Page last updated: 2024-10-22

amiodarone and Hemorrhage

amiodarone has been researched along with Hemorrhage in 43 studies

Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Hemorrhage: Bleeding or escape of blood from a vessel.

Research Excerpts

ExcerptRelevanceReference
" The primary efficacy endpoint of stroke or systemic embolic event was significantly lower with LDE compared with warfarin in amiodarone treated patients vs."9.20Edoxaban vs. warfarin in patients with atrial fibrillation on amiodarone: a subgroup analysis of the ENGAGE AF-TIMI 48 trial. ( Antman, EM; Atar, D; Braunwald, E; Camm, AJ; Giugliano, RP; Heidbuchel, H; Murphy, SA; Ruff, CT; Steffel, J, 2015)
"Amiodarone, which inhibits CYP2C9 and P-glycoprotein, is commonly prescribed with non-vitamin K antagonist oral anticoagulants (NOACs) and polypharmacy in high-risk atrial fibrillation (AF) patients."9.01Non-vitamin K antagonist oral anticoagulants with amiodarone, P-glycoprotein inhibitors, or polypharmacy in patients with atrial fibrillation: Systematic review and meta-analysis. ( Joung, B; Kim, HJ; Kim, IS; Kim, JY; Kim, TH; Lee, MH; Pak, HN; Uhm, JS; Yu, HT, 2019)
"Direct oral anticoagulants (DOACs) and amiodarone are widely used in the treatment of nonvalvular atrial fibrillation."8.98Efficacy and Safety Outcomes of Direct Oral Anticoagulants and Amiodarone in Patients with Atrial Fibrillation. ( Briceno, D; Di Biase, L; Ferrick, K; Fisher, J; Gross, JN; Kim, S; Krumerman, A; Lupercio, F; Maraboto, C; Peltzer, B; Romero, J; Villablanca, P, 2018)
"Amiodarone is a commonly used pharmacotherapy in patients with atrial fibrillation (AF), with a potential for drug-drug interactions with direct oral anticoagulants (DOACs)."8.31Association Between Concurrent Use of Amiodarone and DOACs and Risk of Bleeding in Patients With Atrial Fibrillation. ( Andrade, JG; Austin, PC; Caswell, J; Crystal, E; Jackevicius, CA; Ko, DT; Michael, F; Qiu, F; Shurrab, M; Singh, SM; Tu, K, 2023)
"Amiodarone, the most effective antiarrhythmic drug in atrial fibrillation, inhibits apixaban and rivaroxaban elimination, thus possibly increasing anticoagulant-related risk for bleeding."8.31Risk for Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients With Atrial Fibrillation : A Retrospective Cohort Study. ( Chung, CP; Daugherty, JR; Dickson, AL; Dupont, WD; Hung, AM; Murray, KT; Ray, WA; Smalley, W; Stein, CM; Zimmerman, E, 2023)
"The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population."8.12Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin. ( Chen, W; Fu, J; Jiang, S; Lv, M; Wu, T; Xia, X; Zhang, J, 2022)
"To investigate whether co-administration of antiarrhythmic dronedarone and anticoagulant rivaroxaban would increase the risks of hemorrhage after atrial fibrillation (AF) ablation."8.12Comparison of co-administration of amiodarone and rivaroxaban to co-administration of dronedarone and rivaroxaban for hemorrhage risks after atrial fibrillation ablation. ( Cai, S; Liu, W; Pan, Y; Sun, P; Wang, M; Zhang, P; Zhao, Q, 2022)
"Rivaroxaban reduces the risk of thromboembolism in atrial fibrillation (AF) patients, who often also receive antiarrhythmic drugs (AADs) to maintain sinus rhythm."8.02Safety and Effectiveness of Rivaroxaban in Combination with Various Antiarrhythmic Drugs in Patients with Non-Permanent Atrial Fibrillation. ( Chen, CY; Chiou, WR; Chuang, JY; Huang, CC; Kuo, JY; Lee, YH; Liao, FC; Lin, PL; Liu, LY; Su, MI; Tsai, CT; Wu, YJ, 2021)
"Median trough plasma concentration of dabigatran in our study was observed to be similar to median trough plasma concentration of dabigatran at a dose of 150 mg bid without concomitant dronedarone in earlier studies with low reported rate of bleeding and thrombosis."7.81Concomitant use of dronedarone with dabigatran in patients with atrial fibrillation in clinical practice. ( Juhlin, T; Mochalina, N; Platonov, PG; Svensson, PJ; Wieloch, M, 2015)
