Page last updated: 2024-10-22

amiodarone and Peripheral Nerve Diseases

amiodarone has been researched along with Peripheral Nerve Diseases in 43 studies

Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Research Excerpts

ExcerptRelevanceReference
"Amiodarone was found to produce a statistically significant decrease in heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain after intraperitoneal injection."7.72Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. ( Datta, S; Glusman, S; Torres, M; Waghray, T, 2004)
"A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment."7.67Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy. ( Abarbanel, JM; Frisher, S; Herishanu, Y; Osiman, A, 1987)
"Amiodarone was found to produce a statistically significant decrease in heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain after intraperitoneal injection."3.72Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. ( Datta, S; Glusman, S; Torres, M; Waghray, T, 2004)
"A 67 years-old man under amiodarone treatment for thirteen months due to a cardiac arrhythmia developed a mixed sensory-motor neuropathy."3.68[Peripheral neuropathy possibly caused by amiodarone therapy]. ( de Carvalho, FB; Oliveira Júnior, W; Oliveira, LF, 1991)
"A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment."3.67Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy. ( Abarbanel, JM; Frisher, S; Herishanu, Y; Osiman, A, 1987)
"One hundred two patients with recurrent, drug-refractory tachyarrhythmias were treated with amiodarone for nine +/- eight months (mean +/- SD) (range, one to 50 months)."3.67Unusual neurotoxicity associated with amiodarone therapy. ( Iyer, V; Meckler, RJ; Palakurthy, PR, 1987)
"Amiodarone, a drug used to treat refractory cardiac arrhythmias, produced a peripheral neuropathy in 5 of 50 cases (10%)."3.66Amiodarone neuropathy. ( Martinez-Arizala, A; McCarty, GE; Nichols, BR; Rakita, L; Sobol, SM, 1983)
"Although the pathogenesis of demyelination induced by these drugs remain largely obscure, the recent in vivo and in vitro studies have implicated the involvement of metabolic abnormalities and impaired autophagy in Schwann cells and immune system disorders in the disruption of neuron-Schwann cell contact and interactions."2.61Drug-Induced Demyelinating Neuropathies. ( Niimi, N; Sango, K; Takaku, S; Yako, H, 2019)
"Amiodarone was injected endoneurially at increasing doses into the exposed tibial nerve of rats to study its electrophysiologic and pathologic effects on peripheral nerve fibers."1.28Amiodarone-induced experimental acute neuropathy in rats. ( Barbieri, F; Battaglia, F; Caruso, G; Crispi, F; Greco, P; Nucciotti, R; Ragno, M; Santoro, L, 1992)
"The amiodarone was withdrawn."1.27Neuropathy and fatal hepatitis in a patient receiving amiodarone. ( Hole, DW; Lim, PK; Storey, GC; Trewby, PN, 1984)
"We describe a patient in whom respiratory failure, due to extreme neuromuscular weakness, was produced by procainamide intoxication superimposed on a peripheral neuropathy secondary to long-term amiodarone therapy."1.27Respiratory failure produced by severe procainamide intoxication in a patient with preexisting peripheral neuropathy caused by amiodarone. ( Bigman, O; Miller, B; Rubenfire, M; Skupin, A, 1988)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199030 (69.77)18.7374
1990's4 (9.30)18.2507
2000's5 (11.63)29.6817
2010's4 (9.30)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Niimi, N1
Takaku, S1
Yako, H1
Sango, K1
Wu, C1
Tcherny-Lessenot, S1
Dai, W1
Wang, Y1
Kechemir, H1
Gandhi, S1
Lin, S1
Juhaeri, J1
Flanagan, EP1
Harper, CM1
St Louis, EK1
Silber, MH1
Josephs, KA1
Matsumoto, H1
Ugawa, Y1
Datta, S1
Waghray, T1
Torres, M1
Glusman, S1
Azzam, I1
Tov, N1
Elias, N1
Naschitz, JE1
London, Z1
Albers, JW1
Kono, Y1
Nagata, H1
Domínguez, R1
Molina, HA1
Lia Taratuto, A1
Leiguarda, R1
Larre, P1
Coquet, M1
Maupetit, J1
Lubbe, WF1
Mercer, CJ1
Waxman, HL1
Groh, WC1
Marchlinski, FE1
Buxton, AE1
Sadowski, LM1
Horowitz, LN1
Josephson, ME1
Kastor, JA1
Harris, L1
McKenna, WJ1
Rowland, E1
Holt, DW2
Storey, GC3
Krikler, DM1
Martinez-Arizala, A1
Sobol, SM1
McCarty, GE1
Nichols, BR1
Rakita, L1
Patte, D1
Léger, FA1
Savoie, JC1
Ménage, JJ1
Samson, Y1
Nivet, M1
Goulon, M1
Duboureau, J1
Jacquemier, JM1
Mazieres, B1
Arlet, J1
Wilkinson, PR1
Rees, JR1
Pellissier, JF1
Pouget, J1
Cros, D1
De Victor, B1
Serratrice, G1
Toga, M1
Lim, PK1
Trewby, PN1
Hole, DW1
Dubois, A1
Blin, B1
Bosc, E1
Marty-Double, C1
Pignodel, C1
Munoz, A1
Hertault, J1
Schwartz Calero, P1
Torelló Iserte, J1
Giner Calzada, E1
Cuder Ambel, A1
Meier, C1
Kauer, B1
Müller, U1
Ludin, HP1
Fischer, C1
Bady, B2
Trillet, M2
Schott, B1
Dudognon, P1
Hauw, JJ1
de Baecque, C1
Escourolle, R1
Derrida, JP1
Nick, J1
Ahmad, S1
Bourrat, C1
Girard, PF1
Carrier, H1
Santoro, L1
Barbieri, F1
Nucciotti, R1
Battaglia, F1
Crispi, F1
Ragno, M1
Greco, P1
Caruso, G1
Oliveira, LF1
Oliveira Júnior, W1
de Carvalho, FB1
Fernando Roth, R1
Itabashi, H1
Louie, J1
Anderson, T1
Narahara, KA1
Abarbanel, JM1
Osiman, A1
Frisher, S1
Herishanu, Y1
Beghi, E1
Simone, P1
Apollo, F1
Di Viesti, P1
Treviso, M1
Tonali, P1
Willems, AR1
Schöttelndreiër, MA1
Miller, B1
Skupin, A1
Rubenfire, M1
Bigman, O1
Fraser, AG1
McQueen, IN1
Watt, AH1
Stephens, MR1
Jacobs, JM2
Costa-Jussà, FR2
Costa, C1
Visalli, N1
Natoli, A1
Morcamp, D1
Espérou, H1
Bercoff, E1
Bourreille, J1
Fossati, C1
Palakurthy, PR1
Iyer, V1
Meckler, RJ1

