Page last updated: 2024-10-22

amiodarone and Lipidoses

amiodarone has been researched along with Lipidoses in 43 studies

Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.

Research Excerpts

ExcerptRelevanceReference
"Phospholipidosis is a metabolic disorder characterized by intracellular accumulation of phospholipids."1.48Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone. ( Boeckmans, J; De Boe, V; De Kock, J; Desmae, T; Natale, A; Rodrigues, RM; Rogiers, V; Vanhaecke, T, 2018)
"Drug-induced phospholipidosis (DIPL), in which phospholipids accumulate, is a known entity."1.46Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver. ( Ishida, Y; Kotake, Y; Ohta, S; Sanoh, S; Tamura, Y; Tateno, C; Yamachika, Y; Yoshizane, Y, 2017)
"To determine if amiodarone induces hepatic phospholipidosis (PLD) sufficient to detect changes in hepatobiliary transporter function as assessed by gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), rats were orally dosed with vehicle (1% methyl cellulose) or amiodarone (300 mg/kg/day) for 7 consecutive days."1.43Hepatic Phospholipidosis Is Associated with Altered Hepatobiliary Function as Assessed by Gadoxetate Dynamic Contrast-enhanced Magnetic Resonance Imaging. ( Goulbourne, CN; Jucker, BM; Lenhard, SC; Lev, M; Miller, RT; Peterson, RA; Webster, LO, 2016)
"Phospholipidosis (PLD) is characterized by an intracellular accumulation of phospholipids in lysosomes and concurrent development of concentric lamellar bodies."1.42Molecular biomarkers of phospholipidosis in rat blood and heart after amiodarone treatment. ( Bocchini, N; Cristofori, P; Crivellente, F; Dacasto, M; Faustinelli, I; Ferraresso, S; Giantin, M, 2015)
"Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids."1.38In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012)
"Phospholipidosis (PLD), an abnormal accumulation of phospholipids within tissues, is observed during the preclinical testing of many pharmaceutical drugs."1.38Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats. ( Colatsky, T; Mans, D; Rosenzweig, BA; Shea, K; Stewart, S; Thompson, KL; Zhang, J, 2012)
"Phospholipidosis (PLD) is a topic of concern in drug development because it may be associated with toxicological consequences."1.37Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis. ( Atienzar, FA; Cossu-Leguille, C; Depelchin, O; Dhalluin, S; Gerets, HH; Hanon, E; Tilmant, K; Vasseur, P, 2011)
"Drug-induced phospholipidosis is marked by an excessive accumulation of phospholipids in lysosomes which can occur after exposure to cationic amphiphilic drugs."1.37High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis. ( Havinga, J; Horbach, GJ; Ravesloot, WT; Schoonen, WG; van de Water, FM, 2011)
"Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types."1.36Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010)
" Amiodarone (30 mg/kg daily, a dosage corresponding to that used clinically) or vehicle was administered by gavage in 33 Wistar rats for two weeks."1.36Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cells. ( Agelaki, MG; Kapatou, E; Kolettis, TM; Malamou-Mitsi, V; Pantos, C; Skyrlas, A, 2010)
"Phospholipidosis (PLD) is an accumulation of phospholipids in lysosome-derived multilamellar vesicles."1.35Phospholipidosis assay in HepG2 cells and rat or rhesus hepatocytes using phospholipid probe NBD-PE. ( Bhandari, N; Figueroa, DJ; Gerhold, DL; Lawrence, JW, 2008)
"Drug candidates under development by industry frequently show phospholipidosis as a side-effect in pre-clinical toxicity studies."1.35Relationship between in vitro phospholipidosis assay using HepG2 cells and 2-week toxicity studies in rats. ( Horinouchi, A; Matsumoto, A; Miyamoto, S; Mori, I, 2009)
"Rats treated with gentamicin also had increased urinary levels of several phosphatidylinositol (PI), phosphatidylcholine (PC), and phosphatidylethanolamine (PE) species."1.34Biomarkers to monitor drug-induced phospholipidosis. ( Alden, C; Baronas, ET; Hsieh, FY; Lee, JW, 2007)
"Exposure to the toxic mineral dust silica has been shown to produce an acute inflammatory response in the lungs of both humans and laboratory animals."1.29Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis. ( Antonini, JM; McCloud, CM; Reasor, MJ, 1994)
