Page last updated: 2024-09-05

aminopterin and Carcinoma, Non-Small Cell Lung

aminopterin has been researched along with Carcinoma, Non-Small Cell Lung in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.85)	18.7374
1990's	16 (61.54)	18.2507
2000's	5 (19.23)	29.6817
2010's	4 (15.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Evande, RE; Grem, JL; Kos, ME; Meza, JL; Schwarz, JK	1
Molina, JR	1
O'Connor, O; Zain, J	1
Azzoli, CG; Dunne, M; Ginsberg, M; Huntington, M; James, L; Kris, MG; Krug, LM; May, J; Miller, V; Patel, JD; Saunders, M; Sirotnak, FM; Subzwari, S; Tyson, L	1
Albert, I; Azzoli, CG; Bodkin, D; Iannotti, NO; Jiang, PY; Juhász, E; Kelly, K; Koutsoukos, T; Patel, JD; Pereira, JR; Weems, G; Zatloukal, P	1
Azzoli, CG; Baez, V; Ginsberg, MS; Khokhar, NZ; Kris, MG; Krug, LM; Miller, VA; Ng, KK; Pizzo, B; Sirotnak, FM; Tong, W; Tyson, L; Venkatraman, E	1
Gralla, RJ	1
Cheson, B; Christian, M; Feigal, EG; Friedman, MA; Grever, M	1
Grant, SC; Kris, MG	1
Klastersky, J	1
Grant, SC; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR	1
Chou, TC; Fletcher, TS; Hack, FM; Perez, EA	1
Allen, R; Harland, SJ; Hartley, JM; Lamond, P; Nicholson, PW; Souhami, RL	1
Edelman, MJ; Gandara, DR	1
Crowley, JJ; Edelman, MJ; Gandara, DR; Lau, DH; Livingston, RB	1
Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM	1
Grant, SC; Heelan, RT; Kelly, J; Kris, MG; Krug, LM; Leon, L; Leung, D; Miller, VA; Ng, KK; Sirotnak, FM; Tong, W	1
Chronowski, G; Heelan, RT; Kris, MG; Laurie, SA; Pfister, DG; Pisters, KM; Sirotnak, FM; Tong, WP	1
Colon-Otero, G; Geyer, S; Hillman, SH; Jett, JJ; Krook, JE; Marks, RS; Niedringhaus, RD; Sloan, J; Tschetter, LK; Wiesenfeld, M; Windschitl, HE	1
Dimery, IW; Fossella, FV; Glisson, BS; Hong, WK; Lee, JS; Libshitz, HI; Lippman, SM; Murphy, WK; Pang, AC; Shin, DM	2
Allen, R; Harper, PG; Lamond, P; Rudd, RM; Souhami, RL; Spiro, SG	1
Hong, WK; Lee, JS; Murphy, WK; Pang, A; Shirinian, MH	1
Hong, WK; Jeffries, D; Lee, JS; Libshitz, HI; Murphy, WK	1
Burke, MT; Gralla, RJ; Heelan, RT; Kris, MG; Marks, LD; Shum, KY	1

Reviews

8 review(s) available for aminopterin and Carcinoma, Non-Small Cell Lung

Article	Year
Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies. IDrugs : the investigational drugs journal, 2008, Volume: 11, Issue:7 Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin	2008
Pralatrexate: basic understanding and clinical development. Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:10 Topics: Aminopterin; Animals; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Lung Neoplasms; Lymphoma; Neoplasms	2010
Edatrexate studies in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 1995, Volume: 12 Suppl 1 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Folic Acid Antagonists; Humans; Lung Neoplasms	1995
New chemotherapeutic agents in non-small-cell lung cancer. Seminars in oncology, 1993, Volume: 20, Issue:2 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Design; Humans; Interferons; Irinotecan; Lung Neoplasms; Paclitaxel; Topotecan; Vinblastine; Vinorelbine	1993
New antineoplastic agents in lung cancer 1988-1993. Cancer treatment and research, 1995, Volume: 72 Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Humans; Irinotecan; Lung Neoplasms; Nitrosourea Compounds; Organophosphorus Compounds; Paclitaxel; Teniposide; Vinblastine; Vinorelbine	1995
New drug for therapy of non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands), 1994, Volume: 11 Suppl 3 Topics: Aminopterin; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine	1994
New chemotherapeutic agents for non-small cell lung cancer. Chest, 1995, Volume: 107, Issue:6 Suppl Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Quinoxalines; Sulfanilamides; Taxoids; Topotecan; Vinblastine; Vinorelbine	1995
Promising new agents in the treatment of non-small cell lung cancer. Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:5 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine	1996

