amiodarone has been researched along with Drug-Related Side Effects and Adverse Reactions in 76 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The multichannel blocker dronedarone is currently indicated for the maintenance of sinus rhythm after successful cardioversion in adult clinically stable patients with paroxysmal or persistent atrial fibrillation (AF), with careful monitoring of cardiac, hepatic and renal function." | 9.20 | One-year safety and quality of life outcomes in patients with atrial fibrillation on dronedarone: prospective, non-interventional study in German ambulatory care. ( Benninger, G; Bosch, RF; Goette, A; Paar, WD; Pittrow, D; von Stritzky, B, 2015) |
| "While ataxia, neuropathy, and tremors are more commonly seen forms of amiodarone neurotoxicity, very few cases of nystagmus are reported." | 7.01 | Amiodarone-Induced Nystagmus and Ataxia: Case Report and Systematic Review of Case Reports. ( Dumic, I; Kaur, A; Kaur, P; Khaliq, W; Singh, A; Sinha, A, 2023) |
| "Amiodarone was found to be responsible after evaluating for the possible causes of hyponatremia." | 5.91 | Amiodarone-Induced Hyponatremia in An Elderly Patient: A Rare Case Report. ( Chalasani, SH; Jodiya, A; Mahadevappa, M; Pereira, P; Ramesh, M; Syed, JM, 2023) |
| "The multichannel blocker dronedarone is currently indicated for the maintenance of sinus rhythm after successful cardioversion in adult clinically stable patients with paroxysmal or persistent atrial fibrillation (AF), with careful monitoring of cardiac, hepatic and renal function." | 5.20 | One-year safety and quality of life outcomes in patients with atrial fibrillation on dronedarone: prospective, non-interventional study in German ambulatory care. ( Benninger, G; Bosch, RF; Goette, A; Paar, WD; Pittrow, D; von Stritzky, B, 2015) |
| "Amiodarone is one of the more frequently used drugs in the treatment of supraventricular and ventricular arrhythmias." | 4.02 | Amiodarone induced pulmonary toxicity. ( Brázdil, V; Doubková, M; Hetmer, M; Hudec, M; Kala, P; Poloczek, M; Vysočanová, P, 2021) |
| " Monitoring adherence is important as other studies have shown that up to 93% of patients on amiodarone experience an adverse drug event leading to a potentially lethal event." | 3.88 | Frequency of Adverse Event Monitoring in Ambulatory Patients on Amiodarone or Dofetilide. ( Dick, T; Negrelli, J; Olson, JL; Rickard, JP, 2018) |
| " Positive control was amiodarone and thyroxine, as a marker of amiodarone-induced hypothyroidism, a known adverse event with a clear temporal relationship to amiodarone initiation." | 3.81 | Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries. ( Chan, EW; Choi, NK; Kao Yang, YH; Kimura, M; Kimura, T; Kubota, K; Lai, EC; Man, KK; Ooba, N; Park, BJ; Pratt, N; Roughead, EE; Sato, T; Shin, JY; Wong, IC, 2015) |
