amiodarone has been researched along with Chagas Cardiomyopathy in 31 studies
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Low-dose (7 mg/kg per day) disopyramide administration to arrhythmic chagasic patients decreased the frequency of ventricular extrasystoles in 4 of 17 patients (24%) and suppressed most complex ventricular arrhythmias in 12 of 15 patients (80%)." | 9.05 | Effect of low oral doses of disopyramide and amiodarone on ventricular and atrial arrhythmias of chagasic patients with advanced myocardial damage. ( Carrasco, HA; Fuenmayor, A; Landaeta, A; López, F; Molina, C; Reynosa, J; Vicuña, AV; Vicuña, N, 1985) |
| " Ventricular arrhythmias are common in patients with Chagas cardiomyopathy, and amiodarone has been widely used for this purpose." | 8.98 | Amiodarone for arrhythmia in patients with Chagas disease: A systematic review and individual patient data meta-analysis. ( Colpani, V; Cruz, LN; da Rosa, PR; Falavigna, M; Giordani, NE; Migliavaca, CB; Miguel, SRPS; Polanczyk, CA; Ribeiro, ALP; Sganzerla, D; Stein, C, 2018) |
| "To evaluate the efficacy and safety of long-term empiric amiodarone therapy in patients with recurrent Sustained Ventricular Tachycardia (SVT) and Chronic Chagasic Myocarditis (CCM)." | 7.68 | [Empiric therapy with amiodarone in patients with chronic Chagas cardiomyopathy and sustained ventricular tachycardia]. ( Bellotti, G; Lee, JH; Pileggi, F; Scanavacca, MI; Sosa, EA, 1990) |
| "Oral amiodarone was administered to 24 patients with chronic chagasic myocarditis (CCM) and malignant ventricular arrhythmias." | 7.67 | Efficacy of amiodarone during long-term treatment of malignant ventricular arrhythmias in patients with chronic chagasic myocarditis. ( Chiale, PA; Elizari, MV; Halpern, MS; Lázzari, JO; Nau, GJ; Przybylski, J; Rosenbaum, MB; Tambussi, AM, 1984) |
| "Fourteen patients with congestive heart failure due to chronic Chagas' disease had hemodynamic studies before and 20, 40 and 60 minutes and 24 hours after intravenous amiodarone." | 7.66 | Hemodynamic effects of intravenous administration of amiodarone in congestive heart failure from chronic Chagas' disease. ( Bellotti, G; da Luz, P; de Moraes, AV; Esteves Filho, A; Pileggi, F; Ramires, JA; Rati, M; Silva, LA, 1983) |
| "Low-dose (7 mg/kg per day) disopyramide administration to arrhythmic chagasic patients decreased the frequency of ventricular extrasystoles in 4 of 17 patients (24%) and suppressed most complex ventricular arrhythmias in 12 of 15 patients (80%)." | 5.05 | Effect of low oral doses of disopyramide and amiodarone on ventricular and atrial arrhythmias of chagasic patients with advanced myocardial damage. ( Carrasco, HA; Fuenmayor, A; Landaeta, A; López, F; Molina, C; Reynosa, J; Vicuña, AV; Vicuña, N, 1985) |
| " Ventricular arrhythmias are common in patients with Chagas cardiomyopathy, and amiodarone has been widely used for this purpose." | 4.98 | Amiodarone for arrhythmia in patients with Chagas disease: A systematic review and individual patient data meta-analysis. ( Colpani, V; Cruz, LN; da Rosa, PR; Falavigna, M; Giordani, NE; Migliavaca, CB; Miguel, SRPS; Polanczyk, CA; Ribeiro, ALP; Sganzerla, D; Stein, C, 2018) |
