Page last updated: 2024-10-22

amiodarone and Bradycardia

amiodarone has been researched along with Bradycardia in 77 studies

Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.

Research Excerpts

ExcerptRelevanceReference
"Dronedarone is a new antiarrhythmic drug that is being developed for the treatment of patients with atrial fibrillation."9.14Effect of dronedarone on cardiovascular events in atrial fibrillation. ( Connolly, SJ; Crijns, HJ; Gaudin, C; Hohnloser, SH; Page, RL; Torp-Pedersen, C; van Eickels, M, 2009)
"Intraoperative prophylactic use of amiodarone does not prevent new onset of atrial fibrillation in patients undergoing coronary artery bypass grafting and had no effect on outcome."9.09Intraoperative amiodarone as prophylaxis against atrial fibrillation after coronary operations. ( Dörge, H; Messmer, BJ; Schoberer, M; Schoendube, FA; Stellbrink, C; Voss, M, 2000)
"If tolerated, continuous intravenous verapamil infusion showed only a modest prophylactic efficacy for the occurrence of atrial fibrillation after lung operations."9.08Verapamil as prophylactic treatment for atrial fibrillation after lung operations. ( Demedts, M; Demuynck, K; Deneffe, G; Lacquet, L; Tits, G; Tjandra-Maga, T; Van Mieghem, W, 1996)
"MEDLINE search of published, randomized, controlled trials assessing the efficacy and safety of intravenous amiodarone in recent-onset (< 7 days) atrial fibrillation, supplemented with searches of reference lists of identified articles and bibliographies of secondary and tertiary review articles."8.81Conversion of recent-onset atrial fibrillation with intravenous amiodarone: a meta-analysis of randomized controlled trials. ( Hilleman, DE; Spinler, SA, 2002)
"The use of amiodarone for postoperative atrial fibrillation (AF) is widespread; however, there is a paucity of data on the optimal duration of overlap when transitioning from intravenous (IV) to oral amiodarone."8.12Intravenous to Oral Transition of Amiodarone (IOTA): Effect of Various Durations of Overlap on Atrial Fibrillation Recurrence After Cardiothoracic Surgery. ( Lam, JC; Lee, YG; Maurer, J; Patanwala, AE; Radosevich, JJ; Stevenson, B, 2022)
"Amiodarone, prescribed for cardiac conditions, including dysrhythmia, is associated with bradycardia."7.96Severe Bradycardia Induced by Sofosbuvir and Amiodarone which Resolved after the Discontinuation of Both Drugs. ( Funakoshi, H; Kitaguchi, K; Monoe, C; Shimizu, H, 2020)
" In 2015, the Food and Drug Administration and European Medical Agency warned that bradycardia could occur when amiodarone was administered in combination with sofosbuvir, but no case reports had been published."7.81Extreme bradycardia after first doses of sofosbuvir and daclatasvir in patients receiving amiodarone: 2 cases including a rechallenge. ( Algalarrondo, V; Antonini, T; Chaumais, MC; Duclos-Vallée, JC; Renet, S; Samuel, D; Savoure, A; Thomas, L; Zhao, A, 2015)
"Cardiac disorders caused by sofosbuvir are liable to be worsened by concomitant use of one of the many drugs that provoke cardiac arrhythmia."7.81Sofosbuvir + amiodarone: bradycardia and conduction disturbances. ( , 2015)
"Our study showed that during the intra- and postoperative periods, both amiodarone and magnesium sulfate are effective at preventing the incidence of atrial fibrillation following lung resection surgery in comparison to the control group."7.79A comparative study between amiodarone and magnesium sulfate as antiarrhythmic agents for prophylaxis against atrial fibrillation following lobectomy. ( Abdel Azeem, MS; Al-Agaty, AE; Ali, WG; Khalil, MA, 2013)
"This study suggests that the use of amiodarone in elderly patients with AF and a previous MI increases the risk of bradyarrhythmia requiring a permanent pacemaker."7.72Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardial infarction. ( Essebag, V; Hadjis, T; Pilote, L; Platt, RW, 2003)
"Gestational exposure to amiodarone may be complicated by perinatal hypothyroidism or hyperthyroidism and possibly neurologic abnormalities, intrauterine growth retardation or fetal bradycardia."7.69Pregnancy outcome after gestational exposure to amiodarone in Canada. ( Allen, LC; Boulton, BC; Downar, E; Koren, G; Magee, LA; Sermer, M, 1995)
"In 23 patients with symptomatic severe supraventricular and ventricular tachyarrhythmias the effectiveness and the side effects of a long-term therapy with the class III antiarrhythmic drug Amiodarone (Cordarone) in a dosage of 100-800 mg/die in monotherapy and combination therapy were investigated."7.67[Long-term therapy with amiodarone in tachyarrhythmias--report on various experiences with special reference to its side effects]. ( Assmann, I, 1985)
"Amiodarone, 600 mg orally daily, was used in an attempt to control supraventricular tachyarrhythmias in a patient with the sick sinus syndrome."7.66Amiodarone-induced ventricular fibrillation. ( Adgey, AA; Geddes, JS; Khan, MM; Logan, KR; McComb, JM, 1980)
"Five patients with the bradycardia-tachycardia syndrome have been treated successfully with the antiarrhythmic agent amiodarone."7.66Use of amiodarone in bradycardia-tachycardia syndrome. ( Brown, AK; Newton, P; Primhak, RA, 1978)
"Bradycardia was observed less in the study group (76 ± 29) than in the control group (93 ± 18; P < ."6.79Effectiveness of biatrial epicardial application of amiodarone-releasing adhesive hydrogel to prevent postoperative atrial fibrillation. ( Feng, XD; Wang, W; Wang, XN; Yuan, XH, 2014)
"Amiodarone has been shown to improve survival in patients with impaired left ventricular function and ventricular trachyarrhythmias."5.29[Symptomatic bradycardia with amiodarone in patients with pre-existing conduction disorders]. ( Hofmann, R; Leisch, F, 1995)
"Dronedarone is a new antiarrhythmic drug that is being developed for the treatment of patients with atrial fibrillation."5.14Effect of dronedarone on cardiovascular events in atrial fibrillation. ( Connolly, SJ; Crijns, HJ; Gaudin, C; Hohnloser, SH; Page, RL; Torp-Pedersen, C; van Eickels, M, 2009)
"Intraoperative prophylactic use of amiodarone does not prevent new onset of atrial fibrillation in patients undergoing coronary artery bypass grafting and had no effect on outcome."5.09Intraoperative amiodarone as prophylaxis against atrial fibrillation after coronary operations. ( Dörge, H; Messmer, BJ; Schoberer, M; Schoendube, FA; Stellbrink, C; Voss, M, 2000)
