amiodarone has been researched along with Disease Models, Animal in 127 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The readers will gain an understanding of the findings of recent trials performed with dronedarone, which will provide important information for this relatively new antiarrhythmic drug, used for the treatment of atrial fibrillation." | 8.87 | Dronedarone as a new treatment option for atrial fibrillation patients: pharmacokinetics, pharmacodynamics and clinical practice. ( Lip, GY; Pamukcu, B, 2011) |
| " Dronedarone, the first noniodinated amiodarone congener, has been developed largely to obtain the antiarrhythmic efficacy in the control of atrial fibrillation without the known adverse side effects of dronedarone." | 8.86 | A new agent for atrial fibrillation: electrophysiological properties of dronedarone. ( Cingolani, E; Singh, BN, 2010) |
| " ibutilide) on ventricular fibrillation (VF) and hemodynamic status in a canine heart failure (HF) model." | 7.96 | Ibutilide Reduces Ventricular Defibrillation Threshold and Organizes Ventricular Fibrillation Activation in Canine Heart Failure Model. ( Chen, K; Han, Y; Huang, S; Jin, Q; Lin, C; Luo, Q; Shen, W; Wei, Y; Wu, L; Zhang, N, 2020) |
| "The purpose of this study was to evaluate the effect of atorvastatin administration on amiodarone-induced pulmonary fibrosis in rats." | 7.83 | Coadministration of Atorvastatin and Amiodarone Increases the Risk of Pulmonary Fibrosis in Rats. ( Dabiri, S; Joukar, S; Kheradmand, H; Nasri, HR; Poursalehi, HR, 2016) |
| "This study compared the effects of amiodarone via tibial intraosseous (TIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to ROSC, maximum drug concentration (Cmax), time to maximum concentration (Tmax), and mean concentrations over time in a hypovolemic cardiac arrest model." | 7.83 | The effects of tibial intraosseous versus intravenous amiodarone administration in a hypovolemic cardiac arrest procine model. ( Argame, JI; Bateman, T; Craig, W; Hampton, K; Johnson, D; Wang, E, 2016) |
| "To compare the effects of amiodarone administration by humerus intraosseous (HIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to maximum concentration (Tmax), maximum plasma drug concentration (Cmax), time to ROSC, and mean concentrations over time in a hypovolemic cardiac arrest model." | 7.83 | Effects of humerus intraosseous versus intravenous amiodarone administration in a hypovolemic porcine model. ( Adams, LT; Benham, BE; Bragdon, LG; Garcia-Blanco, JC; Green, LR; Holloway, CM; Johnson, D; Jurina, CS; Orszag, CJ, 2016) |
| "The purpose of the experiment was to compare the effects of nifekalant and amiodarone on the return of spontaneous circulation (ROSC), survival, as well as on the hemodynamic parameters in a swine model of prolonged ventricular fibrillation (VF)." | 7.81 | Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation. ( Iacovidou, N; Karlis, G; Lelovas, P; Mentzelopoulos, S; Niforopoulou, P; Papalois, A; Siafaka, I; Xanthos, T, 2015) |
| "Ranolazine is evaluated for antiarrhythmic therapy of atrial fibrillation (AF)." | 7.79 | Antiarrhythmic effect of ranolazine in combination with class III drugs in an experimental whole-heart model of atrial fibrillation. ( Breithardt, G; Eckardt, L; Frommeyer, G; Kaese, S; Kaiser, D; Milberg, P; Uphaus, T, 2013) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 7.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| " The sheep were prophylactically treated with amiodarone plus lidocaine before ligation of the four to six coronary artery branches supplying the apex of the heart (arrhythmia prevention [AP] group, n = 45) and with epinephrine (shock prevention [SP] group, n = 49), respectively." | 7.79 | Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction. ( Griffith, BP; Li, T; Sanchez, PG; Watkins, AC; Wei, X; Wu, ZJ, 2013) |
| "In clinical trials, dronedarone lowers ventricular rate during atrial fibrillation (AF)." | 7.79 | Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation. ( Belardinelli, L; Kanas, AF; Machado, AD; Nearing, BD; Pagotto, VP; Sobrado, LF; Sobrado, MF; Varone, BB; Verrier, RL; Zeng, D, 2013) |
| "To examine whether low-dose ranolazine and/or dronedarone can protect against vulnerability to atrial fibrillation (AF) and ventricular tachyarrhythmias." | 7.79 | Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia. ( Belardinelli, L; Kanas, AF; Nearing, BD; Pagotto, VP; Sobrado, MF; Verrier, RL; Zeng, D, 2013) |
| ") and amiodarone on the conduction system and on reverse use-dependence in the isolated hearts of normal rats and rats with myocardial infarction (MI)." | 7.78 | The effects of allitridi and amiodarone on the conduction system and reverse use-dependence in the isolated hearts of rats with myocardial infarction. ( Chen, J; Gao, Y; Guo, L; Lu, P; Niu, W; Wang, J; Wang, S; Xing, Y; Zhao, M; Zhu, H, 2012) |
| "The effects of amiodarone on ventricular electrophysiological parameters, especially the dispersion of ventricular repolarization, were investigated in a canine model of congestive heart failure (CHF)." | 7.78 | Effect of amiodarone on dispersion of ventricular repolarization in a canine congestive heart failure model. ( Fang, C; Lei, J; Wang, JF; Zhang, YL; Zheng, SX; Zhou, SX, 2012) |
| " The effects of amiodarone on circadian variation of these variables were determined in rats with myocardial infarction and subsequent congestive heart failure (CHF)." | 7.77 | Circadian changes in autonomic function in conscious rats with heart failure: effects of amiodarone on sympathetic surge. ( Asanoi, H; Hirai, T; Inoue, H; Joho, S; Kameyama, T; Nozawa, T; Ohori, T, 2011) |
| "Amiodarone is a potent anti-atrial fibrillation (AF) agent; however, its systemic administration induces serious side effects such as interstitial pneumonia." | 7.77 | Topical application of a biodegradable disc with amiodarone for atrial fibrillation. ( Hyon, SH; Ikeda, T; Marui, A; Minakata, K; Miwa, S; Nakajima, N; Saito, N; Sakata, R; Shimamoto, T; Takeda, T; Uehara, K, 2011) |
| " Food and Drug Administration for the treatment of patients with atrial fibrillation (AF) as a safe alternative to amiodarone." | 7.76 | Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria. ( Antzelevitch, C; Belardinelli, L; Burashnikov, A, 2010) |
| "The aim of this study was to evaluate the effectiveness of a combination of dronedarone and ranolazine in suppression of atrial fibrillation (AF)." | 7.76 | Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation. ( Antzelevitch, C; Belardinelli, L; Burashnikov, A; Di Diego, JM; Sicouri, S, 2010) |
| "Although amiodarone is one of the most effective pharmacologic agents used in clinical management of atrial fibrillation (AF), little is known about its differential effects in atrial and ventricular myocardium." | 7.74 | Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation. ( Antzelevitch, C; Burashnikov, A; Carlsson, L; Di Diego, JM; Ferreiro, M; Sicouri, S, 2008) |
| "The effects of dronedarone, a non-iodinated derivative of amiodarone, on ventricular tachycardia and ventricular fibrillation post-myocardial infarction are not well established." | 7.74 | Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats. ( Agelaki, MG; Baltogiannis, GG; Fotopoulos, A; Kolettis, TM; Korantzopoulos, P; Pantos, C; Tsalikakis, DG, 2007) |
| "We previously showed that amiodarone, an iodine-rich benzofuranic derivative, interferes with the progression of myocarditis using a rat model of experimental autoimmune myocarditis." | 7.74 | Involvement of thymus in amiodarone-treated autoimmune myocarditis in rats. ( Fu, ML; Han, JF; Katsuda, S; Matsui, S; Zong, ZP, 2008) |
| "Amiodarone is an effective antiarrhythmic drug rarely associated with torsade de pointes arrhythmias (TdP)." | 7.71 | Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome. ( de Groot, SH; Leunissen, JD; Molenschot, MM; Schoenmakers, M; van Der Hulst, FF; van Opstal, JM; Verduyn, SC; Vos, MA; Wellens, HJ, 2001) |
| "The aim of this study was to evaluate the efficacy of a single dose of intravenous amiodarone in facilitating defibrillation of ventricular fibrillation refractory to lidocaine and epinephrine plus direct current countershocks in experimental acute myocardial infarction." | 7.69 | Effects of amiodarone on refractory ventricular fibrillation in acute myocardial infarction: experimental study. ( Anastasiou-Nana, MI; Moulopoulos, SD; Nanas, JN; Nanas, SN; Poyadjis, A; Rapti, A; Stathaki, S, 1994) |
| "We compared the ability of a new amiodarone-like agent, SR 33589, with that of amiodarone, D,L-sotalol, and lignocaine to reduce the incidence of ventricular fibrillation (VF) and associated arrhythmias caused by acute coronary artery occlusion in anesthetized pigs." | 7.69 | Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs. ( Chatelain, P; Finance, O; Manning, A, 1995) |