| " Patient had atrial fibrillation on 3rd post-operative day requiring loading dose of amiodarone followed by maintenance dose to control the arrhythmia." | 3.77 | Ultra-short course of low-dose amiodarone-induced post-operative fatal pulmonary toxicity. ( Nair, SG; Patel, V; Viswam, D, 2011) |
| "While ataxia, neuropathy, and tremors are more commonly seen forms of amiodarone neurotoxicity, very few cases of nystagmus are reported." | 3.01 | Amiodarone-Induced Nystagmus and Ataxia: Case Report and Systematic Review of Case Reports. ( Dumic, I; Kaur, A; Kaur, P; Khaliq, W; Singh, A; Sinha, A, 2023) |
| " Amiodarone possesses a significant adverse reaction profile." | 2.72 | Acute Amiodarone Pulmonary Toxicity. ( Feduska, ET; Goldhammer, JE; Thoma, BN; Torjman, MC, 2021) |
| "Cornea verticillata/vortex keratopathy was the most common ocular adverse effect in cases where amiodarone was administered." | 2.66 | Ocular Adverse Effects of Amiodarone: A Systematic Review of Case Reports. ( Alshehri, M; Joury, A, 2020) |
| "Amiodarone has been associated with adverse events that may restrict its use." | 2.61 | Meta-Analysis Comparing the Relative Risk of Adverse Events for Amiodarone Versus Placebo. ( Aboujamous, NM; Foy, AJ; Ghahramani, M; Mandrola, J; Moroi, MK; Naccarelli, GV; Ruzieh, M, 2019) |
| "Although the pathogenesis of demyelination induced by these drugs remain largely obscure, the recent in vivo and in vitro studies have implicated the involvement of metabolic abnormalities and impaired autophagy in Schwann cells and immune system disorders in the disruption of neuron-Schwann cell contact and interactions." | 2.61 | Drug-Induced Demyelinating Neuropathies. ( Niimi, N; Sango, K; Takaku, S; Yako, H, 2019) |
| " However, adverse effects, especially potentially fatal and non-reversible acute and chronic pulmonary toxicity, continue to be observed." | 2.46 | Amiodarone: review of pulmonary effects and toxicity. ( Kolilekas, L; Manali, ED; Markoulaki, D; Papiris, SA; Triantafillidou, C, 2010) |
| "chronic interstitial pneumonitis, organizing pneumonia, ARDS, a solitary pulmonary mass of fibrosis." | 2.46 | Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect? ( Berghaus, T; Haeckel, T; Schwaiblmair, M; von Scheidt, W; Wagner, T, 2010) |
| "Ranolazine is a new antianginal substance which influences the atrial ion channels and leads to a significant reduction of atrial and more specifically ventricular tachyarrhythmias." | 2.46 | [New developments in the antiarrhythmic therapy of atrial fibrillation]. ( Brachmann, J; Ritscher, G; Simon Demel, K; Simon, H; Turschner, O, 2010) |
| "Damage of the optic nerve (optic neuropathy) may be caused, apart from other reasons, by an adverse drug effect." | 2.44 | [Adverse effect optic neuropathy]. ( Martini, BC, 2008) |
| "The term optic neuropathy is used to describe optic nerve damage caused by any of four main etiologies: ischemic, hereditary, nutritional and toxic." | 2.44 | Drug-induced optic neuropathies. ( Fraunfelder, FW; Lloyd, MJ, 2007) |
