amiodarone has been researched along with Disease Exacerbation in 16 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although trials of amiodarone therapy in patients with congestive heart failure have produced discordant results with regard to effects on survival, most studies have reported a significant rise in left ventricular ejection fraction during long-term therapy." | 9.08 | Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators. ( Deedwania, PC; Fisher, SG; Fletcher, RD; Massie, BM; Radford, M; Singh, BN; Singh, SN, 1996) |
| "To describe a challenging patient case in which dronedarone was selected for a patient with atrial fibrillation and heart failure; the drug may have been associated with worsening heart failure, leading to acute renal and hepatic failure." | 7.76 | Worsening heart failure in the setting of dronedarone initiation. ( Coons, JC; Plauger, KM; Seybert, AL; Sokos, GG, 2010) |
| "We previously showed that amiodarone, an iodine-rich benzofuranic derivative, interferes with the progression of myocarditis using a rat model of experimental autoimmune myocarditis." | 7.74 | Involvement of thymus in amiodarone-treated autoimmune myocarditis in rats. ( Fu, ML; Han, JF; Katsuda, S; Matsui, S; Zong, ZP, 2008) |
| "Although trials of amiodarone therapy in patients with congestive heart failure have produced discordant results with regard to effects on survival, most studies have reported a significant rise in left ventricular ejection fraction during long-term therapy." | 5.08 | Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators. ( Deedwania, PC; Fisher, SG; Fletcher, RD; Massie, BM; Radford, M; Singh, BN; Singh, SN, 1996) |
| "Reports published with the following search terms were searched:, thyroid, hypothyroidism, hyperthyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, levothyroxine, triiodothyronine, antithyroid drugs, radioiodine, deiodinases, clinical symptoms, heart rate, HF, systolic function, diastolic function, systemic vascular resistance, endothelial function, amiodarone and atrial fibrillation." | 4.88 | Mechanisms in endocrinology: Heart failure and thyroid dysfunction. ( Biondi, B, 2012) |
| " The study revealed hypothyroidism, iatrogenic due to the use of amiodarone." | 3.96 | An unexpected cause of residual renal function loss. ( Abrantes, C; Assunção, J; Furtado, T; Soares, E; Valério, P; Vaz, AG, 2020) |
| "Patients with amiodarone-induced thyrotoxicosis (AIT) and severely reduced left ventricular ejection fraction (LVEF) have a high mortality rate that may be reduced by total thyroidectomy." | 3.96 | Duration of Exposure to Thyrotoxicosis Increases Mortality of Compromised AIT Patients: the Role of Early Thyroidectomy. ( Bartalena, L; Bogazzi, F; Cappellani, D; Cosentino, G; Di Certo, AM; Manetti, L; Marconcini, G; Martino, E; Materazzi, G; Morganti, R; Papini, P; Tanda, ML; Urbani, C, 2020) |
| "To describe a challenging patient case in which dronedarone was selected for a patient with atrial fibrillation and heart failure; the drug may have been associated with worsening heart failure, leading to acute renal and hepatic failure." | 3.76 | Worsening heart failure in the setting of dronedarone initiation. ( Coons, JC; Plauger, KM; Seybert, AL; Sokos, GG, 2010) |
| "We previously showed that amiodarone, an iodine-rich benzofuranic derivative, interferes with the progression of myocarditis using a rat model of experimental autoimmune myocarditis." | 3.74 | Involvement of thymus in amiodarone-treated autoimmune myocarditis in rats. ( Fu, ML; Han, JF; Katsuda, S; Matsui, S; Zong, ZP, 2008) |
| "The effect of oral amiodarone (AMD) therapy on left ventricular (LV) function was evaluated retrospectively in Japanese patients with ventricular tachyarrhythmias and congestive heart failure." | 3.70 | Effect of relatively low dose amiodarone therapy on left ventricular function in patients with ventricular tachyarrhythmias. ( Yamada, S; Yamaguchi, I, 1998) |
| "Amiodarone is a lipophilic drug that concentrates in the liver and usually, over a period of time, leads to toxicity related to drug accumulation." | 1.35 | Drug-induced steatohepatitis leading to cirrhosis: long-term toxicity of amiodarone use. ( Chang, C; Fiel, MI; Raja, K; Thung, SN, 2009) |
| " However, because the discoloration developed before surgery and was bilateral, long-term administration of amiodarone may also have played a role." | 1.30 | Progressive brown discoloration of silicone intraocular lenses after vitrectomy in a patient on amiodarone. ( Katai, N; Yokoyama, R; Yoshimura, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Soares, E | 1 |
| Valério, P | 1 |
| Abrantes, C | 1 |
| Furtado, T | 1 |
| Assunção, J | 1 |
| Vaz, AG | 1 |
| Cappellani, D | 1 |
| Papini, P | 1 |
| Di Certo, AM | 1 |
| Morganti, R | 1 |
| Urbani, C | 1 |
| Manetti, L | 1 |
| Tanda, ML | 1 |
| Cosentino, G | 1 |
| Marconcini, G | 1 |
| Materazzi, G | 1 |
| Martino, E | 1 |
| Bartalena, L | 1 |
| Bogazzi, F | 1 |
| López Brunsó, M | 1 |
| Toro Blanch, C | 1 |
| Sais Girona, E | 1 |