Reviews

6 reviews available for amiodarone and Peripheral Nerve Diseases

ArticleYear
Drug-Induced Demyelinating Neuropathies.
    Advances in experimental medicine and biology, 2019, Volume: 1190

    Topics: Amiodarone; Axons; Demyelinating Diseases; Dichloroacetic Acid; Drug-Related Side Effects and Advers

2019
Toxic neuropathies associated with pharmaceutic and industrial agents.
    Neurologic clinics, 2007, Volume: 25, Issue:1

    Topics: Amiodarone; Antineoplastic Agents; Arsenic; Drug-Related Side Effects and Adverse Reactions; Hazardo

2007
[Etiological mechanism of peripheral nervous system diseases induced by drug therapy].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Aug-10, Volume: 96, Issue:8

    Topics: Amiodarone; Antineoplastic Agents; Axons; Colchicine; Humans; Hydroxymethylglutaryl-CoA Reductase In

2007
[Toxic neurologic manifestations during angina pectoris treatment (perhexiline maleate and amiotadone hydrochloride)].
    International journal of neurology, 1978, Volume: 11, Issue:4

    Topics: Amiodarone; Angina Pectoris; Benzofurans; Cerebrospinal Fluid Proteins; Electromyography; Humans; In

1978
[Amiodarone and its side effects].
    Nederlands tijdschrift voor geneeskunde, 1988, Mar-26, Volume: 132, Issue:13

    Topics: Amiodarone; Chemical and Drug Induced Liver Injury; Corneal Diseases; Humans; Lung Diseases; Periphe

1988
[Collateral effects of an anti-arrhythmic agent: amiodarone].
    La Clinica terapeutica, 1985, Sep-30, Volume: 114, Issue:6

    Topics: Amiodarone; Benzofurans; Chemical and Drug Induced Liver Injury; Eye Diseases; Humans; Hyperthyroidi

1985

Other Studies

37 other studies available for amiodarone and Peripheral Nerve Diseases

ArticleYear
Assessing the Risk for Peripheral Neuropathy in Patients Treated With Dronedarone Compared With That in Other Antiarrhythmics.
    Clinical therapeutics, 2018, Volume: 40, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cohort Stud