| "Patients with chronic Chagas cardiopathy (CCC), which may be associated with cardiac arrhythmias, frequently use amiodarone, an antiarrhythmic drug that, experimentally, appears to modulate the cardiac autonomic function." | 3.88 | Cardiac autonomic modulation and long-term use of amiodarone in patients with chronic Chagasic cardiopathy. ( Correia, D; de Almeida, RS; Dias da Silva, VJ; Fortes Silva, HE; Llaguno, M; Resende, LAPR; Silveira, DB, 2018) |
| "To evaluate the efficacy and safety of long-term empiric amiodarone therapy in patients with recurrent Sustained Ventricular Tachycardia (SVT) and Chronic Chagasic Myocarditis (CCM)." | 3.68 | [Empiric therapy with amiodarone in patients with chronic Chagas cardiomyopathy and sustained ventricular tachycardia]. ( Bellotti, G; Lee, JH; Pileggi, F; Scanavacca, MI; Sosa, EA, 1990) |
| "Oral amiodarone was administered to 24 patients with chronic chagasic myocarditis (CCM) and malignant ventricular arrhythmias." | 3.67 | Efficacy of amiodarone during long-term treatment of malignant ventricular arrhythmias in patients with chronic chagasic myocarditis. ( Chiale, PA; Elizari, MV; Halpern, MS; Lázzari, JO; Nau, GJ; Przybylski, J; Rosenbaum, MB; Tambussi, AM, 1984) |
| "Arrhythmias may be controlled in most patients with recurrent supraventricular tachycardia or atrial fibrillation with small to moderate maintenance doses of amiodarone (100 to 400 mg/day)." | 3.66 | Ten years of experience with amiodarone. ( Chiale, PA; Elizari, MV; Haedo, A; Lázzari, JO; Rosenbaum, MB, 1983) |
| "Fourteen patients with congestive heart failure due to chronic Chagas' disease had hemodynamic studies before and 20, 40 and 60 minutes and 24 hours after intravenous amiodarone." | 3.66 | Hemodynamic effects of intravenous administration of amiodarone in congestive heart failure from chronic Chagas' disease. ( Bellotti, G; da Luz, P; de Moraes, AV; Esteves Filho, A; Pileggi, F; Ramires, JA; Rati, M; Silva, LA, 1983) |
| "Amiodarone was also used in 90% of the ICD group." | 1.40 | Implantable cardioverter-defibrillators for treatment of sustained ventricular arrhythmias in patients with Chagas' heart disease: comparison with a control group treated with amiodarone alone. ( Baggio, JM; Ferreira, LG; Gali, WL; Gomes, GG; Junqueira, LF; Marin-Neto, JA; Sarabanda, AV, 2014) |
| "Cardiac mortality and sudden cardiac death rates also were higher in group 3 patients." | 1.32 | Clinical usefulness of electrophysiologic testing in patients with ventricular tachycardia and chronic chagasic cardiomyopathy treated with amiodarone or sotalol. ( de Paola, AA; Fenelon, G; Friedman, PA; Leite, LR; Silva, GG; Simoes, A, 2003) |
| "Amiodarone was the only one of the four drugs that caused a substantial reduction of ventricular premature complexes (logarithmic mean 97." | 1.27 | Comparative antiarrhythmic efficacy of verapamil, 17-monochloracetylajmaline, mexiletine and amiodarone in patients with severe chagasic myocarditis: relation with the underlying arrhythmogenic mechanisms. ( Bandieri, JD; Chiale, PA; Elizari, MV; Haedo, AH; Lázzari, JO; Rosenbaum, MB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (38.71) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Malcolm, EL | 1 |
| Saunders, AB | 1 |
| Vitt, JP | 1 |
