Page last updated: 2024-10-22

amiodarone and Ventricular Dysfunction

amiodarone has been researched along with Ventricular Dysfunction in 8 studies

Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Ventricular Dysfunction: A condition in which HEART VENTRICLES exhibit impaired function.

Research Excerpts

ExcerptRelevanceReference
"We sought to assess the association of amiodarone use with mortality during consecutive periods in patients with post-acute myocardial infarction with left ventricular systolic dysfunction and/or HF treated with a contemporary medical regimen."9.13Amiodarone use after acute myocardial infarction complicated by heart failure and/or left ventricular dysfunction may be associated with excess mortality. ( Al-Khatib, SM; Califf, RM; Kober, L; Lokhnygina, Y; McMurray, JJ; Solomon, SD; Thomas, KL; Velazquez, EJ, 2008)
"Fetuses with incessant tachycardia and either hydrops fetalis (n=24) or ventricular dysfunction (n=2) for whom digoxin monotherapy and secondary antiarrhythmic agents (n=13) were not effective were treated transplacentally with a loading dose of oral amiodarone for 2 to 7 days, followed by daily maintenance therapy for <1 to 15 weeks."7.72Amiodarone therapy for drug-refractory fetal tachycardia. ( Cuneo, BF; Deal, BJ; Feinkind, L; Gotteiner, NL; Hussey, M; McGregor, SN; Meijboom, EJ; Michon, MM; Oudijk, MA; Parilla, BV; Strasburger, JF, 2004)
"We sought to assess the association of amiodarone use with mortality during consecutive periods in patients with post-acute myocardial infarction with left ventricular systolic dysfunction and/or HF treated with a contemporary medical regimen."5.13Amiodarone use after acute myocardial infarction complicated by heart failure and/or left ventricular dysfunction may be associated with excess mortality. ( Al-Khatib, SM; Califf, RM; Kober, L; Lokhnygina, Y; McMurray, JJ; Solomon, SD; Thomas, KL; Velazquez, EJ, 2008)
"The European Myocardial Infarct Amiodarone Trial (EMIAT) investigated the effects of amiodarone versus placebo in patients after myocardial infarction who had left ventricular ejection fraction 3.73Usefulness of ventricular repolarization dynamicity in predicting arrhythmic deaths in patients with ischemic cardiomyopathy (from the European Myocardial Infarct Amiodarone Trial). ( Badilini, F; Benchetrit, C; Coumel, P; Leenhardt, A; Maisonblanche, P; Milliez, P; Siliste, C; Vicaut, E, 2005)
"Fetuses with incessant tachycardia and either hydrops fetalis (n=24) or ventricular dysfunction (n=2) for whom digoxin monotherapy and secondary antiarrhythmic agents (n=13) were not effective were treated transplacentally with a loading dose of oral amiodarone for 2 to 7 days, followed by daily maintenance therapy for <1 to 15 weeks."3.72Amiodarone therapy for drug-refractory fetal tachycardia. ( Cuneo, BF; Deal, BJ; Feinkind, L; Gotteiner, NL; Hussey, M; McGregor, SN; Meijboom, EJ; Michon, MM; Oudijk, MA; Parilla, BV; Strasburger, JF, 2004)
"The general principles of management of congestive heart failure encompass patient evaluation and confirmation of the diagnosis, consideration, and correction of underlying remediable causes and precipitating factors, pharmacological treatment, patient education and counseling, and planned follow-up, as summarized in recently published guidelines."2.40Symptomatic systolic ventricular failure. ( Sharpe, N, 1999)
"Carvedilol is an effective additional therapy for the patients with chronic heart failure already receiving Amiodarone."1.46THE SAFETY AND EFFICACY OF AMIODARONE AND CARVEDILOL COMBINATION IN TREATMENT OF PATIENTS WITH SEVERE CARDIAC RHYTHM DISORDERS. ( Khintibidze, I; Tsetskhladze, E, 2017)
"Knowledge on ventricular tachycardia (VT) in isolated ventricular noncompaction (IVNC) is limited."1.36Septal ventricular tachycardia with alternating LBBB-RBBB morphology in isolated ventricular noncompaction. ( Bulková, V; Fiala, M; Januska, J; Pleva, M, 2010)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tsetskhladze, E1
Khintibidze, I1
Fiala, M1
Januska, J1
Bulková, V1
Pleva, M1
Strasburger, JF1
Cuneo, BF1
Michon, MM1
Gotteiner, NL1
Deal, BJ1
McGregor, SN1
Oudijk, MA1
Meijboom, EJ1
Feinkind, L1
Hussey, M1
Parilla, BV1
Milliez, P1
Leenhardt, A1
Maisonblanche, P1
Vicaut, E1
Badilini, F1
Siliste, C1
Benchetrit, C1
Coumel, P1
Olesin, AI1
Shabrov, AV1
Sinenko, VI1
Popik, GS1
Boldueva, SA1
Leonova, IA1
Poloskina, OA1
Satomi, K1
Kurita, T1
Takatsuki, S1
Yokoyama, Y1
Chinushi, M1
Tsuboi, N1
Nitta, T1
Shoda, M1
Mitamura, H1
Thomas, KL1
Al-Khatib, SM1
Lokhnygina, Y1
Solomon, SD1
Kober, L1
McMurray, JJ1
Califf, RM1
Velazquez, EJ1
Sharpe, N1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pragmatic Randomized Clinical Trial of Early Dronedarone Versus Usual Care to Change and Improve Outcomes in Persons With First-Detected Atrial Fibrillation[NCT05130268]Phase 43,000 participants (Anticipated)Interventional2021-10-29Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for amiodarone and Ventricular Dysfunction