"If tolerated, continuous intravenous verapamil infusion showed only a modest prophylactic efficacy for the occurrence of atrial fibrillation after lung operations."5.08Verapamil as prophylactic treatment for atrial fibrillation after lung operations. ( Demedts, M; Demuynck, K; Deneffe, G; Lacquet, L; Tits, G; Tjandra-Maga, T; Van Mieghem, W, 1996)
" β blockers, alone or in combination with digoxin, or non-dihydropyridine calcium-channel blockers (not in heart failure) effectively lower the heart rate."4.93Rate control in atrial fibrillation. ( Crijns, HJ; Olshansky, B; Rienstra, M; Van Gelder, IC, 2016)
"Amiodarone remains one of the preferred antiarrhythmic medications for patients with advanced heart failure awaiting cardiac transplant."4.91Impact of pre-implant amiodarone exposure on outcomes in cardiac transplant recipients. ( Jennings, DL; Lanfear, DE; Martinez, B; Montalvo, S, 2015)
"MEDLINE search of published, randomized, controlled trials assessing the efficacy and safety of intravenous amiodarone in recent-onset (< 7 days) atrial fibrillation, supplemented with searches of reference lists of identified articles and bibliographies of secondary and tertiary review articles."4.81Conversion of recent-onset atrial fibrillation with intravenous amiodarone: a meta-analysis of randomized controlled trials. ( Hilleman, DE; Spinler, SA, 2002)
"Amiodarone, an investigational drug in the United States, has had considerable use in this country and worldwide in the treatment of cardiac arrhythmias."4.76Clinical use and pharmacology of amiodarone. ( Heger, JJ; Miles, WM; Prystowsky, EN; Zipes, DP, 1984)
"The use of amiodarone for postoperative atrial fibrillation (AF) is widespread; however, there is a paucity of data on the optimal duration of overlap when transitioning from intravenous (IV) to oral amiodarone."4.12Intravenous to Oral Transition of Amiodarone (IOTA): Effect of Various Durations of Overlap on Atrial Fibrillation Recurrence After Cardiothoracic Surgery. ( Lam, JC; Lee, YG; Maurer, J; Patanwala, AE; Radosevich, JJ; Stevenson, B, 2022)
"Amiodarone, prescribed for cardiac conditions, including dysrhythmia, is associated with bradycardia."3.96Severe Bradycardia Induced by Sofosbuvir and Amiodarone which Resolved after the Discontinuation of Both Drugs. ( Funakoshi, H; Kitaguchi, K; Monoe, C; Shimizu, H, 2020)
"Administration of acute or chronic pretransplant amiodarone was not related to an increased occurrence of bradycardia, requirement for permanent pacemaker implantation, or mortality after HTX."3.85Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation. ( Bruckner, T; Darche, FF; Doesch, AO; Helmschrott, M; Katus, HA; Rivinius, R; Ruhparwar, A; Thomas, D, 2017)
"Cardiac disorders caused by sofosbuvir are liable to be worsened by concomitant use of one of the many drugs that provoke cardiac arrhythmia."3.81Sofosbuvir + amiodarone: bradycardia and conduction disturbances. ( , 2015)
" In 2015, the Food and Drug Administration and European Medical Agency warned that bradycardia could occur when amiodarone was administered in combination with sofosbuvir, but no case reports had been published."3.81Extreme bradycardia after first doses of sofosbuvir and daclatasvir in patients receiving amiodarone: 2 cases including a rechallenge. ( Algalarrondo, V; Antonini, T; Chaumais, MC; Duclos-Vallée, JC; Renet, S; Samuel, D; Savoure, A; Thomas, L; Zhao, A, 2015)
"Between January 1, 2000 and March 10, 2012, a total of 930 consecutive patients who had been treated with amiodarone for arrhythmia were reviewed retrospectively."3.80The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice. ( Chung, WY; Kim, HL; Kim, MA; Kim, SH; Seo, JB; Zo, JH, 2014)
"Multiple studies have shown that amiodarone is effective in treating atrial fibrillation (AF), but is associated with a relatively high incidence of side effects; however, due to amiodarone's long elimination half-life (20-100 days), physicians may hesitate to start other drugs until it has fully cleared."3.79Effects of dronedarone started rapidly after amiodarone discontinuation. ( Aliot, E; Capucci, A; Connolly, S; Crijns, H; Hohnloser, S; Immordino, L; Kowey, P; Radzik, D; Roy, D, 2013)
"Our study showed that during the intra- and postoperative periods, both amiodarone and magnesium sulfate are effective at preventing the incidence of atrial fibrillation following lung resection surgery in comparison to the control group."3.79A comparative study between amiodarone and magnesium sulfate as antiarrhythmic agents for prophylaxis against atrial fibrillation following lobectomy. ( Abdel Azeem, MS; Al-Agaty, AE; Ali, WG; Khalil, MA, 2013)
"Treatment with amiodarone is often associated with sinus bradycardia."3.74[Effect of treatment with amiodarone on sinus node function]. ( Reĭngardene, DI, 2007)
"Amiodarone and cedilanid may be the proper drugs for the treatment of paroxysmal atrial fibrillation in the elderly."3.73Drug therapy of paroxysmal atrial fibrillation in the elderly over 75 years old. ( Cao, J; Chen, DY; Zhu, BP, 2006)
"This study suggests that the use of amiodarone in elderly patients with AF and a previous MI increases the risk of bradyarrhythmia requiring a permanent pacemaker."3.72Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardial infarction. ( Essebag, V; Hadjis, T; Pilote, L; Platt, RW, 2003)
"Bradyarrhythmia requiring permanent pacemaker insertion has been associated with amiodarone use but the effect of amiodarone dose has not been investigated."3.72Effect of amiodarone dose on the risk of permanent pacemaker insertion. ( Abrahamowicz, M; Essebag, V; Hadjis, T; Pilote, L; Platt, RW, 2004)
"Gestational exposure to amiodarone may be complicated by perinatal hypothyroidism or hyperthyroidism and possibly neurologic abnormalities, intrauterine growth retardation or fetal bradycardia."3.69Pregnancy outcome after gestational exposure to amiodarone in Canada. ( Allen, LC; Boulton, BC; Downar, E; Koren, G; Magee, LA; Sermer, M, 1995)
"Recurrent atypical ventricular tachycardia, with a long QT interval, was documented in a 56-year-old patient 16 days after discontinuing amiodarone 200 mg and 400 mg on alternate days."3.67Torsade de pointes after amiodarone withdrawal; effects of mild hypokalaemia on repolarization. ( Forfar, JC; Gribbin, B, 1984)
