amiridine and Stroke

Topics: Aged; Aminoquinolines; Female; Humans; Male; Movement Disorders; Physical Therapy Modalities; Stroke; Stroke Rehabilitation

Efficacy of neuromidin was studied in 62 patients with a small ischemic stroke and cognitive disorders. Patients of the main group received neuromidin as an add-on to basic treatment and patients of the comparison group received only basic treatment (antiaggregant, antihypertensive, cardiac and antidiabetic drugs with the exclusion of nootropic and psychotropic medications). The decrease of subjective complaints, improvement of memory, attention, abstract and practical reasoning assessed by neuropsychological tests were seen in 32 patients of the main group after the end of treatment course. Neuromidin did not cause side-effects and was well tolerated. The long use of this led to the reduction of cognitive impairment, a predictor of vascular dementia.

Topics: Adult; Aged; Aminoquinolines; Cholinesterase Inhibitors; Cognition Disorders; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Stroke

The efficacy and safety of axamon was studied in a trial with parallel groups in patients, aged 65-88 years, with movement and cognitive disorders in the residual period of stroke. Twenty-five patients received basic therapy and 25 patients were treated with axamon as an add-on drug in dosage of 20 mg 3 times a day during 12 weeks. Along with the neurological examination, a battery of neuropsychological scales and tests was used. The reduction of cognitive and movement deficits was observed. Axamon promotes the optimization of restoration potential of patients in the residual period of stroke.

Topics: Aged; Aged, 80 and over; Aminoquinolines; Cholinesterase Inhibitors; Cognition Disorders; Female; Humans; Male; Motor Activity; Paresis; Stroke; Treatment Outcome

Cognitive functions were assessed in 116 patients, aged from 18 to 84 years, in the early rehabilitation period of the first ischemic stroke of hemispheric localization and in 44 patients with cerebrovascular disorders without history of stroke. MMSE, FAB, CDT, 5 words' test, the Schulte test, verbal fluency test, CES-D were administered. The statistically significant decrease in cognitive functions was seen in the index group compared with the control one. The level of cognitive impairment was correlated with the severity of neurological deficit and age and was aggravated by depression. Neuromidin (ipidacrinum) was used in the treatment of 31 patients in incremental doses (intramuscular injections of 10 mg/day during the first two weeks and later--60 mg/day during 40 days per os). As a result, the significant increase in cognitive function with the recovery of attention, memory and lobe functions was noted.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoquinolines; Attention; Cholinesterase Inhibitors; Cognition Disorders; Female; Humans; Male; Memory; Middle Aged; Neuropsychological Tests; Stroke; Stroke Rehabilitation; Young Adult

The medical and social significance of acute cerebrovascular disturbances in the Russian Federation is considered. Purpose and tasks of early rehabilitation of patients with stroke are presented, its technology is described. Non-drug and pharmacological methods of rehabilitation are presented. The efficacy of neuromidin in the early rehabilitation of patients with a stroke is shown.

Topics: Aminoquinolines; Cholinesterase Inhibitors; Combined Modality Therapy; Humans; Russia; Stroke; Stroke Rehabilitation