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 7.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "Associated with amiodarone use is pneumonitis which may progress to life-threatening pulmonary fibrosis." | 7.67 | Pulmonary fibrosis induced in the hamster by amiodarone and desethylamiodarone. ( Brien, JF; Daniels, JM; Massey, TE, 1989) |
| "Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats." | 5.51 | Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. ( Jabbari, R; Jespersen, T; Lubberding, AF; Sattler, SM; Skibsbye, L; Tfelt-Hansen, J; Wakili, R, 2019) |
| "Amiodarone is an effective medication for AF but has limited clinical utility because of off-target tissue toxicity." | 5.48 | Minimally Invasive Delivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces Atrial Fibrillation. ( Bhatia, NK; Campbell, PF; Cesar, L; Deppen, JN; García, AJ; Garcia, JR; Kumar, G; Langberg, JJ; Levit, RD; Robinson, B; Schneider, F; Shin, EY; Wang, L; Xu, K, 2018) |
| "Dronedarone has an atrial-selective property and has been used for management of AF in humans, but limited information is available in dogs." | 5.46 | Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillation. ( Hamlin, RL; Kijtawornrat, A; Limprasutr, V; Saengklub, N; Sawangkoon, S, 2017) |
| "The amiodarone pre-treatment group received 50 mg/kg of amiodarone 1 h before MCAO; the amiodarone post-treatment groups received 50 mg/kg of amiodarone immediately after MCAO; the control group received vehicle only." | 5.46 | Neuroprotective effects of amiodarone in a mouse model of ischemic stroke. ( Hishiyama, S; Ishiyama, T; Kotoda, M; Matsukawa, T; Mitsui, K, 2017) |
| "Swine were anesthetized and placed into cardiac arrest." | 5.43 | The effects of sternal intraosseous and intravenous administration of amiodarone in a hypovolemic swine cardiac arrest model. ( Annelin, J; Borgkvist, B; Johnson, D; Kist, T; Long, R; Smith, S, 2016) |
| "Dronedarone has been demonstrated to be harmful in patients with recent decompensated heart failure." | 5.42 | Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction. ( Bukowska, A; Evert, M; Goette, A; Kühn, JP; Lendeckel, U; Linke, J; Peters, B; Utpatel, K; Wolke, C, 2015) |
| "The score of arrhythmia severity also decreased, but was statistically significant only in the Amio group (p < 0." | 5.40 | Efficacy of Melissa officinalis in suppressing ventricular arrhythmias following ischemia-reperfusion of the heart: a comparison with amiodarone. ( Bashiri, A; Joukar, S; Sepehri, G; Zarisfi, Z, 2014) |
| "Amiodarone pre-treatment led to a prolongation of APD(90) (+19 ms) as compared with sham-controlled hearts but showed only a marginal effect on APD(90) in failing hearts." | 5.37 | A new mechanism preventing proarrhythmia in chronic heart failure: rapid phase-III repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacing-induced heart failure. ( Breithardt, G; Eckardt, L; Fehr, M; Frommeyer, G; Koopmann, M; Lücke, M; Milberg, P; Osada, N; Stypmann, J; Witte, P, 2011) |
| "Amiodarone is effective in treating persistent atrial fibrillation compared with other antiarrhythmic drugs." | 5.33 | Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced persistent atrial fibrillation model. ( Ashikaga, K; Furukawa, K; Iwasa, A; Kimura, M; Kobayashi, T; Motomura, S; Okumura, K; Owada, S; Sasaki, S, 2006) |
| "Bretylium was removed from Advanced Cardiac Life Support guidelines, and, to date, efficacy of amiodarone in hypothermia is unknown." | 5.32 | Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model. ( Ehlers, J; Martin, G; O'Mara, K; Stoner, J; Tomlanovich, M, 2003) |
| "The amiodarone-treated animals showed a significant reduction in the coefficient of diffusion (kCO) and a significant increase in lung hydroxyproline levels as compared to the control group." | 5.29 | Amiodarone-induced pulmonary fibrosis in Fischer 344 rats. ( Gairola, CG; Lai, YL; Reinhart, PG, 1996) |
| " It also has antiarrhythmic properties and may thus be an alternative to amiodarone for the treatment of ventricular fibrillation (VF)." | 5.24 | Dantrolene versus amiodarone for cardiopulmonary resuscitation: a randomized, double-blinded experimental study. ( Dersch, W; Eschbach, D; Feldmann, C; Freitag, D; Irqsusi, M; Steinfeldt, T; Wiesmann, T; Wulf, H, 2017) |
| " The heart rhythm was monitored continuously and ventricular arrhythmias were treated with amiodarone and cardioversion." | 5.12 | Decreased mortality in a rat model of acute postinfarction heart failure. ( Lorentzon, M; Omerovic, E; Råmunddal, T, 2006) |
| "The readers will gain an understanding of the findings of recent trials performed with dronedarone, which will provide important information for this relatively new antiarrhythmic drug, used for the treatment of atrial fibrillation." | 4.87 | Dronedarone as a new treatment option for atrial fibrillation patients: pharmacokinetics, pharmacodynamics and clinical practice. ( Lip, GY; Pamukcu, B, 2011) |
| " Dronedarone, the first noniodinated amiodarone congener, has been developed largely to obtain the antiarrhythmic efficacy in the control of atrial fibrillation without the known adverse side effects of dronedarone." | 4.86 | A new agent for atrial fibrillation: electrophysiological properties of dronedarone. ( Cingolani, E; Singh, BN, 2010) |
| "We conducted a literature review between 1990 and 2006 in MEDLINE using the following MeSH headings: swine, dogs, resuscitation, heart arrest, EMS, EMT, ambulance, ventricular fibrillation, drug therapy, epinephrine, vasopressin, amiodarone, lidocaine, magnesium, and sodium bicarbonate." | 4.84 | Drug administration in animal studies of cardiac arrest does not reflect human clinical experience. ( Menegazzi, JJ; Reynolds, JC; Rittenberger, JC, 2007) |
| " ibutilide) on ventricular fibrillation (VF) and hemodynamic status in a canine heart failure (HF) model." | 3.96 | Ibutilide Reduces Ventricular Defibrillation Threshold and Organizes Ventricular Fibrillation Activation in Canine Heart Failure Model. ( Chen, K; Han, Y; Huang, S; Jin, Q; Lin, C; Luo, Q; Shen, W; Wei, Y; Wu, L; Zhang, N, 2020) |
| " Acute amiodarone at the dose of 75 mg/kg significantly potentiated the anticonvulsive effect of carbamazepine, but not that of valproate, phenytoin or phenobarbital in the maximal electroshock-induced seizures in mice." | 3.88 | Amiodarone, a multi-channel blocker, enhances anticonvulsive effect of carbamazepine in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2018) |
| "The purpose of this study was to evaluate the effect of atorvastatin administration on amiodarone-induced pulmonary fibrosis in rats." | 3.83 | Coadministration of Atorvastatin and Amiodarone Increases the Risk of Pulmonary Fibrosis in Rats. ( Dabiri, S; Joukar, S; Kheradmand, H; Nasri, HR; Poursalehi, HR, 2016) |
| "This study compared the effects of amiodarone via tibial intraosseous (TIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to ROSC, maximum drug concentration (Cmax), time to maximum concentration (Tmax), and mean concentrations over time in a hypovolemic cardiac arrest model." | 3.83 | The effects of tibial intraosseous versus intravenous amiodarone administration in a hypovolemic cardiac arrest procine model. ( Argame, JI; Bateman, T; Craig, W; Hampton, K; Johnson, D; Wang, E, 2016) |
| "To compare the effects of amiodarone administration by humerus intraosseous (HIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to maximum concentration (Tmax), maximum plasma drug concentration (Cmax), time to ROSC, and mean concentrations over time in a hypovolemic cardiac arrest model." | 3.83 | Effects of humerus intraosseous versus intravenous amiodarone administration in a hypovolemic porcine model. ( Adams, LT; Benham, BE; Bragdon, LG; Garcia-Blanco, JC; Green, LR; Holloway, CM; Johnson, D; Jurina, CS; Orszag, CJ, 2016) |
| "The purpose of the experiment was to compare the effects of nifekalant and amiodarone on the return of spontaneous circulation (ROSC), survival, as well as on the hemodynamic parameters in a swine model of prolonged ventricular fibrillation (VF)." | 3.81 | Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation. ( Iacovidou, N; Karlis, G; Lelovas, P; Mentzelopoulos, S; Niforopoulou, P; Papalois, A; Siafaka, I; Xanthos, T, 2015) |
| "Ranolazine is evaluated for antiarrhythmic therapy of atrial fibrillation (AF)." | 3.79 | Antiarrhythmic effect of ranolazine in combination with class III drugs in an experimental whole-heart model of atrial fibrillation. ( Breithardt, G; Eckardt, L; Frommeyer, G; Kaese, S; Kaiser, D; Milberg, P; Uphaus, T, 2013) |
| "To compare the early postarrest inflammatory cytokine response between animals administered amiodarone (AMIO) and lidocaine (LIDO) intra-arrest during resuscitation from ventricular fibrillation (VF)." | 3.79 | Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. ( Niemann, JT; Rosborough, JP; Shah, AP; Thomas, JL; Youngquist, ST, 2013) |