" Individual differences between the longest and the shortest RV MAP durations indicate that: normally (40 subjects) ventricular repolarization is almost synchronous; QT prolongation due either to bradycardia or to amiodarone treatment (eight cases) may be the result of a uniform lengthening of ventricular repolarization, when ventricular arrhythmias are not present; in long QT syndromes (LQTSs) of differing etiology (10 cases), in which severe ventricular arrhythmias are present, marked individual differences in RV MAP duration are present and correspond with pathological asynchrony of ventricular repolarization."3.67Monophasic action potential studies in human subjects with prolonged ventricular repolarization and long QT syndromes. ( Bonatti, V; Botti, G; Rolli, A, 1985)
"A 67 year old man with recurrent hypotensive ventricular tachycardia, amiodarone-induced bradyarrhythmias and severe cardiac dysfunction underwent simultaneous implantation of an automatic cardioverter/defibrillator and bipolar atrioventricular (AV) pacemaker."3.67Combined bipolar dual chamber pacing and automatic implantable cardioverter/defibrillator. ( Kim, SS; Kouchoukos, NT; Lal, R; Ruffy, R, 1986)
"In 23 patients with symptomatic severe supraventricular and ventricular tachyarrhythmias the effectiveness and the side effects of a long-term therapy with the class III antiarrhythmic drug Amiodarone (Cordarone) in a dosage of 100-800 mg/die in monotherapy and combination therapy were investigated."3.67[Long-term therapy with amiodarone in tachyarrhythmias--report on various experiences with special reference to its side effects]. ( Assmann, I, 1985)
"Amiodarone, 600 mg orally daily, was used in an attempt to control supraventricular tachyarrhythmias in a patient with the sick sinus syndrome."3.66Amiodarone-induced ventricular fibrillation. ( Adgey, AA; Geddes, JS; Khan, MM; Logan, KR; McComb, JM, 1980)
"Five patients with the bradycardia-tachycardia syndrome have been treated successfully with the antiarrhythmic agent amiodarone."3.66Use of amiodarone in bradycardia-tachycardia syndrome. ( Brown, AK; Newton, P; Primhak, RA, 1978)
"Bradycardia was observed less in the study group (76 ± 29) than in the control group (93 ± 18; P < ."2.79Effectiveness of biatrial epicardial application of amiodarone-releasing adhesive hydrogel to prevent postoperative atrial fibrillation. ( Feng, XD; Wang, W; Wang, XN; Yuan, XH, 2014)
" Adverse events occurred in 17 patients (3 died, 3 had bradycardia that required permanent pacemaker implantation, and 11 had bradycardia requiring a decrease in the dose of antiarrhythmic or rate-controlling medication)."2.71Safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications in patients with atrial fibrillation or atrial flutter. ( Hauser, TH; Josephson, ME; Pinto, DS; Zimetbaum, P, 2003)
" However, there was no clear dose-response relation observed in this trial with respect to success rates (primary end point), time to first recurrence of tachyarrhythmia (post hoc analysis) or mortality (secondary end point) over 24 h."2.68Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias. Intravenous Amiodarone Multicenter Trial Group. ( Chilson, DA; Gomes, A; Levine, JH; Massumi, A; Platia, EV; Scheinman, MM; Winkle, RA; Woosley, RL, 1996)
"For patients who have not had sustained ventricular tachycardia or ventricular fibrillation antiarrhythmic therapy should generally be avoided, but may benefit some high risk patients."2.40Pharmacologic and nonpharmacologic treatment of ventricular arrhythmias in heart failure. ( Stevenson, WG; Sweeney, MO, 1997)
"Drugs can cause cardiac arrhythmias in a number of clinical situations, and many of the implicated agents are used to treat non-cardiac conditions."2.40Drug-induced cardiac arrhythmias: incidence, prevention and management. ( Doig, JC, 1997)
"Amiodarone is an extremely potent drug which is effective for both supraventricular as well as ventricular arrhythmias."2.36New antiarrhythmic drugs. ( Hess, DS; Scheinman, MM, 1983)
"Amiodarone use was associated with higher metoprolol concentrations following adjustment for different covariates (p = ."1.91Impact of amiodarone use on metoprolol concentrations, α-OH-metoprolol concentrations, metoprolol dosing and heart rate: A cross-sectional study. ( Busseuil, D; de Denus, S; Dubé, MP; Gaulin, MJ; Jutras, M; Leclair, G; Meloche, M; Mongrain, I; Oussaïd, E; Pilon, MO; Robert, S; Tardif, JC, 2023)
"Eight patients were hospitalized for bradyarrhythmia."1.42Cardiovascular Events of Electrical Cardioversion Under Optimal Anticoagulation in Atrial Fibrillation: The Multicenter Analysis. ( Cho, I; Hartaigh, Bó; Hwang, ES; Joung, B; Lee, HY; Lee, MH; Mun, HS; Pak, HN; Park, JK; Shin, DG; Uhm, JS, 2015)
"When dronedarone injection was preceded by ivabradine, no further decrease in heart rate or change in MAP was observed (N = 6)."1.39Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect. ( Belardinelli, L; Machado, AD; Nearing, BD; Sobrado, LF; Varone, BB; Verrier, RL; Zeng, D, 2013)
"Ventricular tachycardias have a broad QRS complex (>or=0."1.36[Life-threatening brady- and tachyarrhythmias]. ( Trappe, HJ, 2010)
"We report a case of a patient with paroxysmal atrial fibrillation (PAF) and with a permanent AAIR (bipolar atrial-inhibited adaptive rate) pacemaker who suffered life-threatening episodes of arrhythmias during operation."1.33Anesthetic management of an AAI pacemaker patient with paroxysmal atrial fibrillation during colorectal surgery. ( Borel, CO; Lin, JA; Wang, WB; Wong, CS; Wu, CT; Yang, CP; Yeh, CC, 2006)
"The most prevalent inclusion bradyarrhythmia was > or =second-degree AV block (82%)."1.32Predictors of in-hospital ventricular fibrillation or torsades de pointes in patients with acute symptomatic bradycardia. ( Almendral, J; Arenal, A; Díaz-Castro, O; Martínez-Selles, M; Puchol, A; Torrecilla, EG, 2004)
"Amiodarone has been shown to improve survival in patients with impaired left ventricular function and ventricular trachyarrhythmias."1.29[Symptomatic bradycardia with amiodarone in patients with pre-existing conduction disorders]. ( Hofmann, R; Leisch, F, 1995)