"A patient with mechanical heart valves developed bleeding, after the introduction of amiodarone and azithromycin."7.70Bleeding complication during coumarin therapy due to amiodarone and azithromycin. ( Bharat, V; Mohanty, B, 2000)
"Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug."7.67Amiodarone-induced pulmonary fibrosis in hamsters. ( Cantor, JO; Cerreta, JM; Mandl, I; Osman, M; Suarez, R; Turino, GM, 1984)
"Diffuse alveolar hemorrhage is a rare reaction, with few case reports documented in the literature since amiodarone became widely used in the early 1980s."5.38A rare case of acute diffuse alveolar hemorrhage following initiation of amiodarone: a case report. ( Bennett, S; Borders, CW; Claassen, SL; Mount, C, 2012)
" The primary efficacy endpoint of stroke or systemic embolic event was significantly lower with LDE compared with warfarin in amiodarone treated patients vs."5.20Edoxaban vs. warfarin in patients with atrial fibrillation on amiodarone: a subgroup analysis of the ENGAGE AF-TIMI 48 trial. ( Antman, EM; Atar, D; Braunwald, E; Camm, AJ; Giugliano, RP; Heidbuchel, H; Murphy, SA; Ruff, CT; Steffel, J, 2015)
"Amiodarone, which inhibits CYP2C9 and P-glycoprotein, is commonly prescribed with non-vitamin K antagonist oral anticoagulants (NOACs) and polypharmacy in high-risk atrial fibrillation (AF) patients."5.01Non-vitamin K antagonist oral anticoagulants with amiodarone, P-glycoprotein inhibitors, or polypharmacy in patients with atrial fibrillation: Systematic review and meta-analysis. ( Joung, B; Kim, HJ; Kim, IS; Kim, JY; Kim, TH; Lee, MH; Pak, HN; Uhm, JS; Yu, HT, 2019)
"Direct oral anticoagulants (DOACs) and amiodarone are widely used in the treatment of nonvalvular atrial fibrillation."4.98Efficacy and Safety Outcomes of Direct Oral Anticoagulants and Amiodarone in Patients with Atrial Fibrillation. ( Briceno, D; Di Biase, L; Ferrick, K; Fisher, J; Gross, JN; Kim, S; Krumerman, A; Lupercio, F; Maraboto, C; Peltzer, B; Romero, J; Villablanca, P, 2018)
"Increased bleeding risk was found associated with concurrent prescription of rivaroxaban and amiodarone."4.31Model-Based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population. ( Chan, ECY; Cheong, EJY; Kojodjojo, P; Wang, Z, 2023)
"Amiodarone is a commonly used pharmacotherapy in patients with atrial fibrillation (AF), with a potential for drug-drug interactions with direct oral anticoagulants (DOACs)."4.31Association Between Concurrent Use of Amiodarone and DOACs and Risk of Bleeding in Patients With Atrial Fibrillation. ( Andrade, JG; Austin, PC; Caswell, J; Crystal, E; Jackevicius, CA; Ko, DT; Michael, F; Qiu, F; Shurrab, M; Singh, SM; Tu, K, 2023)
"Amiodarone, the most effective antiarrhythmic drug in atrial fibrillation, inhibits apixaban and rivaroxaban elimination, thus possibly increasing anticoagulant-related risk for bleeding."4.31Risk for Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients With Atrial Fibrillation : A Retrospective Cohort Study. ( Chung, CP; Daugherty, JR; Dickson, AL; Dupont, WD; Hung, AM; Murray, KT; Ray, WA; Smalley, W; Stein, CM; Zimmerman, E, 2023)
"The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population."4.12Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin. ( Chen, W; Fu, J; Jiang, S; Lv, M; Wu, T; Xia, X; Zhang, J, 2022)
"To investigate whether co-administration of antiarrhythmic dronedarone and anticoagulant rivaroxaban would increase the risks of hemorrhage after atrial fibrillation (AF) ablation."4.12Comparison of co-administration of amiodarone and rivaroxaban to co-administration of dronedarone and rivaroxaban for hemorrhage risks after atrial fibrillation ablation. ( Cai, S; Liu, W; Pan, Y; Sun, P; Wang, M; Zhang, P; Zhao, Q, 2022)
"Rivaroxaban reduces the risk of thromboembolism in atrial fibrillation (AF) patients, who often also receive antiarrhythmic drugs (AADs) to maintain sinus rhythm."4.02Safety and Effectiveness of Rivaroxaban in Combination with Various Antiarrhythmic Drugs in Patients with Non-Permanent Atrial Fibrillation. ( Chen, CY; Chiou, WR; Chuang, JY; Huang, CC; Kuo, JY; Lee, YH; Liao, FC; Lin, PL; Liu, LY; Su, MI; Tsai, CT; Wu, YJ, 2021)