"The presence of the phospholipidosis had no effect on the phagocytosis of heat-killed yeast cells, the induction of luminol-dependent chemiluminescence, or the spontaneous release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), or spontaneous and LPS-stimulated release of IL-1 by alveolar macrophages in vitro."1.29Effects of amiodarone-induced phospholipidosis on pulmonary host defense functions in rats. ( DiMatteo, M; Ima, A; Lemaire, I; McCloud, CM; Reasor, MJ; Schafer, R, 1996)
"Amiodarone is an antiarrhythmic drug that concentrates in the lungs and can cause pulmonary damage in humans."1.28Influence of a pre-existing phospholipidosis on the accumulation of amiodarone and desethylamiodarone in rat alveolar macrophages. ( Reasor, MJ, 1991)
"Amiodarone pulmonary toxicity represents an example of a life-threatening adverse drug reaction."1.27Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects. ( Martin, WJ; Standing, JE, 1988)
"Typical phospholipidosis-like light and electron microscopic alterations were seen in the lung, their severity related to the extent of biochemical changes induced by amiodarone."1.27Amiodarone induced phospholipidosis. Biochemical, morphological and functional changes in the lungs of rats chronically treated with amiodarone. ( Bertani, T; Bizzi, A; Boeri, R; Cini, M; Latini, R; Marchi, S; Pesenti, A; Riva, E; Tavbani, E; Veneroni, E, 1987)
"Treatment with amiodarone leads to an accumulation in the liver of this iodinated compound and hence an increase in the CT density of the liver."1.27Increased hepatic density and phospholipidosis due to amiodarone. ( Barker, ME; Boyer, TD; Goldberg, HI; Goldman, IS; Keung, E; Raper, SE; Winkler, ML, 1985)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199016 (37.21)18.7374
1990's7 (16.28)18.2507
2000's6 (13.95)29.6817
2010's14 (32.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lowe, R1
Glen, RC1
Mitchell, JB1
Fischer, H1
Atzpodien, EA1
Csato, M1
Doessegger, L1
Lenz, B1
Schmitt, G1
Singer, T1
Dexter, A1
Steven, RT1
Patel, A1
Dailey, LA1
Taylor, AJ1
Ball, D1
Klapwijk, J1
Forbes, B1
Page, CP1
Bunch, J1
Sanoh, S1
Yamachika, Y1
Tamura, Y1
Kotake, Y1
Yoshizane, Y1
Ishida, Y1
Tateno, C1
Ohta, S1
Tomida, T1
Ishimura, M1
Iwaki, M1
Natale, A1
Boeckmans, J1
Desmae, T1
De Boe, V1
De Kock, J1
Vanhaecke, T1
Rogiers, V1
Rodrigues, RM1
Yamagiwa, Y1
Takei, Y1
Koizumi, H1
Nemoto, S1
Kurata, M1
Satoh, H1
Bocchini, N1
Giantin, M1
Crivellente, F1
Ferraresso, S1
Faustinelli, I1
Dacasto, M1
Cristofori, P1
Lenhard, SC1
Lev, M1
Webster, LO1
Peterson, RA1
Goulbourne, CN1
Miller, RT1
Jucker, BM1
Bhandari, N1
Figueroa, DJ1
Lawrence, JW1
Gerhold, DL1
Ikeda, K1
Hirayama, M1
Hirota, Y1
Asa, E1
Seki, J1
Tanaka, Y1
Miyamoto, S1
Matsumoto, A1
Mori, I1
Horinouchi, A1
Kapatou, E1
Skyrlas, A1
Agelaki, MG1
Pantos, C1
Kolettis, TM1
Malamou-Mitsi, V1
Tilmant, K1
Gerets, HH1
Dhalluin, S1
Hanon, E1
Depelchin, O1
Cossu-Leguille, C1
Vasseur, P1
Atienzar, FA1
van de Water, FM1
Havinga, J1
Ravesloot, WT1
Horbach, GJ1
Schoonen, WG1
Mesens, N1
Desmidt, M1
Verheyen, GR1
Starckx, S1
Damsch, S1
De Vries, R1
Verhemeldonck, M1
Van Gompel, J1
Lampo, A1
Lammens, L1
Thompson, KL1
Zhang, J1
Stewart, S1
Rosenzweig, BA1
Shea, K1
Mans, D1
Colatsky, T1
Baronas, ET1
Lee, JW1
Alden, C1
Hsieh, FY1
Hasegawa, M1
Takenaka, S1
Kuwamura, M1
Yamate, J1
Tsuyama, S1
Pintavorn, P1
Larre, P1
Coquet, M1
Maupetit, J1
Mazue, G1
Vic, P2
Gouy, D1
Remandet, B1
Lacheretz, F1
Berthe, J1
Barchewitz, G1
Gagnol, JP1
D'Amico, DJ1
Kenyon, KR1
Clemett, RS1
MacKintosh, HT1
Lüllmann-Rauch, R3
Chew, E1
Ghosh, M1
McCulloch, C1
Palmeri, S1
Battisti, C1
Malandrini, A1
Federico, A1
Antonini, JM1
McCloud, CM3
Reasor, MJ5
Lee, P1
Kirk, RG1
Beard, TL1
Ebert, DC1
Kacew, S1
Gardner, MF1
Aldern, KA1
Hostetler, KY1
DiMatteo, M1
Schafer, R1
Ima, A1
Lemaire, I1
Bedrossian, CW1
Warren, CJ1
Ohar, J1
Bhan, R1
Dudognon, P1
Hauw, JJ1
de Baecque, C1
Escourolle, R1
Derrida, JP1
Nick, J1
Bockhardt, H2
Drenckhahn, D2
Martin, WJ1
Standing, JE1
Joshi, UM1
Kodavanti, PR1
Coudert, B1
Dwyer, TM1
Mehendale, HM2
Michel, FB1
Godard, P1
Aubas, P1
Riva, E1
Marchi, S1
Pesenti, A1
Bizzi, A1
Cini, M1
Veneroni, E1
Tavbani, E1
Boeri, R1
Bertani, T1
Latini, R1
Camus, P1
Elving, LD1
Hoefnagels, WH1
Van Haelst, UJ1
Griffioen, G1
Janssens, AR1
Ruiter, DJ1
Goldman, IS1
Winkler, ML1
Raper, SE1
Barker, ME1
Keung, E1
Goldberg, HI1
Boyer, TD1