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-199021 (27.27)18.7374
1990's11 (14.29)18.2507
2000's21 (27.27)29.6817
2010's21 (27.27)24.3611
2020's3 (3.90)2.80

Authors

AuthorsStudies
Lam, JC1
Stevenson, B1
Lee, YG1
Maurer, J1
Patanwala, AE1
Radosevich, JJ1
Robert, S1
Pilon, MO1
Oussaïd, E1
Meloche, M1
Leclair, G1
Jutras, M1
Gaulin, MJ1
Mongrain, I1
Busseuil, D1
Tardif, JC1
Dubé, MP1
de Denus, S1
Monoe, C1
Shimizu, H1
Kitaguchi, K1
Funakoshi, H1
Rivinius, R1
Helmschrott, M1
Ruhparwar, A1
Darche, FF1
Thomas, D1
Bruckner, T1
Katus, HA1
Doesch, AO1
Maghrabi, K1
Uzun, O1
Kirsh, JA1
Balaji, S1
Von Bergen, NH1
Sanatani, S1
Dalgaard, F1
Pallisgaard, JL1
Lindhardt, TB1
Torp-Pedersen, C2
Gislason, GH1
Ruwald, MH1
Sobrado, LF1
Varone, BB1
Machado, AD1
Nearing, BD1
Zeng, D1
Belardinelli, L1
Verrier, RL1
Feng, XD1
Wang, XN1
Yuan, XH1
Wang, W1
Kim, HL1
Seo, JB1
Chung, WY1
Kim, SH1
Kim, MA1
Zo, JH1
Jennings, DL1
Martinez, B1
Montalvo, S1
Lanfear, DE1
Renet, S1
Chaumais, MC1
Antonini, T1
Zhao, A1
Thomas, L1
Savoure, A1
Samuel, D1
Duclos-Vallée, JC1
Algalarrondo, V1
Back, DJ1
Burger, DM1
Shin, DG1
Cho, I1
Hartaigh, Bó1
Mun, HS1
Lee, HY1
Hwang, ES1
Park, JK1
Uhm, JS1
Pak, HN1
Lee, MH1
Joung, B1
Brainard, DM1
McHutchison, JG1
Fontaine, H1
Lazarus, A1
Pol, S1
Pecriaux, C1
Bagate, F1
Sultanik, P1
Boueyre, E1
Corouge, M1
Mallet, V1
Vallet-Pichard, A1
Sogni, P1
Duboc, D1
Ghembaza, Mel A1
Lounici, A1
Van Gelder, IC1
Rienstra, M1
Crijns, HJ2
Olshansky, B1
Hohnloser, SH2
van Eickels, M1
Gaudin, C1
Page, RL1
Connolly, SJ1
Stiefelhagen, P1
Bariş, S1
Güzeltaş, A1
Seymen, G1
Ozyilmaz, I1
Güler Eroğlu, A1
Oztunç, F1
González Oliva, JC1
Saurina i Solé, A1
Pou Potau, M1
Salas Gama, KR1
Ramírez de Arellano Serna, M1
Trappe, HJ1
Jan, SL1
Fu, YC1
Lin, MC1
Hwang, B1
Khalil, MA1
Al-Agaty, AE1
Ali, WG1
Abdel Azeem, MS1
Immordino, L1
Connolly, S1
Crijns, H1
Roy, D1
Capucci, A1
Radzik, D1
Aliot, E1
Hohnloser, S1
Kowey, P1
Dias Da Silva, VJ2
Gnecchi-Ruscone, T1
Lavelli, B1
Bellina, V1
Manzella, D1
Porta, A1
Malliani, A1
Montano, N2
Essebag, V2
Hadjis, T2
Platt, RW2
Pilote, L2
Goldstein, DR1
Coffey, CS1
Benza, RL1
Nanda, NC1
Bourge, RC1
Hauser, TH1
Pinto, DS1
Josephson, ME1
Zimetbaum, P1
Arxer, A1
Novoa, L1
Vieito Amor, M1
Hernández Iniesta, J1
Villalonga, A1
Díaz-Castro, O1
Puchol, A1
Almendral, J1
Torrecilla, EG1
Arenal, A1
Martínez-Selles, M1
Abrahamowicz, M1
Rajawat, YS1
Patel, VV1
Gerstenfeld, EP1
Nayak, H1
Marchlinski, FE1
Chen, DY1
Cao, J1
Zhu, BP1
Trombert, V1
Graf, C1
Lin, JA1
Borel, CO1
Wang, WB1
Wong, CS1
Yeh, CC1
Yang, CP1
Wu, CT1
Parsai, C1
Bonvini, RF1
Schnetzler, B1
Sunthorn, H1
Wegener, FT1
Ehrlich, JR1
Reĭngardene, DI1
Heger, JJ1
Prystowsky, EN1
Miles, WM1
Zipes, DP1
Scheinman, MM3
Hess, DS1
Conte, MR2
Gaita, F2
Mangiardi, L1
Asteggiano, R2
Rosettani, E2
Brusca, A1
Meulendyk, J1
Buchser, E1
Chiolero, R1
Martin, P1
Freeman, J1
Forfar, JC1
Gribbin, B1
Bocchiardo, M1
Riccioni, N1
Bartolomei, C1
McComb, JM1
Logan, KR1
Khan, MM1
Geddes, JS1
Adgey, AA1
Desnos, M1
Hagège, A1
Guérot, C1
Williamson, BD1
Hummel, J1
Niebauer, M1
Man, KC1
Strickberger, SA1
Daoud, E1
Morady, F1
Magee, LA1
Downar, E1
Sermer, M1
Boulton, BC1
Allen, LC1
Koren, G1
Schwartz, J1
Rafael, C1
Rozenfeld, V1
Abu-Much, Z1
Schoham, H1
Hancock, EW2
Levine, JH1
Massumi, A1
Winkle, RA1
Platia, EV1
Chilson, DA1
Gomes, A1
Woosley, RL1
Hofmann, R1
Leisch, F1
Van Mieghem, W1
Tits, G1
Demuynck, K1
Lacquet, L1
Deneffe, G1
Tjandra-Maga, T1
Demedts, M1
Stevenson, WG1
Sweeney, MO1
Doig, JC1
Dörge, H1
Schoendube, FA1
Schoberer, M1
Stellbrink, C1
Voss, M1
Messmer, BJ1
Cavalcante Viana, PC1
de Melo Alves, R1
Salgado, HC1
Fazan, R1
Hilleman, DE1
Spinler, SA1
Cosma, C1
Crepin, D1
Py, J1
Posse, RA1
Zuelgaray, JT1
Brown, AK1
Primhak, RA1
Newton, P1
Modica, G1
Di Fazzio, S1
Timpanaro, V1
Centamore, G1
Guarnieri, T1
Tomaselli, G1
Griffith, LS1
Brinker, J1
Bonatti, V1
Rolli, A1
Botti, G1
Murthy, VS1
Hwang, TF1
Leor, J1
Levartowsky, D1
Sharon, C1
Farfel, Z1
Helmy, I1
Herre, JM1
Gee, G1
Sharkey, H1
Malone, P1
Sauve, MJ1
Griffin, JC1
Ruffy, R1
Lal, R1
Kouchoukos, NT1
Kim, SS1
Ben-Chetrit, E1
Ackerman, Z1
Eliakim, M1
Assmann, I1
Liberman, BA1
Teasdale, SJ1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Study Using Intra-Pericardial Amiodarone for the Prevention of Postoperative Atrial Fibrillation (POAF) in Patients Undergoing Cardiac Arterial Bypass Grafting and/or Valve Surgery[NCT06063538]Early Phase 163 participants (Anticipated)Interventional2023-11-30Not yet recruiting
A Placebo-controlled,Double-blind,Parallel Arm Trial to Assess the Efficacy of Dronedarone 400mg Bid for the Prevention of Cardiovascular Hospitalization or Death From Any Cause in Patients With Atrial Fibrillation/Atrial Flutter (AF/AFL)[NCT00174785]Phase 34,628 participants (Actual)Interventional2005-06-30Completed
Effect of Dronedarone on Atrial Fibrosis Progression and Atrial Fibrillation Recurrence Post Ablation: The EDORA Trial[NCT04704050]Phase 422 participants (Actual)Interventional2021-05-15Terminated (stopped due to Sponsor withdrew funding)
Pragmatic Randomized Clinical Trial of Early Dronedarone Versus Usual Care to Change and Improve Outcomes in Persons With First-Detected Atrial Fibrillation[NCT05130268]Phase 43,000 participants (Anticipated)Interventional2021-10-29Active, not recruiting
Using Time-dependent Intravenous Infusions of Amiodarone for Conversions to Sinus Rhythms in Patients With Paroxysmal Atrial Fibrillation[NCT03432663]Phase 460 participants (Actual)Interventional2008-08-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Adjudicated Cardiovascular Death

