aminopterin has been researched along with Neoplasms in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (68.18) | 18.7374 |
| 1990's | 11 (16.67) | 18.2507 |
| 2000's | 4 (6.06) | 29.6817 |
| 2010's | 6 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barrows, LR; Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ; Queener, SF | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L | 1 |
| Hou, Z; Matherly, LH; Wilson, MR | 1 |
| Goldman, ID; Unal, ES; Visentin, M | 1 |
| Campos, D; Diaz, A; Izbicka, E; Saunders, M; Steffen, R; Streeper, R; Wick, M | 1 |
| Marchi, E; Zain, JM | 1 |
| O'Connor, O; Zain, J | 1 |
| Awada, A; Azim, HA | 1 |
| COLSKY, J; GREENSPAN, EM; SCHOENBACH, EB | 1 |
| BARTLETT, GR; MARLOW, AA | 1 |
| MANIL, P; STRASZEWSKA, Z | 1 |
| BRANCHE, GC; DOWNING, V; HOMBURGER, F; SHEN, SC; ZAMCHECK, N | 1 |
| BLACK, MM; SPEER, FD | 1 |
| LUHRS, W | 1 |
| GRINBERG, R | 1 |
| DUVALL, LR | 1 |
| AKASHI, A; HANO, K; IWATA, H | 1 |
| SAMITZ, MH; WEINBERG, RA | 1 |
| DRACHMAN, DA; KARON, M; WINTER, TS | 1 |
| KATCHMAN, BJ; MURPHY, JP; ZIPF, RE | 1 |
| FREEMAN, RG; KNOX, JM; ROSSMAN, RE | 1 |
| VIGI, F | 1 |
| AKASHI, A; HANO, K | 1 |
| EISMAN, SG; RICHARDSON, FM | 1 |
| BIGNOTTI, G; TOGNELLA, S | 1 |
| MOORE, FD | 1 |
| CSANYI, E; HORVATH, P; INSTITORIS, L | 1 |
| NEWELL, FW | 1 |
| ROOK, A | 1 |
| ANDERSON, RE; MORROW, LB | 1 |
| JIJI, RM; LINBERG, EJ; SACKS, MS; SPURLING, CL | 1 |
| ALBAUM, HG; ZAHL, PA | 1 |
| GOLDIN, A; GREENSPAN, EM; SCHOENBACH, EB | 2 |
| CRUMRINE, JL; HASS, GM; SLAUGHTER, DP; TAYLOR, SG | 1 |
| Azzoli, CG; Fury, MG; Kemeny, N; Kris, MG; Krug, LM; Rizvi, NA; Sharma, S; Wu, N | 1 |
| Azzoli, CG; Dunne, M; Farmer, A; Ginsberg, MS; Gomez, J; Henry, R; Jones, J; Kris, MG; Krug, LM; Miller, VA; Pizzo, B; Sirotnak, FM; Steffen, R; Tyson, L; Venkatraman, E | 1 |
| MOORE, AE; STOCK, CC; SUGIURA, K | 1 |
| STOCK, CC; THIERSCH, JB | 1 |
| THIERSCH, JB | 1 |
| Bertino, JR; Chang, PK; Johns, DG; Lefkowitz, E; Spencer, RP | 1 |
| Diehl, V; Engelhardt, P; Oellerich, M; Schaadt, M | 1 |
| McCormack, JJ | 1 |
| Cheson, BD; Phillips, PH; Sorenson, JM | 1 |
| Allegra, CJ; Takimoto, CH | 1 |
| Chen, TL; Hausheer, FH; Rowinsky, EK; Su, H | 1 |
| Hum, M; Kamen, BA; Marling-Cason, M; Ratliff, AF; Rose, K; Wilson, J; Winick, N | 1 |
| Edelman, MJ; Gandara, DR; Lau, D; Lauder, I; Meyers, F; Perez, EA; Turrell, C; Uhrich, M | 1 |
| Bertino, JR; Densmore, CL; Fleisher, M; Grant, SC; Heelan, RT; Kris, MG; Krol, G; Miller, VA; Pfister, DG; Pisters, KM; Rigas, JR; Sirotnak, FM; Tong, W; Tyson, LB | 1 |
| Sirotnak, FM | 1 |
| Aghi, M; Breakefield, XO; Kramm, CM | 1 |
| Chou, TC; Fennelly, DW; Grant, SC; Heelan, RT; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR; Sirotnak, FM | 1 |
| Fresen, KO; zur Hausen, H | 1 |
| Goldin, A | 1 |
| Ensminger, WD; Frei, E; Glode, LM; Papathanasopoulos, N; Pitman, SW; Rosowsky, A | 1 |
| Fleming, GF; Schilsky, RL | 1 |
| Fanucchi, MP; Farag, F; Kinahan, JJ; Samuels, LL; Sirotnak, FM; Vidal, PM; Young, CW | 1 |
| Fanucchi, MP; Farag, F; Gralla, RJ; Kinahan, JJ; Kris, MG; Marks, LD; O'Connell, JP; Wertheim, MS; Williams, L; Young, CW | 1 |
| Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| Miller, RW | 1 |
| Sokal, JE; Stutzman, L | 1 |
| Frohberg, H | 1 |
| Baker, BR; Ho, BT; Lourens, GJ | 1 |
| Bose, SK; Majumdar, A | 1 |
| Bertino, JR; Chang, PK; Johns, DG; Spencer, RP | 1 |
10 review(s) available for aminopterin and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction | 2015 |
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.
Topics: Aminopterin; Animals; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein | 2014 |