| " The sheep were prophylactically treated with amiodarone plus lidocaine before ligation of the four to six coronary artery branches supplying the apex of the heart (arrhythmia prevention [AP] group, n = 45) and with epinephrine (shock prevention [SP] group, n = 49), respectively." | 3.79 | Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction. ( Griffith, BP; Li, T; Sanchez, PG; Watkins, AC; Wei, X; Wu, ZJ, 2013) |
| "In clinical trials, dronedarone lowers ventricular rate during atrial fibrillation (AF)." | 3.79 | Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation. ( Belardinelli, L; Kanas, AF; Machado, AD; Nearing, BD; Pagotto, VP; Sobrado, LF; Sobrado, MF; Varone, BB; Verrier, RL; Zeng, D, 2013) |
| "To examine whether low-dose ranolazine and/or dronedarone can protect against vulnerability to atrial fibrillation (AF) and ventricular tachyarrhythmias." | 3.79 | Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia. ( Belardinelli, L; Kanas, AF; Nearing, BD; Pagotto, VP; Sobrado, MF; Verrier, RL; Zeng, D, 2013) |
| "Targeting the delivery of liposomal amiodarone to ischemic/reperfused myocardium reduces the mortality due to lethal arrhythmia and the negative hemodynamic changes caused by amiodarone." | 3.79 | Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model. ( Asai, T; Asakura, M; Asano, Y; Asanuma, H; Fu, HY; Kitakaze, M; Komuro, I; Matsuzaki, T; Minamino, T; Oku, N; Okuda, K; Sanada, S; Shigematsu, H; Takahama, H; Yamato, M, 2013) |
| "Amiodarone has a moderate slowing effect on the VT cycle length." | 3.79 | Interactions between implantable cardioverter-defibrillators and class III agents. ( Marchlinski, FE; Movsowitz, C, 1998) |
| ") and amiodarone on the conduction system and on reverse use-dependence in the isolated hearts of normal rats and rats with myocardial infarction (MI)." | 3.78 | The effects of allitridi and amiodarone on the conduction system and reverse use-dependence in the isolated hearts of rats with myocardial infarction. ( Chen, J; Gao, Y; Guo, L; Lu, P; Niu, W; Wang, J; Wang, S; Xing, Y; Zhao, M; Zhu, H, 2012) |
| "The effects of amiodarone on ventricular electrophysiological parameters, especially the dispersion of ventricular repolarization, were investigated in a canine model of congestive heart failure (CHF)." | 3.78 | Effect of amiodarone on dispersion of ventricular repolarization in a canine congestive heart failure model. ( Fang, C; Lei, J; Wang, JF; Zhang, YL; Zheng, SX; Zhou, SX, 2012) |
| " The effects of amiodarone on circadian variation of these variables were determined in rats with myocardial infarction and subsequent congestive heart failure (CHF)." | 3.77 | Circadian changes in autonomic function in conscious rats with heart failure: effects of amiodarone on sympathetic surge. ( Asanoi, H; Hirai, T; Inoue, H; Joho, S; Kameyama, T; Nozawa, T; Ohori, T, 2011) |
| "Amiodarone is a potent anti-atrial fibrillation (AF) agent; however, its systemic administration induces serious side effects such as interstitial pneumonia." | 3.77 | Topical application of a biodegradable disc with amiodarone for atrial fibrillation. ( Hyon, SH; Ikeda, T; Marui, A; Minakata, K; Miwa, S; Nakajima, N; Saito, N; Sakata, R; Shimamoto, T; Takeda, T; Uehara, K, 2011) |
| "Clinical studies have demonstrated the efficacy of oral and intravenous amiodarone therapy to prevent postoperative atrial fibrillation." | 3.76 | Atrium-targeted drug delivery through an amiodarone-eluting bilayered patch. ( Boerakker, MJ; Bolderman, RW; Bruin, P; Dias, AA; Hermans, JJ; Maessen, JG; van der Veen, FH, 2010) |
| " Food and Drug Administration for the treatment of patients with atrial fibrillation (AF) as a safe alternative to amiodarone." | 3.76 | Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria. ( Antzelevitch, C; Belardinelli, L; Burashnikov, A, 2010) |
| "After 4min of untreated ventricular fibrillation, animals were randomly treated with nifekalant (2mgkg(-1)), amiodarone (5mgkg(-1)) or saline placebo (n=12 pigs per group)." | 3.76 | Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest. ( Cong, LH; Ji, XF; Li, CS; Wang, S; Yang, L, 2010) |
| "The aim of this study was to evaluate the effectiveness of a combination of dronedarone and ranolazine in suppression of atrial fibrillation (AF)." | 3.76 | Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation. ( Antzelevitch, C; Belardinelli, L; Burashnikov, A; Di Diego, JM; Sicouri, S, 2010) |
| "Although amiodarone is one of the most effective pharmacologic agents used in clinical management of atrial fibrillation (AF), little is known about its differential effects in atrial and ventricular myocardium." | 3.74 | Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation. ( Antzelevitch, C; Burashnikov, A; Carlsson, L; Di Diego, JM; Ferreiro, M; Sicouri, S, 2008) |
| "The effects of dronedarone, a non-iodinated derivative of amiodarone, on ventricular tachycardia and ventricular fibrillation post-myocardial infarction are not well established." | 3.74 | Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats. ( Agelaki, MG; Baltogiannis, GG; Fotopoulos, A; Kolettis, TM; Korantzopoulos, P; Pantos, C; Tsalikakis, DG, 2007) |
| "We previously showed that amiodarone, an iodine-rich benzofuranic derivative, interferes with the progression of myocarditis using a rat model of experimental autoimmune myocarditis." | 3.74 | Involvement of thymus in amiodarone-treated autoimmune myocarditis in rats. ( Fu, ML; Han, JF; Katsuda, S; Matsui, S; Zong, ZP, 2008) |
| "The long-term cardiac effects of amiodarone resemble many aspects of hypothyroidism." | 3.74 | Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile. ( Futaki, S; Hayashi, Y; Kambe, F; Kodama, I; Lee, JK; Murata, Y; Seo, H; Shi, RQ; Takeuchi, Y, 2008) |
| "Pretreatment with amiodarone does not appear to significantly alter the lethality of amitriptyline poisoning in mice." | 3.73 | Amiodarone fails to improve survival in amitriptyline-poisoned mice. ( Barrueto, F; Chuang, A; Cotter, BW; Hoffman, RS; Nelson, LS, 2005) |
| " Amiodarone is recommended for treatment of wide complex tachycardia, but its hemodynamic effects in wide complex tachycardia induced by tricyclic antidepressant poisoning are unknown." | 3.73 | Effects of amiodarone in a swine model of nortriptyline [corrected] toxicity. ( Barrueto, F; Brewer, K; Meggs, W; Meltzer, A; Murr, I, 2006) |
| " Intratracheal AM administration resulted in pulmonary fibrosis 21 days posttreatment, as evidenced by an increased hydroxyproline content and histological damage." | 3.72 | Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity. ( Brien, JF; Card, JW; Margolin, SB; Massey, TE; Racz, WJ, 2003) |
| "Data from this experimental animal model suggest that vasopressin and amiodarone may not be beneficial for treatment of ventricular fibrillation associated with severe hypothermia when concomitant measures at core rewarming are not applied." | 3.72 | Neither vasopressin nor amiodarone improve CPR outcome in an animal model of hypothermic cardiac arrest. ( Girg, S; Lindner, KH; Mair, P; Schwarz, B; Stadlbauer, KH; Wagner-Berger, H; Wenzel, V, 2003) |
| "Amiodarone is an effective antiarrhythmic drug rarely associated with torsade de pointes arrhythmias (TdP)." | 3.71 | Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome. ( de Groot, SH; Leunissen, JD; Molenschot, MM; Schoenmakers, M; van Der Hulst, FF; van Opstal, JM; Verduyn, SC; Vos, MA; Wellens, HJ, 2001) |
| "We evaluated the effect of two different doses of desethylamiodarone (DEA) and amiodarone on the ventricular fibrillation threshold (VFT)." | 3.70 | A comparison of the antifibrillatory effects of desethylamiodarone to amiodarone in a swine model. ( Chen, BP; Chow, MS; Fan, C; Kluger, J; White, CM; Zhou, L, 1999) |
| "The aim of this study was to evaluate the efficacy of a single dose of intravenous amiodarone in facilitating defibrillation of ventricular fibrillation refractory to lidocaine and epinephrine plus direct current countershocks in experimental acute myocardial infarction." | 3.69 | Effects of amiodarone on refractory ventricular fibrillation in acute myocardial infarction: experimental study. ( Anastasiou-Nana, MI; Moulopoulos, SD; Nanas, JN; Nanas, SN; Poyadjis, A; Rapti, A; Stathaki, S, 1994) |
| "Intratracheal instillation of the antiarrhythmic drug amiodarone (AD) in hamsters is an established animal model of AD-induced pulmonary fibrosis." | 3.69 | Metabolism of amiodarone following intratracheal instillation in hamsters. ( Blake, TL; Reasor, MJ, 1995) |
| "We compared the ability of a new amiodarone-like agent, SR 33589, with that of amiodarone, D,L-sotalol, and lignocaine to reduce the incidence of ventricular fibrillation (VF) and associated arrhythmias caused by acute coronary artery occlusion in anesthetized pigs." | 3.69 | Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs. ( Chatelain, P; Finance, O; Manning, A, 1995) |