| Roa García, D | 1 |
| Hernández Martínez, A | 1 |
| Izquierdo Font, A | 1 |
| Guerra Prió, S | 1 |
| Mas Pueyo, HG | 1 |
| Bosch-Barrera, J | 1 |
| Bobbo, M | 1 |
| Pinamonti, B | 1 |
| Merlo, M | 1 |
| Stolfo, D | 1 |
| Iorio, A | 1 |
| Ramani, F | 1 |
| Barbati, G | 1 |
| Carriere, C | 1 |
| Massa, L | 1 |
| Poli, S | 1 |
| Scapol, S | 1 |
| Gigli, M | 1 |
| Di Lenarda, A | 1 |
| Sinagra, G | 1 |
| Pintavorn, P | 1 |
| Cook, WJ | 1 |
| Basargina, EN | 1 |
| Belova, NR | 1 |
| Raja, K | 1 |
| Thung, SN | 1 |
| Fiel, MI | 1 |
| Chang, C | 1 |
| Mishkin, JD | 1 |
| Saxonhouse, SJ | 1 |
| Woo, GW | 1 |
| Burkart, TA | 1 |
| Miles, WM | 1 |
| Conti, JB | 1 |
| Schofield, RS | 1 |
| Sears, SF | 1 |
| Aranda, JM | 1 |
| Coons, JC | 1 |
| Plauger, KM | 1 |
| Seybert, AL | 1 |
| Sokos, GG | 1 |
| Duckers, HJ | 1 |
| Houtgraaf, J | 1 |
| Hehrlein, C | 1 |
| Schofer, J | 1 |
| Waltenberger, J | 1 |
| Gershlick, A | 1 |
| Bartunek, J | 1 |
| Nienaber, C | 1 |
| Macaya, C | 1 |
| Peters, N | 1 |
| Smits, P | 1 |
| Siminiak, T | 1 |
| van Mieghem, W | 1 |
| Legrand, V | 1 |
| Serruys, PW | 1 |
| Biondi, B | 1 |
| Zong, ZP | 1 |
| Matsui, S | 1 |
| Han, JF | 1 |
| Katsuda, S | 1 |
| Fu, ML | 1 |
| Chen, SA | 1 |
| Chiang, CE | 1 |
| Tai, CT | 1 |
| Lee, SH | 1 |
| Chiou, CW | 1 |
| Ueng, KC | 1 |
| Wen, ZC | 1 |
| Cheng, CC | 1 |
| Chang, MS | 1 |
| Massie, BM | 1 |
| Fisher, SG | 1 |
| Radford, M | 1 |
| Deedwania, PC | 1 |
| Singh, BN | 1 |
| Fletcher, RD | 1 |
| Singh, SN | 1 |
| Yamada, S | 1 |
| Yamaguchi, I | 1 |
| Katai, N | 1 |
| Yokoyama, R | 1 |
| Yoshimura, N | 1 |
2 reviews available for amiodarone and Disease Exacerbation
| Article | Year |
|---|---|
Appropriate evaluation and treatment of heart failure patients after implantable cardioverter-defibrillator discharge: time to go beyond the initial shock.
Topics: Adrenergic beta-Antagonists; Algorithms; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; | 2009 |
Mechanisms in endocrinology: Heart failure and thyroid dysfunction.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Coronary Disease; | 2012 |
2 trials available for amiodarone and Disease Exacerbation
| Article | Year |
|---|---|
Final results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cells, Cultured; Disease Prog | 2011 |
Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure. CHF-STAT Investigators.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Disease Progression; Double-Blind Method; Female; Heart Fa | 1996 |
12 other studies available for amiodarone and Disease Exacerbation
| Article | Year |
|---|---|
An unexpected cause of residual renal function loss.
Topics: Amiodarone; Disease Progression; Glomerular Filtration Rate; Humans; Hypothyroidism; Kidney Failure, | 2020 |
Duration of Exposure to Thyrotoxicosis Increases Mortality of Compromised AIT Patients: the Role of Early Thyroidectomy.
Topics: Aged; Amiodarone; Cohort Studies; Disease Progression; Early Medical Intervention; Female; Humans; M | 2020 |
Probable drug-drug interaction between erlotinib and amiodarone causes severe neurotoxicity in a patient with advanced lung cancer.
Topics: Amiodarone; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Non-Small-Cell Lung; | 2018 |
Comparison of Patient Characteristics and Course of Hypertensive Hypokinetic Cardiomyopathy Versus Idiopathic Dilated Cardiomyopathy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Angiotensin Receptor Antagonists; Angiotensin- | 2017 |
Progressive renal insufficiency associated with amiodarone-induced phospholipidosis.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Disease Progression; Female; Humans; Idiopathic Interstiti | 2008 |
[Immediate and late results of combined treatment of dilatated cardiomyopathy in children].
Topics: Adolescent; Amiodarone; Cardiomyopathy, Dilated; Child; Child, Preschool; Disease Progression; Femal | 2008 |
Drug-induced steatohepatitis leading to cirrhosis: long-term toxicity of amiodarone use.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Biopsy; Chemical and Drug Induced Liver Injury; Diagnosis, | 2009 |
Worsening heart failure in the setting of dronedarone initiation.
Topics: Acute Kidney Injury; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disease Progression; D | 2010 |
Involvement of thymus in amiodarone-treated autoimmune myocarditis in rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lym | 2008 |
Longitudinal clinical and electrophysiological assessment of patients with symptomatic Wolff-Parkinson-White syndrome and atrioventricular node reentrant tachycardia.
Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular N | 1996 |
Effect of relatively low dose amiodarone therapy on left ventricular function in patients with ventricular tachyarrhythmias.
Topics: Administration, Oral; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Disease Pro | 1998 |
Progressive brown discoloration of silicone intraocular lenses after vitrectomy in a patient on amiodarone.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood-Aqueous Barrier; Color; Diseas | 1999 |