: Adult; Amitriptyline; Anus Diseases; Humans; Male; Muscle Relaxants, Central; Pain | 2012 |
Mandatory palliative care education for surgical residents: initial focus on teaching pain management.
Topics: Adult; Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Curriculum; | 2013 |
Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails.
Topics: Acetates; Amitriptyline; Anticonvulsants; Desipramine; Drug Approval; France; Herpes Zoster; Humans; | 2002 |
[Treatment of pain in a case of osteogenesis imperfecta type III].
Topics: Adolescent; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Drug Therapy, Combination; Female; | 2002 |
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response | 2003 |
An East-West approach to the management of central post-stroke pain.
Topics: Acetates; Acupuncture; Aged; Amines; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Secon | 2003 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pain; Pain M | 2004 |
Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A | 2004 |
Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran.
Topics: Amitriptyline; Animals; Antidepressive Agents; Catheterization; Cyclopropanes; Dose-Response Relatio | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthesia, Local; Cell Line; Dose-Response Relationship, D | 2004 |
Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Anima | 2004 |
Interactions of cyclobenzaprine and tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal | 2005 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra | 2005 |
Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain.
Topics: Adult; Amitriptyline; Amputation, Surgical; Analgesics, Non-Narcotic; Chronic Disease; Disability Ev | 2005 |
[Low doses of prazosin potantiates the antinociceptive/analgesic effect of amitriptyline].
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Animals; Dose-Response Relati | 2005 |
Computed tomography guided lumbar sympathetic block for complex regional pain syndrome in a child: a case report and review.
Topics: Amines; Amitriptyline; Analgesics; Anesthetics, Local; Antidepressive Agents, Tricyclic; Autonomic N | 2006 |
Painful mononeuritis multiplex in idiopathic thrombocytopenic purpura.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combin | 2005 |
Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby.
Topics: Amitriptyline; Anticonvulsants; Apnea; Autonomic Nervous System Diseases; Bradycardia; Bronchial Spa | 2005 |
GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2006 |
Motor cortex stimulation for central pain following a traumatic brain injury.
Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju | 2006 |
Bilateral hemifacial spasm and trigeminal neuralgia: a unique form of painful tic convulsif.
Topics: Aged; Amines; Amitriptyline; Analgesics; Arachnoid Cysts; Botulinum Toxins, Type A; Cyclohexanecarbo | 2007 |
Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model.
Topics: Amitriptyline; Anesthesia, Conduction; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic | 2007 |
Tramadol is more effective than morphine and amitriptyline against ischaemic pain but not thermal pain in rats.
Topics: Amitriptyline; Analgesics; Animals; Female; Hot Temperature; Hyperalgesia; Ischemia; Male; Morphine; | 2007 |
Antinociceptive effect of amitriptyline in mice of acute pain models.
Topics: Acute Disease; Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Respon | 2007 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia.
Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio | 2007 |
Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome--type I.
Topics: Amitriptyline; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dos | 2008 |
Dependence on dextromoramide.
Topics: Aged; Amitriptyline; Chlorpromazine; Codeine; Dextromoramide; Humans; Levorphanol; Male; Pain; Subst | 1967 |
Chronic pain syndromes and disordered cortical inhibition: effects of tricyclic compounds.
Topics: Amitriptyline; Animals; Anticonvulsants; Cerebral Cortex; Humans; Imipramine; Mice; Pain; Paresthesi | 1967 |
Chronic pain and the risks of psychotropics.
Topics: Amitriptyline; Chronic Disease; Female; Fluphenazine; Heart Failure; Humans; Meperidine; Middle Aged | 1984 |
Tricyclic antidepressants in chronic pain.
Topics: Adult; Aged; Amitriptyline; Chronic Disease; Female; Humans; Male; Middle Aged; Pain; Pilot Projects | 1984 |
The effects of propranolol and amitriptyline on vascular and EMG biofeedback training.
Topics: Adolescent; Adult; Aged; Amitriptyline; Biofeedback, Psychology; Female; Humans; Male; Middle Aged; | 1984 |
Diabetic neuropathic pain: control by amitriptyline and fluphenazine in renal insufficiency.
Topics: Adult; Aged; Amitriptyline; Diabetic Neuropathies; Drug Therapy, Combination; Female; Fluphenazine; | 1983 |
A regimen of tricyclic compounds and carbamazepine for treating trigeminal neuralgia pain.
Topics: Amitriptyline; Carbamazepine; Chlordiazepoxide; Drug Combinations; Humans; Pain; Trigeminal Neuralgi | 1981 |
Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine.
Topics: Adult; Aged; Amitriptyline; Drug Combinations; Female; Herpes Zoster; Humans; Male; Middle Aged; Neu | 1982 |
Psychotropic drugs in the treatment of pain in chronic pancreatitis.
