amiodarone has been researched along with Metabolic Acidosis in 3 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Conditions leading to localized extracellular acidosis may facilitate heterogeneity of action of dofetilide and flecainide, but not amiodarone via modification of hERG channel blockade." | 3.77 | Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis. ( DU, CY; El Harchi, A; Hancox, JC; Orchard, CH; Zhang, YH, 2011) |
| "For amiodarone, the IC50 was 38." | 1.33 | The influence of extracellular acidosis on the effect of IKr blockers. ( Cvetanovic, I; Ke, X; Lin, C; Ranade, V; Somberg, J, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DU, CY | 1 |
| El Harchi, A | 1 |
| Zhang, YH | 1 |
| Orchard, CH | 1 |
| Hancox, JC | 1 |
| Lin, C | 1 |
| Ke, X | 1 |
| Cvetanovic, I | 1 |
| Ranade, V | 1 |
| Somberg, J | 1 |
| Campbell, TJ | 1 |
| Wyse, KR | 1 |
| Hemsworth, PD | 1 |
3 other studies available for amiodarone and Metabolic Acidosis
| Article | Year |
|---|---|
Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis.
Topics: Acidosis; Amiodarone; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; ERG1 Potassium Chann | 2011 |
The influence of extracellular acidosis on the effect of IKr blockers.
Topics: Acidosis; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship | 2005 |
Effects of hyperkalemia, acidosis, and hypoxia on the depression of maximum rate of depolarization by class I antiarrhythmic drugs in guinea pig myocardium: differential actions of class Ib and Ic agents.
Topics: Acidosis; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Elec | 1991 |