| "We have assessed the ability of the new amiodarone-like antiarrhythmic agent, SR 33589, to reduce the incidence of ischemia- and reperfusion-induced arrhythmias, in comparison to amiodarone, D-sotalol, and lignocaine." | 3.69 | SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. ( Bruyninckx, C; Chatelain, P; Manning, AS; Ramboux, J, 1995) |
| "Associated with amiodarone use is pneumonitis which may progress to life-threatening pulmonary fibrosis." | 3.67 | Pulmonary fibrosis induced in the hamster by amiodarone and desethylamiodarone. ( Brien, JF; Daniels, JM; Massey, TE, 1989) |
| "Drug-induced interstitial lung disease has been reported as a severe adverse effect of some drugs, such as bleomycin, amiodarone, and methotrexate." | 2.82 | Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics. ( Li, S; Shi, J; Tang, H, 2022) |
| "Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds." | 2.52 | Mechanistic review of drug-induced steatohepatitis. ( Guo, GL; Schumacher, JD, 2015) |
| "Dronedarone is a benzofuran derivative structurally similar to amiodarone but non-iodinated." | 2.46 | [Clinical pharmacology and electrophysiological properties of dronedarone]. ( Goette, A; Hohnloser, S; Kirch, W; Lewalter, T; Pittrow, D, 2010) |
| "Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces numerous adverse effects." | 2.39 | Mechanisms in the pathogenesis of amiodarone-induced pulmonary toxicity. ( Brien, JF; Leeder, RG; Massey, TE; Rafeiro, E, 1995) |
| "Chrysin were effective in reducing injury area, reducing inflammation, and promoting the secretion of bFGF, it can promote the healing of skin injury induced by amiodarone extravasation in rats." | 1.72 | Experimental study on the effect of chrysin on skin injury induced by amiodarone extravasation in rats. ( Chen, K; Liang, Y; Liu, L; Mai, Y; Zhou, X, 2022) |
| "Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats." | 1.51 | Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. ( Jabbari, R; Jespersen, T; Lubberding, AF; Sattler, SM; Skibsbye, L; Tfelt-Hansen, J; Wakili, R, 2019) |
| "Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive deposition of droplets in hepatocytes." | 1.51 | Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats. ( Eguchi, A; Ichikawa, R; Masuda, S; Mizukami, S; Nakamura, K; Nakamura, M; Okada, R; Shibutani, M; Tanaka, T; Yoshida, T, 2019) |
| "Amiodarone is an effective medication for AF but has limited clinical utility because of off-target tissue toxicity." | 1.48 | Minimally Invasive Delivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces Atrial Fibrillation. ( Bhatia, NK; Campbell, PF; Cesar, L; Deppen, JN; García, AJ; Garcia, JR; Kumar, G; Langberg, JJ; Levit, RD; Robinson, B; Schneider, F; Shin, EY; Wang, L; Xu, K, 2018) |
| "Dronedarone has an atrial-selective property and has been used for management of AF in humans, but limited information is available in dogs." | 1.46 | Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillation. ( Hamlin, RL; Kijtawornrat, A; Limprasutr, V; Saengklub, N; Sawangkoon, S, 2017) |
| "The amiodarone pre-treatment group received 50 mg/kg of amiodarone 1 h before MCAO; the amiodarone post-treatment groups received 50 mg/kg of amiodarone immediately after MCAO; the control group received vehicle only." | 1.46 | Neuroprotective effects of amiodarone in a mouse model of ischemic stroke. ( Hishiyama, S; Ishiyama, T; Kotoda, M; Matsukawa, T; Mitsui, K, 2017) |
| "Anti-atrial fibrillatory and proarrhythmic potentials of amiodarone were simultaneously analyzed by using the halothane-anesthetized beagle dogs (n = 4) in order to begin to prepare standard protocol for clarifying both efficacy and adverse effects of anti-atrial fibrillatory drugs." | 1.46 | Anti-atrial Fibrillatory Versus Proarrhythmic Potentials of Amiodarone: A New Protocol for Safety Evaluation In Vivo. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| "for 4 weeks to induce pulmonary injury in rats and OM-treated groups received 0." | 1.43 | Impact of Olmesartan Medoxomil on Amiodarone-Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor-ß1. ( Abd Allah, OM; Sharaf El-Din, AA, 2016) |
| "In this study, we assessed influence of electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits." | 1.43 | Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits. ( Chiba, T; Kondo, N; Takahara, A, 2016) |
| "Swine were anesthetized and placed into cardiac arrest." | 1.43 | The effects of sternal intraosseous and intravenous administration of amiodarone in a hypovolemic swine cardiac arrest model. ( Annelin, J; Borgkvist, B; Johnson, D; Kist, T; Long, R; Smith, S, 2016) |
| "Dronedarone has been demonstrated to be harmful in patients with recent decompensated heart failure." | 1.42 | Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction. ( Bukowska, A; Evert, M; Goette, A; Kühn, JP; Lendeckel, U; Linke, J; Peters, B; Utpatel, K; Wolke, C, 2015) |
| "Survival after out-of-hospital cardiac arrest (OHCA) remains poor." | 1.40 | Early coronary revascularization improves 24h survival and neurological function after ischemic cardiac arrest. A randomized animal study. ( Caldwell, E; Garcia, S; Henry, P; Lurie, K; Magkoutis, N; McKnite, S; Rees, J; Sarraf, M; Sharma, A; Sideris, G; Yannopoulos, D, 2014) |
| "Treatment with dronedarone 200mg/kg/day had no effect on body weight, serum transaminases and bilirubin, and hepatic mitochondrial function in both wild-type and jvs(+/-) mice." | 1.40 | Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. ( Bouitbir, J; Donzelli, M; Felser, A; Krähenbühl, S; Morand, R; Schnell, D; Stoller, A; Terracciano, L, 2014) |
| "The score of arrhythmia severity also decreased, but was statistically significant only in the Amio group (p < 0." | 1.40 | Efficacy of Melissa officinalis in suppressing ventricular arrhythmias following ischemia-reperfusion of the heart: a comparison with amiodarone. ( Bashiri, A; Joukar, S; Sepehri, G; Zarisfi, Z, 2014) |
| "Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects." | 1.40 | Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis. ( Chambers, RC; Guenther, A; Henneke, I; Knudsen, L; Korfei, M; Liebisch, G; Mahavadi, P; Ochs, M; Ruppert, C; Schmitz, G; Seeger, W; Vancheri, C; Venkatesan, S, 2014) |
| "The results suggest that pretreatment with saffron, especially at the dosage of 100 mg/kg/day, attenuates the susceptibility and incidence of fatal ventricular arrhythmia during the reperfusion period in the rat." | 1.39 | Protective effects of saffron (Crocus sativus) against lethal ventricular arrhythmias induced by heart reperfusion in rat: a potential anti-arrhythmic agent. ( Bashiri, A; Ghasemipour-Afshar, E; Joukar, S; Naghsh, N; Sheibani, M, 2013) |
| "Amiodarone treatment caused a significant increase in the percentage of chromosomal aberrations, decreased the mitotic index and increased DNA damage." | 1.39 | Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats. ( El-Shafey, SS; Sakr, SA; Zoil, Mel-S, 2013) |
| "Sheep experiencing life-threatening arrhythmias, most commonly ventricular fibrillation, were either resuscitated according to operator-driven instructions or the standardized protocol." | 1.39 | Benefits of standardizing the treatment of arrhythmias in the sheep (Ovis aries) model of chronic heart failure after myocardial infarction. ( Cheng, Y; Conditt, GB; Dardenne, A; Feeney, WP; Fernandez, C; Granada, JF; Kaluza, GL; Milewski, K; Mount, PA; Ordanes, DR; Tellez, A; Wagner, A; Yi, GH, 2013) |
| "Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism." | 1.39 | Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes. ( Ben-Eltriki, M; Brocks, DR; El-Kadi, AO; Hamdy, DA; Patel, JP, 2013) |
| "Amiodarone pre-treatment led to a prolongation of APD(90) (+19 ms) as compared with sham-controlled hearts but showed only a marginal effect on APD(90) in failing hearts." | 1.37 | A new mechanism preventing proarrhythmia in chronic heart failure: rapid phase-III repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacing-induced heart failure. ( Breithardt, G; Eckardt, L; Fehr, M; Frommeyer, G; Koopmann, M; Lücke, M; Milberg, P; Osada, N; Stypmann, J; Witte, P, 2011) |
| "Cardiac arrhythmias include problems with impulse formation and/or conduction abnormalities." | 1.36 | Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity. ( Adlerz, K; Chen, JN; Chi, N; Hamdan, MH; Hsiai, TK; Huang, J; Jadvar, H; Yu, F, 2010) |
| "Hyperlipidemia caused large increases in plasma concentrations of amiodarone." | 1.35 | The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat. ( Brocks, DR; El-Kadi, AO; Korashy, H; Patel, JP; Shayeganpour, A, 2008) |
| "Treatment with amiodarone solution containing high concentration of calcium had a lower potentiating effect compared with that of perfusion with either of them." | 1.35 | [Possible role of sarcoplasmatic reticulum in anti-arrhythmic effects of the class III agent amiodarone]. ( Afanas'ev, SA; Falaleeva, LP; Kondrat'eva, DS; Popov, SV, 2009) |
