amiodarone has been researched along with Hyperlipemia in 11 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with amiodarone may lead to changes in thyroid tests results and to development of hypothyroidism or thyrotoxicosis." | 4.82 | [Thyroid and cardiovascular disorders]. ( Gajek, J; Zyśko, D, 2004) |
| " This article focuses on those drugs that are known to have an adverse effect on the serum lipid profile and the clinical significance of this effect." | 2.38 | [Adverse effects of drugs on serum lipids. Clinical implications]. ( Ghizzoni, G; Rusconi, C; Sabatini, T, 1991) |
| "The objectives of the current study were to characterize the pharmacokinetic profile of dronedarone in the rat, and to examine the effect of hyperlipidemia on its pharmacokinetics." | 1.43 | The pharmacokinetics of dronedarone in normolipidemic and hyperlipidemic rats. ( Brocks, DR; Jardan, YA, 2016) |
| "Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism." | 1.39 | Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes. ( Ben-Eltriki, M; Brocks, DR; El-Kadi, AO; Hamdy, DA; Patel, JP, 2013) |
| "Hyperlipidemia caused large increases in plasma concentrations of amiodarone." | 1.35 | The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat. ( Brocks, DR; El-Kadi, AO; Korashy, H; Patel, JP; Shayeganpour, A, 2008) |
| "To assess the influence of hyperlipidemia (HL) on amiodarone (AM) effect in the heart, rats were pretreated with either 1 g/kg poloxamer 407 (to induce HL) or saline intraperitoneally." | 1.35 | Experimental hyperlipidemia causes an increase in the electrocardiographic changes associated with amiodarone. ( Brocks, DR; Hamdy, DA, 2009) |
| "The objective of this study was to examine the effect of a high fat meal and hyperlipidemia on the pharmacokinetic behavior of amiodarone." | 1.33 | Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models. ( Brocks, DR; Jun, AS; Shayeganpour, A, 2005) |
| "To establish a novel arrhythmia model in rats." | 1.33 | [Establishment of a novel arrhythmia model in rats]. ( Dong, DL; Du, ZM; Jiao, JD; Pan, ZW; Wang, ZY; Yang, BF, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jardan, YA | 1 |
| Brocks, DR | 5 |
| Shayeganpour, A | 2 |
| Korashy, H | 1 |
| Patel, JP | 2 |
| El-Kadi, AO | 2 |
| Hamdy, DA | 2 |
| Ben-Eltriki, M | 1 |
| Zyśko, D | 1 |
| Gajek, J | 1 |
| Jun, AS | 1 |
| Pan, ZW | 1 |
| Wang, ZY | 1 |
| Du, ZM | 1 |
| Jiao, JD | 1 |
| Dong, DL | 1 |
| Yang, BF | 1 |
| Merz, T | 1 |
| Fuller, SH | 1 |
| Esterhuysen, AJ | 1 |
| Potgieter, GM | 1 |
| Kleynhans, PH | 1 |
| Ahmad, S | 1 |
| Ghizzoni, G | 1 |
| Rusconi, C | 1 |
| Sabatini, T | 1 |
2 reviews available for amiodarone and Hyperlipemia
| Article | Year |
|---|---|
[Thyroid and cardiovascular disorders].
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiovascular Diseases; Coronary Artery B | 2004 |
[Adverse effects of drugs on serum lipids. Clinical implications].
Topics: Adrenal Cortex Hormones; Amiodarone; Antihypertensive Agents; Gonadal Steroid Hormones; Humans; Hype | 1991 |
9 other studies available for amiodarone and Hyperlipemia
| Article | Year |
|---|---|
The pharmacokinetics of dronedarone in normolipidemic and hyperlipidemic rats.
Topics: Administration, Intravenous; Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Area | 2016 |
The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cytochrome P-450 Enzyme System; Disease Models, Animal; | 2008 |
Experimental hyperlipidemia causes an increase in the electrocardiographic changes associated with amiodarone.
Topics: Amiodarone; Animals; Cholesterol; Electrocardiography; Heart Rate; Hyperlipidemias; Injections, Intr | 2009 |
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes.
Topics: Alcohol Oxidoreductases; Amiodarone; Animals; ATP Binding Cassette Transporter, Subfamily B; Cells, | 2013 |
Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models.
Topics: Amiodarone; Animals; Area Under Curve; Blood Proteins; Dietary Fats; Hyperlipidemias; Lipoproteins; | 2005 |
[Establishment of a novel arrhythmia model in rats].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Disease Models, | 2005 |
Elevated serum transaminase levels resulting from concomitant use of rosuvastatin and amiodarone.
Topics: Aged; Alanine Transaminase; Amiodarone; Anti-Arrhythmia Agents; Aortic Valve; Aortic Valve Stenosis; | 2007 |
Amiodarone and hyperlipidemia.
Topics: Aged; Amiodarone; Benzofurans; Humans; Hyperlipidemias; Male | 1983 |
Amiodarone and lipid disorder.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Humans; Hyperlipidemias; Lipids; Male; Tachycardia, Ventr | 1995 |