Reviews

1 review available for amiodarone and Lipidoses

ArticleYear
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1981, Volume: 215, Issue:4

    Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Per

1981

Other Studies

42 other studies available for amiodarone and Lipidoses

ArticleYear
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio

2010
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse

2012
Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis.
    Analytical and bioanalytical chemistry, 2019, Volume: 411, Issue:30

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Biomarkers; Lipidoses; Lung; Male; Mass Spectrometry; R

2019
Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:5

    Topics: Amiodarone; Animals; Chromatography, Liquid; Hepatocytes; Humans; Lipidoses; Liver; Mice; Phosphatid

2017
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:5

    Topics: Amikacin; Amiodarone; Amitriptyline; Biological Assay; Chlorpromazine; Female; Hep G2 Cells; Humans;

2017
Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone.
    Toxicology letters, 2018, Mar-01, Volume: 284

    Topics: Amiodarone; Cell Differentiation; Cells, Cultured; Drug Evaluation, Preclinical; Drug-Related Side E

2018
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
    Toxicologic pathology, 2019, Volume: 47, Issue:1

    Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal;

2019
Molecular biomarkers of phospholipidosis in rat blood and heart after amiodarone treatment.
    Journal of applied toxicology : JAT, 2015, Volume: 35, Issue:1

    Topics: Amiodarone; Animals; Biomarkers; Cardiotoxicity; Drug Evaluation, Preclinical; Gene Ontology; Leukoc

2015
Hepatic Phospholipidosis Is Associated with Altered Hepatobiliary Function as Assessed by Gadoxetate Dynamic Contrast-enhanced Magnetic Resonance Imaging.
    Toxicologic pathology, 2016, Volume: 44, Issue:1