| "Amiodarone was administered to groups of rats once per day for 30 days." | 1.35 | Preventive effect of amiodarone during acute period in isoproterenol-induced myocardial injury in Wistar rats. ( Albayrak, F; Bakan, E; Bayir, Y; Bayram, E; Halici, Z; Kabalar, E; Keles, MS; Kurt, M; Ozturk, C; Suleyman, H, 2009) |
| "Amiodarone treatment improved left ventricular pressure, central venous pressure, and rate of isovolumetric contraction and decreased ventricular weight (P<0." | 1.33 | Amiodarone improves cardiac sympathetic nerve function to hold norepinephrine in the heart, prevents left ventricular remodeling, and improves cardiac function in rat dilated cardiomyopathy. ( Aizawa, Y; Hanawa, H; Hirono, S; Ito, M; Kashimura, T; Kato, K; Kodama, M; Ma, M; Okura, Y; Tachikawa, H; Takahashi, T; Watanabe, K, 2005) |
| "To establish a novel arrhythmia model in rats." | 1.33 | [Establishment of a novel arrhythmia model in rats]. ( Dong, DL; Du, ZM; Jiao, JD; Pan, ZW; Wang, ZY; Yang, BF, 2005) |
| "Amiodarone is effective in treating persistent atrial fibrillation compared with other antiarrhythmic drugs." | 1.33 | Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced persistent atrial fibrillation model. ( Ashikaga, K; Furukawa, K; Iwasa, A; Kimura, M; Kobayashi, T; Motomura, S; Okumura, K; Owada, S; Sasaki, S, 2006) |
| " Second, based on preliminary investigations, an approximate intraperitoneal LD50 dose of cocaine (110 mg/kg) was identified and used as the cocaine dose in this study." | 1.33 | The effect of amiodarone pretreatment on survival of mice with cocaine toxicity. ( Cleveland, N; Dart, RC; DeWitt, CR; Heard, K, 2005) |
| "Bretylium was removed from Advanced Cardiac Life Support guidelines, and, to date, efficacy of amiodarone in hypothermia is unknown." | 1.32 | Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model. ( Ehlers, J; Martin, G; O'Mara, K; Stoner, J; Tomlanovich, M, 2003) |
| "Amiodarone is a widely used and potent antiarrhythmic agent that is metabolized to desethylamiodarone." | 1.32 | Protective effect of amiodarone but not N-desethylamiodarone on postischemic hearts through the inhibition of mitochondrial permeability transition. ( Bognar, Z; Gallyas, F; Sumegi, B; Tapodi, A; Toth, A; Varbiro, G; Veres, B, 2003) |
| "Tachyarrhythmia was evoked in isolated rat right atria by trains of electric stimuli." | 1.32 | Cholinergic-adrenergic antagonism in the induction of tachyarrhythmia by electrical stimulation in isolated rat atria. ( Bassani, JW; Bassani, RA; Zafalon, N, 2004) |
| "In amiodarone-treated, hypokalemic hearts, no EAD or TdP occurred." | 1.32 | Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block. ( Breithardt, G; Eckardt, L; Haverkamp, W; Milberg, P; Mönnig, G; Osada, N; Ramtin, S; Wasmer, K, 2004) |
| " Male F344 rats were intratracheally dosed with AD (6." | 1.31 | Quantitative image analysis of drug-induced lung fibrosis using laser scanning confocal microscopy. ( Antonini, JM; Hubbs, AF; Reasor, MJ; Roberts, JR; Taylor, MD, 2002) |
| "Exposure to the toxic mineral dust silica has been shown to produce an acute inflammatory response in the lungs of both humans and laboratory animals." | 1.29 | Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis. ( Antonini, JM; McCloud, CM; Reasor, MJ, 1994) |
| "Amiodarone is an effective antidysrhythmic agent, restricted in use by the development of pulmonary toxicity." | 1.29 | Resistance of the hamster to amiodarone-induced pulmonary toxicity following repeated intraperitoneal administration. ( Brien, JF; Evans, CD; Leeder, RG; Massey, TE, 1994) |
| "The amiodarone-treated animals showed a significant reduction in the coefficient of diffusion (kCO) and a significant increase in lung hydroxyproline levels as compared to the control group." | 1.29 | Amiodarone-induced pulmonary fibrosis in Fischer 344 rats. ( Gairola, CG; Lai, YL; Reinhart, PG, 1996) |
| "Protection from arrhythmias seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation." | 1.27 | The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. ( Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (2.36) | 18.7374 |
| 1990's | 16 (12.60) | 18.2507 |
| 2000's | 34 (26.77) | 29.6817 |
| 2010's | 66 (51.97) | 24.3611 |
| 2020's | 8 (6.30) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Nakamura, K | 2 |
| Neidig, LE | 1 |
| Yang, X | 1 |
| Weber, GJ | 1 |
| El-Nachef, D | 1 |
| Tsuchida, H | 1 |
| Dupras, S | 1 |
| Kalucki, FA | 1 |
| Jayabalu, A | 1 |
| Futakuchi-Tsuchida, A | 1 |
| Nakamura, DS | 1 |
| Marchianò, S | 1 |
| Bertero, A | 1 |
| Robinson, MR | 1 |
| Cain, K | 1 |
| Whittington, D | 1 |
| Tian, R | 1 |
| Reinecke, H | 1 |
| Pabon, L | 1 |
| Knollmann, BC | 1 |
| Kattman, S | 1 |
| Thies, RS | 1 |
| MacLellan, WR | 1 |
| Murry, CE | 1 |
| Liu, L | 1 |
| Mai, Y | 1 |
| Liang, Y | 1 |
| Zhou, X | 1 |
| Chen, K | 2 |
| Li, S | 1 |
| Shi, J | 1 |
| Tang, H | 1 |
| Barbosa, JMC | 1 |
| Pedra Rezende, Y | 1 |
| de Melo, TG | 1 |
| de Oliveira, G | 1 |
| Cascabulho, CM | 1 |
| Pereira, ENGDS | 1 |
| Daliry, A | 1 |
| Salem, KS | 1 |
| Venugopal, J | 1 |
| Wang, J | 3 |
| Guo, C | 1 |
| Eitzman, DT | 1 |
| Xie, X | 1 |
| Chen, Y | 1 |
| Hu, Y | 1 |
| He, Y | 1 |
| Zhang, H | 1 |
| Li, Y | 1 |
| Zhang, N | 2 |
| Luo, Q | 1 |
| Jin, Q | 2 |
| Han, Y | 1 |
| Huang, S | 1 |
| Wei, Y | 1 |
| Lin, C | 2 |
| Shen, W | 2 |
| Wu, L | 2 |
| Banach, M | 2 |
| Rudkowska, M | 1 |
| Sumara, A | 1 |
| Borowicz-Reutt, K | 1 |
| Saengklub, N | 1 |
| Limprasutr, V | 1 |
| Sawangkoon, S | 1 |
| Hamlin, RL | 1 |
| Kijtawornrat, A | 1 |
| Anversa, L | 1 |
| Salles Tiburcio, MG | 1 |
| Batista, LR | 1 |
| Cuba, MB | 1 |
| Nogueira Nascentes, GA | 1 |
| Martins, TY | 1 |
| Richini Pereira, VB | 1 |
| Ruiz, LDS | 1 |
| Dias da Silva, VJ | 1 |
| Ramirez, LE | 1 |
| Kotoda, M | 1 |
| Ishiyama, T | 1 |
| Mitsui, K | 1 |
| Hishiyama, S | 1 |
| Matsukawa, T | 1 |
| Popławska, M | 1 |
| Borowicz-Reutt, KK | 1 |
| Garcia, JR | 1 |
| Campbell, PF | 1 |
| Kumar, G | 1 |
| Langberg, JJ | 1 |
| Cesar, L | 1 |
| Deppen, JN | 1 |
| Shin, EY | 1 |
| Bhatia, NK | 1 |
| Wang, L | 1 |
| Xu, K | 1 |
| Schneider, F | 1 |
| Robinson, B | 1 |
| García, AJ | 1 |
| Levit, RD | 1 |
| Yamagiwa, Y | 1 |
| Takei, Y | 1 |
| Koizumi, H | 1 |
| Nemoto, S | 1 |
| Kurata, M | 1 |
| Satoh, H | 1 |
| Sattler, SM | 1 |
| Lubberding, AF | 1 |
| Skibsbye, L | 1 |
| Jabbari, R | 1 |
| Wakili, R | 1 |
| Jespersen, T | 1 |
| Tfelt-Hansen, J | 1 |
| Masuda, S | 1 |
| Mizukami, S | 1 |
| Eguchi, A | 1 |
| Ichikawa, R | 1 |
| Nakamura, M | 1 |
| Okada, R | 1 |
| Tanaka, T | 1 |
| Shibutani, M | 1 |
| Yoshida, T | 1 |
| Glover, BM | 1 |
| Hu, X | 1 |
| Aves, T | 1 |
| Ramadeen, A | 1 |
| Zou, L | 1 |
| Leong-Poi, H | 1 |
| Fujii, H | 1 |
| Dorian, P | 1 |
| Joukar, S | 3 |
| Ghasemipour-Afshar, E | 1 |
| Sheibani, M | 1 |
| Naghsh, N | 1 |
| Bashiri, A | 2 |
| Frommeyer, G | 4 |
| Milberg, P | 5 |
| Uphaus, T | 1 |
| Kaiser, D | 1 |
| Kaese, S | 1 |
| Breithardt, G | 5 |
| Eckardt, L | 6 |
| Youngquist, ST | 1 |
| Niemann, JT | 1 |
| Shah, AP | 1 |
| Thomas, JL | 1 |
| Rosborough, JP | 1 |
| Li, T | 1 |
| Wei, X | 1 |
| Watkins, AC | 1 |
| Sanchez, PG | 1 |
| Wu, ZJ | 1 |
| Griffith, BP | 1 |
| Sakr, SA | 1 |
| Zoil, Mel-S | 1 |
| El-Shafey, SS | 1 |
| Dardenne, A | 1 |
| Fernandez, C | 1 |
| Wagner, A | 1 |
| Milewski, K | 1 |
| Ordanes, DR | 1 |
| Mount, PA | 1 |
| Cheng, Y | 1 |
| Yi, GH | 1 |
| Conditt, GB | 1 |
| Tellez, A | 1 |
| Kaluza, GL | 1 |
| Granada, JF | 1 |
| Feeney, WP | 1 |
| Lan, SH | 1 |
| Wu, SY | 1 |
| Zuchini, R | 1 |
| Lin, XZ | 1 |
| Su, IJ | 1 |
| Tsai, TF | 1 |
| Lin, YJ | 1 |
| Wu, CT | 1 |
| Liu, HS | 1 |
| Verrier, RL | 2 |
| Sobrado, MF | 2 |
| Pagotto, VP | 2 |
| Kanas, AF | 2 |
| Machado, AD | 1 |
| Varone, BB | 1 |
| Sobrado, LF | 1 |
| Nearing, BD | 2 |
| Zeng, D | 2 |
| Belardinelli, L | 4 |
| Sideris, G | 1 |
| Magkoutis, N | 1 |
| Sharma, A | 1 |
| Rees, J | 1 |
| McKnite, S | 1 |
| Caldwell, E | 1 |
| Sarraf, M | 1 |
| Henry, P | 1 |
| Lurie, K | 1 |
| Garcia, S | 1 |
| Yannopoulos, D | 1 |
| Vitins, AP | 1 |
| Kienhuis, AS | 1 |
| Speksnijder, EN | 1 |
| Roodbergen, M | 1 |
| Luijten, M | 1 |
| van der Ven, LT | 1 |
| Beckerman, Z | 1 |
| Azran, A | 1 |
| Cohen, O | 1 |
| Nir, RR | 1 |
| Maessen, JG | 3 |
| Bianco-Peled, H | 1 |
| Bolotin, G | 1 |
| Zoerner, F | 1 |
| Semenas, E | 1 |
| Felser, A | 1 |
| Stoller, A | 1 |
| Morand, R | 1 |
| Schnell, D | 1 |
| Donzelli, M | 1 |
| Terracciano, L | 1 |
| Bouitbir, J | 1 |
| Krähenbühl, S | 1 |
| Zarisfi, Z | 1 |
| Sepehri, G | 1 |
| Mahavadi, P | 2 |
| Henneke, I | 2 |
| Ruppert, C | 2 |
| Knudsen, L | 2 |
| Venkatesan, S | 1 |
| Liebisch, G | 1 |
| Chambers, RC | 1 |
| Ochs, M | 2 |
| Schmitz, G | 1 |
| Vancheri, C | 1 |
| Seeger, W | 1 |
| Korfei, M | 1 |
| Guenther, A | 1 |
| Birkelbach, B | 1 |
| Lutz, D | 1 |
| Lopez-Rodriguez, E | 1 |
| Günther, A | 1 |
| Karlis, G | 1 |
| Iacovidou, N | 2 |
| Lelovas, P | 1 |
| Niforopoulou, P | 1 |
| Papalois, A | 2 |
| Siafaka, I | 1 |
| Mentzelopoulos, S | 1 |
| Xanthos, T | 2 |
| Linke, J | 1 |