"Amiodarone inhibits warfarin metabolism and is associated with major bleeding during warfarin therapy."3.96The Magnitude of the Warfarin-Amiodarone Drug-Drug Interaction Varies With Renal Function: A Propensity-Matched Cohort Study. ( Brown, JR; Hennessy, S; Miano, TA; Shashaty, MGS; Yang, W; Zuppa, A, 2020)
"Median trough plasma concentration of dabigatran in our study was observed to be similar to median trough plasma concentration of dabigatran at a dose of 150 mg bid without concomitant dronedarone in earlier studies with low reported rate of bleeding and thrombosis."3.81Concomitant use of dronedarone with dabigatran in patients with atrial fibrillation in clinical practice. ( Juhlin, T; Mochalina, N; Platonov, PG; Svensson, PJ; Wieloch, M, 2015)
" He had been on amiodarone for atrial fibrillation and developed hemorrhagic manifestations due to factor V inhibitors within a few months of initiating amiodarone therapy."3.78A rare case of factor V inhibitor in a patient on amiodarone therapy. ( Lipshitz, J; Patel, D; Shreenivas, AV, 2012)
"Authors describe a case of drug interaction between amiodarone and warfarin in 66-year-old man with recurrent atrial fibrillation."3.72[Long-term drug interaction of warfarin with amiodarone]. ( Hirmerová, J; Mádr, T; Suchý, D, 2003)
"A patient with mechanical heart valves developed bleeding, after the introduction of amiodarone and azithromycin."3.70Bleeding complication during coumarin therapy due to amiodarone and azithromycin. ( Bharat, V; Mohanty, B, 2000)
"Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug."3.67Amiodarone-induced pulmonary fibrosis in hamsters. ( Cantor, JO; Cerreta, JM; Mandl, I; Osman, M; Suarez, R; Turino, GM, 1984)
"Stroke and systemic thromboembolism are serious problems for patients with atrial fibrillation (AF), but their incidence can be substantially reduced by appropriate anticoagulation."2.71Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. ( Corley, SD; DiMarco, JP; Flaker, G; Greene, HL; Mitrani, G; Nemeth, M; Rosenfeld, LE; Safford, RE; Waldo, AL, 2005)
"Amiodarone is an antiarrhythmic agent that is used commonly in clinical practice."1.51Amiodarone-induced diffuse alveolar haemorrhage: a rare but potentially life-threatening complication of a commonly prescribed medication. ( Abdullah, HMA; Khan, UI; Saeed, J; Waqas, QA, 2019)
" Objectives An investigation of how initiation of amiodarone affects the anticoagulant effect and dosing of warfarin, using data from three nationwide registries."1.46The effect of amiodarone on warfarin anticoagulation: a register-based nationwide cohort study involving the Swedish population. ( Andersson, ML; Holm, J; Lindh, JD; Mannheimer, B, 2017)
"Recent infection was present in 40."1.39Adverse drug events associated with vitamin K antagonists: factors of therapeutic imbalance. ( Ajrouche, R; Al-Hajje, A; Awada, S; El-Helou, N; Rachidi, S; Salameh, P; Zein, S, 2013)
"Diffuse alveolar hemorrhage is a rare reaction, with few case reports documented in the literature since amiodarone became widely used in the early 1980s."1.38A rare case of acute diffuse alveolar hemorrhage following initiation of amiodarone: a case report. ( Bennett, S; Borders, CW; Claassen, SL; Mount, C, 2012)
" Patients received both amiodarone and warfarin for at least 1 year, and the dosage of warfarin was adjusted as clinically necessary to achieve an international normalized ratio of 2 to 3."1.31Clinical observations with the amiodarone/warfarin interaction: dosing relationships with long-term therapy. ( Bauman, JL; Sanoski, CA, 2002)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19904 (9.30)18.7374
1990's3 (6.98)18.2507
2000's11 (25.58)29.6817
2010's15 (34.88)24.3611
2020's10 (23.26)2.80