The considered event is cardiovascular death, as assessed by the blinded adjudication of the Steering Committee. The analysis is performed on the time from randomization to this event. The Measured Values table below presents the numbers of patients with the event at the end of the study period. (NCT00174785)
Timeframe: minimum follow-up duration: 1 year ; maximum: 2.5 years

Interventionparticipants (Number)
Dronedarone 400mg Bid63
Placebo90

Cardiovascular Death

The considered event is cardiovascular death, as assessed by the Investigator. The analysis is performed on the time from randomization to this event. The Measured Values table below presents the numbers of patients with the event at the end of the study period. (NCT00174785)
Timeframe: minimum follow-up duration: 1 year ; maximum: 2.5 years

Interventionparticipants (Number)
Dronedarone 400mg Bid65
Placebo94

Death From Any Cause

The considered event is death from any cause. The analysis is performed on the time from randomization to this event. The Measured Values table below presents the numbers of patients with the event at the end of the study period. (NCT00174785)
Timeframe: minimum follow-up duration: 1 year ; maximum: 2.5 years

Interventionparticipants (Number)
Dronedarone 400mg Bid116
Placebo139

First Hospitalization for Cardiovascular Reason

The considered event is the first hospitalization for cardiovascular reason, as assessed by the Investigator. The analysis is performed on the time from randomization to this event. The Measured Values table below presents the numbers of patients with the event at the end of the study period. (NCT00174785)
Timeframe: minimum follow-up duration: 1 year ; maximum: 2.5 years

Interventionparticipants (Number)
Dronedarone 400mg Bid675
Placebo859

First Hospitalization for Cardiovascular Reason or Death From Any Cause

The primary event is the first hospitalization for cardiovascular reason or death from any cause, whichever is earlier, as assessed by the investigator. The primary efficacy analysis is performed on the time from randomization to this primary event. The Measured Values table below presents the numbers of patients with the event at the end of the study period. (NCT00174785)
Timeframe: minimum follow-up duration: 1 year ; maximum: 2.5 years

Interventionparticipants (Number)
Dronedarone 400mg Bid734
Placebo917

Reviews

7 reviews available for amiodarone and Bradycardia

ArticleYear
Impact of pre-implant amiodarone exposure on outcomes in cardiac transplant recipients.
    Heart failure reviews, 2015, Volume: 20, Issue:5

    Topics: Amiodarone; Anti-Arrhythmia Agents; Biological Availability; Bradycardia; Drug Interactions; Heart F

2015
Rate control in atrial fibrillation.
    Lancet (London, England), 2016, Aug-20, Volume: 388, Issue:10046

    Topics: Adrenergic beta-Antagonists; Age Factors; Amiodarone; Anti-Arrhythmia Agents; Atenolol; Atrial Fibri

2016
Clinical use and pharmacology of amiodarone.
    The Medical clinics of North America, 1984, Volume: 68, Issue:5

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Autonomic Ne

1984
New antiarrhythmic drugs.
    American journal of surgery, 1983, Volume: 145, Issue:6

    Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half

1983
Pharmacologic and nonpharmacologic treatment of ventricular arrhythmias in heart failure.
    Current opinion in cardiology, 1997, Volume: 12, Issue:3