    Topics: Amiodarone; Animals; Biliary Tract; Gadolinium DTPA; Lipidoses; Liver; Magnetic Resonance Imaging; M

2016
Phospholipidosis assay in HepG2 cells and rat or rhesus hepatocytes using phospholipid probe NBD-PE.
    Assay and drug development technologies, 2008, Volume: 6, Issue:3

    Topics: Amiodarone; Animals; Cells, Cultured; Hepatocytes; Humans; Lipidoses; Macaca mulatta; Male; Phosphat

2008
Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes.
    Biochemical and biophysical research communications, 2008, Dec-05, Volume: 377, Issue:1

    Topics: Amiodarone; Animals; beta-N-Acetylhexosaminidases; Cells, Cultured; Endosomes; Kidney; Lipidoses; Ly

2008
Relationship between in vitro phospholipidosis assay using HepG2 cells and 2-week toxicity studies in rats.
    Toxicology mechanisms and methods, 2009, Volume: 19, Issue:8

    Topics: Amiodarone; Animal Testing Alternatives; Animals; Cytoplasmic Vesicles; Enzyme Inhibitors; Female; F

2009
Amiodarone attenuates apoptosis, but induces phospholipidosis in rat alveolar epithelial cells.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010, Volume: 61, Issue:6

    Topics: Amiodarone; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 8; Caspase Inhibit

2010
Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:7

    Topics: Amiodarone; Animal Testing Alternatives; Animals; Anti-Arrhythmia Agents; Fluorescent Dyes; Foam Cel

2011
High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:8

    Topics: Amiodarone; Amitriptyline; Animals; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Drug-Relate

2011
Phospholipidosis in rats treated with amiodarone: serum biochemistry and whole genome micro-array analysis supporting the lipid traffic jam hypothesis and the subsequent rise of the biomarker BMP.
    Toxicologic pathology, 2012, Volume: 40, Issue:3

    Topics: Amiodarone; Animals; Biomarkers; Cholesterol; Gene Expression Regulation; Glycerophospholipids; Lipi

2012
Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats.
    Toxicology letters, 2012, Sep-03, Volume: 213, Issue:2

    Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Histocytoche

2012
Biomarkers to monitor drug-induced phospholipidosis.
    Toxicology and applied pharmacology, 2007, Jan-01, Volume: 218, Issue:1

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Azithromycin; Biomarkers; Chroma

2007
Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2007, Volume: 59, Issue:2

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Biomarkers; Disease Models, Animal; Drug Evaluation, Pr

2007
A wild zebra chase.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:5

    Topics: Amiodarone; Animals; Diagnosis, Differential; Fabry Disease; Female; Humans; Iatrogenic Disease; Kid

2008
[Neuropathy induced by amiodarone].
    La Nouvelle presse medicale, 1981, Sep-19, Volume: 10, Issue:33

    Topics: Aged; Amiodarone; Benzofurans; Female; Humans; Lipidoses; Peripheral Nervous System Diseases

1981
Recovery from amiodarone-induced lipidosis in laboratory animals: a toxicological study.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:6

    Topics: Amiodarone; Animals; Benzofurans; Cholesterol; Dogs; Foam Cells; Lipidoses; Lung; Lymph Nodes; Papio

1984
Drug-induced lipidoses of the cornea and conjunctiva.
    International ophthalmology, 1981, Volume: 4, Issue:1-2

    Topics: Amiodarone; Amodiaquine; Chloroquine; Conjunctival Diseases; Corneal Diseases; Fabry Disease; Female

1981
Drug induced ocular lipoidosis.
    Transactions of the Ophthalmological Society of New Zealand, 1982, Volume: 34

    Topics: Adolescent; Adult; Aged; Amiodarone; Benzofurans; Cataract; Color Vision Defects; Corneal Diseases;

1982
Amiodarone-induced cornea verticillata.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1982, Volume: 17, Issue:3

    Topics: Adult; Aged; Amiodarone; Benzofurans; Cornea; Corneal Diseases; Humans; Lipidoses; Microscopy, Elect

1982
Amiodarone induced lipidosis similar to Niemann-Pick C disease. Biochemical and morphological study.
    Life sciences, 1995, Volume: 57, Issue:21

