amiodarone has been researched along with Niemann-Pick Diseases in 3 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Niemann-Pick Diseases: A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amiodarone analogues were also studied, including the recently developed derivative dronedarone." | 1.37 | Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype. ( Baritussio, A; Bergonzini, V; Bigler, L; Calistri, A; Caretta, CM; Dal Zoppo, D; Del Vecchio, C; Faggin, E; Ha, HR; Nadai, M; Orlando, R; Palù, G; Pettenazzo, A; Piccoli, E; Salata, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Piccoli, E | 1 |
| Nadai, M | 1 |
| Caretta, CM | 1 |
| Bergonzini, V | 1 |
| Del Vecchio, C | 1 |
| Ha, HR | 1 |
| Bigler, L | 1 |
| Dal Zoppo, D | 1 |
| Faggin, E | 1 |
| Pettenazzo, A | 1 |
| Orlando, R | 1 |
| Salata, C | 1 |
| Calistri, A | 1 |
| Palù, G | 1 |
| Baritussio, A | 1 |
| Palmeri, S | 1 |
| Battisti, C | 1 |
| Malandrini, A | 1 |
| Federico, A | 1 |
| Brown, WJ | 1 |
| Sullivan, TR | 1 |
| Greenspan, P | 1 |
3 other studies available for amiodarone and Niemann-Pick Diseases
| Article | Year |
|---|---|
Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype.
Topics: Amiodarone; Androstenes; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Cholesterol; Dose-Respons | 2011 |
Amiodarone induced lipidosis similar to Niemann-Pick C disease. Biochemical and morphological study.
Topics: Amiodarone; Cells, Cultured; Cholesterol; Culture Media; Fibroblasts; Humans; Hydrolases; Kinetics; | 1995 |
Nile red staining of lysosomal phospholipid inclusions.
Topics: Amiodarone; Animals; Cells, Cultured; Cholesterol; Cholesterol Esters; Fluorescent Dyes; Humans; Inc | 1992 |