amitriptyline has been researched along with Abdominal Pain in 20 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Abdominal Pain: Sensation of discomfort, distress, or agony in the abdominal region.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline improves symptoms in functional abdominal pain disorders (FAPD) in adults with variable results in pediatric studies." | 9.51 | Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial. ( Poddar, U; Seetharaman, J; Sen Sarma, M; Srivastava, A; Yachha, SK, 2022) |
| "To observe the therapeutic effect of low-dose amitriptyline (AMT) on epigastric pain syndrome (EPS) in patients with functional dyspepsia." | 9.41 | Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients. ( Jia, L; Jiang, SM; Liu, J; Liu, Y; Xu, J; Zhou, WC, 2021) |
| "To determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents." | 9.13 | Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. ( Ament, ME; Bahar, RJ; Collins, BS; Steinmetz, B, 2008) |
| "Amitriptyline (AMT) is commonly used in the management of children with irritable bowel syndrome." | 7.78 | Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain. ( Hussain, SZ; Jackson, R; Patra, KP; Sankararaman, S, 2012) |
| "Amitriptyline improves symptoms in functional abdominal pain disorders (FAPD) in adults with variable results in pediatric studies." | 5.51 | Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial. ( Poddar, U; Seetharaman, J; Sen Sarma, M; Srivastava, A; Yachha, SK, 2022) |
| "To observe the therapeutic effect of low-dose amitriptyline (AMT) on epigastric pain syndrome (EPS) in patients with functional dyspepsia." | 5.41 | Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients. ( Jia, L; Jiang, SM; Liu, J; Liu, Y; Xu, J; Zhou, WC, 2021) |
| "80 children with functional abdominal pain participated in a study of the efficacy of amitriptyline." | 5.20 | Abdominal pain endpoints currently recommended by the FDA and EMA for adult patients with irritable bowel syndrome may not be reliable in children. ( Lavigne, JV; Saps, M, 2015) |
| "In this multicenter placebo-controlled trial, children with irritable bowel syndrome, functional abdominal pain, or functional dyspepsia were randomized to 4 weeks of placebo or amitriptyline (10 mg/d, weight <35 kg; 20 mg/d, weight >35 kg)." | 5.14 | Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. ( Cocjin, J; Di Lorenzo, C; Hyman, P; Miranda, A; Nurko, S; Saps, M; Youssef, N, 2009) |
| "To determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents." | 5.13 | Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. ( Ament, ME; Bahar, RJ; Collins, BS; Steinmetz, B, 2008) |
| "Amitriptyline (AMT) is commonly used in the management of children with irritable bowel syndrome." | 3.78 | Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain. ( Hussain, SZ; Jackson, R; Patra, KP; Sankararaman, S, 2012) |
| "Irritable bowel syndrome is a multisymptom construct, with abdominal pain (AP) acting as the driving symptom of patient-reported severity." | 2.79 | Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change? ( Di Lorenzo, C; Hyman, P; Miranda, A; Mohammad, S; Nurko, S; Saps, M; Youssef, NN, 2014) |
| "Abdominal pain-related functional gastrointestinal disorders (FGIDs) are among the most common medical problems in paediatric medicine." | 2.47 | Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents. ( Chapman, A; Gartlehner, G; Kaminski, A; Kamper, A; Thaler, K, 2011) |
| "Chronic nausea is a major, disabling symptom that requires increased recognition as a separate functional entity." | 1.40 | Chronic idiopathic nausea of childhood. ( Chelimsky, G; Kovacic, K; Li, BU; Miranda, A; Simpson, P; Williams, S, 2014) |
| "Abdominal migraine is a rarely recognized functional intestinal disorder, manifesting as recurrent paroxysmal abdominal pain of neurogenic origin." | 1.33 | [Abdominal migraine as a cause of chronic recurrent abdominal pain in a 9-years-old girl--case report]. ( Karczewska, K; Kasner, J; KwiecieĊ, J; Piasecki, L, 2005) |
| " Three months later the dosage was reduced to 100 mg mexiletine and 25 mg Amitriptyline daily." | 1.33 | [An uncommon cause of recurrent abdominal pain in a 63-year-old obese woman]. ( Schuppert, F; Tiesmeier, J; Warnecke, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seetharaman, J | 1 |
| Poddar, U | 1 |
| Yachha, SK | 1 |
| Srivastava, A | 1 |
| Sen Sarma, M | 1 |
| Liu, J | 1 |
| Jia, L | 1 |
| Jiang, SM | 1 |
| Zhou, WC | 1 |
| Liu, Y | 1 |
| Xu, J | 1 |
| de Bruijn, CMA | 1 |
| Rexwinkel, R | 1 |
| Gordon, M | 1 |
| Benninga, M | 1 |
| Tabbers, MM | 1 |
| Cooper, TE | 1 |
| Heathcote, LC | 1 |
| Clinch, J | 1 |
| Gold, JI | 1 |
| Howard, R | 1 |
| Lord, SM | 1 |
| Schechter, N | 1 |
| Wood, C | 1 |
| Wiffen, PJ | 1 |
| Mohammad, S | 1 |
| Di Lorenzo, C | 3 |
| Youssef, NN | 2 |