ArticleYear
Symptomatic systolic ventricular failure.
    Current cardiology reports, 1999, Volume: 1, Issue:1

    Topics: Adrenergic beta-Antagonists; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel B

1999

Trials

1 trial available for amiodarone and Ventricular Dysfunction

ArticleYear
Amiodarone use after acute myocardial infarction complicated by heart failure and/or left ventricular dysfunction may be associated with excess mortality.
    American heart journal, 2008, Volume: 155, Issue:1

    Topics: Aged; Amiodarone; Captopril; Cause of Death; Dose-Response Relationship, Drug; Double-Blind Method;

2008

Other Studies

6 other studies available for amiodarone and Ventricular Dysfunction

ArticleYear
THE SAFETY AND EFFICACY OF AMIODARONE AND CARVEDILOL COMBINATION IN TREATMENT OF PATIENTS WITH SEVERE CARDIAC RHYTHM DISORDERS.
    Georgian medical news, 2017, Issue:267

    Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibril

2017
Septal ventricular tachycardia with alternating LBBB-RBBB morphology in isolated ventricular noncompaction.
    Journal of cardiovascular electrophysiology, 2010, Jun-01, Volume: 21, Issue:6

    Topics: Adolescent; Amiodarone; Anti-Arrhythmia Agents; Bundle-Branch Block; Catheter Ablation; Echocardiogr

2010
Amiodarone therapy for drug-refractory fetal tachycardia.
    Circulation, 2004, Jan-27, Volume: 109, Issue:3

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Digoxin; Electrocardiography; Female; Fetal Dise

2004
Usefulness of ventricular repolarization dynamicity in predicting arrhythmic deaths in patients with ischemic cardiomyopathy (from the European Myocardial Infarct Amiodarone Trial).
    The American journal of cardiology, 2005, Apr-01, Volume: 95, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiomyopathies; Death; Electrocard

2005
[Possibility of differentiated treatment of ventricular heart rate disturbances based on mechanism of their development].
    Kardiologiia, 2005, Volume: 45, Issue:5

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Sotalol; Ventricular Dysfunction

2005
Amiodarone therapy in patients implanted with cardioverter-defibrillator for life-threatening ventricular arrhythmias.
    Circulation journal : official journal of the Japanese Circulation Society, 2006, Volume: 70, Issue:8

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia

2006