| Utpatel, K | 1 |
| Wolke, C | 1 |
| Evert, M | 1 |
| Kühn, JP | 1 |
| Bukowska, A | 1 |
| Goette, A | 2 |
| Lendeckel, U | 1 |
| Peters, B | 1 |
| Schumacher, JD | 1 |
| Guo, GL | 1 |
| Lin, CW | 1 |
| Chen, YS | 1 |
| Lin, CC | 1 |
| Chen, YJ | 1 |
| Lo, GH | 1 |
| Lee, PH | 1 |
| Kuo, PL | 1 |
| Dai, CY | 1 |
| Huang, JF | 1 |
| Chung, WL | 1 |
| Yu, ML | 1 |
| Nasri, HR | 1 |
| Kheradmand, H | 1 |
| Poursalehi, HR | 1 |
| Dabiri, S | 1 |
| Chen, KH | 1 |
| Xu, XH | 1 |
| Sun, HY | 1 |
| Du, XL | 1 |
| Liu, H | 1 |
| Yang, L | 2 |
| Xiao, GS | 1 |
| Wang, Y | 1 |
| Jin, MW | 1 |
| Li, GR | 1 |
| Sharaf El-Din, AA | 1 |
| Abd Allah, OM | 1 |
| Chiba, T | 1 |
| Kondo, N | 1 |
| Takahara, A | 1 |
| Matsukura, S | 1 |
| Nakamura, Y | 1 |
| Cao, X | 1 |
| Wada, T | 1 |
| Izumi-Nakaseko, H | 1 |
| Ando, K | 1 |
| Sugiyama, A | 1 |
| Psichalakis, N | 1 |
| Russell, D | 1 |
| Koutsovasilis, A | 1 |
| Athanasopoulos, D | 1 |
| Gkiokas, G | 1 |
| Chalkias, A | 1 |
| Puckhaber, D | 1 |
| Ellermann, C | 1 |
| Dechering, DG | 1 |
| Kochhäuser, S | 1 |
| Leitz, P | 1 |
| Reinke, F | 1 |
| Wiesmann, T | 1 |
| Freitag, D | 1 |
| Dersch, W | 1 |
| Eschbach, D | 1 |
| Irqsusi, M | 1 |
| Steinfeldt, T | 1 |
| Wulf, H | 1 |
| Feldmann, C | 1 |
| O'Sullivan, M | 1 |
| Martinez, A | 1 |
| Long, A | 1 |
| Johnson, M | 1 |
| Blouin, D | 1 |
| Johnson, AD | 1 |
| Burgert, JM | 1 |
| Hampton, K | 1 |
| Wang, E | 1 |
| Argame, JI | 1 |
| Bateman, T | 1 |
| Craig, W | 1 |
| Johnson, D | 3 |
| Smith, S | 1 |
| Borgkvist, B | 1 |
| Kist, T | 1 |
| Annelin, J | 1 |
| Long, R | 1 |
| Holloway, CM | 1 |
| Jurina, CS | 1 |
| Orszag, CJ | 1 |
| Bragdon, LG | 1 |
| Green, LR | 1 |
| Garcia-Blanco, JC | 1 |
| Benham, BE | 1 |
| Adams, LT | 1 |
| Shayeganpour, A | 1 |
| Korashy, H | 1 |
| Patel, JP | 2 |
| El-Kadi, AO | 2 |
| Brocks, DR | 2 |
| Fedorov, VV | 1 |
| Burashnikov, A | 3 |
| Di Diego, JM | 2 |
| Sicouri, S | 2 |
| Ferreiro, M | 1 |
| Carlsson, L | 1 |
| Antzelevitch, C | 3 |
| Kondrat'eva, DS | 1 |
| Afanas'ev, SA | 2 |
| Falaleeva, LP | 1 |
| Popov, SV | 2 |
| Albayrak, F | 1 |
| Bayir, Y | 1 |
| Halici, Z | 1 |
| Kabalar, E | 1 |
| Bayram, E | 1 |
| Ozturk, C | 1 |
| Suleyman, H | 1 |
| Keles, MS | 1 |
| Kurt, M | 1 |
| Bakan, E | 1 |
| Serrano-Martín, X | 1 |
| Payares, G | 1 |
| De Lucca, M | 1 |
| Martinez, JC | 1 |
| Mendoza-León, A | 1 |
| Benaim, G | 1 |
| Bolderman, RW | 2 |
| Hermans, JJ | 2 |
| Rademakers, LM | 1 |
| de Jong, MM | 1 |
| Bruin, P | 2 |
| Dias, AA | 2 |
| van der Veen, FH | 2 |
| Lewalter, T | 1 |
| Pittrow, D | 1 |
| Kirch, W | 1 |
| Hohnloser, S | 1 |
| Boerakker, MJ | 1 |
| Ji, XF | 1 |
| Li, CS | 1 |
| Wang, S | 2 |
| Cong, LH | 1 |
| Ohori, T | 1 |
| Hirai, T | 1 |
| Joho, S | 1 |
| Kameyama, T | 1 |
| Nozawa, T | 1 |
| Asanoi, H | 1 |
| Inoue, H | 1 |
| Nakagawa, H | 1 |
| Honjo, H | 1 |
| Ishiguro, YS | 1 |
| Yamazaki, M | 1 |
| Okuno, Y | 1 |
| Harada, M | 1 |
| Takanari, H | 1 |
| Sakuma, I | 1 |
| Kamiya, K | 1 |
| Kodama, I | 2 |
| Yu, F | 1 |
| Huang, J | 2 |
| Adlerz, K | 1 |
| Jadvar, H | 1 |
| Hamdan, MH | 1 |
| Chi, N | 1 |
| Chen, JN | 1 |
| Hsiai, TK | 1 |
| Singh, BN | 1 |
| Cingolani, E | 1 |
| Pamukcu, B | 1 |
| Lip, GY | 1 |
| Takeda, T | 1 |
| Shimamoto, T | 1 |
| Marui, A | 1 |
| Saito, N | 1 |
| Uehara, K | 1 |
| Minakata, K | 1 |
| Miwa, S | 1 |
| Nakajima, N | 1 |
| Ikeda, T | 1 |
| Hyon, SH | 1 |
| Sakata, R | 1 |
| Pang, Y | 1 |
| Ren, S | 1 |
| Zhou, J | 1 |
| Ling, T | 1 |
| Gu, G | 1 |
| Huang, C | 1 |
| Witte, P | 1 |
| Stypmann, J | 2 |
| Koopmann, M | 1 |
| Lücke, M | 1 |
| Osada, N | 3 |
| Fehr, M | 1 |
| Engelhorn, T | 1 |
| Schwarz, MA | 1 |
| Heusch, G | 1 |
| Doerfler, A | 1 |
| Schulz, R | 1 |
| Xing, Y | 1 |
| Chen, J | 1 |
| Gao, Y | 1 |
| Niu, W | 1 |
| Zhao, M | 1 |
| Zhu, H | 1 |
| Guo, L | 1 |
| Lu, P | 1 |
| Pott, C | 1 |
| Fink, M | 1 |
| Ruhe, M | 1 |
| Matsuda, T | 1 |
| Baba, A | 1 |
| Klocke, R | 1 |
| Quang, TH | 1 |
| Nikol, S | 1 |
| Müller, FU | 1 |
| Noble, D | 1 |
| Zhou, SX | 1 |
| Fang, C | 1 |
| Zheng, SX | 1 |
| Zhang, YL | 1 |
| Lei, J | 1 |
| Wang, JF | 1 |
| Billman, GE | 1 |
| Gögelein, H | 1 |
| Ruetten, H | 1 |
| Wirth, KJ | 1 |
| Chevalier, P | 1 |
| Timour, Q | 1 |
| Morel, E | 1 |
| Bui-Xuan, B | 1 |
| Hamdy, DA | 1 |
| Ben-Eltriki, M | 1 |
| Takahama, H | 1 |
| Shigematsu, H | 1 |
| Asai, T | 1 |
| Matsuzaki, T | 1 |
| Sanada, S | 1 |
| Fu, HY | 1 |
| Okuda, K | 1 |
| Yamato, M | 1 |
| Asanuma, H | 1 |
| Asano, Y | 1 |
| Asakura, M | 1 |
| Oku, N | 1 |
| Komuro, I | 1 |
| Kitakaze, M | 1 |
| Minamino, T | 1 |
| Stoner, J | 2 |
| Martin, G | 2 |
| O'Mara, K | 1 |
| Ehlers, J | 1 |
| Tomlanovich, M | 1 |
| Malfatto, G | 1 |
| Facchini, M | 1 |
| Zaza, A | 2 |
| Kirchhof, P | 1 |
| Degen, H | 1 |
| Franz, MR | 1 |
| Fabritz, L | 1 |
| Läer, S | 1 |
| Neumann, J | 1 |
| Haverkamp, W | 2 |
| Card, JW | 1 |
| Racz, WJ | 1 |
| Brien, JF | 4 |
| Margolin, SB | 1 |
| Massey, TE | 4 |
| Schwarz, B | 1 |
| Mair, P | 1 |
| Wagner-Berger, H | 1 |
| Stadlbauer, KH | 1 |
| Girg, S | 1 |
| Wenzel, V | 1 |
| Lindner, KH | 1 |
| Varbiro, G | 1 |
| Toth, A | 1 |
| Tapodi, A | 1 |
| Bognar, Z | 1 |
| Veres, B | 1 |
| Sumegi, B | 1 |
| Gallyas, F | 1 |
| Zafalon, N | 1 |
| Bassani, JW | 1 |
| Bassani, RA | 1 |
| Ramtin, S | 1 |
| Mönnig, G | 1 |
| Wasmer, K | 1 |
| Tachikawa, H | 1 |
| Kodama, M | 1 |
| Watanabe, K | 1 |
| Takahashi, T | 1 |
| Ma, M | 1 |
| Kashimura, T | 1 |
| Ito, M | 1 |
| Hirono, S | 1 |
| Okura, Y | 1 |
| Kato, K | 1 |
| Hanawa, H | 1 |
| Aizawa, Y | 1 |
| Ugdyzhekova, DS | 1 |
| Antonchenko, IV | 1 |
| Akhmedov, ShD | 1 |
| Barrueto, F | 2 |
| Chuang, A | 1 |
| Cotter, BW | 1 |
| Hoffman, RS | 1 |
| Nelson, LS | 1 |
| Pan, ZW | 1 |
| Wang, ZY | 1 |
| Du, ZM | 1 |
| Jiao, JD | 1 |
| Dong, DL | 1 |
| Yang, BF | 1 |
| Råmunddal, T | 1 |
| Lorentzon, M | 1 |
| Omerovic, E | 1 |
| Ashikaga, K | 1 |
| Kobayashi, T | 1 |
| Kimura, M | 1 |
| Owada, S | 1 |
| Sasaki, S | 1 |
| Iwasa, A | 1 |
| Furukawa, K | 1 |
| Motomura, S | 1 |
| Okumura, K | 1 |
| Wira, C | 1 |
| Margolis, K | 1 |
| Donnino, M | 1 |
| Zhou, L | 2 |
| Jiang, B | 1 |
| Li, HX | 1 |
| Chen, T | 1 |
| Cheng, XJ | 1 |
| Jiang, WP | 1 |
| Reynolds, JC | 1 |
| Rittenberger, JC | 1 |
| Menegazzi, JJ | 1 |
| Agelaki, MG | 1 |
| Pantos, C | 1 |
| Korantzopoulos, P | 1 |
| Tsalikakis, DG | 1 |
| Baltogiannis, GG | 1 |
| Fotopoulos, A | 1 |
| Kolettis, TM | 1 |
| Zong, ZP | 1 |
| Matsui, S | 1 |
| Han, JF | 1 |
| Katsuda, S | 1 |
| Fu, ML | 1 |
| Hasegawa, M | 1 |
| Takenaka, S | 1 |
| Kuwamura, M | 1 |
| Yamate, J | 1 |
| Tsuyama, S | 1 |
| Shi, RQ | 1 |
| Lee, JK | 1 |
| Hayashi, Y | 1 |
| Takeuchi, Y | 1 |
| Kambe, F | 1 |
| Futaki, S | 1 |
| Seo, H | 1 |
| Murata, Y | 1 |
| DeWitt, CR | 1 |
| Cleveland, N | 1 |
| Dart, RC | 1 |
| Heard, K | 1 |
| Murr, I | 1 |
| Meltzer, A | 1 |
| Brewer, K | 1 |
| Meggs, W | 1 |
| Spadaro, J | 1 |
| Hashimoto, LM | 1 |
| Franco, RS | 1 |
| Bregagnollo, EA | 1 |
| Tucci, PJ | 1 |
| Antonini, JM | 2 |
| McCloud, CM | 1 |
| Reasor, MJ | 3 |
| Leeder, RG | 2 |
| Evans, CD | 1 |
| Anastasiou-Nana, MI | 1 |
| Nanas, JN | 1 |
| Nanas, SN | 1 |
| Rapti, A | 1 |
| Poyadjis, A | 1 |
| Stathaki, S | 1 |
| Moulopoulos, SD | 1 |
| Blake, TL | 1 |
| Finance, O | 1 |
| Manning, A | 1 |
| Chatelain, P | 2 |
| Manning, AS | 1 |
| Bruyninckx, C | 1 |
| Ramboux, J | 1 |
| Reinhart, PG | 1 |
| Lai, YL | 1 |
| Gairola, CG | 1 |
| Israël-Biet, D | 1 |
| Cadranel, J | 1 |
| Rafeiro, E | 1 |
| Liu, P | 1 |
| Fei, L | 1 |
| Wu, W | 1 |
| Li, J | 1 |
| Zhang, X | 1 |
| Wiersinga, WM | 1 |
| Nagata, N | 1 |
| Suematsu, R | 1 |
| Yoshii, C | 1 |
| Miyazaki, H | 1 |
| Sueishi, K | 1 |
| Kido, M | 1 |
| Movsowitz, C | 1 |
| Marchlinski, FE | 1 |
| White, CM | 1 |
| Chen, BP | 1 |
| Chow, MS | 1 |
| Fan, C | 1 |
| Kluger, J | 1 |
| Sasayama, S | 2 |
| Matsumori, A | 2 |
| Kihara, Y | 1 |
| Gyönös, I | 1 |
| Agoston, M | 1 |
| Kovács, A | 1 |
| Szénási, G | 1 |
| Vereckei, A | 1 |
| van Opstal, JM | 1 |
| Schoenmakers, M | 1 |
| Verduyn, SC | 1 |
| de Groot, SH | 1 |
| Leunissen, JD | 1 |
| van Der Hulst, FF | 1 |
| Molenschot, MM | 1 |
| Wellens, HJ | 1 |
| Vos, MA | 1 |
| Kudenchuk, PJ | 1 |
| Ito, H | 1 |
| Ono, K | 1 |
| Nishio, R | 1 |
| Taylor, MD | 1 |
| Roberts, JR | 1 |
| Hubbs, AF | 1 |
| Gøtzsche, LB | 1 |
| Pedersen, EM | 1 |
| Keld, D | 1 |
| Paulsen, PK | 1 |
| Daniels, JM | 1 |
| Schwartz, PJ | 1 |
| Vanoli, E | 1 |
| Zuanetti, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single Site, Interventional, Comparative Study to Evaluate the Safety and Efficacy of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences[NCT03162120] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2018-09-01 | Withdrawn (stopped due to new study type, it will be re-organiZed as an Investigator Initiated Study (IIS)) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for amiodarone and Disease Models, Animal
| Article | Year |
|---|---|
Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics.
