amiodarone has been researched along with Graves Disease in 30 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amiodarone-induced thyrotoxicosis (AIT) develops in 3% of amiodarone-treated patients in North America." | 8.85 | Amiodarone-induced thyrotoxicosis: a review. ( Houlden, RL; Tsang, W, 2009) |
| "Amiodarone-induced thyrotoxicosis (AIT) type I describes inducement of clinical hyperthyroidism by excessive thyroidal iodine in the setting of latent Graves disease, and therapy differs from that used for AIT type II." | 7.83 | 99mTc Sestamibi Thyroid Scan in Amiodarone-Induced Thyrotoxicosis Type I. ( Lee, H; Patel, NR; Tamara, LA, 2016) |
| "Amiodarone-induced thyrotoxicosis (AIT) may be caused by excessive thyroidal hormone synthesis and release (type 1) or by a destructive process (type 2)." | 7.74 | Color-flow Doppler sonography in the differential diagnosis and management of amiodarone-induced thyrotoxicosis. ( Cianchetti, ME; Loy, M; Mariotti, S; Melis, A; Perra, E; Piga, M; Pinna, G; Serra, A, 2007) |
| " Two were cases of type I amiodarone-induced thyrotoxicosis (AIT) treated with methimazole." | 7.74 | Differential diagnosis and appropriate treatment of four thyrotoxic patients with Graves' disease required to take amiodarone due to life-threatening arrhythmia. ( Kasanuki, H; Kodama, H; Obara, T; Omi, Y; Sato, K; Seki, T; Shiga, T; Takano, K; Yamada, E; Yamazaki, K, 2008) |
| "Amiodarone-induced thyrotoxicosis (AIT) is a challenging management problem, since patients treated with amiodarone invariably have underlying heart disease." | 7.73 | Amiodarone-induced thyrotoxicosis: left ventricular dysfunction is associated with increased mortality. ( Diamond, T; Lewis, M; O'Sullivan, AJ, 2006) |
| "Amiodarone-induced thyrotoxicosis (AIT) occurs both in abnormal thyroid glands (nodular goiter, latent Graves' disease) (type I AIT) or in apparently normal thyroid glands (type II AIT)." | 7.69 | Color flow Doppler sonography rapidly differentiates type I and type II amiodarone-induced thyrotoxicosis. ( Bartalena, L; Bartolozzi, C; Bogazzi, F; Brogioni, S; Burelli, A; Martino, E; Mazzeo, S; Vitti, P, 1997) |
| "Iodine-induced hyperthyroidism has been frequently described when iodine is introduced into an iodine-deficient area." | 7.67 | Five patients with iodine-induced hyperthyroidism. ( Braverman, LE; Mordes, JP; Rajatanavin, R; Safran, M; Stoller, WA, 1984) |
| "Iodine induced hyperthyroidism is frequently observed in patients affected by euthyroid iodine deficient goiter when suddenly exposed to excess iodine." | 6.41 | Iodine excess and hyperthyroidism. ( Roti, E; Uberti, ED, 2001) |
| "Amiodarone-induced thyrotoxicosis (AIT) develops in 3% of amiodarone-treated patients in North America." | 4.85 | Amiodarone-induced thyrotoxicosis: a review. ( Houlden, RL; Tsang, W, 2009) |
| " Ultrasound has a role in the investigation of Graves' disease, subacute thyroiditis, gestational thyrotoxicosis, postpartum thyroiditis, amiodarone thyrotoxicosis and goiter with or without adenoma, but adenomas are usually investigated by endocrine surgeons in Sweden." | 4.12 | [Thyroid ultrasound and its role in the investigation of thyroid disease]. ( Almquist, M; Koutouridou, E; Lantz, M; Mijovic, Z; Pellby, D; Planck, T; Tsoumani, K, 2022) |