Authors

AuthorsStudies
Xia, X1
Fu, J1
Wu, T1
Chen, W1
Jiang, S1
Lv, M1
Zhang, J1
Wang, Z1
Cheong, EJY1
Kojodjojo, P1
Chan, ECY1
Zhang, P1
Wang, M1
Liu, W1
Sun, P1
Cai, S1
Pan, Y1
Zhao, Q1
Shurrab, M1
Jackevicius, CA1
Austin, PC1
Tu, K1
Qiu, F1
Singh, SM1
Crystal, E1
Caswell, J1
Michael, F1
Andrade, JG1
Ko, DT1
Ray, WA1
Chung, CP1
Stein, CM1
Smalley, W1
Zimmerman, E1
Dupont, WD1
Hung, AM1
Daugherty, JR1
Dickson, AL1
Murray, KT1
Favre-Bulle, T1
Saeed, J1
Waqas, QA1
Khan, UI1
Abdullah, HMA1
Miano, TA1
Yang, W1
Shashaty, MGS1
Zuppa, A1
Brown, JR1
Hennessy, S1
Matos, JD1
McIlvaine, S1
Grau-Sepulveda, M1
Jawitz, OK1
Brennan, JM1
Khabbaz, KR1
Sellke, FW1
Yeh, R1
Zimetbaum, P1
Papanikolaou, IC1
Makou, I1
Markatis, E1
Chiou, WR1
Huang, CC1
Lin, PL1
Chuang, JY1
Liu, LY1
Su, MI1
Liao, FC1
Chen, CY1
Kuo, JY1
Tsai, CT1
Wu, YJ1
Lee, YH1
Lupercio, F1
Romero, J1
Peltzer, B1
Maraboto, C1
Briceno, D1
Villablanca, P1
Ferrick, K1
Gross, JN1
Kim, S1
Fisher, J1
Di Biase, L1
Krumerman, A1
Kim, IS1
Kim, HJ1
Yu, HT1
Kim, TH1
Uhm, JS1
Kim, JY1
Joung, B1
Lee, MH1
Pak, HN1
El-Helou, N1
Al-Hajje, A1
Ajrouche, R1
Awada, S1
Rachidi, S1
Zein, S1
Salameh, P1
Lam, J1
Gomes, T1
Juurlink, DN1
Mamdani, MM1
Pullenayegum, EM1
Kearon, C1
Spencer, FA1
Paterson, M1
Zheng, H1
Holbrook, AM1
Semenas, E2
Sharma, HS1
Wiklund, L1
Zoerner, F1
Aguilar, C1
Mochalina, N1
Juhlin, T1
Platonov, PG1
Svensson, PJ1
Wieloch, M1
Steffel, J1
Giugliano, RP1
Braunwald, E1
Murphy, SA1
Atar, D1
Heidbuchel, H1
Camm, AJ1
Antman, EM1
Ruff, CT1
Holm, J1
Lindh, JD1
Andersson, ML1
Mannheimer, B1
Cadiou, G1
Varin, R1
Levesque, H1
Grassi, V1
Benichou, J1
Tiret, I1
Dieu, B1
Lecam-Duchez, V1
Borg, JY1
Muller, JM1
Benhamou, Y1
Marie, I1
Tanawuttiwat, T1
Harindhanavudhi, T1
Hanif, S1
Sahloul, MZ1
Borders, CW1
Bennett, S1
Mount, C1
Claassen, SL1
Shreenivas, AV1
Lipshitz, J1
Patel, D1
Blasco, LM1
Lee, J1
Lee, B1
Kim, K1
Ahn, H1
Suh, O1
Lee, M1
Shin, W1
Hirmerová, J1
Suchý, D1
Mádr, T1
Siguret, V1
Esquirol, C1
Debray, M1
Gouin, I1
Andreux, JP1
Pautas, E1
DiMarco, JP1
Flaker, G1
Waldo, AL1
Corley, SD1
Greene, HL1
Safford, RE1
Rosenfeld, LE1
Mitrani, G1
Nemeth, M1
Singh, S1
Iskandar, SB1
Abi-Saleh, B1
Keith, RL1
Byrd, RP1
Roy, TM1
Tsukada, YT1
Kishida, H1
Cantor, JO1
Osman, M1
Cerreta, JM1
Suarez, R1
Mandl, I1
Turino, GM1
Lee, HS1
Quinn, T1
Boyle, RM1
Iskander, S1
Raible, DG1
Brozena, SC1
Gaitanaru, DM1
Ayala, G1
Iskandrian, AE1
Bharat, V1
Mohanty, B1
Sanoski, CA1
Bauman, JL1
O'Leary, TG1
Kotecha, B1
Rothera, MP1
Caraco, Y2
Chajek-Shaul, T1
Fondevila, C1
Meschengieser, S1
Lazzari, MA1
Raveh, D1
Flugelman, M1
Raz, I1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000556]Phase 30 participants Interventional1995-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for amiodarone and Hemorrhage