| Miranda, A | 4 |
| Nurko, S | 3 |
| Hyman, P | 3 |
| Saps, M | 5 |
| Keller, K | 1 |
| Beule, J | 1 |
| Dippold, W | 1 |
| Kovacic, K | 1 |
| Chelimsky, G | 1 |
| Williams, S | 1 |
| Simpson, P | 1 |
| Li, BU | 1 |
| Lavigne, JV | 1 |
| Rosen, JM | 1 |
| Alioto, A | 1 |
| Youssef, N | 1 |
| Cocjin, J | 2 |
| Benninga, MA | 1 |
| Mayer, EA | 1 |
| Kaminski, A | 1 |
| Kamper, A | 1 |
| Thaler, K | 1 |
| Chapman, A | 1 |
| Gartlehner, G | 1 |
| Teitelbaum, JE | 1 |
| Arora, R | 1 |
| Chogle, A | 1 |
| Sztainberg, M | 1 |
| Bass, L | 1 |
| Patra, KP | 1 |
| Sankararaman, S | 1 |
| Jackson, R | 1 |
| Hussain, SZ | 1 |
| KwiecieĊ, J | 1 |
| Piasecki, L | 1 |
| Kasner, J | 1 |
| Karczewska, K | 1 |
| Tiesmeier, J | 1 |
| Warnecke, H | 1 |
| Schuppert, F | 1 |
| Bahar, RJ | 1 |
| Collins, BS | 1 |
| Steinmetz, B | 1 |
| Ament, ME | 1 |
| Bertherat, J | 1 |
| Netter, JM | 1 |
| Timsit, J | 1 |
| Chanson, P | 1 |
| Blumberg-Tick, J | 1 |
| Guillausseau, PJ | 1 |
| Warnet, A | 1 |
| Lubetzki, J | 1 |
| Hyams, JS | 1 |
| Hyman, PE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| Evaluation of Liquid Gastric Emptying and Plasma Ghrelin in Children With Functional Dyspepsia[NCT01591174] | 30 participants (Actual) | Observational | 2012-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for amitriptyline and Abdominal Pain
| Article | Year |
|---|---|
Antidepressants for functional abdominal pain disorders in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive | 2021 |
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
Advances in Pain-Predominant Functional Gastrointestinal Disorders in the Adolescent.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Cognitive Behavioral Th | 2016 |
Antidepressants for the treatment of abdominal pain-related functional gastrointestinal disorders in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Gastrointestinal | 2011 |
Recurrent abdominal pain and the biopsychosocial model of medical practice.
Topics: Abdominal Pain; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Di | 1998 |
7 trials available for amitriptyline and Abdominal Pain
| Article | Year |
|---|---|
Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial.
Topics: Abdominal Pain; Adult; Aged, 80 and over; Amitriptyline; Child; Double-Blind Method; Humans; Irritab | 2022 |
Effects of Low-Dose Amitriptyline on Epigastric Pain Syndrome in Functional Dyspepsia Patients.
Topics: Abdominal Pain; Adult; Amitriptyline; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Dy | 2021 |
Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change?
Topics: Abdominal Pain; Activities of Daily Living; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Chi | 2014 |
Abdominal pain endpoints currently recommended by the FDA and EMA for adult patients with irritable bowel syndrome may not be reliable in children.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Double-Blind Method; Fem | 2015 |
Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders.
Topics: Abdominal Pain; Activities of Daily Living; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Anx | 2009 |
Accuracy of pain recall in children.
Topics: Abdominal Pain; Adolescent; Age Factors; Amitriptyline; Analysis of Variance; Child; Double-Blind Me | 2012 |
Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe | 2008 |
8 other studies available for amitriptyline and Abdominal Pain
| Article | Year |
|---|---|
Cyclic vomiting syndrome in adults.
Topics: Abdominal Pain; Adult; Amitriptyline; Antiemetics; Combined Modality Therapy; Diagnosis, Differentia | 2013 |
Chronic idiopathic nausea of childhood.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety; Child; Chronic | 2014 |
The power of placebo in pediatric functional gastrointestinal disease.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Child; Dyspepsia; Gastrointesti | 2009 |
Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool | 2011 |
Significance of screening electrocardiogram before the initiation of amitriptyline therapy in children with functional abdominal pain.
Topics: Abdominal Pain; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Arrhythmias, Cardiac; Child; Dr | 2012 |
[Abdominal migraine as a cause of chronic recurrent abdominal pain in a 9-years-old girl--case report].
Topics: Abdominal Pain; Amitriptyline; Analgesics, Non-Narcotic; Child; Chronic Disease; Diagnosis, Differen | 2005 |
[An uncommon cause of recurrent abdominal pain in a 63-year-old obese woman].
Topics: Abdominal Pain; Adiposis Dolorosa; Amitriptyline; Analgesics, Non-Narcotic; Diagnosis, Differential; | 2006 |
[Diabetic thoracoabdominal neuropathy. Clinical and electrophysiological study with evaluation of the autonomic nervous system].
Topics: Abdominal Pain; Adult; Aged; Amitriptyline; Analgesics; Autonomic Nervous System Diseases; Chest Pai | 1993 |