amiridine and Cerebellar-Ataxia

The selectivity of action of anticholinesterase drugs (ACE drugs) in hereditary ataxias was studied using methods of registration of short latent stem-induced potentials to acoustic stimulation and assessment of the parameters of visual motor coordination. The findings obtained show the involvement in the pathological process of the brain stem in hereditary ataxias and the heterogeneity of action of ACE drugs. Thus, amiridine acted predominantly on efferent while galanthamine on afferent conduction of impulses.

Topics: Adolescent; Adult; Aminoquinolines; Brain Stem; Cerebellar Ataxia; Charcot-Marie-Tooth Disease; Child; Cholinesterase Inhibitors; Evoked Potentials, Auditory; Friedreich Ataxia; Galantamine; Humans; Psychomotor Performance; Syndrome