Topics: Amitriptyline; Drug Therapy, Combination; Humans; Pain; Pancreatitis; Psychotropic Drugs; Trifluoper | 1982 |
The depression-pain syndrome and its response to antidepressants.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Fem | 1981 |
Effect of amitriptyline on the analgesia induced by adrenal medullary tissue transplanted in the rat spinal subarachnoid space as measured by an experimental model of acute pain.
Topics: Acute Disease; Adrenal Medulla; Amitriptyline; Analgesia; Animals; Drug Administration Schedule; Mal | 1994 |
Successful treatment of painful crises of Fabry disease with low dose morphine.
Topics: Amitriptyline; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, | 1995 |
Prevention and treatment of the complications of diabetes mellitus.
Topics: Amitriptyline; Analgesics, Opioid; Diabetic Neuropathies; Humans; Pain | 1995 |
Prevention and treatment of the complications of diabetes mellitus.
Topics: Aged; Amitriptyline; Desipramine; Diabetic Neuropathies; Humans; Pain | 1995 |
Out-patient cognitive-behavioural therapy with amitriptyline for chronic non-malignant pain: a comparative study with 6-month follow-up.
Topics: Adult; Amitriptyline; Behavior Therapy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain; | 1995 |
Diagnosis and treatment of persistent pain after trauma to the head and neck.
Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He | 1994 |
Pain medication.
Topics: Amitriptyline; Family Practice; Humans; Pain | 1994 |
Pain medication.
Topics: Amitriptyline; Chronic Disease; Humans; Pain | 1994 |
Clonazepam for the treatment of lancinating phantom limb pain.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clonazepam; Disarticulation; Drug Therapy, Co | 1996 |
The use of amitriptyline in patients with urinary frequency and pain.
Topics: Adult; Aged; Amitriptyline; Female; Humans; Male; Middle Aged; Pain; Patient Satisfaction; Urination | 1998 |
Managing the aftermath of shingles.
Topics: Acyclovir; Amitriptyline; Antidepressive Agents, Tricyclic; Antiviral Agents; Drug Therapy, Combinat | 1998 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Effect of analgesics on audible and ultrasonic pain-induced vocalization in the rat.
Topics: Amitriptyline; Analgesics; Animals; Aspirin; Cricetinae; Electric Stimulation; Male; Morphine; Nalox | 1998 |
Use of transdermal amitriptyline gel in a patient with chronic pain and depression.
Topics: Administration, Cutaneous; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; | 1999 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Dose-Resp | 1999 |
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus | 1999 |
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; HIV Infections; Humans; Pain; | 1999 |
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; HIV Infections; Humans; Pain; | 1999 |
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Administration Schedule; | 1999 |
The relationship between pupil diameter and pain by the administration of morphine and antidepressant drugs in mice.
Topics: Amitriptyline; Analgesia; Analgesics, Opioid; Animals; Antidepressive Agents; Desipramine; Male; Mic | 1999 |
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Precli | 1999 |
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen.
Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic A | 1999 |
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination; | 2001 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; | 1995 |
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models | 2001 |
Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Formaldehyde; Injections, Intrap | 2002 |
The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cy | 2002 |
Evolution of visceral sensitivity in patients with irritable bowel syndrome.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Catheterization; Colonic Diseases, Functional; | 2002 |
Problems recruiting cancer patients to a comparative clinical trial of drug treatments for neuropathic pain in palliative care.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Multicenter Studies as Topic; Neoplasms; Ne | 2002 |
Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine.
Topics: Adult; Aged; Amitriptyline; Diabetic Neuropathies; Drug Therapy, Combination; Female; Fluphenazine; | 1977 |
The management of post herpetic pain using sodium valproate and amitriptyline.
Topics: Amitriptyline; Herpes Zoster; Humans; Pain; Valproic Acid | 1979 |
Weight gain from combined phenothiazine and tricyclic therapy.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Body Weight; Humans; Pain; Phenothiazines; Thiorida | 1978 |
Atypical facial pain: an analysis of 100 patients with discussion.
Topics: Adult; Age Factors; Amitriptyline; Anxiety Disorders; Chlordiazepoxide; Depression; Diagnosis, Diffe | 1975 |
Letter: Painful shoulder syndrome.
Topics: Amitriptyline; Carbonates; Depression; Humans; Lithium; Pain; Shoulder; Syndrome | 1975 |
Drug use and distribution in a pain rehabilitation center.
Topics: Adult; Amitriptyline; Barbiturates; Chronic Disease; Diet; Female; Formularies, Hospital as Topic; H | 1975 |
Letter: Drug use in a pain rehabilitation center.
Topics: Amitriptyline; Chronic Disease; Drug Combinations; Humans; Methadone; Pain; Phenytoin; Snake Venoms | 1975 |
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory | 1992 |
Predictors of outcome in the treatment of chronic "psychogenic" pain with amitriptyline and brief psychotherapy.
