Page last updated: 2024-09-05

aminopterin and Neoplasms

aminopterin has been researched along with Neoplasms in 66 studies

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-199045 (68.18)18.7374
1990's11 (16.67)18.2507
2000's4 (6.06)29.6817
2010's6 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barrows, LR; Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ; Queener, SF1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L1
Hou, Z; Matherly, LH; Wilson, MR1
Goldman, ID; Unal, ES; Visentin, M1
Campos, D; Diaz, A; Izbicka, E; Saunders, M; Steffen, R; Streeper, R; Wick, M1
Marchi, E; Zain, JM1
O'Connor, O; Zain, J1
Awada, A; Azim, HA1
COLSKY, J; GREENSPAN, EM; SCHOENBACH, EB1
BARTLETT, GR; MARLOW, AA1
MANIL, P; STRASZEWSKA, Z1
BRANCHE, GC; DOWNING, V; HOMBURGER, F; SHEN, SC; ZAMCHECK, N1
BLACK, MM; SPEER, FD1
LUHRS, W1
GRINBERG, R1
DUVALL, LR1
AKASHI, A; HANO, K; IWATA, H1
SAMITZ, MH; WEINBERG, RA1
DRACHMAN, DA; KARON, M; WINTER, TS1
KATCHMAN, BJ; MURPHY, JP; ZIPF, RE1
FREEMAN, RG; KNOX, JM; ROSSMAN, RE1
VIGI, F1
AKASHI, A; HANO, K1
EISMAN, SG; RICHARDSON, FM1
BIGNOTTI, G; TOGNELLA, S1
MOORE, FD1
CSANYI, E; HORVATH, P; INSTITORIS, L1
NEWELL, FW1
ROOK, A1
ANDERSON, RE; MORROW, LB1
JIJI, RM; LINBERG, EJ; SACKS, MS; SPURLING, CL1
ALBAUM, HG; ZAHL, PA1
GOLDIN, A; GREENSPAN, EM; SCHOENBACH, EB2
CRUMRINE, JL; HASS, GM; SLAUGHTER, DP; TAYLOR, SG1
Azzoli, CG; Fury, MG; Kemeny, N; Kris, MG; Krug, LM; Rizvi, NA; Sharma, S; Wu, N1
Azzoli, CG; Dunne, M; Farmer, A; Ginsberg, MS; Gomez, J; Henry, R; Jones, J; Kris, MG; Krug, LM; Miller, VA; Pizzo, B; Sirotnak, FM; Steffen, R; Tyson, L; Venkatraman, E1
MOORE, AE; STOCK, CC; SUGIURA, K1
STOCK, CC; THIERSCH, JB1
THIERSCH, JB1
Bertino, JR; Chang, PK; Johns, DG; Lefkowitz, E; Spencer, RP1
Diehl, V; Engelhardt, P; Oellerich, M; Schaadt, M1
McCormack, JJ1
Cheson, BD; Phillips, PH; Sorenson, JM1
Allegra, CJ; Takimoto, CH1
Chen, TL; Hausheer, FH; Rowinsky, EK; Su, H1
Hum, M; Kamen, BA; Marling-Cason, M; Ratliff, AF; Rose, K; Wilson, J; Winick, N1
Edelman, MJ; Gandara, DR; Lau, D; Lauder, I; Meyers, F; Perez, EA; Turrell, C; Uhrich, M1
Bertino, JR; Densmore, CL; Fleisher, M; Grant, SC; Heelan, RT; Kris, MG; Krol, G; Miller, VA; Pfister, DG; Pisters, KM; Rigas, JR; Sirotnak, FM; Tong, W; Tyson, LB1
Sirotnak, FM1
Aghi, M; Breakefield, XO; Kramm, CM1
Chou, TC; Fennelly, DW; Grant, SC; Heelan, RT; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR; Sirotnak, FM1
Fresen, KO; zur Hausen, H1
Goldin, A1
Ensminger, WD; Frei, E; Glode, LM; Papathanasopoulos, N; Pitman, SW; Rosowsky, A1
Fleming, GF; Schilsky, RL1
Fanucchi, MP; Farag, F; Kinahan, JJ; Samuels, LL; Sirotnak, FM; Vidal, PM; Young, CW1
Fanucchi, MP; Farag, F; Gralla, RJ; Kinahan, JJ; Kris, MG; Marks, LD; O'Connell, JP; Wertheim, MS; Williams, L; Young, CW1
Moccio, DM; Samuels, LL; Sirotnak, FM1
Miller, RW1
Sokal, JE; Stutzman, L1
Frohberg, H1
Baker, BR; Ho, BT; Lourens, GJ1
Bose, SK; Majumdar, A1
Bertino, JR; Chang, PK; Johns, DG; Spencer, RP1

