amiodarone has been researched along with Rhabdomyolysis in 16 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After administration of atorvastatin, amiodarone, and fluconazole, rhabdomyolysis developed with electrolyte disturbances (hyperphosphatemia, hyopcalcemia) and a massive increase in creatine kinase and myoglobin." | 7.77 | [Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole]. ( Bruggisser, M; Franz, CC; Krähenbühl, S; Rätz Bravo, AE, 2011) |
| " We report a case of rhabdomyolysis in a patient with heart failure on a multi-drug regimen caused by a drug interaction between chronic statin therapy (simvastatin), amiodarone and newly administrated digitoxin." | 7.74 | Rhabdomyolysis after addition of digitoxin to chronic simvastatin and amiodarone therapy. ( Azizi, M; Behrens, S; Hashagen, S; Nägele, H, 2007) |
| "An objective causal assessment suggests that rhabdomyolysis, renal failure, and possibly hepatotoxicity were probably related to an amiodarone-simvastatin interaction." | 7.73 | Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity. ( Guirguis, A; Ricaurte, B; Taylor, HC; Zabriskie, D, 2006) |
| "Amiodarone is a potent inhibitor of several different CYP isoenzymes, including CYP3A4." | 5.32 | Rhabdomyolysis in association with simvastatin and amiodarone. ( Krähenbühl, S; Roten, L; Schlienger, RG; Schoenenberger, RA, 2004) |
| "Of the five cases reviewed (4 males, age range of 37 to 62 years), adult primary hypothyroidism was caused by amiodarone (1 case), chronic autoimmune thyroiditis (1 case), and by uncertain etiologies (3 cases)." | 3.79 | Rare acute kidney injury secondary to hypothyroidism-induced rhabdomyolysis. ( Cai, Y; Tang, L, 2013) |
| " After administration of atorvastatin, amiodarone, and fluconazole, rhabdomyolysis developed with electrolyte disturbances (hyperphosphatemia, hyopcalcemia) and a massive increase in creatine kinase and myoglobin." | 3.77 | [Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole]. ( Bruggisser, M; Franz, CC; Krähenbühl, S; Rätz Bravo, AE, 2011) |
| "The FDA revised the labels of amiodarone and simvastatin in 2002 to warn of increased risk of rhabdomyolysis, the most severe form of myopathy, when the 2 drugs are taken concomitantly in doses greater than 20 milligrams (mg) per day of simvastatin." | 3.76 | Results of a safety initiative for patients on concomitant amiodarone and simvastatin therapy in a Veterans Affairs medical center. ( Beckey, C; Hough, A; Karimi, S; Parra, D, 2010) |
| "To estimate the concurrent use between statins and amiodarone in context with published case reports of drug-interaction-induced rhabdomyolysis." | 3.75 | Concurrent use of statins and amiodarone. ( Borders-Hemphill, V, 2009) |
| " We report a case of rhabdomyolysis in a patient with heart failure on a multi-drug regimen caused by a drug interaction between chronic statin therapy (simvastatin), amiodarone and newly administrated digitoxin." | 3.74 | Rhabdomyolysis after addition of digitoxin to chronic simvastatin and amiodarone therapy. ( Azizi, M; Behrens, S; Hashagen, S; Nägele, H, 2007) |
| "An objective causal assessment suggests that rhabdomyolysis, renal failure, and possibly hepatotoxicity were probably related to an amiodarone-simvastatin interaction." | 3.73 | Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity. ( Guirguis, A; Ricaurte, B; Taylor, HC; Zabriskie, D, 2006) |
| "Rhabdomyolysis is a rare but well-known complication of statin therapy." | 1.43 | [Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone]. ( Filipovic, M; Müller-Höcker, C; Pietsch, U, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krychtiuk, KA | 1 |
| Distelmaier, K | 1 |
| Pfaffenberger, S | 1 |
| Burger-Klepp, U | 1 |