Pralatrexate: basic understanding and clinical development.
Topics: Aminopterin; Animals; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Lung Neoplasms; Lymphoma; Neoplasms | 2010 |
Clinical development of new formulations of cytotoxics in solid tumors.
Topics: Aminopterin; Anthracyclines; Antineoplastic Agents; Camptothecin; Chemistry, Pharmaceutical; Folic Acid Antagonists; Humans; Irinotecan; Neoplasms; Paclitaxel; Topoisomerase I Inhibitors | 2012 |
Dihydrofolate reductase inhibitors as potential drugs.
Topics: Aminopterin; Animals; Antimalarials; Bacterial Infections; Biological Transport; Drug Interactions; Folic Acid; Folic Acid Antagonists; Helminthiasis; Humans; Immunosuppressive Agents; Leukemia, Experimental; Liver; Methotrexate; Mice; Mycoses; Neoplasms; Protozoan Infections; Psoriasis; Quinazolines; Rats; Receptors, Drug; Trypanosoma cruzi | 1981 |
New antifolates in clinical development.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drugs, Investigational; Folic Acid Antagonists; Humans; Neoplasms; Pyrimidines; Quinazolines; Thiophenes; Trimetrexate | 1995 |
Studies with high-dose methotrexate--historical background.
Topics: Aminopterin; Animals; Folic Acid; History, 20th Century; Humans; Leucovorin; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Time Factors | 1978 |
Antifolates: the next generation.
Topics: Aminopterin; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Evaluation; Folic Acid Antagonists; Forecasting; Humans; Neoplasms; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 1992 |
Use of anticancer drugs during pregnancy.
Topics: Alkylating Agents; Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Busulfan; Chlorambucil; Choriocarcinoma; Colchicine; Female; Fetal Death; Folic Acid Antagonists; Gestational Age; Humans; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pregnancy; Pregnancy Complications; Urethane; Vinblastine | 1968 |
[Present position of the toxicology of drugs].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newborn; Aspirin; Carcinogens; Codeine; Dogs; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Female; Fertility; Haplorhini; Humans; Indomethacin; Male; Meclizine; Methods; Mice; Morphine; Mutation; Nalidixic Acid; Neoplasms; Neoplasms, Experimental; Pharmacogenetics; Pregnancy; Pregnancy Complications; Rabbits; Rats; Reproduction; Sex Factors; Statistics as Topic; Time Factors | 1970 |
9 trial(s) available for aminopterin and Neoplasms
| Article | Year |
|---|---|
A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Probenecid; Treatment Outcome | 2006 |
A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Dietary Supplements; Docetaxel; Female; Folic Acid Antagonists; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Neoplasms; Paclitaxel; Taxoids; Vitamins | 2007 |
Novel high-performance liquid chromatographic assay using fluorescence detection for the quantitation of plasma gamma-methylene-10-deazaaminopterin and its major metabolite, 7-hydroxy-gamma-methylene-10-deazaaminopterin, in patients with solid cancers in
Topics: Aminopterin; Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Neoplasms; Pterins; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 1997 |
Phase I and pharmacokinetic trial of aminopterin in patients with refractory malignancies.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aminopterin; Area Under Curve; Biological Availability; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Humans; Injections, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Treatment Outcome | 1998 |
Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy.