| Boutet, BG | 1 |
| Hamer, SA | 1 |
| Rassi, FM | 1 |
| Minohara, L | 1 |
| Rassi, A | 5 |
| Correia, LCL | 1 |
| Marin-Neto, JA | 3 |
| da Silva Menezes, A | 1 |
| Moll-Bernardes, RJ | 1 |
| Saraiva, RM | 1 |
| Oliveira, RS | 1 |
| Pinheiro, MVT | 1 |
| Camargo, GC | 1 |
| Brito, ASX | 1 |
| Almeida, SA | 1 |
| Siqueira, FPR | 1 |
| Mendes, FSNS | 1 |
| Barbosa, RM | 1 |
| Xavier, SS | 1 |
| Rosado de Castro, PH | 1 |
| Sousa, AS | 1 |
| Fortes Silva, HE | 1 |
| de Almeida, RS | 1 |
| Silveira, DB | 1 |
| Llaguno, M | 1 |
| Resende, LAPR | 1 |
| Dias da Silva, VJ | 1 |
| Correia, D | 1 |
| Stein, C | 1 |
| Migliavaca, CB | 1 |
| Colpani, V | 1 |
| da Rosa, PR | 1 |
| Sganzerla, D | 1 |
| Giordani, NE | 1 |
| Miguel, SRPS | 1 |
| Cruz, LN | 1 |
| Polanczyk, CA | 1 |
| Ribeiro, ALP | 1 |
| Falavigna, M | 1 |
| Martinelli, M | 1 |
| de Paola, AA | 2 |
| Berwanger, O | 1 |
| Scanavacca, MI | 2 |
| Kalil, R | 1 |
| de Siqueira, SF | 1 |
| Gali, WL | 1 |
| Sarabanda, AV | 1 |
| Baggio, JM | 1 |
| Ferreira, LG | 1 |
| Gomes, GG | 1 |
| Junqueira, LF | 1 |
| Kalil-Filho, R | 1 |
| Bestetti, R | 1 |
| Cardinalli-Neto, A | 1 |
| Benaim, G | 1 |
| Paniz Mondolfi, AE | 1 |
| Leite, LR | 1 |
| Fenelon, G | 1 |
| Simoes, A | 1 |
| Silva, GG | 1 |
| Friedman, PA | 1 |
| Exner, DV | 1 |
| Klein, GJ | 1 |
| Machado, MN | 1 |
| Suzuki, FA | 1 |
| Mouco, OC | 1 |
| Hernandes, ME | 1 |
| Lemos, MA | 1 |
| Maia, LN | 1 |
| Viotti, R | 1 |
| Vigliano, C | 1 |
| Armenti, A | 1 |
| Gimena, B | 1 |
| Sopeña, B | 1 |
| Sousa, J | 1 |
| Albajar-Viñas, P | 1 |
| González-Mediero, G | 1 |
| Román, F | 1 |
| Martínez-Vázquez, C | 1 |
| Bellotti, G | 4 |
| Silva, LA | 3 |
| Esteves Filho, A | 3 |
| Grupi, C | 1 |
| Rati, M | 3 |
| Galiano, N | 2 |
| de Moraes, AV | 3 |
| Ramires, AF | 1 |
| Pileggi, F | 4 |
| Meruane, J | 1 |
| Manzur, F | 1 |
| Saavedra, M | 1 |
| Rosenbaum, MB | 4 |
| Chiale, PA | 3 |
| Haedo, A | 2 |
| Lázzari, JO | 3 |
| Elizari, MV | 3 |
| Ramires, JA | 2 |
| da Luz, P | 1 |
| Halpern, MS | 1 |
| Nau, GJ | 1 |
| Tambussi, AM | 1 |
| Przybylski, J | 1 |
| Greco, OT | 1 |
| Lorga, AM | 1 |
| Garzon, SA | 1 |
| Younan, I | 1 |
| Bellini, AJ | 1 |
| Bilaqui, A | 1 |
| de Araújo, JD | 1 |
| Nicolau, JC | 1 |
| Jacob, JL | 1 |
| Ardito, RV | 1 |
| Ayoub, JC | 1 |
| Braile, DM | 1 |
| Curti, HV | 1 |
| Sanches, PC | 1 |
| Bittencourt, LA | 1 |
| Manigot, DA | 1 |
| Jorge, PA | 1 |
| Carvalhal, S | 1 |
| Muratore, C | 1 |
| Rabinovich, R | 1 |
| Iglesias, R | 1 |
| González, M | 1 |
| Darú, V | 1 |
| Liprandi, AS | 1 |
| Giniger, AG | 1 |
| Retyk, EO | 1 |
| Laiño, RA | 1 |
| Sananes, EG | 1 |
| Lapuente, AR | 1 |
| Sosa, EA | 1 |
| Lee, JH | 1 |
| Kaski, JC | 1 |
| Chiale, P | 1 |
| Elizari, M | 1 |
| Tomaszewski, R | 1 |
| Carrasco, HA | 1 |
| Vicuña, AV | 1 |
| Molina, C | 1 |
| Landaeta, A | 1 |
| Reynosa, J | 1 |
| Vicuña, N | 1 |
| Fuenmayor, A | 1 |
| López, F | 1 |
| Haedo, AH | 1 |
| Bandieri, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CHronic Use of Amiodarone aGAinSt Implantable Cardioverter-defibrillator Therapy for Primary Prevention of Death in Patients With Chagas Cardiomyopathy Study (CHAGASICS)[NCT01722942] | 1,100 participants (Anticipated) | Interventional | 2014-10-06 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for amiodarone and Chagas Cardiomyopathy