ArticleYear
Efficacy and Safety Outcomes of Direct Oral Anticoagulants and Amiodarone in Patients with Atrial Fibrillation.
    The American journal of medicine, 2018, Volume: 131, Issue:5

    Topics: Administration, Oral; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Drug

2018
Non-vitamin K antagonist oral anticoagulants with amiodarone, P-glycoprotein inhibitors, or polypharmacy in patients with atrial fibrillation: Systematic review and meta-analysis.
    Journal of cardiology, 2019, Volume: 73, Issue:6

    Topics: Administration, Oral; Adult; Aged; Amiodarone; Anticoagulants; ATP Binding Cassette Transporter, Sub

2019
Antithrombotic therapy in a patient with mild haemophilia A and atrial fibrillation: case report and brief review of the literature.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2015, Volume: 26, Issue:3

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Disease Management; Dronedar

2015
[Adverse effects of cardiovascular agents].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Brugada Syndrome; Drug Interactions; Fibrinolyti

2007

Trials

2 trials available for amiodarone and Hemorrhage

ArticleYear
Edoxaban vs. warfarin in patients with atrial fibrillation on amiodarone: a subgroup analysis of the ENGAGE AF-TIMI 48 trial.
    European heart journal, 2015, Sep-01, Volume: 36, Issue:33

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Female; Hemorrhage; H

2015
Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.
    American heart journal, 2005, Volume: 149, Issue:4

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Aspirin; Atrial Fibrillation; Combined Mod

2005

Other Studies

37 other studies available for amiodarone and Hemorrhage

ArticleYear
Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin.
    European journal of clinical pharmacology, 2022, Volume: 78, Issue:2

    Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Apolipoproteins E; Asian People; Bo

2022
Model-Based Risk Prediction of Rivaroxaban with Amiodarone for Moderate Renal Impaired Elderly Population.
    Cardiovascular drugs and therapy, 2023, Volume: 37, Issue:3

    Topics: Aged; Amiodarone; Hemorrhage; Humans; Kidney; Renal Insufficiency; Rivaroxaban

2023
Comparison of co-administration of amiodarone and rivaroxaban to co-administration of dronedarone and rivaroxaban for hemorrhage risks after atrial fibrillation ablation.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2022, Volume: 64, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Catheter Ablation; Dronedarone; Hemorrhage;

2022
Association Between Concurrent Use of Amiodarone and DOACs and Risk of Bleeding in Patients With Atrial Fibrillation.
    The American journal of cardiology, 2023, 01-01, Volume: 186

