Page last updated: 2024-09-05

aminopterin and Acute Lymphoid Leukemia

aminopterin has been researched along with Acute Lymphoid Leukemia in 16 studies

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (31.25)	18.2507
2000's	8 (50.00)	29.6817
2010's	2 (12.50)	24.3611
2020's	1 (6.25)	2.80

Authors

Authors	Studies
Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ	1
Ribera Santasusana, JM	1
Beckwith, KA; Cole, PD; Kamen, BA; Roychowdhury, S; Smith, AK; Vijayanathan, V	1
Hall, CP; Harutyunyan, N; Kang, MH; Lock, RB; Papa, RA	1
Bertino, JR	1
Ribatti, D	1
Mathews, CK	1
Alcaraz, MJ; Cole, PD; Kamen, BA; Smith, AK; Tan, J; Zebala, JA	1
Cate, S; Cole, PD; Drachtman, RA; Hawkins, DS; Holcenberg, J; Kamen, BA; Kelly, K; Larson, RA; Smith, AK	1
Cole, PD; Drachtman, RA; Drapala, DA; Glod, J; Kamen, BA; Lisi, S; Masterson, M; Smith, AK; Zebala, JA	1
Burton, A	1
Cole, PD; Kamen, BA; Smith, AK; Vijayanathan, V; Zebala, JA	1
Erlich, R; Koren, G; Lishner, M; Zemlickis, D	1
Hum, M; Kamen, BA; Smith, A; Winick, NJ	1
Bolanowska, WE; Freitag, CM; Jones, CS; Kalman, TI; McGuire, JJ; Russell, CA	1

Reviews

2 review(s) available for aminopterin and Acute Lymphoid Leukemia

Article	Year
Cancer research: from folate antagonism to molecular targets. Best practice & research. Clinical haematology, 2009, Volume: 22, Issue:4 Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase	2009
Sidney Farber and the treatment of childhood acute lymphoblastic leukemia with a chemotherapeutic agent. Pediatric hematology and oncology, 2012, Volume: 29, Issue:4 Topics: Aminopterin; Antineoplastic Agents; Child; Child, Preschool; Folic Acid Antagonists; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2012

Trials

2 trial(s) available for aminopterin and Acute Lymphoid Leukemia

Article	Year
Phase II trial of oral aminopterin for adults and children with refractory acute leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Nov-15, Volume: 11, Issue:22 Topics: Administration, Oral; Adolescent; Adult; Aged; Aminopterin; Area Under Curve; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome	2005
Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:1 Topics: Adolescent; Aminopterin; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Diseases; Child; Child, Preschool; Drug Overdose; Erythrocytes; Female; Fever; Folic Acid Antagonists; Gastrointestinal Diseases; Humans; Leucovorin; Male; Methotrexate; Neurotoxicity Syndromes; Pilot Projects; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome	2008

Article

Year

Phase II trial of oral aminopterin for adults and children with refractory acute leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Nov-15, Volume: 11, Issue:22

Topics: Administration, Oral; Adolescent; Adult; Aged; Aminopterin; Area Under Curve; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2005

Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia.

Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:1

Topics: Adolescent; Aminopterin; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Diseases; Child; Child, Preschool; Drug Overdose; Erythrocytes; Female; Fever; Folic Acid Antagonists; Gastrointestinal Diseases; Humans; Leucovorin; Male; Methotrexate; Neurotoxicity Syndromes; Pilot Projects; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome

2008

Other Studies

12 other study(ies) available for aminopterin and Acute Lymphoid Leukemia

Article	Year
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19 Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured	1995
Acute lymphoblastic leukemia: From aminopterin to CAR T cells. Medicina clinica, 2020, 04-10, Volume: 154, Issue:7 Topics: Aminopterin; Humans; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Chimeric Antigen; T-Lymphocytes	2020
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia. Pediatric neurology, 2009, Volume: 40, Issue:1 Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult	2009
Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma. British journal of haematology, 2009, Volume: 145, Issue:3 Topics: Aminopterin; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Lymphoma; Methotrexate; Mice; Mice, SCID; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Regression Analysis; Xenograft Model Antitumor Assays	2009
DNA synthesis as a therapeutic target: the first 65 years. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:6 Topics: Aminopterin; Antimetabolites, Antineoplastic; DNA Replication; Fluorouracil; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Hydroxyurea; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase	2012
Pharmacodynamic properties of methotrexate and Aminotrexate during weekly therapy. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:6 Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Folic Acid Antagonists; Humans; Infant; Male; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tissue Distribution	2006
Aminopterin might be safe in ALL. The Lancet. Oncology, 2007, Volume: 8, Issue:10 Topics: Adolescent; Adult; Aminopterin; Child; Child, Preschool; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2007
High-performance liquid chromatography separation of aminopterin-polyglutamates within red blood cells of children treated for acute lymphoblastic leukemia. Translational research : the journal of laboratory and clinical medicine, 2007, Volume: 150, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aminopterin; Antineoplastic Agents; Child; Child, Preschool; Chromatography, High Pressure Liquid; Erythrocytes; Folic Acid Antagonists; Humans; Infant; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Tissue Distribution	2007
Teratogenicity and carcinogenicity in a twin exposed in utero to cyclophosphamide. Teratogenesis, carcinogenesis, and mutagenesis, 1993, Volume: 13, Issue:3 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adrenal Gland Neoplasms; Adult; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Papillary; Cyclophosphamide; Diseases in Twins; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Mercaptopurine; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pregnancy; Pregnancy Complications, Neoplastic; Prenatal Exposure Delayed Effects; Thyroid Neoplasms; Time Factors; Twins, Dizygotic; Vincristine	1993
Clinical trials renew interest in old drug for children with leukemia. Oncology (Williston Park, N.Y.), 1996, Volume: 10, Issue:5 Topics: Aminopterin; Child; Clinical Protocols; Folic Acid Antagonists; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United States	1996
A case for the use of aminopterin in treatment of patients with leukemia based on metabolic studies of blasts in vitro. Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:1 Topics: Aminopterin; Cells, Cultured; Child; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1996
Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group. Cancer research, 1990, Mar-15, Volume: 50, Issue:6 Topics: Aminopterin; Animals; Biological Transport; Cell Division; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	1990