Page last updated: 2024-10-21

aminopropionitrile and Cicatrix

aminopropionitrile has been researched along with Cicatrix in 26 studies

Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.

Cicatrix: The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.

Research Excerpts

ExcerptRelevanceReference
"(1) No toxic signs or symptoms and no unusual laboratory determinations were observed in five patients with posterior urethral strictures treated by dilatation of the urethra and administration of 1 gm per day of beta-aminopropionitrile (BAPN) for twenty-one days."9.04Administration of beta-aminopropionitrile to human beings with urethral strictures: A prelimary report. ( Madden, JW; Peacock, EE, 1978)
"Beta-aminopropionitrile fumarate, an inhibitor of collagen cross-linking, was used topically in patients after filtration surgery for difficult cases of glaucoma (aphakic, repeat surgery, neovascular)."7.67Effects of beta-aminopropionitrile after glaucoma filtration surgery: pilot human trial. ( Kimbrough, R; Moorhead, LC; Smith, J; Stewart, R, 1987)
"(1) No toxic signs or symptoms and no unusual laboratory determinations were observed in five patients with posterior urethral strictures treated by dilatation of the urethra and administration of 1 gm per day of beta-aminopropionitrile (BAPN) for twenty-one days."5.04Administration of beta-aminopropionitrile to human beings with urethral strictures: A prelimary report. ( Madden, JW; Peacock, EE, 1978)
" The most advanced research involves prevention of the development of helical structure and transport of collagen by administration of proline analogues and controlled induction of lathyrism by administration of Beta-aminopropionitrile."4.75Pharmacological control of surgical scar tissue. ( Peacock, EE, 1978)
"Beta-aminopropionitrile fumarate, an inhibitor of collagen cross-linking, was used topically in patients after filtration surgery for difficult cases of glaucoma (aphakic, repeat surgery, neovascular)."3.67Effects of beta-aminopropionitrile after glaucoma filtration surgery: pilot human trial. ( Kimbrough, R; Moorhead, LC; Smith, J; Stewart, R, 1987)
" Ten patients with massive keloids, resistant to conventional therapy by excision, grafting, and/or intralesional injection of steroids, have been treated by excising the keloid, grafting the defect, inducing lathyrism with Beta aminopropionitrile fumurate or penicillamine and administering colchicine."3.66Pharmacologic control of surface scarring in human beings. ( Peacock, EE, 1981)
"Analysis of the area of scar and the intensity of stain was performed with Mocha image analysis software."1.30Pharmacologic inhibition of collagen in an experimental model of subglottic stenosis. ( Doolin, EJ; Santos, MC; Strande, LF; Tsuno, K, 1998)
"Pharmacologic inhibition of scar formation minimized distortion and contracture of intracardiac prosthetic patches and decreased adhesions."1.27Pharmacologic inhibition of scar contracture of intracardiac prosthetic patches. ( Doolin, EJ; Miginsky, MP; Moulton, AL; Richards, WO, 1984)
"In other situations, as in the treatment of keloids, physicians may wish to introduce drugs known to reduce scar formation into the biologic environment in which wound healing ensues."1.26Wound healing: a review. IV. Systemic medications affecting wound healing. ( Pollack, SV, 1982)
"Histological evaluation of the treated scar tissue was consistent with lathyrism."1.26Inhibition of collagen cross-linking: a new approach to ocular scarring. ( Moorhead, LC, 1981)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199025 (96.15)18.7374
1990's1 (3.85)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Richards, WO1
Doolin, EJ2
Miginsky, MP1
Moulton, AL1
Pollack, SV1
Peacock, EE12
Moorhead, LC2
Tsuno, K1
Strande, LF1
Santos, MC1
Madden, JW2
Jackson, DS1
Labandter, H1
Diegelmann, R1
Cohen, IK2
Arem, AJ1
Rasmussen, D1
Chvapil, M4
Gibeault, JD1
Cravens, RB1
Camus, JP1
Koeger, AC1
Smith, J1
Stewart, R1
Kimbrough, R1
Arem, A1
Speer, DP2
Feldman, S1
Bora, FW1
Lane, JM1
Prockop, DJ1
Brendel, K1
Weiner, LJ1
Davis, WM1
Balis, JU1
Chan, AS1
Conen, PE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma[NCT00307606]Phase 440 participants (Anticipated)Interventional2005-12-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for aminopropionitrile and Cicatrix