2018
Amiodarone-associated neuromyopathy: a report of four cases.
    European journal of neurology, 2012, Volume: 19, Issue:5

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electromyography; Female; Follow-Up

2012
[Drug induced peripheral neuropathy].
    Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 6

    Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-HIV Agents; Antibodies, Monoclonal; Anticonvulsants; Antine

2012
Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Amiodarone; Anesthetics, Local; Animals; Cold Temperature; Hot Temperature; Hyperalgesia; Injections

2004
Amiodarone toxicity presenting as pulmonary mass and peripheral neuropathy: the continuing diagnostic challenge.
    Postgraduate medical journal, 2006, Volume: 82, Issue:963

    Topics: Amiodarone; Anti-Arrhythmia Agents; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; S

2006
[Peripheral neuropathy induced by amiodarone].
    Medicina, 1984, Volume: 44, Issue:4

    Topics: Aged; Amiodarone; Benzofurans; Electromyography; Female; Humans; Male; Middle Aged; Motor Neurons; M

1984
[Neuropathy induced by amiodarone].
    La Nouvelle presse medicale, 1981, Sep-19, Volume: 10, Issue:33

    Topics: Aged; Amiodarone; Benzofurans; Female; Humans; Lipidoses; Peripheral Nervous System Diseases

1981
Amiodarone: its side effects, adverse reactions and dosage schedules.
    The New Zealand medical journal, 1982, Jul-28, Volume: 95, Issue:712

    Topics: Amiodarone; Benzofurans; Central Nervous System Diseases; Drug Administration Schedule; Eye Diseases

1982
Amiodarone for control of sustained ventricular tachyarrhythmia: clinical and electrophysiologic effects in 51 patients.
    The American journal of cardiology, 1982, Volume: 50, Issue:5

    Topics: Adolescent; Adult; Aged; Amiodarone; Benzofurans; Cardiac Pacing, Artificial; Chemical and Drug Indu

1982
Side effects of long-term amiodarone therapy.
    Circulation, 1983, Volume: 67, Issue:1

    Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Corneal Diseases; Dose-Response Relation

1983
Amiodarone neuropathy.
    Neurology, 1983, Volume: 33, Issue:5

    Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Female; Humans; Male; Middle Aged; Nervous Syst

1983
[Thyrotoxicosis, then hypothyroidism caused by iodine overload (amiodarone) associated with neuropathy. Failure of plasma exchange].
    Annales de medecine interne, 1983, Volume: 134, Issue:1

    Topics: Amiodarone; Benzofurans; Female; Humans; Hyperthyroidism; Hypothyroidism; Middle Aged; Peripheral Ne

1983
Adverse reactions during treatment with amiodarone hydrochloride.
    British medical journal (Clinical research ed.), 1983, Aug-27, Volume: 287, Issue:6392

    Topics: Amiodarone; Benzofurans; Female; Humans; Hypothyroidism; Middle Aged; Peripheral Nervous System Dise

1983
[Amiodarone-induced neuropathy of late appearance].
    Presse medicale (Paris, France : 1983), 1983, Nov-26, Volume: 12, Issue:43

    Topics: Amiodarone; Benzofurans; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Time Factors

1983
Amiodarone: prolonged elimination following cessation of chronic therapy.
    American heart journal, 1984, Volume: 107, Issue:4

    Topics: Amiodarone; Benzofurans; Half-Life; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; T

1984
Peripheral neuropathy induced by amiodarone chlorhydrate. A clinicopathological study.
    Journal of the neurological sciences, 1984, Volume: 63, Issue:2

    Topics: Adult; Aged; Amiodarone; Axons; Benzofurans; Heart Diseases; Humans; Inclusion Bodies; Male; Microsc

1984
Neuropathy and fatal hepatitis in a patient receiving amiodarone.
    British medical journal (Clinical research ed.), 1984, Jun-02, Volume: 288, Issue:6431

    Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Chemical and Drug Induced Liver Injury; Humans;

1984
[Neuropathies induced by amiodarone].
    Presse medicale (Paris, France : 1983), 1984, May-19, Volume: 13, Issue:21

    Topics: Amiodarone; Benzofurans; Humans; Peripheral Nervous System Diseases

1984
Antiarrhythmic drugs and polyneuropathy. The Collaborative Group for the Study of Polyneuropathy.
    Journal of neurology, neurosurgery, and psychiatry, 1994, Volume: 57, Issue:3

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Amiodarone; Anti-Arrhythmia Agents; Electrophysiology; Fem