| "Reports of drug-induced pulmonary disease from other countries are also reviewed." | 2.38 | Drug-induced pulmonary disease. ( Bryant, DH, 1992) |
| "Amiodarone was found to be responsible after evaluating for the possible causes of hyponatremia." | 1.91 | Amiodarone-Induced Hyponatremia in An Elderly Patient: A Rare Case Report. ( Chalasani, SH; Jodiya, A; Mahadevappa, M; Pereira, P; Ramesh, M; Syed, JM, 2023) |
| " However, chronic use is associated with multisystem toxic side effects." | 1.91 | A Rare Case of Blue-Gray Discoloration Induced by Low-Dose Amiodarone. ( Kaur, A; Mahmood, K; Mehta, D; Tamis-Holland, J, 2023) |
| "We failed to find any signal of parkinsonism with amiodarone." | 1.62 | Amiodarone and Parkinsonism: a pharmacovigilance study. ( Durrieu, G; Montastruc, JL, 2021) |
| "Phospholipidosis is a metabolic disorder characterized by intracellular accumulation of phospholipids." | 1.48 | Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone. ( Boeckmans, J; De Boe, V; De Kock, J; Desmae, T; Natale, A; Rodrigues, RM; Rogiers, V; Vanhaecke, T, 2018) |
| " Incidence and predictors of adverse effects were described." | 1.48 | Adverse effects of amiodarone therapy in adults with congenital heart disease. ( Celermajer, DS; Cordina, RL; McGuire, MA; Moore, BM, 2018) |
| "Simvastatin was associated with muscle cramps [ASR = 1·69, 95% CI (1·61-1·77)]." | 1.46 | Exploring New Zealand prescription data using sequence symmetry analyses for predicting adverse drug reactions. ( Chyou, TY; Nishtala, PS, 2017) |
| "for 4 weeks to induce pulmonary injury in rats and OM-treated groups received 0." | 1.43 | Impact of Olmesartan Medoxomil on Amiodarone-Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor-ß1. ( Abd Allah, OM; Sharaf El-Din, AA, 2016) |
| "Background Drug-drug interactions in patients taking warfarin may contribute to a higher risk of adverse events." | 1.43 | Study of warfarin utilization in hospitalized patients: analysis of possible drug interactions. ( Camargo, HP; Girotto, E; Guidoni, CM; Obreli-Neto, PR; Pereira, LR, 2016) |
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Drug-induced phospholipidosis is marked by an excessive accumulation of phospholipids in lysosomes which can occur after exposure to cationic amphiphilic drugs." | 1.37 | High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis. ( Havinga, J; Horbach, GJ; Ravesloot, WT; Schoonen, WG; van de Water, FM, 2011) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "To understand the bioavailability and mechanistic pathways of cytoprotection by IH636 grape seed proanthocyanidin extract (GSPE, commercially known as ActiVin) a series of in vitro and in vivo studies were conducted." | 1.31 | Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. ( Bagchi, D; Bagchi, M; Preuss, HG; Ray, SD; Stohs, SJ, 2002) |