Topics: Amiodarone; Animals; Bleomycin; Disease Models, Animal; Idiopathic Pulmonary Fibrosis; Lung; Lung Di | 2022 |
Mechanistic review of drug-induced steatohepatitis.
Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; F | 2015 |
[Clinical pharmacology and electrophysiological properties of dronedarone].
Topics: Adrenergic Antagonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Biological | 2010 |
A new agent for atrial fibrillation: electrophysiological properties of dronedarone.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dronedaron | 2010 |
Dronedarone as a new treatment option for atrial fibrillation patients: pharmacokinetics, pharmacodynamics and clinical practice.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Clinical Trials as Topic; Disease | 2011 |
Drug administration in animal studies of cardiac arrest does not reflect human clinical experience.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Clinical Trials as Topic; Disease Models, Animal; Drug | 2007 |
[Physiopathologic mechanisms of drug-induced lung diseases in man].
Topics: Adjuvants, Immunologic; Amiodarone; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antibiotics, Anti | 1996 |
Mechanisms in the pathogenesis of amiodarone-induced pulmonary toxicity.
Topics: Amiodarone; Animals; Disease Models, Animal; Humans; Lung; Lung Diseases | 1995 |
Interactions between implantable cardioverter-defibrillators and class III agents.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Defibrillators, Implantable; Dise | 1998 |
New insights into the pathophysiological role for cytokines in heart failure.
Topics: Amiodarone; Anti-Arrhythmia Agents; Cytokines; Disease Models, Animal; Heart Failure; Humans; Interl | 1999 |
Advanced cardiac life support antiarrhythmic drugs.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Cardiopulmonary Resuscitation; Cli | 2002 |
3 trials available for amiodarone and Disease Models, Animal
| Article | Year |
|---|---|
Dantrolene versus amiodarone for cardiopulmonary resuscitation: a randomized, double-blinded experimental study.
Topics: Amiodarone; Animals; Blood Gas Analysis; Brain; Cardiopulmonary Resuscitation; Dantrolene; Disease M | 2017 |
Decreased mortality in a rat model of acute postinfarction heart failure.
Topics: Amiodarone; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Critical Care; Diseas | 2006 |
Interactions between implantable cardioverter-defibrillators and class III agents.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Defibrillators, Implantable; Dise | 1998 |
114 other studies available for amiodarone and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Line; Cell- and Tissue-Based | 2021 |
Experimental study on the effect of chrysin on skin injury induced by amiodarone extravasation in rats.
Topics: Amiodarone; Animals; Anti-Inflammatory Agents; Cell Proliferation; Disease Models, Animal; Endotheli | 2022 |
Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.
Topics: Amiodarone; Animals; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Heart; Heart | 2022 |
Amiodarone improves anemia in a murine model of sickle cell disease and is associated with increased erythrocyte bis(monoacylglycerol) phosphate.
Topics: Amiodarone; Anemia, Sickle Cell; Animals; Antibodies, Neutralizing; Disease Models, Animal; Erythroc | 2022 |
Lenalidomide Augments the Antitumor Activities of Eps8 Peptide-Specific Cytotoxic T Lymphocytes against Multiple Myeloma.
Topics: Adaptor Proteins, Signal Transducing; Amiodarone; Animals; Cell Line, Tumor; Disease Models, Animal; | 2019 |
Ibutilide Reduces Ventricular Defibrillation Threshold and Organizes Ventricular Fibrillation Activation in Canine Heart Failure Model.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Arterial Pressure; Disease Models, A | 2020 |
Amiodarone Enhances Anticonvulsive Effect of Oxcarbazepine and Pregabalin in the Mouse Maximal Electroshock Model.
Topics: Amiodarone; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Disease Models, A | 2021 |
Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillation.
Topics: Action Potentials; Administration, Oral; Amiodarone; Animals; Atrial Fibrillation; Disease Models, A | 2017 |
Amiodarone and itraconazole improve the activity of pentavalent antimonial in the treatment of experimental cutaneous leishmaniasis.
Topics: Amiodarone; Animals; Cricetinae; Disease Models, Animal; Drug Therapy, Combination; Hindlimb; Histoc | 2017 |
Neuroprotective effects of amiodarone in a mouse model of ischemic stroke.
Topics: Amiodarone; Animals; Brain Ischemia; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuropr | 2017 |
Amiodarone, a multi-channel blocker, enhances anticonvulsive effect of carbamazepine in the mouse maximal electroshock model.
Topics: Amiodarone; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Re | 2018 |
Minimally Invasive Delivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces Atrial Fibrillation.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Drug Carri | 2018 |
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal; | 2019 |
Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Female; Hear | 2019 |
Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats.
Topics: Amiodarone; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Chloroquine; Diet, High | 2019 |
Dronedarone and Captisol-enabled amiodarone in an experimental cardiac arrest.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiopulmonary Resuscitation; Disease | 2013 |
Protective effects of saffron (Crocus sativus) against lethal ventricular arrhythmias induced by heart reperfusion in rat: a potential anti-arrhythmic agent.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Crocus; Disease Models, Animal; Dose | 2013 |
Antiarrhythmic effect of ranolazine in combination with class III drugs in an experimental whole-heart model of atrial fibrillation.
Topics: Acetanilides; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; D | 2013 |
Administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Coronary Vessels; Diseas | 2013 |
Prophylactic amiodarone and lidocaine improve survival in an ovine model of large size myocardial infarction.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disease Mode | 2013 |
Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antioxidants; Chromosome Aberrations; Citrus paradisi; | 2013 |
Benefits of standardizing the treatment of arrhythmias in the sheep (Ovis aries) model of chronic heart failure after myocardial infarction.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Catheters; Disease Models, Animal | 2013 |
Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224.
Topics: Amiodarone; Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Disease Models, Animal; D | 2014 |
Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.
Topics: Amiodarone; Animals; Atrial Fibrillation; Atrioventricular Node; Benzazepines; Cyclic Nucleotide-Gat | 2013 |
Early coronary revascularization improves 24h survival and neurological function after ischemic cardiac arrest. A randomized animal study.
Topics: Amiodarone; Animals; Cardiac Catheterization; Cardiopulmonary Resuscitation; Disease Models, Animal; | 2014 |
Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models.
Topics: Amiodarone; Animals; Binding Sites; Cell Line; Chemical and Drug Induced Liver Injury; Disease Model | 2014 |
A novel amiodarone-eluting biological glue for reducing postoperative atrial fibrillation: first animal trial.
Topics: Alginates; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Biocompatible Materials | 2014 |
Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs.
Topics: Amiodarone; Animals; Antidiuretic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation.
Topics: Alanine Transaminase; Amiodarone; Animals; Anti-Arrhythmia Agents; bcl-2-Associated X Protein; Disea | 2014 |
Efficacy of Melissa officinalis in suppressing ventricular arrhythmias following ischemia-reperfusion of the heart: a comparison with amiodarone.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Disease Models, A | 2014 |
Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Apoptosis; Cathepsin D; Cell Culture Techniques; Cell L | 2014 |
Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model.
Topics: Airway Remodeling; Amiodarone; Animals; Apoptosis; Cell Size; Disease Models, Animal; Epithelial Cel | 2015 |
Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation.
Topics: Amiodarone; Animals; Blood Pressure; Cardiopulmonary Resuscitation; Disease Models, Animal; Electric | 2015 |
Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Biomarkers; Coronary Vessels; Disease Models, Animal; D | 2015 |
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
Topics: Amiodarone; Animals; Autophagy; Autophagy-Related Protein 7; Chloroquine; Disease Models, Animal; He | 2015 |
Coadministration of Atorvastatin and Amiodarone Increases the Risk of Pulmonary Fibrosis in Rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Lung; Male; Pulmonary Alveoli; | 2016 |
Distinctive property and pharmacology of voltage-gated sodium current in rat atrial vs ventricular myocytes.
Topics: Amiodarone; Animals; Cells, Cultured; Disease Models, Animal; Dronedarone; Heart Atria; Heart Ventri | 2016 |
Impact of Olmesartan Medoxomil on Amiodarone-Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor-ß1.
Topics: Amiodarone; Animals; Collagen Type I; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2016 |
Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits.
Topics: Amiodarone; Animals; Anisoles; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Remodeling; Bepri | 2016 |
Anti-atrial Fibrillatory Versus Proarrhythmic Potentials of Amiodarone: A New Protocol for Safety Evaluation In Vivo.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Blood Pressure; | 2017 |
Intralipid™ administration attenuates the hypotensive effects of acute intravenous amiodarone overdose in a swine model.
Topics: Acute Disease; Amiodarone; Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationsh | 2016 |
Interactions of digitalis and class-III antiarrhythmic drugs: Amiodarone versus dronedarone.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Digitalis Glycosides; Disease Models | 2017 |
Comparison of the effects of sternal and tibial intraosseous administered resuscitative drugs on return of spontaneous circulation in a swine model of cardiac arrest.
Topics: Administration, Intravenous; Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitat | 2016 |
The effects of tibial intraosseous versus intravenous amiodarone administration in a hypovolemic cardiac arrest procine model.