ArticleYear
Pharmacological control of surgical scar tissue.
    The American surgeon, 1978, Volume: 44, Issue:11

    Topics: Aminopropionitrile; Animals; Cicatrix; Colchicine; Collagen; Connective Tissue; Humans; Lathyrism; P

1978
Possible modification of scar tissue by biochemical methods.
    Equine veterinary journal, 1979, Volume: 11, Issue:2

    Topics: Aminopropionitrile; Animals; Cicatrix; Collagen; Cortisone; Humans; Hydroxylysine; Hydroxyproline; L

1979
[D-penicillamine and collagen].
    Annales de biologie clinique, 1986, Volume: 44, Issue:3

    Topics: Aminopropionitrile; Arthritis, Rheumatoid; Autoantibodies; Bronchi; Cicatrix; Collagen; Collagen Dis

1986
Collagen modifications.
    Clinics in plastic surgery, 1985, Volume: 12, Issue:2

    Topics: Aminopropionitrile; Animals; Antigens; Biocompatible Materials; Biological Dressings; Cicatrix; Coll

1985
Biology of wound repair.
    Life sciences, 1973, Aug-16, Volume: 13, Issue:4

    Topics: Aminopropionitrile; Cicatrix; Collagen; Connective Tissue; Dactinomycin; Epithelium; Fibroblasts; Hu

1973
Biologic principles affecting repair of flexor tendons.
    Advances in surgery, 1971, Volume: 5

    Topics: Adult; Aminopropionitrile; Blood Vessels; Child, Preschool; Cicatrix; Collagen; Connective Tissue; C

1971

Trials

1 trial available for aminopropionitrile and Cicatrix

ArticleYear
Administration of beta-aminopropionitrile to human beings with urethral strictures: A prelimary report.
    American journal of surgery, 1978, Volume: 136, Issue:5

    Topics: Aminopropionitrile; Cicatrix; Clinical Trials as Topic; Collagen; Drug Evaluation; Drug Hypersensiti

1978

Other Studies

19 other studies available for aminopropionitrile and Cicatrix

ArticleYear
Pharmacologic inhibition of scar contracture of intracardiac prosthetic patches.
    The Journal of surgical research, 1984, Volume: 37, Issue:1

    Topics: Aminopropionitrile; Animals; Bioprosthesis; Blood Vessel Prosthesis; Cicatrix; Contracture; Dogs; He

1984
Wound healing: a review. IV. Systemic medications affecting wound healing.
    The Journal of dermatologic surgery and oncology, 1982, Volume: 8, Issue:8

    Topics: Adrenal Cortex Hormones; Aminopropionitrile; Animals; Anti-Inflammatory Agents; Anticoagulants; Anti

1982
Pharmacologic control of surface scarring in human beings.
    Annals of surgery, 1981, Volume: 193, Issue:5

    Topics: Adolescent; Adult; Aged; Aminopropionitrile; Child; Cicatrix; Colchicine; Drug Administration Schedu

1981
Control of wound healing and scar formation in surgical patients.
    Archives of surgery (Chicago, Ill. : 1960), 1981, Volume: 116, Issue:10

    Topics: Adolescent; Aminopropionitrile; Animals; Child; Cicatrix; Colchicine; Collagen; Dermatologic Surgica

1981
Inhibition of collagen cross-linking: a new approach to ocular scarring.
    Current eye research, 1981, Volume: 1, Issue:2

    Topics: Aminopropionitrile; Animals; Cicatrix; Collagen; Conjunctiva; Disease Models, Animal; Rabbits; Wound