| "In five patients, after resolution of pneumonitis and after an almost normal BAL cell profile was obtained, resumption of treatment with the suspected drug for two to four weeks induced a rise in lymphocyte population in a third BAL." | 1.28 | Bronchoalveolar lavage cell data in 19 patients with drug-associated pneumonitis (except amiodarone) ( Akoun, GM; Cadranel, JL; D'Ortho, MP; Mayaud, CM; Milleron, BJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (7.89) | 18.7374 |
| 1990's | 8 (10.53) | 18.2507 |
| 2000's | 17 (22.37) | 29.6817 |
| 2010's | 31 (40.79) | 24.3611 |
| 2020's | 14 (18.42) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Mahadevappa, M | 1 |
| Jodiya, A | 1 |
| Chalasani, SH | 1 |
| Syed, JM | 1 |
| Ramesh, M | 1 |
| Pereira, P | 1 |
| Hudec, M | 1 |
| Vysočanová, P | 1 |
| Brázdil, V | 1 |
| Poloczek, M | 1 |
| Hetmer, M | 1 |
| Doubková, M | 1 |
| Kala, P | 1 |
| Gelfman, DM | 1 |
| Yang, PS | 1 |
| Kim, D | 1 |
| Joung, B | 1 |
| Balint Ilie, C | 1 |
| Montón Dito, JM | 1 |
| Esteban Molina, A | 1 |
| Kaur, A | 3 |
| Mehta, D | 2 |
| Mahmood, K | 2 |
| Tamis-Holland, J | 2 |
| Lu, YT | 1 |
| Chao, HJ | 1 |
| Chiang, YC | 1 |
| Chen, HY | 1 |
| Kaur, P | 1 |
| Sinha, A | 1 |
| Khaliq, W | 1 |
| Dumic, I | 1 |
| Singh, A | 1 |
| Nezu, M | 1 |
| Sakuma, M | 1 |
| Nakamura, T | 1 |
| Sonoyama, T | 1 |
| Matsumoto, C | 1 |
| Takeuchi, J | 1 |
| Ohta, Y | 1 |
| Kosaka, S | 1 |
| Morimoto, T | 1 |
| Ruzieh, M | 1 |
| Moroi, MK | 1 |
| Aboujamous, NM | 1 |
| Ghahramani, M | 1 |
| Naccarelli, GV | 1 |
| Mandrola, J | 1 |
| Foy, AJ | 1 |
| Niimi, N | 1 |
| Takaku, S | 1 |
| Yako, H | 1 |
| Sango, K | 1 |
| Alshehri, M | 1 |
| Joury, A | 1 |
| Montastruc, JL | 1 |
| Durrieu, G | 1 |
| Feduska, ET | 1 |
| Thoma, BN | 1 |
| Torjman, MC | 1 |
| Goldhammer, JE | 1 |
| Takahashi, K | 1 |
| Rôlo Silvestre, CM | 1 |
| Nunes, A | 1 |
| Cordeiro, RJ | 1 |
| Eusébio, JP | 1 |
| Vilaça, MT | 1 |
| Falcão, T | 1 |
| Domingos, AC | 1 |
| Takada, M | 1 |
| Yamato, M | 1 |
| Wada, K | 1 |
| Fujimoto, M | 1 |
| Hosomi, K | 1 |
| Hayashi, T | 1 |
| Oita, A | 1 |
| Rowland, A | 2 |
| Sorich, MJ | 1 |
| Mangoni, AA | 1 |
| Rickard, JP | 1 |
| Negrelli, J | 1 |
| Olson, JL | 1 |
| Dick, T | 1 |
| Natale, A | 1 |
| Boeckmans, J | 1 |
| Desmae, T | 1 |
| De Boe, V | 1 |
| De Kock, J | 1 |
| Vanhaecke, T | 1 |
| Rogiers, V | 1 |
| Rodrigues, RM | 1 |
| Roden, AC | 1 |
| Camus, P | 2 |
| Moore, BM | 1 |
| Cordina, RL | 1 |
| McGuire, MA | 1 |
| Celermajer, DS | 1 |
| Moffett, BS | 1 |
| Valdes, SO | 1 |
| Kim, JJ | 1 |
| Otero, MJ | 1 |
| Moreno-Gómez, AM | 1 |
| Santos-Ramos, B | 1 |
| Agra, Y | 1 |
| Goette, A | 1 |
| Benninger, G | 1 |
| Pittrow, D | 1 |
| Paar, WD | 1 |
| von Stritzky, B | 1 |
| Bosch, RF | 1 |
| Pratt, N | 1 |
| Chan, EW | 1 |
| Choi, NK | 1 |
| Kimura, M | 1 |
| Kimura, T | 1 |
| Kubota, K | 1 |
| Lai, EC | 1 |
| Man, KK | 1 |
| Ooba, N | 1 |
| Park, BJ | 1 |
| Sato, T | 1 |
| Shin, JY | 1 |
| Wong, IC | 1 |
| Kao Yang, YH | 1 |
| Roughead, EE | 1 |
| Sharaf El-Din, AA | 1 |
| Abd Allah, OM | 1 |
| Guidoni, CM | 1 |
| Camargo, HP | 1 |