1994
[Peripheral neuropathy and amiodarone].
    Atencion primaria, 2000, Apr-15, Volume: 25, Issue:6

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Humans; Male; Peripheral Nervous System Diseases

2000
Neuromyopathy during chronic amiodarone treatment. A case report.
    Journal of neurology, 1979, Jan-05, Volume: 220, Issue:4

    Topics: Aged; Amiodarone; Benzofurans; Humans; Iodine; Male; Microscopy, Electron; Muscles; Neuromuscular Di

1979
[2 cases of peripheral neuropathy caused by amiodarone].
    La Nouvelle presse medicale, 1977, Nov-19, Volume: 6, Issue:39

    Topics: Aged; Amiodarone; Benzofurans; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases

1977
[Amiodaron neuropathy: drug-induced lipidosis (author's transl)].
    La Nouvelle presse medicale, 1979, May-12, Volume: 8, Issue:21

    Topics: Aged; Amiodarone; Benzofurans; Humans; Lipidoses; Male; Peripheral Nervous System Diseases

1979
Amiodarone.
    Archives of internal medicine, 1979, Volume: 139, Issue:11

    Topics: Amiodarone; Benzofurans; Peripheral Nervous System Diseases

1979
Amiodarone-induced experimental acute neuropathy in rats.
    Muscle & nerve, 1992, Volume: 15, Issue:7

    Topics: Amiodarone; Animals; Axons; Demyelinating Diseases; Male; Microscopy, Electron; Neural Conduction; P

1992
[Peripheral neuropathy possibly caused by amiodarone therapy].
    Arquivos brasileiros de cardiologia, 1991, Volume: 57, Issue:1

    Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Demyelinating Diseases; Humans; Male; Peripheral Nervous Sys

1991
Amiodarone toxicity: myopathy and neuropathy.
    American heart journal, 1990, Volume: 119, Issue:5

    Topics: Amiodarone; Humans; Male; Middle Aged; Muscular Diseases; Myofibrils; Peripheral Nervous System Dise

1990
Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.
    Israel journal of medical sciences, 1987, Volume: 23, Issue:8

    Topics: Amiodarone; Biopsy; Cardiac Complexes, Premature; Cerebellar Diseases; Female; Humans; Middle Aged;

1987
Polyneuropathy in an adult hospital population. Assessment of the prevalence through a simple screening procedure.
    Neuroepidemiology, 1988, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Amiodarone; Child; Diabetic Neuropathies; Epidemiologic Method

1988
Respiratory failure produced by severe procainamide intoxication in a patient with preexisting peripheral neuropathy caused by amiodarone.
    Chest, 1988, Volume: 94, Issue:3

    Topics: Amiodarone; Humans; Male; Middle Aged; Neuromuscular Junction; Peripheral Nervous System Diseases; P

1988
Myeloneuropathy, neurologic toxicity, and amiodarone.
    Neurology, 1985, Volume: 35, Issue:2

    Topics: Amiodarone; Benzofurans; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Peripheral Nerv

1985
Peripheral neuropathy during longterm high-dose amiodarone therapy.
    Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:6

    Topics: Aged; Amiodarone; Benzofurans; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases

1985
The pathology of amiodarone neurotoxicity. II. Peripheral neuropathy in man.
    Brain : a journal of neurology, 1985, Volume: 108 ( Pt 3)

    Topics: Adult; Aged; Amiodarone; Benzofurans; Humans; Male; Peripheral Nervous System Diseases

1985
The pathology of amiodarone neurotoxicity. I. Experimental studies with reference to changes in other tissues.
    Brain : a journal of neurology, 1985, Volume: 108 ( Pt 3)

    Topics: Amiodarone; Animals; Benzofurans; Mice; Mice, Inbred BALB C; Nervous System Diseases; Neurotoxins; P

1985
[Adverse effects during chronic treatment with low-dose amiodarone].
    La Clinica terapeutica, 1985, Jul-15, Volume: 114, Issue:1

    Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Child; Drug Interactions; Eye Diseases;

1985
[Delayed neuropathy caused by amiodarone hydrochloride].
    La Revue de medecine interne, 1985, Volume: 6, Issue:3

    Topics: Amiodarone; Benzofurans; Humans; Male; Middle Aged; Paresthesia; Peripheral Nervous System Diseases;

1985
Unusual neurotoxicity associated with amiodarone therapy.
    Archives of internal medicine, 1987, Volume: 147, Issue:5

    Topics: Aged; Amiodarone; Brain Diseases; Brain Stem; Female; Humans; Jaw; Male; Middle Aged; Movement Disor

1987