Topics: Amitriptyline; Humans; Pain; Pain Management; Prognosis; Psychiatric Status Rating Scales; Psychothe | 1992 |
Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury.
Topics: Adult; Amitriptyline; Carbamazepine; Female; Humans; Pain; Spinal Cord Injuries | 1992 |
Amitriptyline produces analgesia in the formalin pain test.
Topics: Amitriptyline; Analgesia; Analgesics; Analysis of Variance; Animals; Formaldehyde; Male; Pain; Rats; | 1992 |
[Pain therapy for urologic cancer patients at the Potsdam district hospital--initial results].
Topics: Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Aspirin; Carbamazepine; Codeine; Dipyrone; Drug | 1990 |
The analgesic effect of tricyclic antidepressants.
Topics: Amitriptyline; Analgesia; Analgesics; Animals; Fenclonine; Imipramine; Male; Pain; Rats; Rats, Inbre | 1990 |
Recurrent gastroesophageal symptoms and precordial pain in a gastrectomized man improved by amitriptyline. Physiologic, metabolic, endocrine, neurochemical and psychiatric findings.
Topics: Amitriptyline; Depression; Gastrectomy; Gastrointestinal Diseases; Gastrointestinal Motility; Hormon | 1989 |
Use of amitriptyline (Elavil) for phantom limb pain in younger children.
Topics: Administration, Oral; Amitriptyline; Amputation, Surgical; Child; Femoral Neoplasms; Humans; Male; O | 1989 |
Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Male; Pain; Rats; Rats, Inbred Strains; Se | 1989 |
Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline.
Topics: Amitriptyline; Animals; Behavior, Animal; Denervation; Diazepam; Hindlimb; Male; Pain; Peripheral Ne | 1989 |
Ongoing treatment of a Hmong widow who suffers from pain and depression.
Topics: Acculturation; Amitriptyline; Asian; Combined Modality Therapy; Counseling; Depressive Disorder; Dia | 1989 |
Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin.
Topics: Amitriptyline; Animals; Antidepressive Agents; Dibenzazepines; Drug Tolerance; Endorphins; Fenclonin | 1986 |
Selected tricyclic antidepressants in the management of chronic benign pain.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Doxepin; Huma | 1988 |
Lack of correlation between plasma levels of amitriptyline (and nortriptyline) and clinical improvement of chronic pain of peripheral neurologic origin.
Topics: Adult; Aged; Amitriptyline; Analgesics; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pain | 1987 |
Your CE topic this month (No. 28). Update on pain therapy (Part 1).
Topics: Amitriptyline; Education, Nursing, Continuing; Humans; Narcotics; Nursing, Practical; Pain | 1987 |
[Modification of tumor pain by psychotropic drugs].
Topics: Adult; Aged; Amitriptyline; Bone Neoplasms; Breast Neoplasms; Chlorprothixene; Drug Therapy, Combina | 1987 |
Amitriptyline and fluphenazine for painful diabetic neuropathy.
Topics: Amitriptyline; Diabetic Neuropathies; Fluphenazine; Humans; Pain; Placebos; Research Design | 1986 |
Do acute or chronic tricyclic antidepressants modify morphine antinociception in arthritic rats?
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arthritis; Arthritis, Experimental; Drug S | 1986 |
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di | 1987 |
Amitriptyline for pain of cortical origin.
Topics: Adult; Amitriptyline; Cerebral Cortex; Female; Humans; Pain | 1986 |
Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis.
Topics: Amitriptyline; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Body Weight; Disease M | 1985 |
Relief of postherpetic neuralgia with psychotropic drugs.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents; Antipsychotic Agents; Female; Fluphenazine; | 1973 |
Outpatient group therapy with geriatric patients.
Topics: Aged; Amitriptyline; Antidepressive Agents; Anxiety; Depression; Female; Geriatrics; Humans; Imipram | 1967 |
Letter: Painful shoulder syndrome.
Topics: Amitriptyline; Bursitis; Chronic Disease; Depression; Humans; Lithium; Pain; Shoulder; Tendinopathy | 1974 |
Psychological significance of the irritable colon syndrome.
Topics: Abdomen; Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Amitriptyline; Child; Colonic Dis | 1971 |
Drug treatment of chronic intractable pain in patients referred to a psychiatry clinic.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Chlordiazepoxide; Chronic Disease; Depression; Fema | 1971 |
[Possibilities and limits of modification of symptoms in the spondylogenous syndrome with psychotropic substances].
Topics: Adult; Amitriptyline; Antidepressive Agents; Depression; Diazepam; Humans; Middle Aged; Pain; Rheuma | 1969 |
[On the management of pain using antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain | 1967 |