| Obreli-Neto, PR | 1 |
| Girotto, E | 1 |
| Pereira, LR | 1 |
| Nishtala, PS | 1 |
| Chyou, TY | 1 |
| Martini, BC | 1 |
| Li, L | 1 |
| Yang, J | 1 |
| Ding, JW | 1 |
| Bischoff, A | 1 |
| Prystowsky, EN | 1 |
| Thomas, Z | 1 |
| Bandali, F | 1 |
| McCowen, K | 1 |
| Malhotra, A | 1 |
| Papiris, SA | 1 |
| Triantafillidou, C | 1 |
| Kolilekas, L | 1 |
| Markoulaki, D | 1 |
| Manali, ED | 1 |
| Barbesino, G | 1 |
| Schwaiblmair, M | 1 |
| Berghaus, T | 1 |
| Haeckel, T | 1 |
| Wagner, T | 1 |
| von Scheidt, W | 1 |
| Simon, H | 1 |
| Simon Demel, K | 1 |
| Ritscher, G | 1 |
| Turschner, O | 1 |
| Brachmann, J | 1 |
| Van Summeren, A | 1 |
| Renes, J | 1 |
| Bouwman, FG | 1 |
| Noben, JP | 1 |
| van Delft, JH | 1 |
| Kleinjans, JC | 1 |
| Mariman, EC | 1 |
| van de Water, FM | 1 |
| Havinga, J | 1 |
| Ravesloot, WT | 1 |
| Horbach, GJ | 1 |
| Schoonen, WG | 1 |
| Viswam, D | 1 |
| Nair, SG | 1 |
| Patel, V | 1 |
| Duello, KM | 1 |
| Louh, IK | 1 |
| Burger, CD | 1 |
| Lokajová, J | 1 |
| Holopainen, JM | 1 |
| Wiedmer, SK | 1 |
| Aanderud, S | 1 |
| Bagchi, D | 1 |
| Ray, SD | 1 |
| Bagchi, M | 1 |
| Preuss, HG | 1 |
| Stohs, SJ | 1 |
| Bonniaud, P | 1 |
| Fanton, A | 1 |
| Camus, C | 1 |
| Baudaun, N | 1 |
| Foucher, P | 1 |
| Fraunfelder, FW | 2 |
| Fraunfelder, FT | 1 |
| London, Z | 1 |
| Albers, JW | 1 |
| Cahoon, W | 1 |
| Flattery, MP | 1 |
| Hess, ML | 1 |
| Kubo, K | 1 |
| Lloyd, MJ | 1 |
| Granstein, RD | 1 |
| Sober, AJ | 1 |
| Paoletti, V | 1 |
| Galeotta, G | 1 |
| Mammarella, A | 1 |
| Musca, A | 1 |
| Gittoes, NJ | 1 |
| Franklyn, JA | 1 |
| Wenzel, KW | 1 |
| Mattila, MJ | 1 |
| Carrión Valero, F | 1 |
| Marín Pardo, J | 1 |
| Bhagat, R | 1 |
| Sporn, TA | 1 |
| Long, GD | 1 |
| Folz, RJ | 1 |
| Dereure, O | 1 |
| Chabot, F | 1 |
| Aymard, B | 1 |
| Lesur, O | 1 |
| Kheir, A | 1 |
| Moreau, L | 1 |
| Cornette, A | 1 |
| Gerard, H | 1 |
| Delorme, N | 1 |
| Polu, JM | 1 |
| Bryant, DH | 1 |
| Akoun, GM | 1 |
| Cadranel, JL | 1 |
| Milleron, BJ | 1 |
| D'Ortho, MP | 1 |
| Mayaud, CM | 1 |
| White, JP | 1 |
| Ward, MJ | 1 |
| Taylor, F | 1 |
| Cramarossa, L | 1 |
| D'Angelo, D | 1 |
| Galassi, A | 1 |
| Puletti, M | 1 |
| Adler, M | 1 |
| Ros, P | 1 |
| Cremer, M | 1 |
| Quiriny, M | 1 |
| Henry, JP | 1 |
| Lecocq, E | 1 |
| Lauterburg, BH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Modeling of Amiodarone Effect on Heart Rate Control in Critically Ill Patients With Atrial Tachyarrhythmias[NCT03413150] | 80 participants (Actual) | Observational | 2007-01-31 | Completed | |||
| Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes: a 2-years Prospective Multicentric Study[NCT04298684] | Phase 4 | 90 participants (Anticipated) | Interventional | 2021-01-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
30 reviews available for amiodarone and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Amiodarone-Induced Nystagmus and Ataxia: Case Report and Systematic Review of Case Reports.