    Topics: Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Catheter Ablation; Defibrillators, Implantable; Ele

1997
Drug-induced cardiac arrhythmias: incidence, prevention and management.
    Drug safety, 1997, Volume: 17, Issue:4

    Topics: Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Anti-Infective Agents;

1997
Conversion of recent-onset atrial fibrillation with intravenous amiodarone: a meta-analysis of randomized controlled trials.
    Pharmacotherapy, 2002, Volume: 22, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cohort Studies; Humans; Hypote

2002

Trials

7 trials available for amiodarone and Bradycardia

ArticleYear
Effectiveness of biatrial epicardial application of amiodarone-releasing adhesive hydrogel to prevent postoperative atrial fibrillation.
    The Journal of thoracic and cardiovascular surgery, 2014, Volume: 148, Issue:3

    Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiac Surgical Proced

2014
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Effect of dronedarone on cardiovascular events in atrial fibrillation.
    The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2009
Safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications in patients with atrial fibrillation or atrial flutter.
    The American journal of cardiology, 2003, Jun-15, Volume: 91, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flut

2003
Treatment of the bradycardia-tachycardia syndrome with low doses of amiodarone.
    Cardiology, 1981, Volume: 68, Issue:2

    Topics: Aged; Amiodarone; Benzofurans; Bradycardia; Clinical Trials as Topic; Female; Humans; Male; Middle A

1981
Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias. Intravenous Amiodarone Multicenter Trial Group.
    Journal of the American College of Cardiology, 1996, Volume: 27, Issue:1

    Topics: Amiodarone; Analysis of Variance; Anti-Arrhythmia Agents; Bradycardia; Cause of Death; Chi-Square Di

1996
Verapamil as prophylactic treatment for atrial fibrillation after lung operations.
    The Annals of thoracic surgery, 1996, Volume: 61, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Humans; Hypotension; Incidence

1996
Intraoperative amiodarone as prophylaxis against atrial fibrillation after coronary operations.
    The Annals of thoracic surgery, 2000, Volume: 69, Issue:5

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Coronary Artery Bypass; Female

2000

Other Studies

63 other studies available for amiodarone and Bradycardia

ArticleYear
Intravenous to Oral Transition of Amiodarone (IOTA): Effect of Various Durations of Overlap on Atrial Fibrillation Recurrence After Cardiothoracic Surgery.
    Journal of cardiovascular pharmacology, 2022, 06-01, Volume: 79, Issue:6

    Topics: Administration, Oral; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Humans;

2022
Impact of amiodarone use on metoprolol concentrations, α-OH-metoprolol concentrations, metoprolol dosing and heart rate: A cross-sectional study.
    Pharmacology research & perspectives, 2023, Volume: 11, Issue:5

    Topics: Adult; Amiodarone; Bradycardia; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; Heart Rate; Humans

2023
Severe Bradycardia Induced by Sofosbuvir and Amiodarone which Resolved after the Discontinuation of Both Drugs.
    Internal medicine (Tokyo, Japan), 2020, Oct-15, Volume: 59, Issue:20

    Topics: Amiodarone; Antiviral Agents; Bradycardia; Drug Interactions; Drug Therapy, Combination; Hepatitis C

2020
Comparison of posttransplant outcomes in patients with no, acute, or chronic amiodarone use before heart transplantation.
    Drug design, development and therapy, 2017, Volume: 11

    Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Female; Follow-Up

2017
Cardiovascular Collapse with Intravenous Amiodarone in Children: A Multi-Center Retrospective Cohort Study.
    Pediatric cardiology, 2019, Volume: 40, Issue:5

    Topics: Administration, Intravenous; Adolescent; Age Distribution; Amiodarone; Anti-Arrhythmia Agents; Blood

2019
Rate and rhythm therapy in patients with atrial fibrillation and the risk of pacing and bradyarrhythmia.
    Heart rhythm, 2019, Volume: 16, Issue:9

    Topics: Age Factors; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Denmark; Fe

2019
Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.
    Journal of cardiovascular electrophysiology, 2013, Volume: 24, Issue:8

    Topics: Amiodarone; Analysis of Variance; Animals; Arterial Pressure; Benzazepines; Blood Pressure; Bradycar

2013
The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice.
    The Korean journal of internal medicine, 2014, Volume: 29, Issue:5

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Block; Bradycardia;

2014
In brief: severe bradycardia with sofosbuvir and amiodarone.
    The Medical letter on drugs and therapeutics, 2015, Apr-13, Volume: 57, Issue:1466

    Topics: Amiodarone; Anti-Arrhythmia Agents; Antiviral Agents; Bradycardia; Drug Interactions; Drug Labeling;

2015
Extreme bradycardia after first doses of sofosbuvir and daclatasvir in patients receiving amiodarone: 2 cases including a rechallenge.
    Gastroenterology, 2015, Volume: 149, Issue:6

    Topics: Amiodarone; Antiviral Agents; Bradycardia; Carbamates; Drug Therapy, Combination; Electrocardiograph

2015
Interaction between amiodarone and sofosbuvir-based treatment for hepatitis C virus infection: potential mechanisms and lessons to be learned.
    Gastroenterology, 2015, Volume: 149, Issue:6

    Topics: Amiodarone; Bradycardia; Drug Therapy, Combination; Electrocardiography; Female; Humans; Imidazoles;

2015
Cardiovascular Events of Electrical Cardioversion Under Optimal Anticoagulation in Atrial Fibrillation: The Multicenter Analysis.
    Yonsei medical journal, 2015, Volume: 56, Issue:6

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiovascular Diseases;

2015
Bradyarrhythmias Associated with Sofosbuvir Treatment.
    The New England journal of medicine, 2015, 11-05, Volume: 373, Issue:19

    Topics: Amiodarone; Antiviral Agents; Bradycardia; Female; Humans; Male; Uridine Monophosphate

2015
Bradyarrhythmias Associated with Sofosbuvir Treatment.
    The New England journal of medicine, 2015, 11-05, Volume: 373, Issue:19

    Topics: Aged; Amiodarone; Antiviral Agents; Bradycardia; Drug Therapy, Combination; Female; Hepatitis C, Chr

2015
Sofosbuvir + amiodarone: bradycardia and conduction disturbances.
    Prescrire international, 2015, Volume: 24, Issue:166