Reviews

10 review(s) available for aminopterin and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

2015
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:4

    Topics: Aminopterin; Animals; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein

2014
Pralatrexate: basic understanding and clinical development.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:10

    Topics: Aminopterin; Animals; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Lung Neoplasms; Lymphoma; Neoplasms

2010
Clinical development of new formulations of cytotoxics in solid tumors.
    Current opinion in oncology, 2012, Volume: 24, Issue:3

    Topics: Aminopterin; Anthracyclines; Antineoplastic Agents; Camptothecin; Chemistry, Pharmaceutical; Folic Acid Antagonists; Humans; Irinotecan; Neoplasms; Paclitaxel; Topoisomerase I Inhibitors

2012
Dihydrofolate reductase inhibitors as potential drugs.
    Medicinal research reviews, 1981,Fall, Volume: 1, Issue:3

    Topics: Aminopterin; Animals; Antimalarials; Bacterial Infections; Biological Transport; Drug Interactions; Folic Acid; Folic Acid Antagonists; Helminthiasis; Humans; Immunosuppressive Agents; Leukemia, Experimental; Liver; Methotrexate; Mice; Mycoses; Neoplasms; Protozoan Infections; Psoriasis; Quinazolines; Rats; Receptors, Drug; Trypanosoma cruzi

1981
New antifolates in clinical development.
    Oncology (Williston Park, N.Y.), 1995, Volume: 9, Issue:7

    Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drugs, Investigational; Folic Acid Antagonists; Humans; Neoplasms; Pyrimidines; Quinazolines; Thiophenes; Trimetrexate

1995
Studies with high-dose methotrexate--historical background.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Aminopterin; Animals; Folic Acid; History, 20th Century; Humans; Leucovorin; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Time Factors

1978
Antifolates: the next generation.
    Seminars in oncology, 1992, Volume: 19, Issue:6

    Topics: Aminopterin; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Evaluation; Folic Acid Antagonists; Forecasting; Humans; Neoplasms; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate

1992
Use of anticancer drugs during pregnancy.
    Clinical obstetrics and gynecology, 1968, Volume: 11, Issue:2

    Topics: Alkylating Agents; Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Busulfan; Chlorambucil; Choriocarcinoma; Colchicine; Female; Fetal Death; Folic Acid Antagonists; Gestational Age; Humans; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pregnancy; Pregnancy Complications; Urethane; Vinblastine

1968
[Present position of the toxicology of drugs].
    Munchener medizinische Wochenschrift (1950), 1970, Aug-28, Volume: 112, Issue:35

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newborn; Aspirin; Carcinogens; Codeine; Dogs; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Female; Fertility; Haplorhini; Humans; Indomethacin; Male; Meclizine; Methods; Mice; Morphine; Mutation; Nalidixic Acid; Neoplasms; Neoplasms, Experimental; Pharmacogenetics; Pregnancy; Pregnancy Complications; Rabbits; Rats; Reproduction; Sex Factors; Statistics as Topic; Time Factors

1970

Trials

9 trial(s) available for aminopterin and Neoplasms

ArticleYear
A phase I clinical pharmacologic study of pralatrexate in combination with probenecid in adults with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Probenecid; Treatment Outcome