Topics: Adult; Aged; Aminopterin; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cryotherapy; Exanthema; Female; Humans; Leukopenia; Male; Middle Aged; Mucous Membrane; Neoplasms; Vomiting | 1998 |
High-dose edatrexate with oral leucovorin rescue: a phase I and clinical pharmacological study in adults with advanced cancer.
Topics: Administration, Oral; Adult; Aged; Aminopterin; Antineoplastic Agents; Drug Interactions; Drug Monitoring; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasms | 1996 |
Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Middle Aged; Neoplasms; Paclitaxel | 1999 |
A Phase 1 study of high doses of aminopterin with leucovorin rescue in patients with advanced metastatic tumors.
Topics: Aminopterin; Bone Marrow; Clinical Trials as Topic; Drug Administration Schedule; Humans; Kidney; Leucovorin; Leukopenia; Methotrexate; Neoplasm Metastasis; Neoplasms; Solubility | 1979 |
Phase I trial and clinical pharmacological evaluation of 10-ethyl-10-deazaaminopterin in adult patients with advanced cancer.
Topics: Adult; Aminopterin; Antimetabolites, Antineoplastic; Drug Evaluation; Half-Life; Humans; Neoplasms; Skin Neoplasms | 1988 |
47 other study(ies) available for aminopterin and Neoplasms
| Article | Year |
|---|---|
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid; Folic Acid Antagonists; Humans; Liver; Methotrexate; Molecular Structure; Neoplasms; Pneumocystis; Rats; Recombinant Proteins; Structure-Activity Relationship; Thymidylate Synthase; Toxoplasma; Tumor Cells, Cultured | 1994 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro.
Topics: Aminopterin; Carbon-Nitrogen Ligases; Folic Acid Antagonists; HeLa Cells; Humans; Methotrexate; Neoplasms; Tumor Cells, Cultured | 2014 |
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
Topics: Aminopterin; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kinetics; Methotrexate; Neoplasms; Pemetrexed; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Xenograft Model Antitumor Assays | 2009 |
Pralatrexate - from bench to bedside.
Topics: Aminopterin; Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Design; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Neoplasms | 2010 |
Observations on the effects of the folic acid antagonists, aminopterin and amethopterin, in patients with advanced neoplasms.
Topics: Aminopterin; Folic Acid Antagonists; Methotrexate; Neoplasms | 1952 |
New therapy for leukemia, polycythemia, and lymphoma.
Topics: Aminopterin; Chronic Disease; Hodgkin Disease; Humans; Leukemia; Lymphoma; Mechlorethamine; Multiple Myeloma; Neoplasms; Phlebotomy; Polycythemia; Triethylenemelamine; Urethane; X-Ray Therapy | 1953 |
[Action of aminopterin (4-aminopteroylglutamic acid) on crown-gall tumors].
Topics: Aminopterin; Crowns; Folic Acid Antagonists; Neoplasms; Plant Diseases; Plant Tumors | 1952 |
Observations on ten patients with gastrointestinal cancer during the course of chemotherapy with dichloroaminopterin.
Topics: Aminopterin; Gastrointestinal Neoplasms; Gastrointestinal Tract; Humans; Neoplasms | 1953 |
Further observations on the effects of cancer chemotherapeutic agents on the in vitro dehydrogenase activity of cancer tissue.
Topics: Aminopterin; Antineoplastic Agents; In Vitro Techniques; Neoplasms; Oxidation-Reduction; Oxidoreductases; Triethylenemelamine; Urethane | 1954 |
[Trial of chemotherapeutic control of inoperable bronchial carcinoma not suited for radiotherapy].