| "Amiodarone-induced thyrotoxicosis (AIT) type I describes inducement of clinical hyperthyroidism by excessive thyroidal iodine in the setting of latent Graves disease, and therapy differs from that used for AIT type II." | 3.83 | 99mTc Sestamibi Thyroid Scan in Amiodarone-Induced Thyrotoxicosis Type I. ( Lee, H; Patel, NR; Tamara, LA, 2016) |
| "Amiodarone-induced thyrotoxicosis (AIT) may be caused by excessive thyroidal hormone synthesis and release (type 1) or by a destructive process (type 2)." | 3.74 | Color-flow Doppler sonography in the differential diagnosis and management of amiodarone-induced thyrotoxicosis. ( Cianchetti, ME; Loy, M; Mariotti, S; Melis, A; Perra, E; Piga, M; Pinna, G; Serra, A, 2007) |
| " Two were cases of type I amiodarone-induced thyrotoxicosis (AIT) treated with methimazole." | 3.74 | Differential diagnosis and appropriate treatment of four thyrotoxic patients with Graves' disease required to take amiodarone due to life-threatening arrhythmia. ( Kasanuki, H; Kodama, H; Obara, T; Omi, Y; Sato, K; Seki, T; Shiga, T; Takano, K; Yamada, E; Yamazaki, K, 2008) |
| "Amiodarone-induced thyrotoxicosis (AIT) is a challenging management problem, since patients treated with amiodarone invariably have underlying heart disease." | 3.73 | Amiodarone-induced thyrotoxicosis: left ventricular dysfunction is associated with increased mortality. ( Diamond, T; Lewis, M; O'Sullivan, AJ, 2006) |
| "Of the 347 patients who underwent thyroidectomy, 54 (16%) had thyrotoxicosis, secondary to Graves' disease (32 patients), toxic multinodular goiter (18 patients), thyroiditis (2 patients), or amiodarone (2 patients)." | 3.71 | Thyroidectomy for selected patients with thyrotoxicosis. ( McHenry, CR; Mittendorf, EA, 2001) |
| "Iodine-induced thyrotoxicosis or "jodbasedow phenomenon" has been reported throughout the world since iodine has been administered to treat endemic goitre." | 3.70 | [Iodine-induced hyperthyroidism (iodine-induced Basedow's disease): a current disease picture]. ( Brander, L; Buess, M; Henzen, C, 1999) |
| "Amiodarone-induced thyrotoxicosis (AIT) occurs both in abnormal thyroid glands (nodular goiter, latent Graves' disease) (type I AIT) or in apparently normal thyroid glands (type II AIT)." | 3.69 | Color flow Doppler sonography rapidly differentiates type I and type II amiodarone-induced thyrotoxicosis. ( Bartalena, L; Bartolozzi, C; Bogazzi, F; Brogioni, S; Burelli, A; Martino, E; Mazzeo, S; Vitti, P, 1997) |
| "Plasma iodine was below 40 micrograms/l in 57 (7%) patients, most of whom had hypothyroidism; 40-80 micrograms/l in 439 (55%) patients, most of whom had normal thyroid hormone function; 80-250 micrograms/l in 240 (30%) patients, most of whom had hyperthyroidism; and above 250 micrograms/l in 63 (8%) patients, almost all of whom had iodine overload caused by iodinated drugs, particularly amiodarone, resulting in euthyroidism (24%), hyperthyroidism (36%), and hypothyroidism (16%)." | 3.68 | Use of plasma iodine assay for diagnosing thyroid disorders. ( Allain, P; Barbot, N; Berre, S; Bigorgne, JC; Krari, N; Lainé-Cessac, P; Le Bouil, A; Rohmer, V, 1993) |
| "Iodine-induced hyperthyroidism has been frequently described when iodine is introduced into an iodine-deficient area." | 3.67 | Five patients with iodine-induced hyperthyroidism. ( Braverman, LE; Mordes, JP; Rajatanavin, R; Safran, M; Stoller, WA, 1984) |