1981
Pharmacologic inhibition of collagen in an experimental model of subglottic stenosis.
    The Annals of otology, rhinology, and laryngology, 1998, Volume: 107, Issue:4

    Topics: Aminopropionitrile; Animals; Anti-Inflammatory Agents; Cicatrix; Collagen; Dexamethasone; Dogs; Glot

1998
Some biologic and technical considerations in the repair of long tendons.
    The Orthopedic clinics of North America, 1977, Volume: 8, Issue:2

    Topics: Aminopropionitrile; Animals; Cadaver; Cicatrix; Collagen; Connective Tissue; Dogs; Fingers; Foreign-

1977
Potentiation of colchicine-induced collagenolysis.
    Surgical forum, 1978, Volume: 29

    Topics: Aminopropionitrile; Animals; Cicatrix; Colchicine; Collagen; Drug Therapy, Combination; Female; Prol

1978
Monoamine oxidase inhibition during control of scar formation.
    Surgical forum, 1977, Volume: 28

    Topics: Aminopropionitrile; Animals; Cicatrix; Pargyline; Rats; Wound Healing

1977
Pharmacology of fibrosis: definitions, limits and perspectives.
    Life sciences, 1975, May-01, Volume: 16, Issue:9

    Topics: Aminopropionitrile; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid Deficiency; Biopo

1975
Transport of beta-aminopropionitrile through intact skin or scar tissue.
    The Journal of surgical research, 1989, Volume: 47, Issue:2

    Topics: Absorption; Administration, Cutaneous; Aminopropionitrile; Animals; Carbon Radioisotopes; Cicatrix;

1989
Effects of beta-aminopropionitrile after glaucoma filtration surgery: pilot human trial.
    Annals of ophthalmology, 1987, Volume: 19, Issue:6

    Topics: Administration, Topical; Adult; Aminopropionitrile; Cicatrix; Glaucoma; Humans; Intraocular Pressure

1987
Can collagen metabolism be controlled: theoretical considerations.
    The Journal of trauma, 1985, Volume: 25, Issue:5

    Topics: Aminopropionitrile; Animals; Burns; Cicatrix; Collagen; Humans; Lysine; Proline; Wound Healing

1985
The control of peritendinous adhesions using topical beta-aminopropionitrile base.
    The Journal of surgical research, 1985, Volume: 38, Issue:3

    Topics: Administration, Topical; Aminopropionitrile; Animals; Biomechanical Phenomena; Chickens; Cicatrix; C

1985
Inhibitors of collagen biosynthesis as a means of controlling scar formation in tendon injury.
    The Journal of bone and joint surgery. American volume, 1972, Volume: 54, Issue:7

    Topics: Aminopropionitrile; Animals; Chelating Agents; Cicatrix; Collagen; Hindlimb; Hydroxyproline; Penicil

1972
Use of large-molecular-weight compounds to produce local lathyrism in healing wounds.
    Surgical forum, 1973, Volume: 24

    Topics: Aminopropionitrile; Animals; Chick Embryo; Cicatrix; Disease Models, Animal; Lathyrism; Penicillamin

1973
Prevention of esophageal stenosis with induced lathyrism.
    Surgical forum, 1971, Volume: 22

    Topics: Aminopropionitrile; Animals; Cicatrix; Collagen; Dogs; Esophageal Stenosis; Granulation Tissue; Lath

1971
The effect of postlathyritic medial scar on the progression of experimental atherosclerosis in rats.
    Experimental and molecular pathology, 1968, Volume: 8, Issue:1

    Topics: Aminopropionitrile; Animal Nutritional Physiological Phenomena; Animals; Aorta; Arteriosclerosis; Ba

1968
Symposium on biological control of scar tissue.
    Plastic and reconstructive surgery, 1968, Volume: 41, Issue:1

    Topics: Aminopropionitrile; Animals; Cicatrix; Collagen; Humans; Hydroxyproline; Nitriles; Penicillamine; Ri

1968