Topics: Amiodarone; Animals; Cardiopulmonary Resuscitation; Chromatography, High Pressure Liquid; Disease Mo | 2016 |
The effects of sternal intraosseous and intravenous administration of amiodarone in a hypovolemic swine cardiac arrest model.
Topics: Amiodarone; Animals; Cardiopulmonary Resuscitation; Chromatography, High Pressure Liquid; Disease Mo | 2016 |
Effects of humerus intraosseous versus intravenous amiodarone administration in a hypovolemic porcine model.
Topics: Amiodarone; Animals; Cardiopulmonary Resuscitation; Chromatography, High Pressure Liquid; Disease Mo | 2016 |
The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cytochrome P-450 Enzyme System; Disease Models, Animal; | 2008 |
Does the postrepolarization refractoriness play a role in amiodarone's antiarrhythmic efficacy?
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Disease Models, A | 2008 |
Atrial-selective effects of chronic amiodarone in the management of atrial fibrillation.
Topics: Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Funct | 2008 |
[Possible role of sarcoplasmatic reticulum in anti-arrhythmic effects of the class III agent amiodarone].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Male; Myo | 2009 |
Preventive effect of amiodarone during acute period in isoproterenol-induced myocardial injury in Wistar rats.
Topics: Amiodarone; Animals; Cardiotonic Agents; Disease Models, Animal; Isoproterenol; Male; Myocardial Inf | 2009 |
Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis.
Topics: Amiodarone; Animals; Antiprotozoal Agents; Cricetinae; Disease Models, Animal; Drug Synergism; Femal | 2009 |
Epicardial application of an amiodarone-releasing hydrogel to suppress atrial tachyarrhythmias.
Topics: Administration, Cutaneous; Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; | 2011 |
Atrium-targeted drug delivery through an amiodarone-eluting bilayered patch.
Topics: Action Potentials; Administration, Topical; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibr | 2010 |
Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dogs; Dose | 2010 |
Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Disease Models, Animal; | 2010 |
Circadian changes in autonomic function in conscious rats with heart failure: effects of amiodarone on sympathetic surge.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Autonomic Nervous System Diseases; Chronobiology Disord | 2011 |
Acute amiodarone promotes drift and early termination of spiral wave re-entry.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease | 2010 |
Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation.
Topics: Acetanilides; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; D | 2010 |
Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Electroca | 2010 |
Topical application of a biodegradable disc with amiodarone for atrial fibrillation.
Topics: Absorbable Implants; Administration, Topical; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fi | 2011 |
The effects of acute amiodarone on short- and long-duration ventricular defibrillation threshold in canines.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Electric Countershock; Fo | 2011 |
A new mechanism preventing proarrhythmia in chronic heart failure: rapid phase-III repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacing-induced heart failure.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Electrocardiography; Female; He | 2011 |
Reduction of cerebral infarct size by dronedarone.
Topics: Amiodarone; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dronedarone; Heart Rate; I | 2011 |
The effects of allitridi and amiodarone on the conduction system and reverse use-dependence in the isolated hearts of rats with myocardial infarction.
Topics: Action Potentials; Allyl Compounds; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardia | 2012 |
Acute inhibition of the Na(+)/Ca(2+) exchanger reduces proarrhythmia in an experimental model of chronic heart failure.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Heart; Heart | 2012 |
Effect of amiodarone on dispersion of ventricular repolarization in a canine congestive heart failure model.
Topics: Amiodarone; Animals; Disease Models, Animal; Dogs; Female; Heart Failure; Male; Random Allocation; T | 2012 |
Effects of a novel amiodarone-like compound SAR114646A on the pig atrium and susceptibility to ventricular fibrillation in dogs and pigs.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Models, Animal; Dogs; Elec | 2012 |
Chronic oral amiodarone but not dronedarone therapy increases ventricular defibrillation threshold during acute myocardial ischemia in a closed-chest animal model.
Topics: Acute Disease; Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Coronary Occlusion | 2012 |
Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia.
Topics: Acetanilides; Amiodarone; Animals; Atrial Fibrillation; Chromatography, High Pressure Liquid; Diseas | 2013 |
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes.
Topics: Alcohol Oxidoreductases; Amiodarone; Animals; ATP Binding Cassette Transporter, Subfamily B; Cells, | 2013 |
Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Hemodynam | 2013 |
Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Disease Models, Animal; Dogs; Hypo | 2003 |
Characterization of the non-linear rate-dependency of QT interval in humans.
Topics: Action Potentials; Adolescent; Adult; Aged; Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Mod | 2003 |
Amiodarone-induced postrepolarization refractoriness suppresses induction of ventricular fibrillation.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models | 2003 |
Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.
Topics: Acute Disease; Amiodarone; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2003 |
Neither vasopressin nor amiodarone improve CPR outcome in an animal model of hypothermic cardiac arrest.
Topics: Amiodarone; Animals; Blood Pressure; Cardiopulmonary Resuscitation; Coronary Vessels; Disease Models | 2003 |
Protective effect of amiodarone but not N-desethylamiodarone on postischemic hearts through the inhibition of mitochondrial permeability transition.
Topics: Amiodarone; Animals; Apoptosis Inducing Factor; Biological Transport; Disease Models, Animal; Energy | 2003 |
Cholinergic-adrenergic antagonism in the induction of tachyarrhythmia by electrical stimulation in isolated rat atria.
Topics: 1-Methyl-3-isobutylxanthine; Amiodarone; Animals; Anti-Arrhythmia Agents; Carbachol; Cholinergic Ago | 2004 |
Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block.
Topics: Action Potentials; Administration, Oral; Amiodarone; Animals; Disease Models, Animal; Drug Administr | 2004 |
Amiodarone improves cardiac sympathetic nerve function to hold norepinephrine in the heart, prevents left ventricular remodeling, and improves cardiac function in rat dilated cardiomyopathy.
Topics: 3-Iodobenzylguanidine; Amiodarone; Animals; Blood Pressure; Cardiomyopathy, Dilated; Cytokines; Dise | 2005 |
[Inotropic reactions of myocardium of patients with ischemic heart disease and rats during use of amiodarone].
Topics: Amiodarone; Animals; Disease Models, Animal; Humans; Male; Middle Aged; Myocardial Contraction; Myoc | 2005 |
Amiodarone fails to improve survival in amitriptyline-poisoned mice.
Topics: Amiodarone; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Diseas | 2005 |
[Establishment of a novel arrhythmia model in rats].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Disease Models, | 2005 |
Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced persistent atrial fibrillation model.
Topics: Action Potentials; Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrill | 2006 |
Application of normothermic cardiac arrest algorithms to hypothermic cardiac arrest in a canine model.
Topics: Adrenergic alpha-Agonists; Algorithms; Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, | 2006 |
[The acute electrophysiological effects of amiodarone on normal and hypertrophied rat myocytes].
Topics: Amiodarone; Animals; Cardiomyopathy, Hypertrophic; Disease Models, Animal; Ion Channels; Myocytes, C | 2006 |
Comparative antiarrhythmic efficacy of amiodarone and dronedarone during acute myocardial infarction in rats.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dronedarone; | 2007 |
Involvement of thymus in amiodarone-treated autoimmune myocarditis in rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lym | 2008 |
Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Biomarkers; Disease Models, Animal; Drug Evaluation, Pr | 2007 |
Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Blotting, Northern; Cluster Analysis; Disease Models, A | 2008 |
The effect of amiodarone pretreatment on survival of mice with cocaine toxicity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cocaine; Disease Models, Animal; Drug Antagonism; Injec | 2005 |
Effects of amiodarone in a swine model of nortriptyline [corrected] toxicity.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Bl | 2006 |
[Effect of previous administration of amiodarone on the early incidence of ventricular fibrillation during experimental myocardial ischemia].
Topics: Amiodarone; Animals; Benzofurans; Blood Pressure; Disease Models, Animal; Heart Rate; Male; Myocardi | 1984 |
Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis.
Topics: Acute Disease; Amiodarone; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Lipidoses; | 1994 |
Resistance of the hamster to amiodarone-induced pulmonary toxicity following repeated intraperitoneal administration.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Cricetinae; Disease Models, Animal; Hydro | 1994 |
Effects of amiodarone on refractory ventricular fibrillation in acute myocardial infarction: experimental study.
Topics: Amiodarone; Animals; Disease Models, Animal; Dogs; Electric Stimulation; Epinephrine; Female; Heart | 1994 |
Metabolism of amiodarone following intratracheal instillation in hamsters.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cricetinae; Disease Models, Animal; Intubation, Intratr | 1995 |
Effects of a new amiodarone-like agent, SR 33589, in comparison to amiodarone, D,L-sotalol, and lignocaine, on ischemia-induced ventricular arrhythmias in anesthetized pigs.
Topics: Amiodarone; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans | 1995 |
SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats.
Topics: Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans | 1995 |
Amiodarone-induced pulmonary fibrosis in Fischer 344 rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Carbon Monoxide; Diffusion; Disease Models, Animal; Fem | 1996 |
Effects of hypothyroidism on the vulnerability to ventricular fibrillation in dogs: a comparative study with amiodarone.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Blood Pressure; Disease Models, Anim | 1996 |
Towards an animal model of amiodarone-induced thyroid dysfunction.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Thyroid Diseases; Thyroid Gland | 1997 |
Characterization of amiodarone pneumonitis as related to inflammatory cells and surfactant apoprotein.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Apoproteins; Bronchoalveolar Lavage Fluid; Coloring Age | 1997 |
A comparison of the antifibrillatory effects of desethylamiodarone to amiodarone in a swine model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Dru | 1999 |
Silymarin and vitamin E do not attenuate and vitamin E might even enhance the antiarrhythmic activity of amiodarone in a rat reperfusion arrhythmia model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Disease Models, Ani | 2001 |
Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome.
Topics: Action Potentials; Administration, Oral; Amiodarone; Anesthesia; Animals; Anti-Arrhythmia Agents; Ar | 2001 |
Amiodarone inhibits interleukin 6 production and attenuates myocardial injury induced by viral myocarditis in mice.
Topics: Amiodarone; Animals; Cardiovirus Infections; Cytokines; Disease Models, Animal; Encephalomyocarditis | 2002 |
Quantitative image analysis of drug-induced lung fibrosis using laser scanning confocal microscopy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; Bleomycin; Disease Models, | 2002 |
Reduced cardiac reserve in amiodarone-treated pigs after cardiopulmonary bypass and cardioplegic arrest.
Topics: Amiodarone; Animals; Biological Availability; Cardiac Pacing, Artificial; Cardiopulmonary Bypass; Di | 1992 |
Pulmonary fibrosis induced in the hamster by amiodarone and desethylamiodarone.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Cricetinae; Disease Models, Animal; Histo | 1989 |
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease M | 1985 |