| "We compared results of five sensitive immunometric assays of serum thyrotropin (TSH) in controls and in different groups of patients with hyperthyroidism, untreated or treated; secondary hypothyroidism; nonthyroidal illness (NTI); or depression; or who were being treated with amiodarone." | 3.67 | Clinical significance of a low concentration of thyrotropin: five immunometric "kit" assays compared. ( Askienazy, S; Milhaud, G; Piketty, ML; Talbot, JN, 1987) |
| "Options for treatment of hyperthyroidism include: antithyroid drugs, radioactive iodine therapy (the preferred treatment of hyperthyroidism among US thyroid specialists), or thyroidectomy." | 2.72 | Current approach to surgical management of hyperthyroidism. ( Barczyński, M, 2021) |
| "Treatment options for Graves' disease include antithyroid drugs, radioactive iodine therapy, and surgery, whereas antithyroid drugs are not generally used long term in toxic nodular goitre, because of the high relapse rate of thyrotoxicosis after discontinuation." | 2.53 | Hyperthyroidism. ( Braverman, LE; De Leo, S; Lee, SY, 2016) |
| "The most frequent cause is Graves' disease (autoimmune hyperthyroidism)." | 2.48 | Thyrotoxicosis. ( Boelaert, K; Franklyn, JA, 2012) |
| "Iodine induced hyperthyroidism is frequently observed in patients affected by euthyroid iodine deficient goiter when suddenly exposed to excess iodine." | 2.41 | Iodine excess and hyperthyroidism. ( Roti, E; Uberti, ED, 2001) |
| "Thyrotoxicosis is a well defined clinical entity, determined by an increase of plasma levels of thyroid hormones (T3 and T4)." | 2.41 | [The management of thyrotoxicosis: a schematic approach]. ( Carapezzi, C; Corsello, SM; Papi, G, 2002) |
| "Moreover, the undiagnosed Graves' disease, lack of suspicion, and postponed analysis of thyroid function tests led to a delayed diagnosis of TS." | 1.62 | Delayed diagnosis of dilated thyrotoxic cardiomyopathy with coexistent multifocal atrial tachycardia: a case report. ( Hashimoto, T; Ishibashi-Ueda, H; Monno, S; Ohta-Ogo, K; Yamamoto, H, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (23.33) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lantz, M | 1 |
| Almquist, M | 1 |
| Koutouridou, E | 1 |
| Pellby, D | 1 |
| Planck, T | 1 |
| Tsoumani, K | 1 |
| Mijovic, Z | 1 |
| Barczyński, M | 1 |
| Yamamoto, H | 1 |
| Monno, S | 1 |
| Ohta-Ogo, K | 1 |
| Ishibashi-Ueda, H | 1 |
| Hashimoto, T | 1 |
| Cappellani, D | 1 |
| De Marco, G | 1 |
| Ferrarini, E | 1 |
| Torregrossa, L | 1 |
| Di Certo, AM | 1 |
| Cosentino, G | 1 |
| Urbani, C | 1 |
| Marconcini, G | 1 |
| Mattiello, A | 1 |
| Manetti, L | 1 |
| Agretti, P | 1 |
| Basolo, F | 1 |
| Tonacchera, M | 1 |
| Bartalena, L | 2 |
| Bogazzi, F | 2 |
| De Leo, S | 1 |
| Lee, SY | 1 |
| Braverman, LE | 3 |
| Patel, NR | 1 |
| Tamara, LA | 1 |
| Lee, H | 1 |
| Tsang, W | 1 |
| Houlden, RL | 1 |
| Kimura, H | 1 |
| Kato, Y | 1 |
| Shimizu, S | 1 |
| Takano, K | 3 |
| Sato, K | 3 |
| Franklyn, JA | 1 |
| Boelaert, K | 1 |
| O'Sullivan, AJ | 1 |
| Lewis, M | 1 |
| Diamond, T | 1 |
| Loy, M | 1 |
| Perra, E | 1 |
| Melis, A | 1 |
| Cianchetti, ME | 1 |
| Piga, M | 1 |
| Serra, A | 1 |
| Pinna, G | 1 |
| Mariotti, S | 1 |
| Yamazaki, K | 2 |
| Mitsuhashi, T | 1 |
| Yamada, E | 2 |
| Yamada, T | 1 |
| Kosaka, S | 1 |
| Obara, T | 2 |
| Turner, S | 1 |
| Mathews, L | 1 |
| Pandharipande, P | 1 |
| Thompson, R | 1 |
| Omi, Y | 1 |
| Kodama, H | 1 |
| Seki, T | 1 |
| Shiga, T | 1 |
| Kasanuki, H | 1 |
| Fradkin, JE | 1 |
| Wolff, J | 1 |
| Rajatanavin, R | 2 |
| Safran, M | 1 |