2006
A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, May-01, Volume: 13, Issue:9

    Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Dietary Supplements; Docetaxel; Female; Folic Acid Antagonists; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Neoplasms; Paclitaxel; Taxoids; Vitamins

2007
Novel high-performance liquid chromatographic assay using fluorescence detection for the quantitation of plasma gamma-methylene-10-deazaaminopterin and its major metabolite, 7-hydroxy-gamma-methylene-10-deazaaminopterin, in patients with solid cancers in
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Aug-01, Volume: 695, Issue:2

    Topics: Aminopterin; Antineoplastic Agents; Chromatography, High Pressure Liquid; Humans; Neoplasms; Pterins; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence

1997
Phase I and pharmacokinetic trial of aminopterin in patients with refractory malignancies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aminopterin; Area Under Curve; Biological Availability; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Humans; Injections, Intravenous; Leucovorin; Male; Middle Aged; Neoplasms; Treatment Outcome

1998
Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy.
    Investigational new drugs, 1998, Volume: 16, Issue:1

    Topics: Adult; Aged; Aminopterin; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cryotherapy; Exanthema; Female; Humans; Leukopenia; Male; Middle Aged; Mucous Membrane; Neoplasms; Vomiting

1998
High-dose edatrexate with oral leucovorin rescue: a phase I and clinical pharmacological study in adults with advanced cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:11

    Topics: Administration, Oral; Adult; Aged; Aminopterin; Antineoplastic Agents; Drug Interactions; Drug Monitoring; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasms

1996
Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:5

    Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Middle Aged; Neoplasms; Paclitaxel

1999
A Phase 1 study of high doses of aminopterin with leucovorin rescue in patients with advanced metastatic tumors.
    Cancer research, 1979, Volume: 39, Issue:9

    Topics: Aminopterin; Bone Marrow; Clinical Trials as Topic; Drug Administration Schedule; Humans; Kidney; Leucovorin; Leukopenia; Methotrexate; Neoplasm Metastasis; Neoplasms; Solubility

1979
Phase I trial and clinical pharmacological evaluation of 10-ethyl-10-deazaaminopterin in adult patients with advanced cancer.
    Cancer research, 1988, Oct-01, Volume: 48, Issue:19

    Topics: Adult; Aminopterin; Antimetabolites, Antineoplastic; Drug Evaluation; Half-Life; Humans; Neoplasms; Skin Neoplasms

1988

Other Studies

47 other study(ies) available for aminopterin and Neoplasms

ArticleYear
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
    Journal of medicinal chemistry, 1994, Apr-15, Volume: 37, Issue:8

    Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid; Folic Acid Antagonists; Humans; Liver; Methotrexate; Molecular Structure; Neoplasms; Pneumocystis; Rats; Recombinant Proteins; Structure-Activity Relationship; Thymidylate Synthase; Toxoplasma; Tumor Cells, Cultured

1994
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro.
    Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:5

    Topics: Aminopterin; Carbon-Nitrogen Ligases; Folic Acid Antagonists; HeLa Cells; Humans; Methotrexate; Neoplasms; Tumor Cells, Cultured

2014
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:5

    Topics: Aminopterin; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kinetics; Methotrexate; Neoplasms; Pemetrexed; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Xenograft Model Antitumor Assays

2009
Pralatrexate - from bench to bedside.
    Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46, Issue:2

    Topics: Aminopterin; Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Design; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Neoplasms

2010
Observations on the effects of the folic acid antagonists, aminopterin and amethopterin, in patients with advanced neoplasms.
    Cancer, 1952, Volume: 5, Issue:6

    Topics: Aminopterin; Folic Acid Antagonists; Methotrexate; Neoplasms

1952
New therapy for leukemia, polycythemia, and lymphoma.
    California medicine, 1953, Volume: 78, Issue:2

    Topics: Aminopterin; Chronic Disease; Hodgkin Disease; Humans; Leukemia; Lymphoma; Mechlorethamine; Multiple Myeloma; Neoplasms; Phlebotomy; Polycythemia; Triethylenemelamine; Urethane; X-Ray Therapy

