Page last updated: 2024-10-22

amiodarone and Thyroiditis

amiodarone has been researched along with Thyroiditis in 22 studies

Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Thyroiditis: Inflammatory diseases of the THYROID GLAND. Thyroiditis can be classified into acute (THYROIDITIS, SUPPURATIVE), subacute (granulomatous and lymphocytic), chronic fibrous (Riedel's), chronic lymphocytic (HASHIMOTO DISEASE), transient (POSTPARTUM THYROIDITIS), and other AUTOIMMUNE THYROIDITIS subtypes.

Research Excerpts

ExcerptRelevanceReference
"Amiodarone-induced thyrotoxicosis (AIT) resulting from destructive thyroiditis (type 2) is commonly treated with glucocorticoids, but time needed to restore euthyroidism may be unacceptable for patients with underlying cardiac disorders."9.12Glucocorticoid response in amiodarone-induced thyrotoxicosis resulting from destructive thyroiditis is predicted by thyroid volume and serum free thyroid hormone concentrations. ( Aghini-Lombardi, F; Bartalena, L; Bogazzi, F; Dell'Unto, E; Martino, E; Rossi, G; Tanda, ML; Tomisti, L, 2007)
"Amiodarone (AMIO) is one of the most effective antiarrhythmic drugs available; however, its use is limited by a serious side effect profile, including thyroiditis."7.81Endoplasmic reticulum stress as a novel mechanism in amiodarone-induced destructive thyroiditis. ( Farenholtz, KE; Inabnet, WB; Lombardi, A; Owen, R; Tomer, Y, 2015)
"Type 2 amiodarone-induced thyrotoxicosis (AIT) is a destructive thyroiditis usually responsive to glucocorticoids; however, recent surveys showed that many expert thyroidologists worldwide use thionamides for type 2 AIT patients."7.75Glucocorticoids are preferable to thionamides as first-line treatment for amiodarone-induced thyrotoxicosis due to destructive thyroiditis: a matched retrospective cohort study. ( Bartalena, L; Bogazzi, F; Dell'Unto, E; Martino, E; Pepe, P; Rossi, G; Tomisti, L, 2009)
"Amiodarone-induced thyrotoxicosis (AIT) type 1 occurs in subjects with an underlying thyroid disease, whereas type 2 AIT is a form of destructive thyroiditis."7.73Amiodarone-induced thyrotoxicosis due to destructive thyroiditis: therapeutic recommendations. ( Dietlein, M; Schicha, H, 2005)
"Optimal daily levothyroxine (LT4) dosage is reported to be significantly smaller in the elderly with primary hypothyroidism when compared with their younger counterparts."7.69Influence of age on optimal daily levothyroxine dosage in patients with primary hypothyroidism grouped according to etiology. ( Kabadi, UM, 1997)
"Amiodarone is an iodine-rich drug used in the treatment of resistant cardiac arrhythmias."5.29Thyrotoxicosis followed by hypothyroidism in patients treated with amiodarone. A possible consequence of a destructive process in the thyroid. ( Bianconi, L; Braverman, LE; Gardini, E; Minelli, R; Roti, E, 1993)
"Amiodarone-induced thyrotoxicosis (AIT) resulting from destructive thyroiditis (type 2) is commonly treated with glucocorticoids, but time needed to restore euthyroidism may be unacceptable for patients with underlying cardiac disorders."5.12Glucocorticoid response in amiodarone-induced thyrotoxicosis resulting from destructive thyroiditis is predicted by thyroid volume and serum free thyroid hormone concentrations. ( Aghini-Lombardi, F; Bartalena, L; Bogazzi, F; Dell'Unto, E; Martino, E; Rossi, G; Tanda, ML; Tomisti, L, 2007)
"Type 2 amiodarone-induced thyrotoxicosis (AIT) is a destructive thyroiditis usually responsive to glucocorticoids; however, recent surveys showed that many expert thyroidologists worldwide use thionamides for type 2 AIT patients."3.75Glucocorticoids are preferable to thionamides as first-line treatment for amiodarone-induced thyrotoxicosis due to destructive thyroiditis: a matched retrospective cohort study. ( Bartalena, L; Bogazzi, F; Dell'Unto, E; Martino, E; Pepe, P; Rossi, G; Tomisti, L, 2009)