    Topics: Administration, Oral; Adult; Aged, 80 and over; Amiodarone; Anticoagulants; Atrial Fibrillation; Cas

2023
Risk for Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients With Atrial Fibrillation : A Retrospective Cohort Study.
    Annals of internal medicine, 2023, Volume: 176, Issue:6

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Dabigatran; Embolism;

2023
    Revue medicale suisse, 2023, 07-26, Volume: 19, Issue:836

    Topics: Amiodarone; Hemorrhage; Humans

2023
Amiodarone-induced diffuse alveolar haemorrhage: a rare but potentially life-threatening complication of a commonly prescribed medication.
    BMJ case reports, 2019, Oct-25, Volume: 12, Issue:10

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Diagnosis, Differential; Female; Hemorrhage; Humans; Lung

2019
The Magnitude of the Warfarin-Amiodarone Drug-Drug Interaction Varies With Renal Function: A Propensity-Matched Cohort Study.
    Clinical pharmacology and therapeutics, 2020, Volume: 107, Issue:6

    Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Co

2020
Anticoagulation and amiodarone for new atrial fibrillation after coronary artery bypass grafting: Prescription patterns and 30-day outcomes in the United States and Canada.
    The Journal of thoracic and cardiovascular surgery, 2021, Volume: 162, Issue:2

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Canada; Clinical Deci

2021
Amiodarone and diffuse alveolar hemorrhage.
    Advances in respiratory medicine, 2020, Volume: 88, Issue:2

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Cough; Dyspnea; Female; Hemorrhage; Humans; Lung Diseases;

2020
Safety and Effectiveness of Rivaroxaban in Combination with Various Antiarrhythmic Drugs in Patients with Non-Permanent Atrial Fibrillation.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2021, Volume: 21, Issue:4

    Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiovascular Dis

2021
Adverse drug events associated with vitamin K antagonists: factors of therapeutic imbalance.
    Vascular health and risk management, 2013, Volume: 9

    Topics: Age Factors; Aged; Amiodarone; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Anti-Inflammatory Agen

2013
Hospitalization for hemorrhage among warfarin recipients prescribed amiodarone.
    The American journal of cardiology, 2013, Aug-01, Volume: 112, Issue:3

    Topics: Aged; Algorithms; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Cohort Studies; Drug Synergism

2013
Adrenaline increases blood-brain-barrier permeability after haemorrhagic cardiac arrest in immature pigs.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5

    Topics: Amiodarone; Animals; Blood-Brain Barrier; Capillary Permeability; Cardiopulmonary Resuscitation; Cer

2014
Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs.
    The journal of trauma and acute care surgery, 2014, Volume: 76, Issue:6

    Topics: Amiodarone; Animals; Antidiuretic Agents; Disease Models, Animal; Dose-Response Relationship, Drug;

2014
Concomitant use of dronedarone with dabigatran in patients with atrial fibrillation in clinical practice.
    Thrombosis research, 2015, Volume: 135, Issue:6

    Topics: Aged; Amiodarone; Anticoagulants; Antithrombins; Atrial Fibrillation; Cohort Studies; Dabigatran; Dr

2015
The effect of amiodarone on warfarin anticoagulation: a register-based nationwide cohort study involving the Swedish population.
    Journal of thrombosis and haemostasis : JTH, 2017, Volume: 15, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Blood Coagulatio

2017
Risk factors of vitamin K antagonist overcoagulation. A case-control study in unselected patients referred to an emergency department.
    Thrombosis and haemostasis, 2008, Volume: 100, Issue:4

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amiodarone; Anticoagulants; Blood Coagulation Disorde

2008
Amiodarone-induced alveolar haemorrhage: a rare complication of a common medication.
    Heart, lung & circulation, 2010, Volume: 19, Issue:7

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Fatal Outcome; Hemorrhage; Humans; Lung Di

2010
A rare case of acute diffuse alveolar hemorrhage following initiation of amiodarone: a case report.
    Military medicine, 2012, Volume: 177, Issue:1

    Topics: Acute Disease; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Fatal Outcome; Hemorrh

2012
A rare case of factor V inhibitor in a patient on amiodarone therapy.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2012, Volume: 23, Issue:4