1953
[Action of aminopterin (4-aminopteroylglutamic acid) on crown-gall tumors].
    Revue belge de pathologie et de medecine experimentale, 1952, Volume: 22, Issue:2

    Topics: Aminopterin; Crowns; Folic Acid Antagonists; Neoplasms; Plant Diseases; Plant Tumors

1952
Observations on ten patients with gastrointestinal cancer during the course of chemotherapy with dichloroaminopterin.
    Cancer, 1953, Volume: 6, Issue:4

    Topics: Aminopterin; Gastrointestinal Neoplasms; Gastrointestinal Tract; Humans; Neoplasms

1953
Further observations on the effects of cancer chemotherapeutic agents on the in vitro dehydrogenase activity of cancer tissue.
    Journal of the National Cancer Institute, 1954, Volume: 14, Issue:5

    Topics: Aminopterin; Antineoplastic Agents; In Vitro Techniques; Neoplasms; Oxidation-Reduction; Oxidoreductases; Triethylenemelamine; Urethane

1954
[Trial of chemotherapeutic control of inoperable bronchial carcinoma not suited for radiotherapy].
    Therapie der Gegenwart, 1957, Volume: 96, Issue:1

    Topics: Aminopterin; Bronchi; Bronchial Neoplasms; Carcinoma, Bronchogenic; Humans; Mercaptopurine; Neoplasms; Triethylenemelamine

1957
[Nitrogen mustards, triethylenethiophosphoramide, triethylene melamine & aminopterin in the treatment of advanced cancer].
    Revista de la Asociacion Medica Argentina, 1959, Volume: 73, Issue:4

    Topics: Aminopterin; Antineoplastic Agents; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Thiotepa; Triethylenemelamine

1959
The clinical effect of methotexate on tumors other than acute leukemia and choriocarcinoma.
    Cancer chemotherapy reports, 1961, Volume: 14

    Topics: Aminopterin; Antineoplastic Agents; Choriocarcinoma; Leukemia; Neoplasms

1961
Influences of anticancer agents on the activities of liver catalase, uricase, and xanthine oxidase in normal and tumor-bearing mice.
    Gan, 1963, Volume: 54

    Topics: Aminopterin; Animals; Antineoplastic Agents; Azaguanine; Carboxylic Acids; Carcinoma, Ehrlich Tumor; Catalase; Cyclopentanes; Liver; Mercaptopurine; Methotrexate; Mice; N-Glycosyl Hydrolases; Neoplasms; Oxidoreductases; Thiotepa; Urate Oxidase; Xanthine Oxidase

1963
Oral florid papillomatosis. Response to aminopterin.
    Archives of dermatology, 1963, Volume: 87

    Topics: Aminopterin; Humans; Mouth Neoplasms; Neoplasms; Papilloma

1963
MEDULLOBLASTOMA WITH EXTRACRANIAL METASTASES.
    Archives of neurology, 1963, Volume: 9

    Topics: Aminopterin; Antineoplastic Agents; Bone Neoplasms; Brain Neoplasms; Cerebellar Neoplasms; Child; Humans; Injections, Spinal; Medulloblastoma; Neoplasm Metastasis; Neoplasms; Neurosurgery; Neurosurgical Procedures; Pathology; Vincristine

1963
THE EFFECT OF CHEMOTHERAPEUTIC AGENTS UPON THE METABOLISM OF INTACT HUMAN CANCER CELLS: AN IN VITRO TECHNIC FOR CELL SENSITIVITY.
    Clinical chemistry, 1963, Volume: 102

    Topics: Aminopterin; Antineoplastic Agents; Azaguanine; Carbohydrate Metabolism; In Vitro Techniques; Lactates; Leukemia; Leukocytes; Mechlorethamine; Mercaptopurine; Metabolism; Neoplasms; Prednisone; Research; Thiotepa; Vinblastine