"Amiodarone-induced thyrotoxicosis (AIT) type 1 occurs in subjects with an underlying thyroid disease, whereas type 2 AIT is a form of destructive thyroiditis."3.73Amiodarone-induced thyrotoxicosis due to destructive thyroiditis: therapeutic recommendations. ( Dietlein, M; Schicha, H, 2005)
" This study was intended to determine whether CRP levels could differentiate between inflammatory and noninflammatory thyroid conditions, especially between type II inflammatory amiodarone-induced thyrotoxicosis (AIT) and type I iodine-induced AIT."3.72The prevalence of elevated serum C-reactive protein levels in inflammatory and noninflammatory thyroid disease. ( Bogazzi, F; Braverman, LE; Brogioni, S; Lazarus, JH; Martino, E; Pardini, E; Parkes, AB; Pearce, EN; Pellegrini, G; Pinchera, A, 2003)
"Optimal daily levothyroxine (LT4) dosage is reported to be significantly smaller in the elderly with primary hypothyroidism when compared with their younger counterparts."3.69Influence of age on optimal daily levothyroxine dosage in patients with primary hypothyroidism grouped according to etiology. ( Kabadi, UM, 1997)
"Amiodarone may cause amiodarone-induced hypothyroidism (AIH) or amiodarone-induced thyrotoxicosis (AIT)."2.82AMIODARONE AND THYROID DYSFUNCTION. ( Alfirević, M; Bakula, M; Marić, N; Medić, F; Mucić, K, 2022)
"Thyrotoxicosis is a common disorder, especially in women."2.48Thyrotoxicosis. ( Boelaert, K; Franklyn, JA, 2012)
"Amiodarone is an iodine-rich drug."2.42[Amiodarone and the thyroid gland]. ( Bednarek-Tupikowska, G; Bugajski, J; Filus, A; Kuliczkowska, J, 2004)
"Amiodarone is an iodine-rich drug used in the treatment of resistant cardiac arrhythmias."1.29Thyrotoxicosis followed by hypothyroidism in patients treated with amiodarone. A possible consequence of a destructive process in the thyroid. ( Bianconi, L; Braverman, LE; Gardini, E; Minelli, R; Roti, E, 1993)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.64)18.7374
1990's3 (13.64)18.2507
2000's10 (45.45)29.6817
2010's4 (18.18)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Cappellani, D1
Torregrossa, L1
Papini, P1
Poma, AM1
Ambrosini, E1
De Napoli, L1
Materazzi, G1
Basolo, F1
Bogazzi, F4
Medić, F1
Bakula, M2
Alfirević, M1
Mucić, K1
Marić, N1
Lombardi, A1
Inabnet, WB1
Owen, R1
Farenholtz, KE1
Tomer, Y1
Rizzo, LF1
Mana, DL1
Bruno, OD1
Tomisti, L2
Rossi, G2
Dell'Unto, E2
Pepe, P1
Bartalena, L2
Martino, E3
Franklyn, JA1
Boelaert, K1
Mete, O1
Asa, SL1
Sniezek, JC1
Francis, TB1
Pearce, EN1
Brogioni, S1
Pardini, E1
Pellegrini, G1
Parkes, AB1
Lazarus, JH1
Pinchera, A1
Braverman, LE2
Bednarek-Tupikowska, G1
Filus, A1
Kuliczkowska, J1
Bugajski, J1
Dietlein, M1
Schicha, H1
Tanda, ML1
Aghini-Lombardi, F1
Blank, W1
Braun, B1
Léger, AF1
Fragu, P1
Rougier, P1
Laurent, MF1
Tubiana, M1
Savoie, JC1
Roti, E1
Minelli, R1
Gardini, E1
Bianconi, L1
Samaras, K1
Marel, GM1
Kabadi, UM1
Ybarra, J1
Fuster, D1
Martín, F1
Lomeña, F1
Torregrossa, JV1
Moreno-Reyes, R1
Corvilain, B1
Goichot, B1
Grunenberger, F1
Schlienger, JL1
Himsworth, RL1
Leung, WH1
Pun, KK1
Lau, CP1
Wong, CK1
Wang, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Open-label, Parallel-group Study to Explore the Efficacy of High-intensity Focused Ultrasound (HIFU) Versus Fixed-dose Radioiodine-131 in the Treatment of Relapsed Graves' Disease[NCT03013257]240 participants (Actual)Interventional2017-04-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for amiodarone and Thyroiditis