Topics: Aminopterin; Bronchi; Bronchial Neoplasms; Carcinoma, Bronchogenic; Humans; Mercaptopurine; Neoplasms; Triethylenemelamine | 1957 |
[Nitrogen mustards, triethylenethiophosphoramide, triethylene melamine & aminopterin in the treatment of advanced cancer].
Topics: Aminopterin; Antineoplastic Agents; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Thiotepa; Triethylenemelamine | 1959 |
The clinical effect of methotexate on tumors other than acute leukemia and choriocarcinoma.
Topics: Aminopterin; Antineoplastic Agents; Choriocarcinoma; Leukemia; Neoplasms | 1961 |
Influences of anticancer agents on the activities of liver catalase, uricase, and xanthine oxidase in normal and tumor-bearing mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Azaguanine; Carboxylic Acids; Carcinoma, Ehrlich Tumor; Catalase; Cyclopentanes; Liver; Mercaptopurine; Methotrexate; Mice; N-Glycosyl Hydrolases; Neoplasms; Oxidoreductases; Thiotepa; Urate Oxidase; Xanthine Oxidase | 1963 |
Oral florid papillomatosis. Response to aminopterin.
Topics: Aminopterin; Humans; Mouth Neoplasms; Neoplasms; Papilloma | 1963 |
MEDULLOBLASTOMA WITH EXTRACRANIAL METASTASES.
Topics: Aminopterin; Antineoplastic Agents; Bone Neoplasms; Brain Neoplasms; Cerebellar Neoplasms; Child; Humans; Injections, Spinal; Medulloblastoma; Neoplasm Metastasis; Neoplasms; Neurosurgery; Neurosurgical Procedures; Pathology; Vincristine | 1963 |
THE EFFECT OF CHEMOTHERAPEUTIC AGENTS UPON THE METABOLISM OF INTACT HUMAN CANCER CELLS: AN IN VITRO TECHNIC FOR CELL SENSITIVITY.
Topics: Aminopterin; Antineoplastic Agents; Azaguanine; Carbohydrate Metabolism; In Vitro Techniques; Lactates; Leukemia; Leukocytes; Mechlorethamine; Mercaptopurine; Metabolism; Neoplasms; Prednisone; Research; Thiotepa; Vinblastine | 1963 |
MULTIPLE KERATOACANTHOMAS. A CASE STUDY OF THE ERUPTIVE TYPE WITH OBSERVATIONS ON PATHOGENESIS.
Topics: Aminopterin; Black People; Carcinoma; Carcinoma, Squamous Cell; Diagnosis, Differential; Foot Diseases; Hand Dermatoses; Histocytochemistry; Humans; Keratoacanthoma; Laryngeal Neoplasms; Methotrexate; Neoplasms; Pathology; Ultraviolet Rays | 1964 |
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Dactinomycin; Fibrosarcoma; Fluoresceins; Humans; Infusions, Parenteral; Injections, Intra-Arterial; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Melphalan; Neoplasms; Pharmacology; Thiotepa; Toxicology | 1963 |
INFLUENCES OF ANTICANCER AGENTS ON THE METABOLISM OF DELTA-AMINOLEVULINIC ACID IN MORMAL AND TUMOR-BEARING MICE.
Topics: Alkylating Agents; Amino Acids; Aminolevulinic Acid; Aminopterin; Animals; Antineoplastic Agents; Azaguanine; Blood Chemical Analysis; Carcinoma, Ehrlich Tumor; Catalase; Copper; Folic Acid Antagonists; Hemoglobins; Hydro-Lyases; Iron; Levulinic Acids; Liver; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Rats; Research | 1964 |
CANCER CHEMOTHERAPY.
Topics: Adrenal Cortex Hormones; Aminopterin; Androgens; Antimetabolites; Antineoplastic Agents; Blood Platelet Disorders; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Cyclophosphamide; Dactinomycin; Estrogens; Fluorouracil; Geriatrics; Humans; Leukopenia; Mechlorethamine; Mercaptopurine; Neoplasms; Nitrogen Mustard Compounds; Surgical Procedures, Operative; Thiotepa; Toxicology; Vinblastine | 1964 |
[LABORATORY TESTS FOR VERIFYING STATES OF FOLIC ACID DEFICIENCY IN THE ORGANISM].