| Stoller, WA | 1 |
| Mordes, JP | 1 |
| Jeng, CY | 1 |
| Bian, TY | 1 |
| Shian, LR | 1 |
| Huang, HW | 1 |
| Shen, DD | 1 |
| Liu, PH | 1 |
| Léger, AF | 1 |
| Fragu, P | 1 |
| Rougier, P | 1 |
| Laurent, MF | 1 |
| Tubiana, M | 1 |
| Savoie, JC | 1 |
| Górowski, T | 1 |
| Matwiszyn, B | 1 |
| Larsen, PR | 1 |
| Allain, P | 1 |
| Berre, S | 1 |
| Krari, N | 1 |
| Lainé-Cessac, P | 1 |
| Le Bouil, A | 1 |
| Barbot, N | 1 |
| Rohmer, V | 1 |
| Bigorgne, JC | 1 |
| Brogioni, S | 1 |
| Mazzeo, S | 1 |
| Vitti, P | 1 |
| Burelli, A | 1 |
| Bartolozzi, C | 1 |
| Martino, E | 1 |
| Henzen, C | 1 |
| Buess, M | 1 |
| Brander, L | 1 |
| Mittendorf, EA | 1 |
| McHenry, CR | 1 |
| Roti, E | 1 |
| Uberti, ED | 1 |
| Papi, G | 1 |
| Carapezzi, C | 1 |
| Corsello, SM | 1 |
| Real, JT | 1 |
| Ascaso, JF | 1 |
| Chailurkit, LO | 1 |
| Kongsuksai, A | 1 |
| Teeravaninthorn, U | 1 |
| Himathongkam, T | 1 |
| Piketty, ML | 1 |
| Talbot, JN | 1 |
| Askienazy, S | 1 |
| Milhaud, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid-Related Upper Lid Retraction With and Without Proptosis[NCT04976816] | Phase 2/Phase 3 | 92 participants (Actual) | Interventional | 2021-12-01 | Completed | ||
| A Randomized, Open-label, Parallel-group Study to Explore the Efficacy of High-intensity Focused Ultrasound (HIFU) Versus Fixed-dose Radioiodine-131 in the Treatment of Relapsed Graves' Disease[NCT03013257] | 240 participants (Actual) | Interventional | 2017-04-25 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for amiodarone and Graves Disease
| Article | Year |
|---|---|
Current approach to surgical management of hyperthyroidism.
Topics: Amiodarone; Antithyroid Agents; Combined Modality Therapy; Graves Disease; Humans; Hyperthyroidism; | 2021 |
Hyperthyroidism.
Topics: Adrenergic beta-Antagonists; Amiodarone; Antithyroid Agents; Diagnosis, Differential; Drug Administr | 2016 |
Amiodarone-induced thyrotoxicosis: a review.
Topics: Amiodarone; Anti-Arrhythmia Agents; Goiter, Nodular; Graves Disease; Humans; Thyroiditis, Subacute; | 2009 |
Thyrotoxicosis.
Topics: Agranulocytosis; Amiodarone; Antithyroid Agents; Atrial Fibrillation; Autoimmune Diseases; Child; Ex | 2012 |
Iodide-induced thyrotoxicosis.
Topics: Adolescent; Adult; Age Factors; Aged; Amiodarone; Child; Clioquinol; Contrast Media; Diagnosis, Diff | 1983 |
Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones.
Topics: Adolescent; Amiodarone; Animals; Brain; Cholecystography; Feedback; Female; Graves Disease; Humans; | 1982 |
Iodine excess and hyperthyroidism.
Topics: Amiodarone; Endemic Diseases; Environmental Exposure; Goiter; Graves Disease; Hyperthyroidism; Iodin | 2001 |
[The management of thyrotoxicosis: a schematic approach].
Topics: Adenoma; Adrenal Cortex Hormones; Adult; Aged; Amiodarone; Antithyroid Agents; Cardiovascular Diseas | 2002 |
[Hyperthyroidism in the aged].
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Amiodarone; Graves Disease; Humans; Hyperthyroidism; | 2002 |
1 trial available for amiodarone and Graves Disease
| Article | Year |
|---|---|
The effect of amiodarone on the control of hyperthyroidism by propylthiouracil.
Topics: Adult; Amiodarone; Drug Therapy, Combination; Female; Graves Disease; Hemodynamics; Humans; Middle A | 1990 |
20 other studies available for amiodarone and Graves Disease
| Article | Year |
|---|---|
[Thyroid ultrasound and its role in the investigation of thyroid disease].