ArticleYear
AMIODARONE AND THYROID DYSFUNCTION.
    Acta clinica Croatica, 2022, Volume: 61, Issue:2

    Topics: Amiodarone; Humans; Hypothyroidism; Iodine; Thyroiditis; Thyrotoxicosis; Thyroxine

2022
[Non-autoimmune thyroiditis].
    Medicina, 2014, Volume: 74, Issue:6

    Topics: Amiodarone; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diagnosis, Differential; Gluco

2014
Thyrotoxicosis.
    Lancet (London, England), 2012, Mar-24, Volume: 379, Issue:9821

    Topics: Agranulocytosis; Amiodarone; Antithyroid Agents; Atrial Fibrillation; Autoimmune Diseases; Child; Ex

2012
Inflammatory thyroid disorders.
    Otolaryngologic clinics of North America, 2003, Volume: 36, Issue:1

    Topics: Amiodarone; Humans; Thyroiditis; Treatment Outcome

2003
[Amiodarone and the thyroid gland].
    Postepy higieny i medycyny doswiadczalnej (Online), 2004, Apr-20, Volume: 58

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antithyroid Agents; Female; Glucocorticoids; Humans; Hy

2004

Trials

1 trial available for amiodarone and Thyroiditis

ArticleYear
Glucocorticoid response in amiodarone-induced thyrotoxicosis resulting from destructive thyroiditis is predicted by thyroid volume and serum free thyroid hormone concentrations.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Cohort Studies; Female; Follow-U

2007

Other Studies

16 other studies available for amiodarone and Thyroiditis

ArticleYear
Salvage total thyroidectomy for amiodarone-induced thyrotoxicosis in a SARS-CoV-2 positive patient: results of the viral genome research on the pathology sample of this destructive thyroiditis.
    Endocrine, 2022, Volume: 76, Issue:2

    Topics: Amiodarone; COVID-19; Genome, Viral; Humans; Hyperthyroidism; SARS-CoV-2; Thyroidectomy; Thyroiditis

2022
Endoplasmic reticulum stress as a novel mechanism in amiodarone-induced destructive thyroiditis.
    The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Cell Line; DNA-Binding Proteins; Down-Regulation; Endoplasmic Re

2015
Glucocorticoids are preferable to thionamides as first-line treatment for amiodarone-induced thyrotoxicosis due to destructive thyroiditis: a matched retrospective cohort study.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:10

    Topics: Academic Medical Centers; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Antith

2009
Images in endocrine pathology: thyrotoxicosis associated with destructive thyroiditis.
    Endocrine pathology, 2012, Volume: 23, Issue:3

    Topics: Amiodarone; Heart Diseases; Humans; Male; Middle Aged; Thyroidectomy; Thyroiditis; Thyrotoxicosis; T

2012
The prevalence of elevated serum C-reactive protein levels in inflammatory and noninflammatory thyroid disease.
    Thyroid : official journal of the American Thyroid Association, 2003, Volume: 13, Issue:7

    Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; C-Reactive Protein; Case-Control Studie

2003
Amiodarone-induced thyrotoxicosis due to destructive thyroiditis: therapeutic recommendations.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2005, Volume: 113, Issue:3

    Topics: Adult; Aged; Amiodarone; Antithyroid Agents; Carbimazole; Drug Therapy, Combination; Female; Glucoco

2005
[Sonography of the thyroid--part 2: thyroid inflammation, impairmant of thyroid function and interventions].
    Ultraschall in der Medizin (Stuttgart, Germany : 1980), 2008, Volume: 29, Issue:2

    Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Chronic Disease; Female; Humans; Hyperthyroidism;

2008
Thyroid iodine content measured by x-ray fluorescence in amiodarone-induced thyrotoxicosis: concise communication.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1983, Volume: 24, Issue:7

    Topics: Amiodarone; Diagnosis, Differential; Female; Follow-Up Studies; Graves Disease; Humans; Hyperthyroid

1983
Thyrotoxicosis followed by hypothyroidism in patients treated with amiodarone. A possible consequence of a destructive process in the thyroid.
    Archives of internal medicine, 1993, Apr-12, Volume: 153, Issue:7

    Topics: Adult; Aged; Amiodarone; Biopsy; Female; Humans; Hypothyroidism; Male; Middle Aged; Thyroiditis; Thy

1993
Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.
    Clinical endocrinology, 1996, Volume: 45, Issue:3

    Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antithyroid Agents; Fatal Outcome; Hum

1996
Influence of age on optimal daily levothyroxine dosage in patients with primary hypothyroidism grouped according to etiology.
    Southern medical journal, 1997, Volume: 90, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Aging; Amiodarone; Anti-Arrhythmia Agents; Antimanic Agents; Female;

1997
Clinical picture: amiodarone-induced thyroiditis.
    Lancet (London, England), 2002, Jan-05, Volume: 359, Issue:9300

    Topics: Amiodarone; Anti-Arrhythmia Agents; Female; Humans; Middle Aged; Thyroiditis; Ultrasonography

2002
Amiodarone-induced thyroiditis.
    Lancet (London, England), 2002, Jun-29, Volume: 359, Issue:9325

    Topics: Amiodarone; Anti-Arrhythmia Agents; Humans; Iodine; Thyroid Gland; Thyroiditis

2002
Amiodarone-induced thyroiditis.
    Lancet (London, England), 2002, Jun-29, Volume: 359, Issue:9325

    Topics: Amiodarone; Anti-Arrhythmia Agents; Humans; Radionuclide Imaging; Thyroid Function Tests; Thyroid Gl

2002
Hyperthyroidism with a low iodine uptake.
    Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:2

    Topics: Amiodarone; Humans; Hyperthyroidism; Iatrogenic Disease; Iodine; Iodine Radioisotopes; Radionuclide

1985
Amiodarone-induced thyroiditis.
    American heart journal, 1989, Volume: 118, Issue:4

    Topics: Aged; Amiodarone; Female; Humans; Thyroiditis

1989