amitriptyline has been researched along with Abnormalities, Autosome in 3 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In general, results of chromosome abnormalities in both somatic and germ cells as well as sperm morphology and count showed that the effect of AT was dose dependent." | 1.38 | Genotoxic evaluation for the tricyclic antidepressant drug, amitriptyline. ( El-Ghor, AA; Hafiz, N; Hassanane, MS; Radwan, W, 2012) |
| "Amitriptyline was found to be nongenotoxic at plasma levels by all the parameters assayed." | 1.27 | Genotoxicity evaluation of the tricyclic antidepressants amitriptyline and imipramine using human lymphocyte cultures. ( Ahuja, YR; Saxena, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hassanane, MS | 1 |
| Hafiz, N | 1 |
| Radwan, W | 1 |
| El-Ghor, AA | 1 |
| Saxena, R | 1 |
| Ahuja, YR | 1 |
| Chowdary, PS | 1 |
| Rao, MS | 1 |
3 other studies available for amitriptyline and Abnormalities, Autosome
| Article | Year |
|---|---|
Genotoxic evaluation for the tricyclic antidepressant drug, amitriptyline.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Bone Marrow Cells; Chromosome Aberrations; | 2012 |
Genotoxicity evaluation of the tricyclic antidepressants amitriptyline and imipramine using human lymphocyte cultures.
Topics: Amitriptyline; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Humans; Imipramine; Lymp | 1988 |
Cytogenetic effects of amitriptyline hydrochloride in somatic and germ cells of mice.
Topics: Amitriptyline; Animals; Chromosome Aberrations; Male; Mice; Mutagens; Spermatozoa | 1987 |