1963
MULTIPLE KERATOACANTHOMAS. A CASE STUDY OF THE ERUPTIVE TYPE WITH OBSERVATIONS ON PATHOGENESIS.
    Archives of dermatology, 1964, Volume: 89

    Topics: Aminopterin; Black People; Carcinoma; Carcinoma, Squamous Cell; Diagnosis, Differential; Foot Diseases; Hand Dermatoses; Histocytochemistry; Humans; Keratoacanthoma; Laryngeal Neoplasms; Methotrexate; Neoplasms; Pathology; Ultraviolet Rays

1964
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
    Minerva medica, 1963, Nov-03, Volume: 54

    Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Dactinomycin; Fibrosarcoma; Fluoresceins; Humans; Infusions, Parenteral; Injections, Intra-Arterial; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Melphalan; Neoplasms; Pharmacology; Thiotepa; Toxicology

1963
INFLUENCES OF ANTICANCER AGENTS ON THE METABOLISM OF DELTA-AMINOLEVULINIC ACID IN MORMAL AND TUMOR-BEARING MICE.
    Gan, 1964, Volume: 55

    Topics: Alkylating Agents; Amino Acids; Aminolevulinic Acid; Aminopterin; Animals; Antineoplastic Agents; Azaguanine; Blood Chemical Analysis; Carcinoma, Ehrlich Tumor; Catalase; Copper; Folic Acid Antagonists; Hemoglobins; Hydro-Lyases; Iron; Levulinic Acids; Liver; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Rats; Research

1964
CANCER CHEMOTHERAPY.
    Medical science, 1964, Volume: 15

    Topics: Adrenal Cortex Hormones; Aminopterin; Androgens; Antimetabolites; Antineoplastic Agents; Blood Platelet Disorders; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Cyclophosphamide; Dactinomycin; Estrogens; Fluorouracil; Geriatrics; Humans; Leukopenia; Mechlorethamine; Mercaptopurine; Neoplasms; Nitrogen Mustard Compounds; Surgical Procedures, Operative; Thiotepa; Toxicology; Vinblastine

1964
[LABORATORY TESTS FOR VERIFYING STATES OF FOLIC ACID DEFICIENCY IN THE ORGANISM].
    Recenti progressi in medicina, 1964, Volume: 36

    Topics: Aminopterin; Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood; Clinical Laboratory Techniques; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Lactobacillus; Leuconostoc; Liver Diseases; Methotrexate; Neoplasms; Nutrition Disorders; Pregnancy; Staphylococcus; Urine; Vitamin B Deficiency

1964
NEW PROBLEMS FOR SURGERY. DRUGS THAT ACT ON THE CELL NUCLEUS AFFECT THE SURGEON'S WORK ON CANCER AND ON TRANSPLANTATION.
    Science (New York, N.Y.), 1964, Apr-24, Volume: 144, Issue:3617

    Topics: Allergy and Immunology; Aminopterin; Antibody Formation; Antineoplastic Agents; Cell Nucleus; Humans; Kidney Transplantation; Mercaptopurine; Neoplasms; Surgeons; Transplantation; Transplantation Immunology

1964
[ON THE EFFECT OF GLUCOSE ON THE TOXIC AND THERAPEUTIC EFFECTS OF 1,6-DIBROMO-1,6-D-DIDESOXYMANNITOL IN ANIMAL EXPERIMENTS].
    Neoplasma, 1964, Volume: 11

    Topics: Aminopterin; Animal Experimentation; Animals; Antineoplastic Agents; Busulfan; Carcinoma, Ehrlich Tumor; Dactinomycin; Glucose; Mannitol; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 37; Sarcoma, Yoshida; Toxicology

1964
ANTICANCER AGENTS.
    Investigative ophthalmology, 1964, Volume: 3

    Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Corneal Transplantation; Drug Therapy; Eye Neoplasms; Female; Fluorouracil; Humans; Maternal-Fetal Exchange; Neoplasms; Nitrogen Mustard Compounds; Ophthalmology; Pregnancy; Pyrimethamine; Toxicology; Toxoplasmosis; Toxoplasmosis, Ocular; Transplantation Immunology; Uveitis