    Topics: Amiodarone; Anti-Arrhythmia Agents; Antiviral Agents; Arrhythmias, Cardiac; Bradycardia; Brugada Syn

2015
Bradyarrhythmia induced by amiodarone-sofosbuvir co-administration.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2016, Volume: 35, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Drug Interactions; Drug Thera

2016
[Cardiac symptoms in endocrinologic disorders. Heart illness caused by the thyroid gland].
    MMW Fortschritte der Medizin, 2009, May-07, Volume: 151, Issue:19

    Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Antithyroid Agents; Arrhythmias, Cardiac; Atrial Fi

2009
Intractable atrial flutter presented with severe bradycardia in an infant.
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2009, Volume: 9, Issue:6

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Bradycardia; Cataract; Electric Countershock; El

2009
[Difficult-to-treat atrial fibrillation in a patient on haemodialysis].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Atrial Fibrillation; Bisoprolol; Bradycardia; Calcium

2010
[Life-threatening brady- and tachyarrhythmias].
    Der Internist, 2010, Volume: 51, Issue:8

    Topics: Adenosine; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atropine; Brad

2010
Precordial thump in a newborn with refractory supraventricular tachycardia and cardiovascular collapse after amiodarone administration.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2012, Volume: 19, Issue:2

    Topics: Amiodarone; Bradycardia; Cardiopulmonary Resuscitation; Drug Resistance; Electrocardiography; Emerge

2012
A comparative study between amiodarone and magnesium sulfate as antiarrhythmic agents for prophylaxis against atrial fibrillation following lobectomy.
    Journal of anesthesia, 2013, Volume: 27, Issue:1

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Female; Humans; Infusion

2013
Effects of dronedarone started rapidly after amiodarone discontinuation.
    Clinical cardiology, 2013, Volume: 36, Issue:2

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Dronedarone; Drug Substi

2013
Opposite effects of iv amiodarone on cardiovascular vagal and sympathetic efferent activities in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:2

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atropine; Autonomic Fibers, Preganglionic; Baroreflex;

2002
Amiodarone and the risk of bradyarrhythmia requiring permanent pacemaker in elderly patients with atrial fibrillation and prior myocardial infarction.
    Journal of the American College of Cardiology, 2003, Jan-15, Volume: 41, Issue:2

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardiac Pacing, Artifici

2003
Relative perioperative bradycardia does not lead to adverse outcomes after cardiac transplantation.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2003, Volume: 3, Issue:4

    Topics: Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Case-Control Studies; Heart Transplantation; Humans

2003
[Bradycardia-tachycardia syndrome during spinal anesthesia].
    Revista espanola de anestesiologia y reanimacion, 2003, Volume: 50, Issue:8

    Topics: Aged; Amiodarone; Anesthesia, Spinal; Aneurysm; Anti-Arrhythmia Agents; Anticoagulants; Bradycardia;

2003
Predictors of in-hospital ventricular fibrillation or torsades de pointes in patients with acute symptomatic bradycardia.
    Journal of electrocardiology, 2004, Volume: 37, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Electrocardiography

2004
Effect of amiodarone dose on the risk of permanent pacemaker insertion.
    Pacing and clinical electrophysiology : PACE, 2004, Volume: 27, Issue:11

    Topics: Age Factors; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cohort Stud

2004
Advantages and pitfalls of combining device-based and pharmacologic therapies for the treatment of ventricular arrhythmias: observations from a tertiary referral center.
    Pacing and clinical electrophysiology : PACE, 2004, Volume: 27, Issue:12

    Topics: Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Combined Modality Therapy; Defibrillators, Implanta

2004
Drug therapy of paroxysmal atrial fibrillation in the elderly over 75 years old.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2006, Volume: 21, Issue:1

    Topics: Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cardi

2006
[Bradycardia in an elderly woman caused by amiodarone assessed by ECG].
    Revue medicale suisse, 2006, Mar-22, Volume: 2, Issue:58

    Topics: Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Electrocardiography; Female; Hum

2006
Anesthetic management of an AAI pacemaker patient with paroxysmal atrial fibrillation during colorectal surgery.
    Journal of clinical anesthesia, 2006, Volume: 18, Issue:5

    Topics: Aged; Amiodarone; Anesthesia, General; Anti-Arrhythmia Agents; Atrial Fibrillation; Atropine; Bradyc

2006
Cardiac transplantation in a patient with emotionally triggered implantable cardioverter defibrillator storms.
    Heart and vessels, 2007, Volume: 22, Issue:5

    Topics: Adrenergic beta-Antagonists; Amiodarone; Anxiety; Bradycardia; Defibrillators, Implantable; Electric

2007
Amiodarone-associated macroscopic T-wave alternans and torsade de pointes unmasking the inherited long QT syndrome.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2008, Volume: 10, Issue:1

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Electrocardiography; Humans; L

2008
[Effect of treatment with amiodarone on sinus node function].
    Kardiologiia, 2007, Volume: 47, Issue:4

    Topics: Administration, Oral; Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Drug Administration Schedule;

2007
[Amiodarone in paroxysmal supra-ventricular tachycardias associated with sinus bradycardia].
    Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76, Issue:10

    Topics: Adult; Aged; Amiodarone; Benzofurans; Bradycardia; Female; Humans; Male; Middle Aged; Tachycardia, P

1983
Anesthetic considerations with amiodarone: report of a case.
    The Journal of the American Osteopathic Association, 1984, Volume: 83, Issue:8

    Topics: Aged; Amiodarone; Anesthesia, General; Benzofurans; Bradycardia; Coronary Artery Bypass; Heart Block

1984
Amiodarone-induced haemodynamic complications during anaesthesia.
    Anaesthesia, 1983, Volume: 38, Issue:10

    Topics: Aged; Amiodarone; Benzofurans; Bradycardia; Female; Humans; Hypotension; Intraoperative Complication

1983
Torsade de pointes after amiodarone withdrawal; effects of mild hypokalaemia on repolarization.
    European heart journal, 1984, Volume: 5, Issue:6

    Topics: Amiodarone; Benzofurans; Bradycardia; Cardiac Pacing, Artificial; Electrocardiography; Female; Human

1984
[Amiodarone in the bradycardia-tachycardia syndrome. 2-year follow-up].
    Cardiologia (Rome, Italy), 1982, Volume: 27, Issue:6

    Topics: Adult; Aged; Amiodarone; Benzofurans; Bradycardia; Female; Follow-Up Studies; Humans; Male; Middle A