Topics: Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Ataxia; Atrial Fibrillation; Dizziness; Drug- | 2023 |
Meta-Analysis Comparing the Relative Risk of Adverse Events for Amiodarone Versus Placebo.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug-Related Side Effects and Adverse Reac | 2019 |
Drug-Induced Demyelinating Neuropathies.
Topics: Amiodarone; Axons; Demyelinating Diseases; Dichloroacetic Acid; Drug-Related Side Effects and Advers | 2019 |
Ocular Adverse Effects of Amiodarone: A Systematic Review of Case Reports.
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Case-Control Studies; Corneal Diseases; | 2020 |
Acute Amiodarone Pulmonary Toxicity.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Humans; Lung Di | 2021 |
[Examples of Malfunction Occurred by Interactions between Pharmaceutical Products and Medical Devices That Pharmacists Should Be Aware of].
Topics: Amiodarone; Awareness; Defibrillators, Implantable; Drug-Related Side Effects and Adverse Reactions; | 2021 |
Iatrogenic pulmonary lesions.
Topics: Amiodarone; Anti-Arrhythmia Agents; Antineoplastic Agents; Drug-Related Side Effects and Adverse Rea | 2018 |
[Adverse effect optic neuropathy].
Topics: Acetamides; Amiodarone; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antitubercular Agents; Drug-R | 2008 |
Drug-induced endocrine disorders in the intensive care unit.
Topics: Amiodarone; Anti-Arrhythmia Agents; Antifungal Agents; Antimanic Agents; Critical Care; Cytochrome P | 2010 |
Amiodarone: review of pulmonary effects and toxicity.
Topics: Adverse Drug Reaction Reporting Systems; Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effec | 2010 |
Drugs affecting thyroid function.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Drug Interactions; Drug Monitorin | 2010 |
Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect?
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug-Related Side Effects and Adverse Reac | 2010 |
[New developments in the antiarrhythmic therapy of atrial fibrillation].
Topics: Acetanilides; Aged; Amiodarone; Animals; Anisoles; Anti-Arrhythmia Agents; Atrial Fibrillation; Dron | 2010 |
Drug-induced and iatrogenic infiltrative lung disease.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Humans; Iatroge | 2004 |
Toxic neuropathies associated with pharmaceutic and industrial agents.
Topics: Amiodarone; Antineoplastic Agents; Arsenic; Drug-Related Side Effects and Adverse Reactions; Hazardo | 2007 |
Amiodarone: development, clinical indications, and safety.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug Interactions; Drug-Related Side Effects and Adverse Reactio | 2007 |
[Drug-induced pulmonary edema].
Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; | 2007 |
Drug-induced optic neuropathies.
Topics: Acetamides; Adverse Drug Reaction Reporting Systems; Amiodarone; Anti-Arrhythmia Agents; Anti-Infect | 2007 |
Drug- and heavy metal--induced hyperpigmentation.
Topics: Adrenocorticotropic Hormone; Amiodarone; Antimalarials; Antineoplastic Agents; Argyria; Arsenic; Bis | 1981 |
[Drug-induced lung diseases].
Topics: Adult; Aged; Amiodarone; Animals; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Ch | 1994 |
Drug-induced thyroid disorders.
Topics: Amiodarone; Drug-Related Side Effects and Adverse Reactions; Humans; Iodine; Lithium; Thyroid Diseas | 1995 |
Disturbances of thyroid function tests by drugs.
Topics: Amiodarone; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Humans; Predic | 1996 |
[Drug induced pulmonary symptoms in medicine].
Topics: Amiodarone; Amphotericin B; Bronchoconstriction; Drug-Related Side Effects and Adverse Reactions; Fe | 1996 |
[Pulmonary toxicity caused by drugs].
Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Anti-Infective Agents, Urinary; Anti-Inflammatory | 1999 |
Drug-induced skin pigmentation. Epidemiology, diagnosis and treatment.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalari | 2001 |
Drug-induced pulmonary disease.