    Topics: Amiodarone; Cells, Cultured; Cholesterol; Culture Media; Fibroblasts; Humans; Hydrolases; Kinetics;

1995
Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis.
    Environmental health perspectives, 1994, Volume: 102, Issue:4

    Topics: Acute Disease; Amiodarone; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Lipidoses;

1994
X-ray microanalysis of cultured alveolar macrophages with phospholipidosis.
    Experimental and molecular pathology, 1993, Volume: 58, Issue:2

    Topics: Amiodarone; Animals; Cell Nucleus; Cells, Cultured; Chlorphentermine; Electron Probe Microanalysis;

1993
Comparative evaluation of amiodarone-induced phospholipidosis and drug accumulation in Fischer-344 and Sprague-Dawley rats.
    Toxicology, 1996, Jan-08, Volume: 106, Issue:1-3

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Kidney; Lipidoses; Liver; Macrophages,

1996
Effects of amiodarone-induced phospholipidosis on pulmonary host defense functions in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1996, Volume: 211, Issue:4

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Immunity, Innate; Interleukins; Lipidoses; Listeriosis;

1996
Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry.
    Annals of diagnostic pathology, 1997, Volume: 1, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Biomarkers; Biopsy; Bronchoalveo

1997
[Amiodaron neuropathy: drug-induced lipidosis (author's transl)].
    La Nouvelle presse medicale, 1979, May-12, Volume: 8, Issue:21

    Topics: Aged; Amiodarone; Benzofurans; Humans; Lipidoses; Male; Peripheral Nervous System Diseases

1979
Amiodarone-induced lipidosis-like alterations in ocular tissues of rats.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1978, Jul-17, Volume: 207, Issue:2

    Topics: Amiodarone; Animals; Benzofurans; Cornea; Female; Keratitis; Lipidoses; Male; Rats; Retina

1978
[Generalized lipidosis in rats following treatment with amiodarone and zimelidine].
    Verhandlungen der Anatomischen Gesellschaft, 1978, Issue:72

    Topics: Adrenal Glands; Allylamine; Amiodarone; Animals; Antidepressive Agents; Benzofurans; Cornea; Female;

1978
Influence of a pre-existing phospholipidosis on the accumulation of amiodarone and desethylamiodarone in rat alveolar macrophages.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 72, Issue:2

    Topics: Amiodarone; Animals; Chlorphentermine; Lipidoses; Macrophages; Male; Phospholipids; Pulmonary Alveol

1991
Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2

    Topics: Amiodarone; Bronchoalveolar Lavage Fluid; Humans; Lipidoses; Lung; Phospholipids

1988
Types of interaction of amphiphilic drugs with phospholipid vesicles.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazi

1988
[Lung, mirror of iatrogenic diseases. Example of amiodarone].
    Bulletin de l'Academie nationale de medecine, 1986, Volume: 170, Issue:1

    Topics: Adult; Aged; Amiodarone; Benzofurans; Female; Humans; Lipidoses; Lung Diseases; Male; Middle Aged; P

1986
Amiodarone induced phospholipidosis. Biochemical, morphological and functional changes in the lungs of rats chronically treated with amiodarone.
    Biochemical pharmacology, 1987, Oct-01, Volume: 36, Issue:19

    Topics: Amiodarone; Animals; Body Weight; Eating; Lipidoses; Lung; Lung Compliance; Male; Phospholipids; Pul

1987
Pulmonary sequestration of amiodarone and desethylamiodarone.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:3

    Topics: Amiodarone; Animals; Benzofurans; Chromatography, High Pressure Liquid; In Vitro Techniques; Lipidos

1986
Amiodarone hepatotoxicity.
    The Netherlands journal of medicine, 1986, Volume: 29, Issue:10

    Topics: Aged; Amiodarone; Chemical and Drug Induced Liver Injury; Female; Humans; Lipidoses; Liver; Male; Mi

1986
Increased hepatic density and phospholipidosis due to amiodarone.
    AJR. American journal of roentgenology, 1985, Volume: 144, Issue:3

    Topics: Aged; Amiodarone; Benzofurans; Biopsy; Humans; Lipidoses; Liver; Lysosomes; Male; Middle Aged; Phosp

1985