1964
SOME CHEMICAL INFLUENCES ON HAIR GROWTH AND PIGMENTATION.
    The British journal of dermatology, 1965, Volume: 77

    Topics: Alopecia; Aminopterin; Anticoagulants; Child; Chloroquine; Colchicine; Cyclophosphamide; Geriatrics; Hair; Humans; Mephenesin; Neoplasms; Pigmentation; Plant Poisoning; Poisoning; Thallium; Toxicology; Triparanol; Tyrosine Decarboxylase; Vitamin A

1965
ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS.
    Archives of pathology, 1965, Volume: 79

    Topics: Alkylating Agents; Aminopterin; Busulfan; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Mercaptopurine; Methotrexate; Multiple Myeloma; Neoplasms; Pathology; Primary Myelofibrosis; Sarcoma; Triethylenemelamine; Tuberculosis; Tuberculosis, Pulmonary; Urethane

1965
FAILURE OF THYMECTOMY TO ALTER THE SUBSEQUENT COURSE OF HUMAN ACUTE LEUKEMIA IN DRUG-INDUCED REMISSION.
    Blood, 1965, Volume: 26

    Topics: Acute Disease; Adolescent; Aminopterin; Child; Humans; Leukemia; Mercaptopurine; Neoplasms; Prednisone; Thymectomy

1965
Effect of aminopterin and certain purine antagonists on adenine nucleotide levels in tissues of tumor-bearing mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1955, Volume: 88, Issue:2

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Aminopterin; Animals; Mice; Neoplasms; Nucleotides; Purines

1955
Studies on the mechanism of action of chemotherapeutic agents in cancer. II. Requirements for the prevention of aminopterin toxicity by folic acid in mice.
    Cancer, 1950, Volume: 3, Issue:5

    Topics: Aminopterin; Animals; Antineoplastic Agents; Biomedical Research; Folic Acid; Folic Acid Antagonists; Mice; Neoplasms

1950
Studies on the mechanism of action of chemotherapeutic agents in cancer. V. Influence of the citrovorum factor and folic acid on the toxic manifestations of aminopterin in mice.
    Cancer, 1951, Volume: 4, Issue:3

    Topics: Aminopterin; Animals; Antineoplastic Agents; Cobalt; Folic Acid; Folic Acid Antagonists; Leadership; Leucovorin; Mice; Neoplasms

1951
Toxic reactions of 4-amino-pteroylglutamic acid (aminopterin) in patients with far-advanced neoplastic disease.
    Cancer, 1950, Volume: 3, Issue:3

    Topics: Aminopterin; Folic Acid; Humans; Neoplasms; Postoperative Complications

1950
The effect of aminopterin on the growth of carcinoma, sarcoma, and melanoma in animals.
    Cancer, 1949, Volume: 2, Issue:3

    Topics: Aminopterin; Animals; Carcinoma; Melanoma; Neoplasms; Sarcoma

1949
Bone marrow of mice bearing sarcoma 180 treated with 4-amino-pteroylglutamic acid and with 4-amino-N10-methyl-pteroylglutaminic acid.
    Cancer, 1949, Volume: 2, Issue:5

    Topics: Aminopterin; Animals; Bone and Bones; Bone Marrow; Bone Neoplasms; Folic Acid; Mice; Neoplasms; Sarcoma 180; Sarcoma, Experimental

1949
Bone-marrow changes in man after treatment with aminopterin, amethopterin, and aminoanfol; with special reference to megaloblastosis and tumor remission.
    Cancer, 1949, Volume: 2, Issue:5

    Topics: Aminopterin; Bone Marrow; Humans; Male; Methotrexate; Neoplasms

1949
Aminopterin--iodine-131, a folate antagonist. Preparation, distribution, and scanning in man.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1967, Volume: 8, Issue:5

