Compounds > aminosalicylic acid
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aminosalicylic acid and Chemical and Drug Induced Liver Injury

aminosalicylic acid has been researched along with Chemical and Drug Induced Liver Injury in 32 studies

Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
4-aminosalicylic acid : An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.

Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Research Excerpts

ExcerptRelevanceReference
"To investigate drug-induced liver injury (DILI) in tuberculosis (TB) patients treated with protionamide (Pto) and (or) para-aminosalicylic acid (PAS), and therefore to provide data for using second-line anti-tuberculosis drugs and risk prediction of liver damage."3.79[Clinical analysis of protionamide and para-aminosalicylic acid induced hepatotoxicity in 129 cases]. ( Chu, NH; Duan, HF; Ge, QP; Wang, J; Wang, QF, 2013)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199023 (71.88)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (28.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Ding, D1
Kelly, R1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Sukhanov, DS1
Vinogradova, TI1
Zabolotnykh, NV1
Okovityĭ, SV1
Vasil'eva, SN1
Vitovskaia, ML1
Ge, QP1
Wang, QF1
Duan, HF1
Wang, J1
Chu, NH1
ORDMAN, JA1
AHMED, Q1
SCHALM, L1
LUSZCZEWSKA-TOMASZEWSKA, D1
KOLOSOWSKA, J1
MERGEL-MADEY, B1
BEK, E1
BOWER, G1
WATTS, C2
GRIFFITHS, HE2
UTKIN, VV1
COTTIN, S1
COZAN, R1
VERAN, P1
CISZEK, J1
CONN, HO1
BINDER, HJ1
ORR, HD1
VULLIEMOZ, P1
FAVEZ, G1
LAJOUANINE, P1
RECOING, J1
CANET, J1
WOROBEC, T1
McKENDRICK, GD1
FERGUSSON, AG1
McINTYRE, JP1
GEMMELL, AR1
Gallofre López, M1
Latorre Murillo, P1
Massons Cirera, J1
Sumalla Suñe, J1
Valerdiz Casasola, S1
Linares Rodríguez, A1
Recarte Alvarez, J1
Rodrigo Sáez, L1
Addington, WW1
Kiseleva, IA1
Mar'enko, GP1
Rana, SV1

Reviews

2 reviews available for aminosalicylic acid and Chemical and Drug Induced Liver Injury

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
[Treatment of tuberculous meningitis in adults: current trends and problems].
    Revista clinica espanola, 1982, Sep-30, Volume: 166, Issue:6

    Topics: Aminosalicylic Acid; Antitubercular Agents; Blood-Brain Barrier; Chemical and Drug Induced Liver Inj

1982

Other Studies

30 other studies available for aminosalicylic acid and Chemical and Drug Induced Liver Injury

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
[Pharmacological activity of runihol and S-adenosyl-L-methionine in rats with experimental liver damage by reserve antituberculosis drugs].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:9

    Topics: Aminosalicylic Acid; Animals; Animals, Outbred Strains; Antitubercular Agents; Bilirubin; Chemical a

2013
[Clinical analysis of protionamide and para-aminosalicylic acid induced hepatotoxicity in 129 cases].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2013, Volume: 36, Issue:10

    Topics: Adolescent; Adult; Aged; Aminosalicylic Acid; Antitubercular Agents; Chemical and Drug Induced Liver

2013
Toxic hepatitis due to para-aminosalicylic acid.
    The Central African journal of medicine, 1961, Volume: 7

    Topics: Aminosalicylic Acid; Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Viral Vaccines

1961
P.A.S. and jundice.
    British medical journal, 1963, May-25, Volume: 1, Issue:5342

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Hepatitis; Humans

1963
[LIVER DAMAGE BY DRUGS].
    Nederlands tijdschrift voor geneeskunde, 1963, Dec-07, Volume: 107

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Arsphenamine; Chemical and Drug Induced Liver Injury; Chl

1963
[A CASE OF AN UNUSUALLY SEVERE SENSITIZATION TO ANTIBACTERIAL DRUGS].
    Gruzlica (Warsaw, Poland : 1926), 1963, Volume: 31

    Topics: Adolescent; Adrenal Cortex Hormones; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agent

1963
[INTOLERANCE AND TOXICITY OF SUBSTITUTE ANTIBACTERIAL DRUGS].
    Gruzlica (Warsaw, Poland : 1926), 1963, Volume: 31

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Chemical and Drug Induced Liver In