Topics: Aminopterin; Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood; Clinical Laboratory Techniques; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Lactobacillus; Leuconostoc; Liver Diseases; Methotrexate; Neoplasms; Nutrition Disorders; Pregnancy; Staphylococcus; Urine; Vitamin B Deficiency | 1964 |
NEW PROBLEMS FOR SURGERY. DRUGS THAT ACT ON THE CELL NUCLEUS AFFECT THE SURGEON'S WORK ON CANCER AND ON TRANSPLANTATION.
Topics: Allergy and Immunology; Aminopterin; Antibody Formation; Antineoplastic Agents; Cell Nucleus; Humans; Kidney Transplantation; Mercaptopurine; Neoplasms; Surgeons; Transplantation; Transplantation Immunology | 1964 |
[ON THE EFFECT OF GLUCOSE ON THE TOXIC AND THERAPEUTIC EFFECTS OF 1,6-DIBROMO-1,6-D-DIDESOXYMANNITOL IN ANIMAL EXPERIMENTS].
Topics: Aminopterin; Animal Experimentation; Animals; Antineoplastic Agents; Busulfan; Carcinoma, Ehrlich Tumor; Dactinomycin; Glucose; Mannitol; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 37; Sarcoma, Yoshida; Toxicology | 1964 |
ANTICANCER AGENTS.
Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Corneal Transplantation; Drug Therapy; Eye Neoplasms; Female; Fluorouracil; Humans; Maternal-Fetal Exchange; Neoplasms; Nitrogen Mustard Compounds; Ophthalmology; Pregnancy; Pyrimethamine; Toxicology; Toxoplasmosis; Toxoplasmosis, Ocular; Transplantation Immunology; Uveitis | 1964 |
SOME CHEMICAL INFLUENCES ON HAIR GROWTH AND PIGMENTATION.
Topics: Alopecia; Aminopterin; Anticoagulants; Child; Chloroquine; Colchicine; Cyclophosphamide; Geriatrics; Hair; Humans; Mephenesin; Neoplasms; Pigmentation; Plant Poisoning; Poisoning; Thallium; Toxicology; Triparanol; Tyrosine Decarboxylase; Vitamin A | 1965 |
ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS.
Topics: Alkylating Agents; Aminopterin; Busulfan; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Mercaptopurine; Methotrexate; Multiple Myeloma; Neoplasms; Pathology; Primary Myelofibrosis; Sarcoma; Triethylenemelamine; Tuberculosis; Tuberculosis, Pulmonary; Urethane | 1965 |
FAILURE OF THYMECTOMY TO ALTER THE SUBSEQUENT COURSE OF HUMAN ACUTE LEUKEMIA IN DRUG-INDUCED REMISSION.
Topics: Acute Disease; Adolescent; Aminopterin; Child; Humans; Leukemia; Mercaptopurine; Neoplasms; Prednisone; Thymectomy | 1965 |
Effect of aminopterin and certain purine antagonists on adenine nucleotide levels in tissues of tumor-bearing mice.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Aminopterin; Animals; Mice; Neoplasms; Nucleotides; Purines | 1955 |
Studies on the mechanism of action of chemotherapeutic agents in cancer. II. Requirements for the prevention of aminopterin toxicity by folic acid in mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Biomedical Research; Folic Acid; Folic Acid Antagonists; Mice; Neoplasms | 1950 |
Studies on the mechanism of action of chemotherapeutic agents in cancer. V. Influence of the citrovorum factor and folic acid on the toxic manifestations of aminopterin in mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cobalt; Folic Acid; Folic Acid Antagonists; Leadership; Leucovorin; Mice; Neoplasms | 1951 |
Toxic reactions of 4-amino-pteroylglutamic acid (aminopterin) in patients with far-advanced neoplastic disease.