Topics: Adrenergic beta-Antagonists; Adverse Drug Reaction Reporting Systems; Aerosols; Amiodarone; Angioten | 1992 |
Drug-induced adverse pulmonary reactions.
Topics: Amiodarone; Asthma; Bleomycin; Carmustine; Drug-Related Side Effects and Adverse Reactions; Gold; Hu | 1985 |
[Drugs and the thyroid gland].
Topics: Adrenergic beta-Antagonists; Amiodarone; Carbamazepine; Danazol; Drug-Related Side Effects and Adver | 1987 |
[Drug-induced hepatic lesions].
Topics: Adenoma; Amiodarone; Amphetamines; Antineoplastic Agents; Budd-Chiari Syndrome; Carcinoma, Hepatocel | 1986 |
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics].
Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adv | 1985 |
1 trial available for amiodarone and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
One-year safety and quality of life outcomes in patients with atrial fibrillation on dronedarone: prospective, non-interventional study in German ambulatory care.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrilla | 2015 |
45 other studies available for amiodarone and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Amiodarone-Induced Hyponatremia in An Elderly Patient: A Rare Case Report.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Female; H | 2023 |
Amiodarone induced pulmonary toxicity.
Topics: Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug-Related Side Effec | 2021 |
Side Effects of Amiodarone.
Topics: Amiodarone; Arrhythmias, Cardiac; Drug-Related Side Effects and Adverse Reactions; Humans | 2022 |
Reply: Side Effects of Amiodarone.
Topics: Amiodarone; Arrhythmias, Cardiac; Drug-Related Side Effects and Adverse Reactions; Humans | 2022 |
[Severe acute hepatic failure secondary to amiodarone overdose].
Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiovascular Agents; Drug-Related Side Effects and Adverse Rea | 2023 |
A Rare Case of Blue-Gray Discoloration Induced by Low-Dose Amiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
A Rare Case of Blue-Gray Discoloration Induced by Low-Dose Amiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
A Rare Case of Blue-Gray Discoloration Induced by Low-Dose Amiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
A Rare Case of Blue-Gray Discoloration Induced by Low-Dose Amiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
Explainable Machine Learning Techniques To Predict Amiodarone-Induced Thyroid Dysfunction Risk: Multicenter, Retrospective Study With External Validation.
Topics: Amiodarone; Drug-Related Side Effects and Adverse Reactions; Hospitals, University; Humans; Machine | 2023 |
Monitoring for adverse drug events of high-risk medications with a computerized clinical decision support system: a prospective cohort study.
Topics: Amiodarone; Decision Support Systems, Clinical; Drug-Related Side Effects and Adverse Reactions; Hum | 2023 |
Amiodarone and Parkinsonism: a pharmacovigilance study.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents | 2021 |
From the Heart to the Lung: A Case of Drug Toxicity.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Female; H | 2021 |
Response: Amiodarone-induced thyroid dysfunction and a perturbed N-desethyl-amiodarone to amiodarone ratio; could a drug-induced toxicity be regulating exposure to the offending agent?
Topics: Amiodarone; Anti-Arrhythmia Agents; Benzofurans; Drug-Related Side Effects and Adverse Reactions; Hu | 2017 |
Amiodarone-induced thyroid dysfunction and a perturbed N-desethyl-amiodarone to amiodarone ratio: could a drug-induced toxicity be regulating exposure to the offending agent?
Topics: Amiodarone; Anti-Arrhythmia Agents; Benzofurans; Drug-Related Side Effects and Adverse Reactions; Hu | 2017 |
Frequency of Adverse Event Monitoring in Ambulatory Patients on Amiodarone or Dofetilide.
Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Cohort Studies; Drug Monitoring; Drug-R | 2018 |
Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone.
Topics: Amiodarone; Cell Differentiation; Cells, Cultured; Drug Evaluation, Preclinical; Drug-Related Side E | 2018 |
Adverse effects of amiodarone therapy in adults with congenital heart disease.
Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Comorbidity; Drug | 2018 |
Amiodarone monitoring practices in pediatric hospitals in the United States.
Topics: Adolescent; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Child; Child, Preschool; Drug | 2013 |
Developing a list of high-alert medications for patients with chronic diseases.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Amiodarone; Analgesics, Opioid; Anti-Arrhythmi | 2014 |
Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries.
Topics: Adverse Drug Reaction Reporting Systems; Amiodarone; Analysis of Variance; Asia; Australia; Chi-Squa | 2015 |
Impact of Olmesartan Medoxomil on Amiodarone-Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor-ß1.
Topics: Amiodarone; Animals; Collagen Type I; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2016 |
Study of warfarin utilization in hospitalized patients: analysis of possible drug interactions.
Topics: Adult; Aged; Amiodarone; Anticoagulants; Aspirin; Brazil; Cross-Sectional Studies; Drug Interactions | 2016 |
Exploring New Zealand prescription data using sequence symmetry analyses for predicting adverse drug reactions.
Topics: Aged; Amiodarone; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Humans; New Z | 2017 |
Drug-induced interstitial pneumonia.
Topics: Amiodarone; Cytotoxins; Drug-Related Side Effects and Adverse Reactions; Humans; Imidazolidines; Lun | 2008 |
[Acute amiodarone-induced hepatotoxicity in a patient].
Topics: Aged; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reac | 2008 |
[Toxic effects on the lung: is "pneumonia" caused by drugs?].
Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-Infective Agents, Urinary; Antibiotics, Antineoplastic; Ant | 2009 |
Drug-induced photosensitivity.
Topics: Aminolevulinic Acid; Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Ca | 2009 |
Atrial fibrillation: Dronedarone and amiodarone-the safety versus efficacy debate.
Topics: Algorithms; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Dronedarone; Drug-Related Side | 2010 |
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
Topics: Acetaminophen; Amiodarone; Blotting, Western; Cell Survival; Chemical and Drug Induced Liver Injury; | 2011 |
High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis.
Topics: Amiodarone; Amitriptyline; Animals; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Drug-Relate | 2011 |
Ultra-short course of low-dose amiodarone-induced post-operative fatal pulmonary toxicity.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Coronary Artery Bypass; Drug-Related Side E | 2011 |
48-Year-old woman with dyspnea, cough, and weight loss.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cough; Diagnosis, Differential; Drug-Relate | 2012 |
Comparison of lipid sinks in sequestering common intoxicating drugs.
Topics: Amiodarone; Amitriptyline; Antidepressive Agents; Drug-Related Side Effects and Adverse Reactions; H | 2012 |
[Drugs and thyroid gland function].
Topics: Amiodarone; Anti-Arrhythmia Agents; Anticonvulsants; Antitubercular Agents; Drug-Related Side Effect | 2002 |
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Analgesics, Non-Narcotic; Ani | 2002 |
Scientific challenges in postmarketing surveillance of ocular adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Amiodarone; Chloramphenicol; Databases, Factual; Drug-Relat | 2007 |
Amiodarone and cyclophosphamide: potential for enhanced lung toxicity.
Topics: Amiodarone; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Synergism; Drug-R | 2001 |
[Drug-induced pulmonary diseases: diagnostic, therapeutic and prognostic aspects. Apropos of 10 personal case reports].
Topics: Adrenal Cortex Hormones; Adult; Aged; Amiodarone; Ampicillin; Antihypertensive Agents; Benzothiadiaz | 1992 |
Bronchoalveolar lavage cell data in 19 patients with drug-associated pneumonitis (except amiodarone)
Topics: Amiodarone; Bronchoalveolar Lavage Fluid; Drug-Related Side Effects and Adverse Reactions; Female; H | 1991 |
Drugs affecting the eye.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Amiodarone; Anti-Inflammatory Agents; Antipsychotic Agen | 1985 |