1963
SKIN RASH, HEPATITIS, AND HEMOLYTIC ANEMIA CAUSED BY PARA-AMINOSALICYLIC ACID.
    The American review of respiratory disease, 1964, Volume: 89

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Anemia; Anemia, Hemolytic; Chemical and Drug Induced Live

1964
BIOCHEMICAL STUDIES OF SEVERE LIVER DAMAGE CAUSED BY P-AMINOSALICYLIC ACID.
    Gastroenterology, 1964, Volume: 46

    Topics: Alanine Transaminase; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransferases; Biliru

1964
[TOXIC EFFECT OF CYCLOSERINE].
    Problemy tuberkuleza, 1963, Volume: 41

    Topics: Alanine Transaminase; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransferases; Centra

1963
[APROPOS OF ETHIONAMIDE JAUNDICE].
    Le Poumon et le coeur, 1964, Volume: 20

    Topics: Alanine Transaminase; Alcoholism; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransfer

1964
[SENSITIZATION TO ANTIBACTERIAL DRUGS WITH SPECIAL REFERENCE TO DIAGNOSIS AND DESENSITIZATION].
    Gruzlica (Warsaw, Poland : 1926), 1964, Volume: 32

    Topics: Adrenal Cortex Hormones; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Arthritis

1964
ETHIONAMIDE-INDUCED HEPATITIS. A REVIEW WITH A REPORT OF AN ADDITIONAL CASE.
    The American review of respiratory disease, 1964, Volume: 90

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Biopsy; Chemical and Drug Induced Liver Injury; Cycloseri

1964
[ENZYMATIC STUDY OF THE LIVER IN PULMONARY TUBERCULOSIS. RESEARCH ON A POSSIBLE HEPATOTOXIC EFFECT OF ANTIBACTERIAL MEDICATIONS].
    Medicina thoracalis, 1964, Volume: 21

    Topics: Alanine Transaminase; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Aspartate Am

1964
[SEVERE AND MULTIPLE MANIFESTATIONS OF INTOLERANCE TO P-AMINOSALICYLIC ACID TREATMENT, WITH A REVIEW OF THE LITERATURE].
    Annales de pediatrie, 1964, Nov-02, Volume: 11

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Child; Drug Erupt

1964
REACTIONS TO ANTITUBERCULOSIS DRUGS AMONG CHINESE IN HONG KONG.
    Tubercle, 1964, Volume: 45

    Topics: Alcoholism; Alopecia; Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Asian People

1964
BLOOD DYSCRASIAS ASSOCIATED WITH ANTITUBERCULOSIS AND/OR TRANQUILIZING CHEMOTHERAPY. A LONG-TERM CLINICAL OBSERVATION.
    Diseases of the chest, 1965, Volume: 47

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver In

1965
HYPERSENSITIVITY TO PARA-AMINOSALICYLIC ACID: A HAZARD IN THE TREATMENT OF ORTHOPAEDIC TUBERCULOSIS.
    The Journal of bone and joint surgery. British volume, 1965, Volume: 47

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Desensitization,

1965
Toxic hepatitis from para-aminosalicylic acid.
    Lancet (London, England), 1951, Oct-13, Volume: 2, Issue:6685

    Topics: Aminosalicylic Acid; Chemical and Drug Induced Liver Injury; Hepatitis; Viral Vaccines

1951
Toxic hepatitis and P.A.S.
    British medical journal, 1952, Apr-19, Volume: 1, Issue:4763

    Topics: Aminosalicylic Acid; Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Viral Vaccines

1952
[Hepatitis caused by drugs. 4].
    Revista espanola de las enfermedades del aparato digestivo, 1982, Volume: 62, Issue:4

    Topics: Adult; Aminosalicylic Acid; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Halothane

1982
The side effects and interactions of antituberculosis drugs.
    Chest, 1979, Volume: 76, Issue:6 Suppl

    Topics: Adult; Aminosalicylic Acid; Antitubercular Agents; Central Nervous System Diseases; Chemical and Dru

1979
[Stevens-Johnson syndrome and toxic-allergic hepatitis in a patient with exudative tuberculous pleuritis].
    Klinicheskaia meditsina, 1977, Volume: 55, Issue:12

    Topics: Adult; Aminosalicylic Acid; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; M

1977
Simultaneous protective effect of a new chelating agent and zinc, on the carbon tetrachloride induced hepatic injury in squirrels.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1977, Jul-18, Volume: 170, Issue:3

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Animals; Azo Compounds; Carbon Tetrachloride Poisoning; C

1977