| Article | Year |
|---|---|
Systematic Review and Meta-Analysis of Clinical Outcome After Implantable Cardioverter-Defibrillator Therapy in Patients With Chagas Heart Disease.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Chagas Cardiomyopathy; Death, Sudde | 2019 |
Amiodarone for arrhythmia in patients with Chagas disease: A systematic review and individual patient data meta-analysis.
Topics: Amiodarone; Arrhythmias, Cardiac; Chagas Cardiomyopathy | 2018 |
The emerging role of amiodarone and dronedarone in Chagas disease.
Topics: Amiodarone; Chagas Cardiomyopathy; Humans; Vasodilator Agents | 2012 |
[Disorders of cardiac rhythm and conduction in Chagas cardiomyopathy].
Topics: Amiodarone; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Chagas Cardiomyopathy; Humans | 1986 |
3 trials available for amiodarone and Chagas Cardiomyopathy
| Article | Year |
|---|---|
CHronic use of Amiodarone aGAinSt Implantable cardioverter-defibrillator therapy for primary prevention of death in patients with Chagas cardiomyopathy Study: rationale and design of a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Brazil; Chagas Cardiomyopathy; Death, S | 2013 |
[Electrocardiographic and hemodynamic effects of amiodarone hydrochloride by intravenous route].
Topics: Adult; Amiodarone; Benzofurans; Chagas Cardiomyopathy; Clinical Trials as Topic; Electrocardiography | 1983 |
Effect of low oral doses of disopyramide and amiodarone on ventricular and atrial arrhythmias of chagasic patients with advanced myocardial damage.
Topics: Administration, Oral; Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Chagas Cardiomyopa | 1985 |
24 other studies available for amiodarone and Chagas Cardiomyopathy
| Article | Year |
|---|---|
Antiparasitic treatment with itraconazole and amiodarone in 2 dogs with severe, symptomatic Chagas cardiomyopathy.
Topics: Amiodarone; Animals; Anti-Infective Agents; Antiparasitic Agents; Arrhythmias, Cardiac; Chagas Cardi | 2022 |
Case Report: Malignant Ventricular Arrhythmias Mimicking Acute Coronary Syndrome in Chagas Disease.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chagas Cardiomyopathy; Clopidogrel; | 2020 |
Cardiac autonomic modulation and long-term use of amiodarone in patients with chronic Chagasic cardiopathy.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Autonomic Nervous System; Chagas Car | 2018 |
Implantable cardioverter-defibrillators for treatment of sustained ventricular arrhythmias in patients with Chagas' heart disease: comparison with a control group treated with amiodarone alone.
Topics: Accelerated Idioventricular Rhythm; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Chagas Cardiomy | 2014 |
Globalization of Chagas Disease Burden and New Treatment Perspectives.
Topics: Amiodarone; Chagas Cardiomyopathy; Cost of Illness; Female; Global Health; Health Expenditures; Huma | 2015 |
Implantable cardioverter defibrillator therapy for patients with chronic Chagas' disease: a randomized trial may not be necessary in high-risk patients.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; | 2009 |
Case 2-2010: a man with abdominal and flank pain.