    Topics: Aminopterin; Humans; Iodine Isotopes; Kidney; Liver; Neoplasms; Radionuclide Imaging; Spleen; Thyroid Gland

1967
Determination of methotrexate in serum by a rapid, fully mechanized enzyme immunoassay (EMIT).
    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1980, Volume: 18, Issue:3

    Topics: Adult; Aminopterin; Autoanalysis; Costs and Cost Analysis; Female; Humans; Immunoenzyme Techniques; Kinetics; Methotrexate; Neoplasms; Osteosarcoma

1980
Clinical trials referral resource. Clinical trials using edatrexate.
    Oncology (Williston Park, N.Y.), 1993, Volume: 7, Issue:7

    Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Female; Humans; Male; Neoplasms

1993
Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?
    Journal of the National Cancer Institute, 1999, Jul-21, Volume: 91, Issue:14

    Topics: Aminopterin; Animals; Antineoplastic Agents; Clone Cells; Folic Acid Antagonists; Genetic Therapy; Humans; Neoplasms; Peptide Synthases; Polyglutamic Acid; Tumor Cells, Cultured

1999
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
    Journal of the National Cancer Institute, 1999, Jul-21, Volume: 91, Issue:14

    Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Chromatography, Thin Layer; Dogs; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Methotrexate; Neoplasms; Peptide Synthases; Rats; Transduction, Genetic; Transfection; Tumor Cells, Cultured

1999
Transient induction of a nuclear antigen unrelated to Epstein-Barr nuclear antigen in cells of two human B-lymphoma lines converted by Epstein-Barr virus.
    Proceedings of the National Academy of Sciences of the United States of America, 1977, Volume: 74, Issue:1

    Topics: Aminopterin; Antigens, Neoplasm; Antigens, Viral; Burkitt Lymphoma; Cell Line; Cell Nucleus; Herpesvirus 4, Human; Hypoxanthines; Idoxuridine; Kinetics; Neoplasms; Virus Replication

1977
Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites.
    Analytical biochemistry, 1985, Volume: 150, Issue:1

    Topics: Aminopterin; Animals; Chromatography, High Pressure Liquid; Humans; Leukemia L1210; Mice; Mice, Nude; Neoplasms; Polyglutamic Acid; Spectrometry, Fluorescence

1985
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
    Cancer research, 1985, Volume: 45, Issue:4

    Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay

1985
Transplacental chemical carcinogenesis in man.
    Journal of the National Cancer Institute, 1971, Volume: 47, Issue:6

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Chloramphenicol; Diethylstilbestrol; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Maternal-Fetal Exchange; Methotrexate; Mice; Neoplasms; Neoplasms, Muscle Tissue; Phenytoin; Pregnancy; Uterine Cervical Neoplasms; Vaginal Neoplasms

1971
Irreversible enzyme inhibitors. LXXXVI. Hydrophobic bonding to dihydrofolic reductase. 8. Substituted-1-aryl-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines.
    Journal of pharmaceutical sciences, 1967, Volume: 56, Issue:6

    Topics: Aminopterin; Chemistry, Organic; Enzymes; Folic Acid; Neoplasms; Organic Chemistry Phenomena; Tetrahydrofolate Dehydrogenase; Triazines

1967
Studies on the isolation and properties of drug resistant mutants from a human malignant cell line.
    Indian journal of cancer, 1968, Volume: 5, Issue:3

    Topics: Aminopterin; Azaguanine; Cell Line; Culture Techniques; Humans; Mutation; Neoplasms

1968
131-I-3'-iodoaminopterin: a gamma-labeled active-site-directed enzyme inhibitor.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1968, Volume: 9, Issue:10

    Topics: Adult; Aged; Aminopterin; Binding Sites; Chromatography; Female; Folic Acid Antagonists; Humans; Injections, Intravenous; Iodine Isotopes; Kidney; Liver; Male; Methods; Methotrexate; Neoplasms; Radionuclide Imaging; Tetrahydrofolate Dehydrogenase; Thyroid Gland

1968