Topics: Aminopterin; Folic Acid; Humans; Neoplasms; Postoperative Complications | 1950 |
The effect of aminopterin on the growth of carcinoma, sarcoma, and melanoma in animals.
Topics: Aminopterin; Animals; Carcinoma; Melanoma; Neoplasms; Sarcoma | 1949 |
Bone marrow of mice bearing sarcoma 180 treated with 4-amino-pteroylglutamic acid and with 4-amino-N10-methyl-pteroylglutaminic acid.
Topics: Aminopterin; Animals; Bone and Bones; Bone Marrow; Bone Neoplasms; Folic Acid; Mice; Neoplasms; Sarcoma 180; Sarcoma, Experimental | 1949 |
Bone-marrow changes in man after treatment with aminopterin, amethopterin, and aminoanfol; with special reference to megaloblastosis and tumor remission.
Topics: Aminopterin; Bone Marrow; Humans; Male; Methotrexate; Neoplasms | 1949 |
Aminopterin--iodine-131, a folate antagonist. Preparation, distribution, and scanning in man.
Topics: Aminopterin; Humans; Iodine Isotopes; Kidney; Liver; Neoplasms; Radionuclide Imaging; Spleen; Thyroid Gland | 1967 |
Determination of methotrexate in serum by a rapid, fully mechanized enzyme immunoassay (EMIT).
Topics: Adult; Aminopterin; Autoanalysis; Costs and Cost Analysis; Female; Humans; Immunoenzyme Techniques; Kinetics; Methotrexate; Neoplasms; Osteosarcoma | 1980 |
Clinical trials referral resource. Clinical trials using edatrexate.
Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Female; Humans; Male; Neoplasms | 1993 |
Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?
Topics: Aminopterin; Animals; Antineoplastic Agents; Clone Cells; Folic Acid Antagonists; Genetic Therapy; Humans; Neoplasms; Peptide Synthases; Polyglutamic Acid; Tumor Cells, Cultured | 1999 |
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Chromatography, Thin Layer; Dogs; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Methotrexate; Neoplasms; Peptide Synthases; Rats; Transduction, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
Transient induction of a nuclear antigen unrelated to Epstein-Barr nuclear antigen in cells of two human B-lymphoma lines converted by Epstein-Barr virus.
Topics: Aminopterin; Antigens, Neoplasm; Antigens, Viral; Burkitt Lymphoma; Cell Line; Cell Nucleus; Herpesvirus 4, Human; Hypoxanthines; Idoxuridine; Kinetics; Neoplasms; Virus Replication | 1977 |
Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites.
Topics: Aminopterin; Animals; Chromatography, High Pressure Liquid; Humans; Leukemia L1210; Mice; Mice, Nude; Neoplasms; Polyglutamic Acid; Spectrometry, Fluorescence | 1985 |
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay | 1985 |
Transplacental chemical carcinogenesis in man.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Chloramphenicol; Diethylstilbestrol; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Maternal-Fetal Exchange; Methotrexate; Mice; Neoplasms; Neoplasms, Muscle Tissue; Phenytoin; Pregnancy; Uterine Cervical Neoplasms; Vaginal Neoplasms | 1971 |
Irreversible enzyme inhibitors. LXXXVI. Hydrophobic bonding to dihydrofolic reductase. 8. Substituted-1-aryl-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines.
Topics: Aminopterin; Chemistry, Organic; Enzymes; Folic Acid; Neoplasms; Organic Chemistry Phenomena; Tetrahydrofolate Dehydrogenase; Triazines | 1967 |
Studies on the isolation and properties of drug resistant mutants from a human malignant cell line.
Topics: Aminopterin; Azaguanine; Cell Line; Culture Techniques; Humans; Mutation; Neoplasms | 1968 |
131-I-3'-iodoaminopterin: a gamma-labeled active-site-directed enzyme inhibitor.
Topics: Adult; Aged; Aminopterin; Binding Sites; Chromatography; Female; Folic Acid Antagonists; Humans; Injections, Intravenous; Iodine Isotopes; Kidney; Liver; Male; Methods; Methotrexate; Neoplasms; Radionuclide Imaging; Tetrahydrofolate Dehydrogenase; Thyroid Gland | 1968 |