Topics: Abdominal Pain; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Chagas | 2010 |
Clinical usefulness of electrophysiologic testing in patients with ventricular tachycardia and chronic chagasic cardiomyopathy treated with amiodarone or sotalol.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Brazil; Chagas Cardiomyopathy; Death, Sudden, Cardiac; Dr | 2003 |
Do we need a randomized trial of defibrillator therapy in every subset of patients with increased risk of sudden death?
Topics: Amiodarone; Anti-Arrhythmia Agents; Chagas Cardiomyopathy; Death, Sudden, Cardiac; Defibrillators, I | 2003 |
[Positive troponin T in a chagasic patient with sustained ventricular tachycardia and no obstructive lesions on cine coronary angiography].
Topics: Amiodarone; Anti-Arrhythmia Agents; Biomarkers; Chagas Cardiomyopathy; Cineangiography; Coronary Ang | 2005 |
A risk score for predicting death in Chagas' heart disease.
Topics: Adrenergic beta-Antagonists; Age Factors; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti | 2006 |
[Chest pain and peripheral eosinophilia].
Topics: Adult; Amiodarone; Chagas Cardiomyopathy; Chest Pain; Diuretics; Drug Therapy, Combination; Electroc | 2007 |
[Torsade de pointes or atypical ventricular tachycardia in a patient with Chagas' cardiomyopathy].
Topics: Aged; Amiodarone; Chagas Cardiomyopathy; Drug Therapy, Combination; Echocardiography; Electrocardiog | 1984 |
Ten years of experience with amiodarone.
Topics: Amiodarone; Arrhythmias, Cardiac; Atrial Fibrillation; Benzofurans; Chagas Cardiomyopathy; Dose-Resp | 1983 |
Hemodynamic effects of intravenous administration of amiodarone in congestive heart failure from chronic Chagas' disease.
Topics: Adult; Amiodarone; Benzofurans; Blood Pressure; Cardiac Output; Chagas Cardiomyopathy; Female; Heart | 1983 |
[Effects of amiodarone on the elastic properties of the left ventricle in chronic Chagas' cardiomyopathy].
Topics: Adult; Amiodarone; Benzofurans; Blood Pressure; Cardiac Output; Chagas Cardiomyopathy; Echocardiogra | 1983 |
Efficacy of amiodarone during long-term treatment of malignant ventricular arrhythmias in patients with chronic chagasic myocarditis.
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Chagas Cardiomyopathy; Chronic Disease; | 1984 |
[Amiodarone in ventricular arrhythmias of chronic Chagas cardiopathy].
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Chagas Cardiomyopathy; Female; Humans; M | 1980 |
[Ventricular tachycardia caused by the use of amiodarone. Report of a case].
Topics: Amiodarone; Benzofurans; Chagas Cardiomyopathy; Electrocardiography; Humans; Male; Middle Aged; Phys | 1981 |
Implantable cardioverter defibrillators in patients with Chagas' disease: are they different from patients with coronary disease?
Topics: Age Factors; Amiodarone; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Chagas Cardiomyopathy; | 1997 |
Ventricular tachycardia in Chagas' disease.
Topics: Adult; Aged; Amiodarone; Chagas Cardiomyopathy; Echocardiography; Electric Stimulation; Electrophysi | 1992 |
[Empiric therapy with amiodarone in patients with chronic Chagas cardiomyopathy and sustained ventricular tachycardia].
Topics: Adult; Aged; Amiodarone; Chagas Cardiomyopathy; Chronic Disease; Female; Heart Rate; Humans; Male; M | 1990 |
Efficacy of amiodarone in patients with Chagas' disease and life-threatening arrhythmias.
Topics: Amiodarone; Arrhythmias, Cardiac; Benzofurans; Chagas Cardiomyopathy; Drug Evaluation; Humans; Progn | 1986 |
Comparative antiarrhythmic efficacy of verapamil, 17-monochloracetylajmaline, mexiletine and amiodarone in patients with severe chagasic myocarditis: relation with the underlying arrhythmogenic mechanisms.
Topics: Adult; Ajmaline; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Chagas Cardiomyopathy; Female; Human | 1986 |