Trials

11 trial(s) available for aminopterin and Carcinoma, Non-Small Cell Lung

Article	Year
A phase 1 clinical trial of sequential pralatrexate followed by a 48-hour infusion of 5-fluorouracil given every other week in adult patients with solid tumors. Cancer, 2015, Nov-01, Volume: 121, Issue:21 Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Incidence; Male; Middle Aged; Mucositis; Pancreatic Neoplasms; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Time Factors; Treatment Outcome	2015
Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2011, Volume: 6, Issue:11 Topics: Adenocarcinoma; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Prognosis; Tissue Distribution; Vitamin B 12; Vitamin B Complex	2011
Randomized phase 2b study of pralatrexate versus erlotinib in patients with stage IIIB/IV non-small-cell lung cancer (NSCLC) after failure of prior platinum-based therapy. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2012, Volume: 7, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Dose-Response Relationship, Drug; ErbB Receptors; Erlotinib Hydrochloride; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Platinum; Protein Kinase Inhibitors; Quinazolines; Retrospective Studies; Survival Rate; Treatment Failure; United States	2012
10-propargyl-10-deazaaminopterin: an antifolate with activity in patients with previously treated non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:6 Topics: Adult; Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Female; Folic Acid Antagonists; Homocysteine; Humans; Lung Neoplasms; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; RNA, Messenger	2003
Phase II trial of edatrexate plus carboplatin in metastatic non-small-cell lung cancer: a Southwest Oncology Group study. Cancer chemotherapy and pharmacology, 1997, Volume: 41, Issue:1 Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mouth Mucosa; Neutropenia; Survival Analysis; Treatment Outcome	1997
Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:9 Topics: Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged	2000
Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:3 Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Time Factors; Treatment Outcome	2001
A phase II trial of edatrexate, vinblastine, adriamycin, cisplastin, and filgrastim (EVAC/G-CSF) in patients with non-small-cell carcinoma of the lungs: a North Central Cancer Treatment Group Trial. American journal of clinical oncology, 2001, Volume: 24, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Doxorubicin; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Male; Middle Aged; Recombinant Proteins; Remission Induction; Sickness Impact Profile; Survival Analysis; Vinblastine	2001
Improved therapeutic index by leucovorin of edatrexate, cyclophosphamide, and cisplatin regimen for non-small-cell lung cancer. Journal of the National Cancer Institute, 1992, Jul-01, Volume: 84, Issue:13 Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cyclophosphamide; Drug Administration Schedule; Drug Evaluation; Humans; Leucovorin; Lung Neoplasms	1992
Phase II study of Edatrexate in stage III and IV non-small-cell lung cancer. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:6 Topics: Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Neoplasm Staging	1992
Edatrexate improves the antitumor effects of cyclophosphamide and cisplatin against non-small cell lung cancer. Cancer, 1991, Sep-01, Volume: 68, Issue:5 Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Drug Synergism; Female; Humans; Lung Neoplasms; Male; Middle Aged	1991

Other Studies

7 other study(ies) available for aminopterin and Carcinoma, Non-Small Cell Lung

Article	Year
Modulation of intrinsic in vitro resistance to carboplatin by edatrexate in the A549 human nonsmall cell lung cancer cell line. Oncology research, 1994, Volume: 6, Issue:3 Topics: Aminopterin; Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Humans; Kinetics; Lung Neoplasms; Time Factors; Tumor Cells, Cultured	1994
Pharmacokinetics of 10-ethyl-10-deaza-aminopterin, edatrexate, given weekly for non-small-cell lung cancer. Cancer chemotherapy and pharmacology, 1993, Volume: 31, Issue:4 Topics: Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chromatography, High Pressure Liquid; Creatinine; Half-Life; Humans; Lung Neoplasms; Metabolic Clearance Rate	1993
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice. Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:4 Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Nude; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1998
Alleviation by leucovorin of the dose-limiting toxicity of edatrexate: potential for improved therapeutic efficacy. Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:3 Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance; Female; Folic Acid Antagonists; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Stomatitis	1991
An important new drug and regimen for non-small-cell lung Ca. Oncology (Williston Park, N.Y.), 1990, Volume: 4, Issue:10 Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Mitomycins; Vinblastine	1990
Phase II study of 10-ethyl-10-deaza-aminopterin (10-EdAM; CGP 30 694) for stage IIIB or IV non-small cell lung cancer. Investigational new drugs, 1990, Volume: 8, Issue:3 Topics: Adult; Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pleural Effusion	1990
Phase II study of 10-ethyl-10-deaza-aminopterin in patients with stage III and IV non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:3 Topics: Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging	1988