amiridine and Brain-Injuries

Authors have studied the efficacy of adaptol and neyromidin in the combined treatment of patients with chronic cerebral circulation insufficiency and consequences of closed head injury using neurophysiological monitoring which included dynamic evaluation of central conductivity, neuropsychological tests and analysis of blood BDNF levels. Severe autonomic disorders, anxiety and low level of learning observed in all patients are correlated with neurophysiological (increased central conductivity time) and neurotrophic (decreased blood BDNF levels) profiles. These indicators may change throughout the treatment. The combination of adaptol and neyromidin enhanced greatly the efficacy of combined treatment. The received data allow recommending neurophysiological monitoring for treatment optimization of numerous neurological diseases that demand neuroplasticity stimulation.

Topics: Adolescent; Adult; Aged; Aminoquinolines; Anxiety; Biureas; Brain Injuries; Brain Ischemia; Brain Waves; Brain-Derived Neurotrophic Factor; Drug Therapy, Combination; Female; Humans; Learning; Male; Middle Aged; Neuronal Plasticity; Neuropsychological Tests; Treatment Outcome

Topics: Aminoquinolines; Brain Injuries; Cognition Disorders; Humans; Intercellular Signaling Peptides and Proteins; Nootropic Agents; Peptides; Piracetam

We studied enzyme systems (lactate dehydrogenase) of mitochondria in cerebral nerve cells in experimental encephalopathy developing after thermal injury. In animals receiving neuromedin at the early terms after injury, the ratio of forward to reverse lactate dehydrogenase reactions significantly increased over the first day after injury and returned to normal on day 7.

Topics: Aminoquinolines; Animals; Brain Injuries; Burns; Enzyme Activation; L-Lactate Dehydrogenase; Male; Mitochondria; Rats; Rats, Wistar