    Topics: Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Coagulation Tests;

2012
Trepopnea due to amiodarone-induced diffuse alveolar hemorrhage.
    Respiratory care, 2013, Volume: 58, Issue:2

    Topics: Acenocoumarol; Aged; Amiodarone; Anemia; Anti-Arrhythmia Agents; Anticoagulants; Dyspnea; Hemoptysis

2013
Factors affecting warfarin therapy following cardiac valve surgery.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:12

    Topics: Adult; Amiodarone; Anticoagulants; Dose-Response Relationship, Drug; Drug Interactions; Ethnicity; F

2002
Interactions between amiodarone and vitamin K antagonists.
    Prescrire international, 2003, Volume: 12, Issue:64

    Topics: Amiodarone; Anticoagulants; Drug Interactions; France; Hemorrhage; Humans; Vitamin K; Warfarin

2003
[Long-term drug interaction of warfarin with amiodarone].
    Casopis lekaru ceskych, 2003, Jan-20, Volume: 142, Issue:1

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Drug Interactions; He

2003
[Excess antivitamin K in elderly hospitalised patients aged over 70. A one-year prospective survey].
    Presse medicale (Paris, France : 1983), 2003, Jun-14, Volume: 32, Issue:21

    Topics: 4-Hydroxycoumarins; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Anti-Bacterial Agen

2003
Amiodarone-induced pulmonary hemorrhage.
    Southern medical journal, 2006, Volume: 99, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Biomarkers; Hemorrhage; Humans; Lung Diseas

2006
Amiodarone-induced alveolar hemorrhage.
    Southern medical journal, 2006, Volume: 99, Issue:4

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Hemorrhage; Humans; Lung Diseases; Ma

2006
Amiodarone-induced pulmonary fibrosis in hamsters.
    Experimental lung research, 1984, Volume: 6, Issue:1

    Topics: Amiodarone; Animals; Benzofurans; Cricetinae; Hemorrhage; Inflammation; Lung; Lung Diseases; Mesocri

1984
Safety of thrombolytic treatment in patients with central venous cannulation.
    British heart journal, 1995, Volume: 73, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Catheterization, Central Venous; Contraindications; Fema

1995
Acute alveolar hemorrhage and orthodeoxia induced by intravenous amiodarone.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 1999, Volume: 47, Issue:1

    Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Biopsy; Hemorrhage; Humans; Hypoxia; Lung Disease

1999
Bleeding complication during coumarin therapy due to amiodarone and azithromycin.
    The Journal of the Association of Physicians of India, 2000, Volume: 48, Issue:7

    Topics: Amiodarone; Anticoagulants; Atrial Fibrillation; Azithromycin; Coumarins; Drug Interactions; Fatal O

2000
Clinical observations with the amiodarone/warfarin interaction: dosing relationships with long-term therapy.
    Chest, 2002, Volume: 121, Issue:1

    Topics: Aged; Amiodarone; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Fe

2002
Upper airway obstruction secondary to anticoagulant induced haemorrhage necessitating a tracheostomy.
    Irish medical journal, 1990, Volume: 83, Issue:4

    Topics: Aged; Aged, 80 and over; Airway Obstruction; Amiodarone; Anticoagulants; Drug Interactions; Female;

1990
The incidence and clinical significance of amiodarone and acenocoumarol interaction.
    Thrombosis and haemostasis, 1989, Nov-24, Volume: 62, Issue:3

    Topics: Acenocoumarol; Aged; Amiodarone; Drug Interactions; Female; Hemorrhage; Humans; Male; Middle Aged

1989
Amiodarone potentiates acenocoumarin.
    Thrombosis research, 1989, Jan-15, Volume: 53, Issue:2

    Topics: Acenocoumarol; Administration, Oral; Amiodarone; Drug Synergism; Hemorrhage; Humans; Injections, Int

1989
Enhanced anticoagulant effect of acenocoumarol induced by amiodarone coadministration.
    Israel journal of medical sciences, 1988, Volume: 24, Issue:11

    Topics: Acenocoumarol; Aged; Amiodarone; Blood Coagulation Disorders; Drug Combinations; Drug Synergism; Fem

1988