1982
Amiodarone-induced ventricular fibrillation.
    European journal of cardiology, 1980, Volume: 11, Issue:5

    Topics: Amiodarone; Benzofurans; Bradycardia; Cardiac Pacing, Artificial; Electric Countershock; Electrocard

1980
[Hypertrophic cardiomyopathy: place and limitations of medical therapy].
    Archives des maladies du coeur et des vaisseaux, 1995, Volume: 88, Issue:4 Suppl

    Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Bradycardia; Calcium Channel Blocke

1995
Bradycardia-facilitated polymorphic ventricular tachycardia caused by amiodarone after radiofrequency modification of atrioventricular conduction.
    American heart journal, 1995, Volume: 130, Issue:2

    Topics: Aged; Amiodarone; Atrial Fibrillation; Atrioventricular Node; Bradycardia; Catheter Ablation; Electr

1995
Pregnancy outcome after gestational exposure to amiodarone in Canada.
    American journal of obstetrics and gynecology, 1995, Volume: 172, Issue:4 Pt 1

    Topics: Adrenergic beta-Antagonists; Adult; Amiodarone; Arrhythmias, Cardiac; Bradycardia; Canada; Cohort St

1995
Change of the degree of septal hypertrophy in hypertrophic obstructive cardiomyopathy under procainamide treatment. A case report.
    Angiology, 1995, Volume: 46, Issue:1

    Topics: Aged; Aged, 80 and over; Amiodarone; Bradycardia; Cardiomyopathy, Hypertrophic; Contraindications; E

1995
Slow pulse in a woman with heart failure.
    Hospital practice (Office ed.), 1994, May-15, Volume: 29, Issue:5

    Topics: Aged; Amiodarone; Bradycardia; Drug Therapy, Combination; Electrocardiography; Female; Heart Failure

1994
[Symptomatic bradycardia with amiodarone in patients with pre-existing conduction disorders].
    Wiener klinische Wochenschrift, 1995, Volume: 107, Issue:21

    Topics: Aged; Amiodarone; Bradycardia; Bundle-Branch Block; Dose-Response Relationship, Drug; Drug Administr

1995
Bradycardia with a changing P-R interval.
    Hospital practice (1995), 2001, Jun-15, Volume: 36, Issue:6

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Electrocardiography; Fem

2001
Antihypertensive action of amiodarone in spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:3 Pt 2

    Topics: Amiodarone; Animals; Antihypertensive Agents; Blood Pressure; Bradycardia; Diastole; Heart Rate; Hyp

2001
[Action and adverse effects of amiodarone in Wolff-Parkinson-White syndrome].
    La Nouvelle presse medicale, 1979, Mar-10, Volume: 8, Issue:11

    Topics: Aged; Amiodarone; Benzofurans; Bradycardia; Female; Heart Rate; Humans; Tachycardia, Paroxysmal; Wol

1979
Use of amiodarone in bradycardia-tachycardia syndrome.
    British heart journal, 1979, Volume: 42, Issue:3

    Topics: Amiodarone; Benzofurans; Bradycardia; Humans; Tachycardia

1979
Use of amiodarone in bradycardia-tachycardia syndrome.
    British heart journal, 1978, Volume: 40, Issue:10

    Topics: Aged; Amiodarone; Benzofurans; Bradycardia; Corneal Diseases; Female; Humans; Male; Middle Aged; Syn

1978
[Use of amiodarone in atrial tachyarrhythmias associated with sinus bradycardia. Evaluation of the results by means of continuous monitoring].
    Bollettino della Societa italiana di cardiologia, 1977, Volume: 22, Issue:11

    Topics: Aged; Amiodarone; Benzofurans; Bradycardia; Electrocardiography; Exercise Test; Humans; Male; Middle

1977
The interaction of antiarrhythmic drugs and the energy for cardioversion of chronic atrial fibrillation.
    Pacing and clinical electrophysiology : PACE, 1991, Volume: 14, Issue:6

    Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Cerebrovascular Disorders; Chr

1991
Monophasic action potential studies in human subjects with prolonged ventricular repolarization and long QT syndromes.
    European heart journal, 1985, Volume: 6 Suppl D

    Topics: Adolescent; Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Bradycardia; Cardiac Complexes, Premature

1985
Antiarrhythmic drugs and the modulation of autonomic control of heart rate in rabbits.
    Federation proceedings, 1986, Volume: 45, Issue:8

    Topics: Adenosine; Amiodarone; Animals; Anti-Arrhythmia Agents; Bradycardia; Female; Heart Conduction System

1986
Amiodarone and beta-adrenergic blockers: an interaction with metoprolol but not with atenolol.
    American heart journal, 1988, Volume: 116, Issue:1 Pt 1

    Topics: Amiodarone; Atenolol; Bradycardia; Cardiomyopathy, Hypertrophic; Drug Interactions; Drug Therapy, Co

1988
Use of intravenous amiodarone for emergency treatment of life-threatening ventricular arrhythmias.
    Journal of the American College of Cardiology, 1988, Volume: 12, Issue:4

    Topics: Amiodarone; Arrhythmias, Cardiac; Bradycardia; Cardiac Pacing, Artificial; Electrocardiography; Emer

1988
Combined bipolar dual chamber pacing and automatic implantable cardioverter/defibrillator.
    Journal of the American College of Cardiology, 1986, Volume: 7, Issue:4

    Topics: Aged; Amiodarone; Bradycardia; Cardiac Pacing, Artificial; Electric Countershock; Electrodes, Implan

1986
Amiodarone-associated hypothyroidism--a possible cause of digoxin intoxication.
    The American journal of the medical sciences, 1985, Volume: 289, Issue:3

    Topics: Aged; Amiodarone; Benzofurans; Bradycardia; Digoxin; Drug Interactions; Electrocardiography; Female;

1985
[Long-term therapy with amiodarone in tachyarrhythmias--report on various experiences with special reference to its side effects].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1985, Jun-01, Volume: 40, Issue:11

    Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Benzofurans; Bradycardia; Drug Therapy, Combination; Elec

1985
Anaesthesia and amiodarone.
    Canadian Anaesthetists' Society journal, 1985, Volume: 32, Issue:6

    Topics: Adult; Aged; Amiodarone; Anesthesia, General; Anesthetics; Atropine; Benzofurans; Bradycardia; Cardi

1985