| Niessner, A | 1 |
| Heinz, G | 1 |
| Speidl, WS | 1 |
| Prom, R | 1 |
| Umscheid, CA | 1 |
| Kasbekar, N | 1 |
| Spinler, SA | 2 |
| Pietsch, U | 1 |
| Müller-Höcker, C | 1 |
| Filipovic, M | 1 |
| Semmo, M | 1 |
| Dhayat, NA | 1 |
| Boucher, BJ | 1 |
| Borders-Hemphill, V | 1 |
| Karimi, S | 1 |
| Hough, A | 1 |
| Beckey, C | 1 |
| Parra, D | 1 |
| Franz, CC | 1 |
| Bruggisser, M | 1 |
| Krähenbühl, S | 2 |
| Rätz Bravo, AE | 1 |
| Tritakarn, T | 1 |
| Teeratchanan, T | 1 |
| Cai, Y | 1 |
| Tang, L | 1 |
| de Denus, S | 1 |
| Roten, L | 1 |
| Schoenenberger, RA | 1 |
| Schlienger, RG | 1 |
| Ricaurte, B | 1 |
| Guirguis, A | 1 |
| Taylor, HC | 1 |
| Zabriskie, D | 1 |
| Nägele, H | 1 |
| Behrens, S | 1 |
| Hashagen, S | 1 |
| Azizi, M | 1 |
| Mallaret, M | 1 |
| Mezin, P | 1 |
| Chartier, A | 1 |
16 other studies available for amiodarone and Rhabdomyolysis
| Article | Year |
|---|---|
Rhabdomyolysis during therapeutic hypothermia in a patient after successful cardio-pulmonary resuscitation.
Topics: Amiodarone; Cardiopulmonary Resuscitation; Drug Therapy, Combination; Electrocardiography; Epinephri | 2013 |
Effect of simvastatin-amiodarone drug interaction alert on appropriate prescribing.
Topics: Amiodarone; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hyd | 2013 |
[Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone].
Topics: Acute Kidney Injury; Aged; Amiodarone; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxymethylgl | 2016 |
Gluteal rhabdomyolysis and renal failure due to simvastatin and amiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Buttocks; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA R | 2016 |
These drugs don't mix.
Topics: Amiodarone; Drug Interactions; Enzyme Inhibitors; Humans; Hypolipidemic Agents; Rhabdomyolysis; Simv | 2008 |
Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use. But what about the amiodarone?
Topics: Amiodarone; Contraindications; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Humans | 2009 |
Concurrent use of statins and amiodarone.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Databases, Factual; Drug Interactions; Drug Monitoring; Fe | 2009 |
Results of a safety initiative for patients on concomitant amiodarone and simvastatin therapy in a Veterans Affairs medical center.
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug | 2010 |
[Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole].
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anticholesteremic Agents; Antifungal Agents; Atorvastatin; | 2011 |
Acute rhabdomyolysis and cardiac arrest following succinylcholine in a patient with Parry-Romberg syndrome.
Topics: Acute Disease; Adolescent; Amiodarone; Anti-Arrhythmia Agents; Calcium Gluconate; Cardiopulmonary Re | 2011 |
Rare acute kidney injury secondary to hypothyroidism-induced rhabdomyolysis.
Topics: Acute Kidney Injury; Adult; Amiodarone; Creatine Kinase; Female; Humans; Hypothyroidism; Kidney Func | 2013 |
Amiodarone's role in simvastatin-associated rhabdomyolysis.
Topics: Amiodarone; Anticholesteremic Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Do | 2003 |
Rhabdomyolysis in association with simvastatin and amiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Humans; H | 2004 |
Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity.
Topics: Aged; Amiodarone; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Male; Rhabdomyo | 2006 |
Rhabdomyolysis after addition of digitoxin to chronic simvastatin and amiodarone therapy.
Topics: Amiodarone; Anti-Arrhythmia Agents; Anticholesteremic Agents; Digitoxin; Drug Interactions; Heart Fa | 2007 |
[Rhabdomyolysis in hypothyroidism. Favourable role of amiodarone].
Topics: Amiodarone; Humans; Hypothyroidism; Rhabdomyolysis | 1993 |