Topics: Amiodarone; Female; Graves Disease; Humans; Thyroid Diseases; Thyrotoxicosis | 2022 |
Delayed diagnosis of dilated thyrotoxic cardiomyopathy with coexistent multifocal atrial tachycardia: a case report.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Delayed Diagnosis; Female; Grave | 2021 |
Identification of Two Different Phenotypes of Patients with Amiodarone-Induced Thyrotoxicosis and Positive Thyrotropin Receptor Antibody Tests.
Topics: Adult; Aged; Amiodarone; Animals; Autoantibodies; Biomarkers; CHO Cells; Cricetulus; Diagnosis, Diff | 2021 |
99mTc Sestamibi Thyroid Scan in Amiodarone-Induced Thyrotoxicosis Type I.
Topics: Aged; Amiodarone; Antithyroid Agents; Graves Disease; Humans; Male; Methimazole; Potassium Channel B | 2016 |
Association of polymorphism at position 49 in exon 1 of the cytotoxic T-lymphocyte-associated factor 4 gene with Graves' disease refractory to medical treatment, but not with amiodarone-associated thyroid dysfunction.
Topics: Adult; Amiodarone; Antigens, CD; CTLA-4 Antigen; Female; Graves Disease; Humans; Male; Middle Aged; | 2009 |
Amiodarone-induced thyrotoxicosis: left ventricular dysfunction is associated with increased mortality.
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Female; Goiter, Nodular; Graves Disease; Humans; Male | 2006 |
Color-flow Doppler sonography in the differential diagnosis and management of amiodarone-induced thyrotoxicosis.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Diagnosis, Differential; Female; Goiter, Nodular; Graves D | 2007 |
Amiodarone reversibly decreases sodium-iodide symporter mRNA expression at therapeutic concentrations and induces antioxidant responses at supraphysiological concentrations in cultured human thyroid follicles.
Topics: Amiodarone; Anti-Arrhythmia Agents; Antioxidants; Cells, Cultured; Dose-Response Relationship, Drug; | 2007 |
Dolasetron-induced torsades de pointes.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Antiemetics; Cardiopulmonary Resusc | 2007 |
Differential diagnosis and appropriate treatment of four thyrotoxic patients with Graves' disease required to take amiodarone due to life-threatening arrhythmia.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Antithyroid Agents; Arrhythmias, Cardiac; Diagnosis, Diff | 2008 |
Five patients with iodine-induced hyperthyroidism.
Topics: Adult; Amiodarone; Chlorobutanol; Coloring Agents; Coronary Artery Bypass; Drug Combinations; Female | 1984 |
A comparative study of the short therapeutic effect of amiodarone and iodine on Graves' thyrotoxicosis.
Topics: Adult; Amiodarone; Benzofurans; Female; Graves Disease; Humans; Iodine; Male; Middle Aged; Thyroid H | 1984 |
Thyroid iodine content measured by x-ray fluorescence in amiodarone-induced thyrotoxicosis: concise communication.
Topics: Amiodarone; Diagnosis, Differential; Female; Follow-Up Studies; Graves Disease; Humans; Hyperthyroid | 1983 |
[Hyperthyroidism following amiodarone treatment].
Topics: Adult; Amiodarone; Benzofurans; Female; Graves Disease; Heart Diseases; Humans | 1982 |
Use of plasma iodine assay for diagnosing thyroid disorders.
Topics: Adult; Aged; Amiodarone; Female; Graves Disease; Humans; Hyperthyroidism; Hypothyroidism; Iodine; Ma | 1993 |
Color flow Doppler sonography rapidly differentiates type I and type II amiodarone-induced thyrotoxicosis.
Topics: Adult; Aged; Amiodarone; Antithyroid Agents; Diagnosis, Differential; Female; Glucocorticoids; Goite | 1997 |
[Iodine-induced hyperthyroidism (iodine-induced Basedow's disease): a current disease picture].
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Antithyroid Agents; Contrast Med | 1999 |
Thyroidectomy for selected patients with thyrotoxicosis.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Female; Graves Disease; Humans; Hypocalcemia; Male; Medi | 2001 |
Iodine induced thyroid disease.
Topics: Amiodarone; Female; Graves Disease; Humans; Hyperthyroidism; Hypothyroidism; Infant, Newborn; Iodine | 1990 |
Clinical significance of a low concentration of thyrotropin: five immunometric "kit" assays compared.
Topics: Adenoma; Adult; Amiodarone; Carbimazole; Depression; Female; Graves Disease; Humans; Hyperthyroidism | 1987 |